{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T07:04:16Z","timestamp":1779087856928,"version":"3.51.4"},"reference-count":209,"publisher":"Impact Journals, LLC","issue":"26","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2016,6,28]]},"DOI":"10.18632\/oncotarget.8396","type":"journal-article","created":{"date-parts":[[2016,3,27]],"date-time":"2016-03-27T16:54:13Z","timestamp":1459097653000},"page":"40860-40881","source":"Crossref","is-referenced-by-count":68,"title":["Neuraminidase-1: A novel therapeutic target in multistage tumorigenesis"],"prefix":"10.18632","volume":"7","author":[{"given":"Fiona","family":"Haxho","sequence":"first","affiliation":[{"name":"Departments of Biomedical and Molecular Sciences, Kingston, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald J.","family":"Neufeld","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Queen's University, Kingston, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myron R.","family":"Szewczuk","sequence":"additional","affiliation":[{"name":"Departments of Biomedical and Molecular Sciences, Kingston, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2016,3,27]]},"reference":[{"issue":"7","key":"1","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/nrgastro.2009.89","article-title":"Pancreatic cancer: molecular pathogenesis and new therapeutic targets","volume":"6","author":"Lemoine","year":"2009","journal-title":"Nature reviews Gastroenterology & hepatology"},{"issue":"7","key":"2","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.2217\/fon.10.70","article-title":"Novel therapies for pancreatic cancer: setbacks and progress","volume":"6","author":"Lemoine","year":"2010","journal-title":"Future oncology"},{"issue":"14","key":"3","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1200\/JCO.2003.01.504","article-title":"Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer","volume":"21","author":"Baselga","year":"2003","journal-title":"J Clin Oncol"},{"issue":"24","key":"4","doi-asserted-by":"crossref","first-page":"7242","DOI":"10.1158\/1078-0432.CCR-06-0646","article-title":"Molecular mechanisms of epidermal growth factor receptor (EGFR) activation and response to gefitinib and other EGFR-targeting drugs","volume":"12","author":"Kuwano","year":"2006","journal-title":"Clinical cancer research"},{"issue":"10","key":"5","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1056\/NEJMe0905763","article-title":"Personalized medicine and inhibition of EGFR signaling in lung cancer","volume":"361","author":"Gazdar","year":"2009","journal-title":"The New England journal of medicine"},{"issue":"Suppl 1","key":"6","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1038\/onc.2009.198","article-title":"Activating and resistance mutations of EGFR in non-small-cell lung cancer: role in clinical response to EGFR tyrosine kinase inhibitors","volume":"28","author":"Gazdar","year":"2009","journal-title":"Oncogene"},{"issue":"10","key":"7","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1002\/dneu.20506","article-title":"PI3K\/Akt and CREB regulate adult neural hippocampal progenitor proliferation and differentiation","volume":"67","author":"Schaffer","year":"2007","journal-title":"Developmental neurobiology"},{"issue":"2","key":"8","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.abb.2007.04.015","article-title":"Stimulation of phosphoinositide 3-kinase\/Akt signaling by copper and zinc ions: mechanisms and consequences","volume":"463","author":"Klotz","year":"2007","journal-title":"Arch Biochem Biophys"},{"issue":"19","key":"9","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.2174\/092986707781368423","article-title":"Targeting the phosphatidylinositol 3-kinase\/Akt\/mammalian target of rapamycin module for acute myelogenous leukemia therapy: from bench to bedside","volume":"14","author":"Cocco","year":"2007","journal-title":"Current medicinal chemistry"},{"issue":"1","key":"10","first-page":"245","article-title":"Epidermal Growth Factor-induced Cell Death and Radiosensitization in Epidermal Growth Factor Receptor-overexpressing Cancer Cell Lines","volume":"35","author":"Jeon","year":"2015","journal-title":"Anticancer Res"},{"key":"11","article-title":"Natural inhibitors of PI3K\/AKT signaling in breast cancer: Emphasis on newly-discovered molecular mechanisms of action","author":"Farajnia","year":"2014","journal-title":"Pharmacol Res"},{"key":"12","article-title":"Sonic Hedgehog and Gli1 expression predict outcome in resected pancreatic adenocarcinoma","author":"Jean-Christophe","year":"2014","journal-title":"Clinical cancer research"},{"key":"13","article-title":"Lipid rafts as major platforms for signaling regulation in cancer","author":"Gajate","year":"2014","journal-title":"Advances in biological regulation"},{"issue":"3","key":"14","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1042\/BJ20131176","article-title":"Insulin-stimulated leptin secretion requires calcium and PI3K\/Akt activation","volume":"458","author":"Han","year":"2014","journal-title":"Biochem J"},{"key":"15","doi-asserted-by":"crossref","first-page":"255","DOI":"10.2147\/DDDT.S53568","article-title":"Insulin induces drug resistance in melanoma through activation of the PI3K\/Akt pathway","volume":"8","author":"Chen","year":"2014","journal-title":"Drug design, development and therapy"},{"issue":"6","key":"16","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s40256-014-0089-9","article-title":"The Cardioprotection of the Insulin-Mediated PI3K\/Akt\/mTOR Signaling Pathway","volume":"14","author":"Han","year":"2014","journal-title":"American journal of cardiovascular drugs : drugs, devices, and other interventions"},{"issue":"9","key":"17","doi-asserted-by":"crossref","first-page":"948","DOI":"10.7150\/ijbs.6426","article-title":"Glutamate, glutamate receptors, and downstream signaling pathways","volume":"9","author":"Koochekpour","year":"2013","journal-title":"International journal of biological sciences"},{"issue":"3","key":"18","doi-asserted-by":"crossref","first-page":"187","DOI":"10.2174\/156800908784293659","article-title":"The PTEN\/PI3K\/AKT signalling pathway in cancer, therapeutic implications","volume":"8","author":"Leal","year":"2008","journal-title":"Current cancer drug targets"},{"issue":"7","key":"19","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1093\/carcin\/bgm052","article-title":"PTEN, more than the AKT pathway","volume":"28","author":"Carnero","year":"2007","journal-title":"Carcinogenesis"},{"issue":"1","key":"20","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.bbapap.2007.09.008","article-title":"PI3K\/PTEN signaling in tumorigenesis and angiogenesis","volume":"1784","author":"Liu","year":"2008","journal-title":"Biochim Biophys Acta"},{"issue":"19","key":"21","doi-asserted-by":"crossref","first-page":"4367","DOI":"10.1111\/febs.12942","article-title":"Glycogen synthase kinase 3 beta in somites plays a role during the angiogenesis of zebrafish embryos","volume":"281","author":"Tsai","year":"2014","journal-title":"Febs j"},{"issue":"9","key":"22","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.4161\/cbt.5.9.3151","article-title":"Cross-talk of WNT and FGF signaling pathways at GSK3beta to regulate beta-catenin and SNAIL signaling cascades","volume":"5","author":"Katoh","year":"2006","journal-title":"Cancer biology & therapy"},{"issue":"1","key":"23","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/s12035-013-8507-6","article-title":"Specific induction of Akt3 in spinal cord motor neurons is neuroprotective in a mouse model of familial amyotrophic lateral sclerosis","volume":"49","author":"Bendotti","year":"2014","journal-title":"Molecular neurobiology"},{"issue":"21","key":"24","doi-asserted-by":"crossref","first-page":"6494","DOI":"10.1158\/1078-0432.CCR-06-1570","article-title":"Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor-mutant lung adenocarcinomas with acquired resistance to kinase inhibitors","volume":"12","author":"Pao","year":"2006","journal-title":"Clinical cancer research"},{"issue":"5827","key":"25","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1126\/science.1141478","article-title":"MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling","volume":"316","author":"Lee","year":"2007","journal-title":"Science"},{"issue":"52","key":"26","doi-asserted-by":"crossref","first-page":"20932","DOI":"10.1073\/pnas.0710370104","article-title":"MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib","volume":"104","author":"Rusch","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"27","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1677\/erc.1.00799","article-title":"Insulin-like growth factor-I receptor signalling and acquired resistance to gefitinib (ZD1839; Iressa) in human breast and prostate cancer cells","volume":"11","author":"Nicholson","year":"2004","journal-title":"Endocr Relat Cancer"},{"issue":"8","key":"28","doi-asserted-by":"crossref","first-page":"3256","DOI":"10.1158\/0008-5472.CAN-08-4055","article-title":"PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFR","volume":"69","author":"Gazdar","year":"2009","journal-title":"Cancer Res"},{"issue":"5","key":"29","first-page":"411","article-title":"EGFR-TKI resistance in NSCLC patients: mechanisms and strategies","volume":"4","author":"Jin","year":"2014","journal-title":"American journal of cancer research"},{"issue":"12","key":"30","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1016\/j.cellsig.2013.08.008","article-title":"A novel epidermal growth factor receptor-signaling platform and its targeted translation in pancreatic cancer","volume":"25","author":"Szewczuk","year":"2013","journal-title":"Cell Signal"},{"key":"31","doi-asserted-by":"crossref","first-page":"17","DOI":"10.2147\/RRBC.S28430","article-title":"A novel G-protein-coupled receptor-signaling platform and its targeted translation in human disease","volume":"3","author":"Szewczuk","year":"2013","journal-title":"Research and Reports in Biochemistry"},{"issue":"11","key":"32","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1007\/s00018-013-1538-3","article-title":"Lysosomal multienzyme complex: pros and cons of working together","volume":"71","author":"d'Azzo","year":"2014","journal-title":"Cell Mol Life Sci"},{"issue":"3","key":"33","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/sj.cdd.4402013","article-title":"Altered gene expression in cells from patients with lysosomal storage disorders suggests impairment of the ubiquitin pathway","volume":"14","author":"Pshezhetsky","year":"2007","journal-title":"Cell Death Differ"},{"issue":"9","key":"34","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1007\/s10719-009-9239-8","article-title":"Dependence of pathogen molecule-induced toll-like receptor activation and cell function on Neu1 sialidase","volume":"26","author":"Szewczuk","year":"2009","journal-title":"Glycoconjugate Journal"},{"issue":"8","key":"35","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.cellsig.2010.03.011","article-title":"Neu1 sialidase and matrix metalloproteinase-9 cross-talk is essential for neurotrophin activation of Trk receptors and cellular signaling","volume":"22","author":"Szewczuk","year":"2010","journal-title":"Cellular signalling"},{"issue":"20","key":"36","doi-asserted-by":"crossref","first-page":"3241","DOI":"10.1038\/sj.onc.1205416","article-title":"Correlation of Snail expression with histological grade and lymph node status in breast carcinomas","volume":"21","author":"Nieto","year":"2002","journal-title":"Oncogene"},{"issue":"Pt 15","key":"37","first-page":"3371","article-title":"Upregulation of MMP-9 in MDCK epithelial cell line in response to expression of the Snail transcription factor","volume":"118","author":"Fabra","year":"2005","journal-title":"J Cell Sci"},{"issue":"6","key":"38","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/j.biocel.2007.03.002","article-title":"Matrix metalloproteinase-induced epithelial-mesenchymal transition: tumor progression at Snail's pace","volume":"39","author":"Radisky","year":"2007","journal-title":"Int J Biochem Cell Biol"},{"issue":"Pt 3","key":"39","first-page":"499","article-title":"The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors","volume":"116","author":"Cano","year":"2003","journal-title":"J Cell Sci"},{"issue":"4","key":"40","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/S0002-9440(10)63501-8","article-title":"Hypoxia attenuates the expression of E-cadherin via up-regulation of SNAIL in ovarian carcinoma cells","volume":"163","author":"Konishi","year":"2003","journal-title":"Am J Pathol"},{"issue":"8","key":"41","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/nrm1175","article-title":"Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis","volume":"4","author":"Beug","year":"2003","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"9","key":"42","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1002\/ijc.24901","article-title":"Snail is critical for tumor growth and metastasis of ovarian carcinoma","volume":"126","author":"Feng","year":"2010","journal-title":"Int J Cancer"},{"issue":"Pt 13","key":"43","first-page":"2827","article-title":"Snail and E47 repressors of E-cadherin induce distinct invasive and angiogenic properties","volume":"117","author":"Cano","year":"2004","journal-title":"J Cell Sci"},{"issue":"1","key":"44","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ygyno.2004.12.043","article-title":"Snail and Slug are major determinants of ovarian cancer invasiveness at the transcription level","volume":"97","author":"Bapat","year":"2005","journal-title":"Gynecologic oncology"},{"issue":"10","key":"45","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1038\/labinvest.2011.111","article-title":"Expression of Snail and Slug in renal cell carcinoma: E-cadherin repressor Snail is associated with cancer invasion and prognosis","volume":"91","author":"Okada","year":"2011","journal-title":"Lab Invest"},{"key":"46","doi-asserted-by":"crossref","first-page":"117","DOI":"10.2147\/OTT.S55344","article-title":"Therapeutic targeting of Neu1 sialidase with oseltamivir phosphate (Tamiflu(R)) disables cancer cell survival in human pancreatic cancer with acquired chemoresistance","volume":"7","author":"Szewczuk","year":"2014","journal-title":"OncoTargets and therapy"},{"issue":"10","key":"47","doi-asserted-by":"crossref","first-page":"3484","DOI":"10.1128\/AAC.00344-08","article-title":"Limited inhibitory effects of oseltamivir and zanamivir on human sialidases","volume":"52","author":"Miyagi","year":"2008","journal-title":"Antimicrob Agents Chemother"},{"issue":"1","key":"48","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1189\/jlb.1105692","article-title":"Sialidase expression in activated human T lymphocytes influences production of IFN-gamma","volume":"81","author":"Stamatos","year":"2007","journal-title":"J Leukoc Biol"},{"issue":"11","key":"49","doi-asserted-by":"crossref","first-page":"8214","DOI":"10.1074\/jbc.M111.292888","article-title":"NEU1 sialidase expressed in human airway epithelia regulates epidermal growth factor receptor (EGFR) and MUC1 protein signaling","volume":"287","author":"Goldblum","year":"2012","journal-title":"J Biol Chem"},{"issue":"8","key":"50","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1073\/pnas.81.8.2384","article-title":"Down-regulation of the epidermal growth factor receptor in KB cells is due to receptor internalization and subsequent degradation in lysosomes","volume":"81","author":"Pastan","year":"1984","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"51","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1006\/excr.1999.4509","article-title":"Modulation of EGF receptor activity by changes in the GM3 content in a human epidermoid carcinoma cell line, A431","volume":"256","author":"Bremer","year":"2000","journal-title":"Exp Cell Res"},{"issue":"2","key":"52","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0092-8674(00)00114-8","article-title":"Cell signaling by receptor tyrosine kinases","volume":"103","author":"Schlessinger","year":"2000","journal-title":"Cell"},{"key":"53","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1146\/annurev.biophys.37.032807.125829","article-title":"Structure-based view of epidermal growth factor receptor regulation","volume":"37","author":"Ferguson","year":"2008","journal-title":"Annual review of biophysics"},{"issue":"3","key":"54","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/jcb.240460307","article-title":"Mutational analysis of leucine 47 in human epidermal growth factor","volume":"46","author":"Niyogi","year":"1991","journal-title":"Journal of Cellular Biochemistry"},{"key":"55","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0014-5793(90)80368-S","article-title":"Human epidermal growth factor. Distinct roles of tyrosine 37 and arginine 41 in receptor binding as determined by site-directed mutagenesis and nuclear magnetic resonance spectroscopy","volume":"271","author":"Niyogi","year":"1990","journal-title":"FEBS letters"},{"issue":"13","key":"56","doi-asserted-by":"crossref","first-page":"4115","DOI":"10.1002\/j.1460-2075.1989.tb08596.x","article-title":"Epidermal growth factor binding induces a conformational change in the external domain of its receptor","volume":"8","author":"McDonald","year":"1989","journal-title":"The EMBO journal"},{"issue":"4","key":"57","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.yexcr.2008.10.024","article-title":"Ligand-induced ErbB receptor dimerization","volume":"315","author":"Lemmon","year":"2009","journal-title":"Experimental Cell Research"},{"issue":"6","key":"58","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/S0092-8674(02)00963-7","article-title":"Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains","volume":"110","author":"Yokoyama","year":"2002","journal-title":"Cell"},{"issue":"6","key":"59","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/j.cellsig.2014.02.015","article-title":"A novel insulin receptor-signaling platform and its link to insulin resistance and type 2 diabetes","volume":"26","author":"Szewczuk","year":"2014","journal-title":"Cellular Signalling"},{"issue":"005","key":"60","first-page":"1","article-title":"Novel Insulin Receptor-Signaling Platform","volume":"1","author":"Szewczuk","year":"2014","journal-title":"Int J Diabetes Clin Res"},{"issue":"42","key":"61","doi-asserted-by":"crossref","first-page":"36532","DOI":"10.1074\/jbc.M111.237578","article-title":"Neu1 sialidase and matrix metalloproteinase-9 cross-talk is essential for Toll-like receptor activation and cellular signaling","volume":"286","author":"Szewczuk","year":"2011","journal-title":"J Biol Chem"},{"issue":"11","key":"62","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1016\/j.cellsig.2012.06.016","article-title":"G-protein coupled receptor agonists mediate Neu1 sialidase and matrix metalloproteinase-9 cross-talk to induce transactivation of TOLL-like receptors and cellular signaling","volume":"24","author":"Szewczuk","year":"2012","journal-title":"Cellular signalling"},{"issue":"43","key":"63","article-title":"Detection of Neu1 sialidase activity in regulating Toll-like receptor activation","author":"Szewczuk","year":"2010","journal-title":"Journal of visualized experiments : JoVE"},{"issue":"2","key":"64","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.cellsig.2009.09.038","article-title":"Neu1 desialylation of sialyl alpha-2,3-linked beta-galactosyl residues of TOLL-like receptor 4 is essential for receptor activation and cellular signaling","volume":"22","author":"Szewczuk","year":"2010","journal-title":"Cell Signal"},{"issue":"11","key":"65","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1016\/j.cellsig.2013.06.010","article-title":"Neu1 sialidase and matrix metalloproteinase-9 cross-talk regulates nucleic acid-induced endosomal TOLL-like receptor-7 and \u22129 activation, cellular signaling and pro-inflammatory responses","volume":"25","author":"Szewczuk","year":"2013","journal-title":"Cellular Signalling"},{"issue":"7","key":"66","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1134\/S0006297913070067","article-title":"Desialylation of surface receptors as a new dimension in cell signaling","volume":"78","author":"Ashmarina","year":"2013","journal-title":"Biochemistry (Mosc)"},{"issue":"3","key":"67","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1534\/genetics.111.136911","article-title":"Gene Overexpression: Uses, Mechanisms, and Interpretation","volume":"190","author":"Prelich","year":"2012","journal-title":"Genetics"},{"issue":"8","key":"68","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1046\/j.1432-1327.2000.01266.x","article-title":"Overexpression of enzymes that repair endogenous damage to DNA","volume":"267","author":"Frosina","year":"2000","journal-title":"European Journal of Biochemistry"},{"issue":"7","key":"69","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1111\/j.1349-7006.2008.00839.x","article-title":"Functional roles of N-glycans in cell signaling and cell adhesion in cancer","volume":"99","author":"Taniguchi","year":"2008","journal-title":"Cancer science"},{"issue":"11","key":"70","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1111\/j.1600-0854.2009.00981.x","article-title":"Adaptive regulation at the cell surface by N-glycosylation","volume":"10","author":"Nabi","year":"2009","journal-title":"Traffic"},{"issue":"1","key":"71","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0167-4889(03)00045-4","article-title":"Galectin-3 expression in macrophages is signaled by Ras\/MAP kinase pathway and up-regulated by modified lipoproteins","volume":"1641","author":"Nachtigal","year":"2003","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"72","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s12307-008-0003-6","article-title":"Regulation of tumor progression by extracellular galectin-3","volume":"1","author":"Raz","year":"2008","journal-title":"Cancer microenvironment"},{"issue":"4","key":"73","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.bbagen.2005.12.020","article-title":"Galectin-3: an open-ended story","volume":"1760","author":"Flogel","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"74","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.ejphar.2010.03.057","article-title":"Neuromedin B receptors regulate EGF receptor tyrosine phosphorylation in lung cancer cells","volume":"637","author":"Jensen","year":"2010","journal-title":"Eur J Pharmacol"},{"key":"75","first-page":"85","article-title":"Dissecting the epidermal growth factor receptor signal transactivation pathway","volume":"327","author":"Ullrich","year":"2006","journal-title":"Methods Mol Biol"},{"issue":"18","key":"76","doi-asserted-by":"crossref","first-page":"4015","DOI":"10.1242\/jcs.01223","article-title":"Matrix metalloproteinases at a glance","volume":"117","author":"Murphy","year":"2004","journal-title":"J Cell Sci"},{"issue":"46","key":"77","doi-asserted-by":"crossref","first-page":"45255","DOI":"10.1074\/jbc.M307745200","article-title":"Regulated cell surface pro-EGF ectodomain shedding is a zinc metalloprotease-dependent process","volume":"278","author":"Mauduit","year":"2003","journal-title":"The Journal of biological chemistry"},{"issue":"12","key":"78","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1161\/01.RES.82.12.1338","article-title":"Angiotensin II Type 1 Receptor-Induced Extracellular Signal\u2013Regulated Protein Kinase Activation Is Mediated by Ca2+\/Calmodulin-Dependent Transactivation of Epidermal Growth Factor Receptor","volume":"82","author":"Matsubara","year":"1998","journal-title":"Circ Res"},{"issue":"30","key":"79","doi-asserted-by":"crossref","first-page":"21004","DOI":"10.1074\/jbc.M512096200","article-title":"5-HT2A Receptor Induces ERK Phosphorylation and Proliferation through ADAM-17 Tumor Necrosis Factor-{alpha}-converting Enzyme (TACE) Activation and Heparin-bound Epidermal Growth Factor-like Growth Factor (HB-EGF) Shedding in Mesangial Cells","volume":"281","author":"Raymond","year":"2006","journal-title":"J Biol Chem"},{"issue":"6764","key":"80","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1038\/47260","article-title":"EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF","volume":"402","author":"Ullrich","year":"1999","journal-title":"Nature"},{"issue":"5434","key":"81","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/246487a0","article-title":"Biochemical parameters correlated with tumour cell implantation","volume":"246","author":"Lione","year":"1973","journal-title":"Nature"},{"issue":"4","key":"82","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1016\/S0006-291X(80)80060-X","article-title":"Cell surface sialic acid expression of lectin-resistant variant clones of B16 melanoma with altered metastasizing potential","volume":"95","author":"Tao","year":"1980","journal-title":"Biochem Biophys Res Commun"},{"issue":"7","key":"83","doi-asserted-by":"crossref","first-page":"4336","DOI":"10.1073\/pnas.77.7.4336","article-title":"Correlation between spontaneous metastatic potential, platelet-aggregating activity of cell surface extracts, and cell surface sialylation in 10 metastatic-variant derivatives of a rat renal sarcoma cell line","volume":"77","author":"Karpatkin","year":"1980","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"84","first-page":"2262","article-title":"A correlation between cell surface sialyltransferase, sialic acid, and glycosidase activities and the implantability of B16 murine melanoma","volume":"41","author":"Bernacki","year":"1981","journal-title":"Cancer Res"},{"issue":"2","key":"85","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/BF00052411","article-title":"Tumor progression, oncogenes and the evolution of metastatic phenotypic diversity","volume":"2","author":"Nicolson","year":"1984","journal-title":"Clin Exp Metastasis"},{"issue":"4","key":"86","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1016\/S0021-9258(17)43350-3","article-title":"Metastatic melanoma cell heparanase. Characterization of heparan sulfate degradation fragments produced by B16 melanoma endoglucuronidase","volume":"259","author":"Nicolson","year":"1984","journal-title":"J Biol Chem"},{"issue":"2","key":"87","first-page":"791","article-title":"Carbohydrate chain analysis by lectin binding to electrophoretically separated glycoproteins from murine B16 melanoma sublines of various metastatic properties","volume":"44","author":"Nicolson","year":"1984","journal-title":"Cancer Res"},{"issue":"1","key":"88","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/BF00047691","article-title":"Generation of phenotypic diversity and progression in metastatic tumor cells","volume":"3","author":"Nicolson","year":"1984","journal-title":"Cancer Metastasis Rev"},{"issue":"1","key":"89","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0014-4827(84)90696-7","article-title":"Cell surface molecules and tumor metastasis. Regulation of metastatic phenotypic diversity","volume":"150","author":"Nicolson","year":"1984","journal-title":"Exp Cell Res"},{"issue":"2","key":"90","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1768-322X.1984.tb00294.x","article-title":"Estimating glycoprotein carbohydrate chain structures by lectin reactivities in polyacrylamide gels","volume":"51","author":"Irimura","year":"1984","journal-title":"Biol Cell"},{"issue":"4801","key":"91","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1126\/science.2953071","article-title":"Beta 1-6 branching of Asn-linked oligosaccharides is directly associated with metastasis","volume":"236","author":"Kerbel","year":"1987","journal-title":"Science"},{"issue":"1","key":"92","first-page":"150","article-title":"Glycosphingolipids of lectin-resistant mutants of the highly metastatic mouse tumor cell line, MDAY-D2","volume":"47","author":"Dennis","year":"1987","journal-title":"Cancer Res"},{"issue":"3","key":"93","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/BF00046998","article-title":"Tumor cell surface carbohydrate and the metastatic phenotype","volume":"5","author":"Laferte","year":"1987","journal-title":"Cancer Metastasis Rev"},{"issue":"7","key":"94","first-page":"3521","article-title":"Cell surface sialic acid and the invasive and metastatic potential of T-cell hybridomas","volume":"46","author":"Roos","year":"1986","journal-title":"Cancer Res"},{"issue":"1","key":"95","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1084\/jem.157.1.371","article-title":"Metastatic potential severely altered by changes in tumor cell adhesiveness and cell-surface sialylation","volume":"157","author":"Schirrmacher","year":"1983","journal-title":"J Exp Med"},{"issue":"11","key":"96","first-page":"5138","article-title":"Different patterns of lectin binding and cell surface sialylation detected on related high- and low-metastatic tumor lines","volume":"43","author":"Schirrmacher","year":"1983","journal-title":"Cancer Res"},{"issue":"2","key":"97","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.bbrc.2005.12.216","article-title":"Soyasaponin I decreases the expression of alpha2,3-linked sialic acid on the cell surface and suppresses the metastatic potential of B16F10 melanoma cells","volume":"341","author":"Tsai","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"issue":"5","key":"98","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1093\/glycob\/4.5.665","article-title":"Sialylation and Malignant Potential in Tumor-Cell Glycosylation Mutants","volume":"4","author":"Dennis","year":"1994","journal-title":"Glycobiology"},{"issue":"5","key":"99","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.3892\/or.2011.1192","article-title":"Differential expression of the alpha2,3-sialic acid residues in breast cancer is associated with metastatic potential","volume":"25","author":"Liu","year":"2011","journal-title":"Oncol Rep"},{"issue":"4502","key":"100","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1126\/science.7233237","article-title":"Metastatic potential is positively correlated with cell surface sialylation of cultured murine tumor cell lines","volume":"212","author":"Salk","year":"1981","journal-title":"Science"},{"issue":"16","key":"101","doi-asserted-by":"crossref","first-page":"7591","DOI":"10.1016\/S0021-9258(18)68540-0","article-title":"Cell surface sialylation and tumor metastasis. Metastatic potential of B16 melanoma variants correlates with their relative numbers of specific penultimate oligosaccharide structures","volume":"263","author":"Hart","year":"1988","journal-title":"J Biol Chem"},{"issue":"2","key":"102","first-page":"180","article-title":"Reduced sialidase expression in highly metastatic variants of mouse colon adenocarcinoma 26 and retardation of their metastatic ability by sialidase overexpression","volume":"97","author":"Miyagi","year":"2002","journal-title":"IntJCancer"},{"issue":"2","key":"103","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0014-5793(94)00682-2","article-title":"Metastatic potential of transformed rat 3Y1 cell lines is inversely correlated with lysosomal-type sialidase activity","volume":"349","author":"Taniguchi","year":"1994","journal-title":"FEBS Lett"},{"issue":"6","key":"104","doi-asserted-by":"crossref","first-page":"629","DOI":"10.5009\/gnl.2013.7.6.629","article-title":"Increasing the alpha 2, 6 sialylation of glycoproteins may contribute to metastatic spread and therapeutic resistance in colorectal cancer","volume":"7","author":"Lee","year":"2013","journal-title":"Gut Liver"},{"issue":"12","key":"105","doi-asserted-by":"crossref","first-page":"3199","DOI":"10.1158\/0008-5472.CAN-14-0728","article-title":"Sialic acids sweeten a tumor's life","volume":"74","author":"Adema","year":"2014","journal-title":"Cancer Res"},{"issue":"1","key":"106","first-page":"238","article-title":"Sweet escape: sialic acids in tumor immune evasion","volume":"1846","author":"Adema","year":"2014","journal-title":"Biochim Biophys Acta"},{"issue":"28","key":"107","doi-asserted-by":"crossref","first-page":"11332","DOI":"10.1073\/pnas.1107385108","article-title":"Sialylation and fucosylation of epidermal growth factor receptor suppress its dimerization and activation in lung cancer cells","volume":"108","author":"Wong","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"22","key":"108","doi-asserted-by":"crossref","first-page":"6955","DOI":"10.1073\/pnas.1507329112","article-title":"Effect of sialylation on EGFR phosphorylation and resistance to tyrosine kinase inhibition","volume":"112","author":"Wong","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"9","key":"109","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1038\/onc.2008.471","article-title":"Contribution of sialidase NEU1 to suppression of metastasis of human colon cancer cells through desialylation of integrin beta4","volume":"28","author":"Miyagi","year":"2009","journal-title":"Oncogene"},{"issue":"2","key":"110","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/ijc.1598","article-title":"Reduced sialidase expression in highly metastatic variants of mouse colon adenocarcinoma 26 and retardation of their metastatic ability by sialidase overexpression","volume":"97","author":"Miyagi","year":"2002","journal-title":"Int J Cancer"},{"issue":"6","key":"111","first-page":"797","article-title":"Overexpression of lysosomal-type sialidase leads to suppression of metastasis associated with reversion of malignant phenotype in murine B16 melanoma cells","volume":"92","author":"Miyagi","year":"2001","journal-title":"IntJCancer"},{"key":"112","first-page":"191","article-title":"Oseltamivir phosphate monotherapy ablates tumor neovascularization, growth, and metastasis in mouse model of human triple-negative breast adenocarcinoma","volume":"6","author":"Szewczuk","year":"2014","journal-title":"Breast Cancer: Targets and Therapy"},{"issue":"9","key":"113","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.1016\/j.bbagen.2014.06.006","article-title":"Sialosignaling: sialyltransferases as engines of self-fueling loops in cancer progression","volume":"1840","author":"Chiricolo","year":"2014","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"114","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.4081\/ejh.2013.e7","article-title":"Expression patterns of alpha2,3-sialyltransferase I and alpha2,6-sialyltransferase I in human cutaneous epithelial lesions","volume":"57","author":"Beltrao","year":"2013","journal-title":"Eur J Histochem"},{"issue":"1","key":"115","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1006\/gyno.2001.6358","article-title":"Altered mRNA expression of sialyltransferase in squamous cell carcinomas of the cervix","volume":"83","author":"Yuan","year":"2001","journal-title":"Gynecologic oncology"},{"key":"116","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/1746-1596-5-74","article-title":"Increased expression of sialic acid in cervical biopsies with squamous intraepithelial lesions","volume":"5","author":"Vallejo-Ruiz","year":"2010","journal-title":"Diagn Pathol"},{"issue":"10","key":"117","doi-asserted-by":"crossref","first-page":"407","DOI":"10.2183\/pjab.84.407","article-title":"Aberrant expression of sialidase and cancer progression","volume":"84","author":"Miyagi","year":"2008","journal-title":"Proceedings of the Japan Academy Series B, Physical and biological sciences"},{"issue":"3","key":"118","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1023\/B:GLYC.0000024250.48506.bf","article-title":"Sialidase and malignancy: A minireview","volume":"20","author":"Hata","year":"2003","journal-title":"Glycoconjugate Journal"},{"issue":"8 Suppl","key":"119","first-page":"1033","article-title":"[Regulation of cellular function by mammalian sialidase]","volume":"48","author":"Moriya","year":"2003","journal-title":"Tanpakushitsu Kakusan Koso"},{"key":"120","first-page":"403","volume-title":"Advances in Carbohydrate Chemistry and Biochemistry","author":"Derek","year":"2010"},{"issue":"7","key":"121","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1093\/glycob\/cws057","article-title":"Mammalian sialidases: physiological and pathological roles in cellular functions","volume":"22","author":"Yamaguchi","year":"2012","journal-title":"Glycobiology"},{"issue":"2","key":"122","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.jmgm.2005.12.006","article-title":"Homology modeling of human sialidase enzymes NEU1, NEU3 and NEU4 based on the crystal structure of NEU2: hints for the design of selective NEU3 inhibitors","volume":"25","author":"Kiso","year":"2006","journal-title":"Journal of molecular graphics & modelling"},{"issue":"37","key":"123","doi-asserted-by":"crossref","first-page":"27526","DOI":"10.1074\/jbc.M605633200","article-title":"Monocyte differentiation up-regulates the expression of the lysosomal sialidase, Neu1, and triggers its targeting to the plasma membrane via major histocompatibility complex class II-positive compartments","volume":"281","author":"Pshezhetsky","year":"2006","journal-title":"The Journal of biological chemistry"},{"issue":"1","key":"124","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.devcel.2008.05.005","article-title":"Neuraminidase 1 is a negative regulator of lysosomal exocytosis","volume":"15","author":"d'Azzo","year":"2008","journal-title":"Dev Cell"},{"issue":"3","key":"125","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/humu.20147","article-title":"Role of beta-galactosidase and elastin binding protein in lysosomal and nonlysosomal complexes of patients with GM1-gangliosidosis","volume":"25","author":"Morrone","year":"2005","journal-title":"Human mutation"},{"issue":"49","key":"126","doi-asserted-by":"crossref","first-page":"46172","DOI":"10.1074\/jbc.M104547200","article-title":"Intracellular distribution of lysosomal sialidase is controlled by the internalization signal in its cytoplasmic tail","volume":"276","author":"Pshezhetsky","year":"2001","journal-title":"The Journal of biological chemistry"},{"issue":"7","key":"127","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S1470-2045(14)70160-3","article-title":"Neoadjuvant carboplatin in patients with triple-negative and HER2-positive early breast cancer (GeparSixto; GBG 66): a randomised phase 2 trial","volume":"15","author":"Costa","year":"2014","journal-title":"The Lancet Oncology"},{"issue":"7","key":"128","doi-asserted-by":"crossref","first-page":"3070","DOI":"10.4049\/jimmunol.158.7.3070","article-title":"The control of IL-4 gene expression in activated murine T lymphocytes: a novel role for neu-1 sialidase","volume":"158","author":"Daynes","year":"1997","journal-title":"J Immunol"},{"issue":"1","key":"129","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.bbrc.2012.10.028","article-title":"Human cytosolic sialidase NEU2-low general tissue expression but involvement in PC-3 prostate cancer cell survival","volume":"428","author":"Miyagi","year":"2012","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"130","first-page":"826","article-title":"Involvement of an endogenous sialidase in skeletal muscle cell differentiation","volume":"221","author":"Miyagi","year":"1996","journal-title":"BiochemBiophysResCommun"},{"issue":"11","key":"131","first-page":"6710","article-title":"Purification and characterization of cytosolic sialidase from rat liver","volume":"260","author":"Tsuiki","year":"1985","journal-title":"JBiolChem"},{"issue":"2","key":"132","first-page":"250","article-title":"Cloning, chromosomal mapping, and characteristic 5\u2032-UTR sequence of murine cytosolic sialidase","volume":"286","author":"Kijimoto-Ochiai","year":"2001","journal-title":"BiochemBiophysResCommun"},{"issue":"2","key":"133","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.bbrc.2008.03.111","article-title":"The enzymatic activity of sialidase Neu2 is inversely regulated duringmyoblast hypertrophy and atrophy","volume":"370","author":"Marchesini","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"134","first-page":"469","article-title":"Crystal structure of the human cytosolic sialidase Neu2. Evidence for the dynamic nature of substrate recognition","volume":"280","author":"Wakatsuki","year":"2005","journal-title":"JBiolChem"},{"issue":"52","key":"135","doi-asserted-by":"crossref","first-page":"36265","DOI":"10.1074\/jbc.M805755200","article-title":"NEU3 sialidase strictly modulates GM3 levels in skeletal myoblasts C2C12 thus favoring their differentiation and protecting them from apoptosis","volume":"283","author":"Venerando","year":"2008","journal-title":"J Biol Chem"},{"issue":"9","key":"136","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1248\/bpb.30.1680","article-title":"Enhanced expression of membrane-associated sialidase Neu3 decreases GD3 and increases GM3 on the surface of Jurkat cells during etoposide-induced apoptosis","volume":"30","author":"Matsumoto","year":"2007","journal-title":"Biol Pharm Bull"},{"issue":"17","key":"137","doi-asserted-by":"crossref","first-page":"16989","DOI":"10.1074\/jbc.M400881200","article-title":"The plasma membrane-associated sialidase MmNEU3 modifies the ganglioside pattern of adjacent cells supporting its involvement in cell-to-cell interactions","volume":"279","author":"Monti","year":"2004","journal-title":"J Biol Chem"},{"key":"138","doi-asserted-by":"crossref","first-page":"3153","DOI":"10.1074\/jbc.M112.404327","article-title":"NEU3 sialidase is activated under hypoxia and protects skeletal muscle cells from apoptosis through the activation of the epidermal growth factor receptor signaling pathway and the hypoxia-inducible factor (HIF)-1alpha","volume":"288","author":"Anastasia","year":"2013","journal-title":"J Biol Chem"},{"issue":"3","key":"139","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.metabol.2006.10.027","article-title":"Increased hepatic expression of ganglioside-specific sialidase, NEU3, improves insulin sensitivity and glucose tolerance in mice","volume":"56","author":"Oka","year":"2007","journal-title":"Metabolism: clinical and experimental"},{"key":"140","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1111\/j.1349-7006.2011.02086.x","article-title":"Membrane sialidase NEU3 is highly expressed in human melanoma cells promoting cell growth with minimal changes in the composition of gangliosides","volume":"102","author":"Furukawa","year":"2011","journal-title":"Cancer science"},{"issue":"1","key":"141","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1186\/1471-2407-14-560","article-title":"Molecular subtyping of metastatic melanoma based on cell ganglioside metabolism profiles","volume":"14","author":"Venerando","year":"2014","journal-title":"BMC cancer"},{"key":"142","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1042\/BJ20100350","article-title":"Regulation of plasma-membrane-associated sialidase NEU3 gene by Sp1\/Sp3 transcription factors","volume":"430","author":"Miyagi","year":"2010","journal-title":"Biochem J"},{"issue":"3","key":"143","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1349-7006.2007.00403.x","article-title":"Down-regulation of sialidase NEU4 may contribute to invasive properties of human colon cancers","volume":"98","author":"Miyagi","year":"2007","journal-title":"Cancer science"},{"issue":"6","key":"144","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s10719-010-9302-5","article-title":"Thymoquinone-induced Neu4 sialidase activates NF\u03baB in macrophage cells and pro-inflammatory cytokines","volume":"27","author":"Szewczuk","year":"2010","journal-title":"Glycoconjugate Journal"},{"issue":"3","key":"145","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s10719-010-9281-6","article-title":"Thymoquinone from nutraceutical black cumin oil activates Neu4 sialidase in live macrophage, dendritic, and normal and type I sialidosis human fibroblast cells via GPCR Galphai proteins and matrix metalloproteinase-9","volume":"27","author":"Szewczuk","year":"2010","journal-title":"Glycoconjugate Journal"},{"key":"146","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s10719-012-9394-1","article-title":"Sialidase significance for cancer progression","volume":"29","author":"Yamaguchi","year":"2012","journal-title":"Glycoconj J"},{"issue":"3","key":"147","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1124\/pr.56.3.4","article-title":"Single Transmembrane Spanning Heterotrimeric G Protein-Coupled Receptors and Their Signaling Cascades","volume":"56","author":"Patel","year":"2004","journal-title":"Pharmacological reviews"},{"issue":"4","key":"148","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.cardiores.2006.12.006","article-title":"Insulin augments matrix metalloproteinase-9 expression in monocytes","volume":"73","author":"Stawowy","year":"2007","journal-title":"Cardiovasc Res"},{"issue":"49","key":"149","doi-asserted-by":"crossref","first-page":"33035","DOI":"10.1074\/jbc.273.49.33035","article-title":"Insulin stimulates sequestration of beta-adrenergic receptors and enhanced association of beta-adrenergic receptors with Grb2 via tyrosine 350","volume":"273","author":"Malbon","year":"1998","journal-title":"J Biol Chem"},{"issue":"46","key":"150","doi-asserted-by":"crossref","first-page":"29347","DOI":"10.1074\/jbc.271.46.29347","article-title":"Insulin-like growth factor receptor-1 stimulates phosphorylation of the beta2-adrenergic receptoron sites distinct from those phosphorylated in response to insulin","volume":"271","author":"Malbon","year":"1996","journal-title":"J Biol Chem"},{"issue":"2","key":"151","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1074\/jbc.271.2.1061","article-title":"The beta-adrenergic receptor is a substrate for the insulin receptor tyrosine kinase","volume":"271","author":"Malbon","year":"1996","journal-title":"J Biol Chem"},{"issue":"43","key":"152","doi-asserted-by":"crossref","first-page":"25305","DOI":"10.1074\/jbc.270.43.25305","article-title":"Phosphorylation of tyrosyl residues 350\/354 of the beta-adrenergic receptor is obligatory for counterregulatory effects of insulin","volume":"270","author":"Malbon","year":"1995","journal-title":"J Biol Chem"},{"issue":"8","key":"153","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.tips.2011.04.002","article-title":"Receptor tyrosine kinase-G-protein-coupled receptor signalling platforms: out of the shadow?","volume":"32","author":"Pyne","year":"2011","journal-title":"Trends Pharmacol Sci"},{"issue":"3","key":"154","first-page":"673","article-title":"siRNA directed against TrkA sensitizes human pancreatic cancer cells to apoptosis induced by gemcitabine through an inactivation of PI3K\/Akt-dependent pathway","volume":"18","author":"Chen","year":"2007","journal-title":"Oncology reports"},{"issue":"2","key":"155","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/ijc.20304","article-title":"Selenoprotein P, as a predictor for evaluating gemcitabine resistance in human pancreatic cancer cells","volume":"112","author":"Maehara","year":"2004","journal-title":"Int J Cancer"},{"issue":"12","key":"156","doi-asserted-by":"crossref","first-page":"3629","DOI":"10.1245\/s10434-007-9583-5","article-title":"Development and characterization of gemcitabine-resistant pancreatic tumor cells","volume":"14","author":"Gallick","year":"2007","journal-title":"Annals of surgical oncology"},{"issue":"12","key":"157","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.1002\/ijc.24349","article-title":"Side population of pancreatic cancer cells predominates in TGF-beta-mediated epithelial to mesenchymal transition and invasion","volume":"124","author":"Hibi","year":"2009","journal-title":"Int J Cancer"},{"issue":"6","key":"158","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1038\/sj.bjc.6604278","article-title":"Activity of lapatinib a novel HER2 and EGFR dual kinase inhibitor in human endometrial cancer cells","volume":"98","author":"Podratz","year":"2008","journal-title":"British journal of cancer"},{"key":"159","first-page":"187","article-title":"The role of epithelial-mesenchymal transition programming in invasion and metastasis: a clinical perspective","volume":"5","author":"Kurie","year":"2013","journal-title":"Cancer management and research"},{"issue":"14","key":"160","doi-asserted-by":"crossref","first-page":"5820","DOI":"10.1158\/0008-5472.CAN-08-2819","article-title":"Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer","volume":"69","author":"Choi","year":"2009","journal-title":"Cancer Res"},{"issue":"14 Pt 1","key":"161","first-page":"4147","article-title":"Chronic oxaliplatin resistance induces epithelial-to-mesenchymal transition in colorectal cancer cell lines","volume":"12","author":"Ellis","year":"2006","journal-title":"Clinical cancer research"},{"issue":"2","key":"162","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.lungcan.2008.05.017","article-title":"Epithelial to mesenchymal transition derived from repeated exposure to gefitinib determines the sensitivity to EGFR inhibitors in A549, a non-small cell lung cancer cell line","volume":"63","author":"Lee","year":"2009","journal-title":"Lung cancer"},{"issue":"37","key":"163","doi-asserted-by":"crossref","first-page":"5764","DOI":"10.1038\/sj.onc.1208927","article-title":"TGF-beta and epithelial-to-mesenchymal transitions","volume":"24","author":"Bottinger","year":"2005","journal-title":"Oncogene"},{"key":"164","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1159\/000320163","article-title":"The Cain and Abl of epithelial-mesenchymal transition and transforming growth factor-beta in mammary epithelial cells","volume":"193","author":"Schiemann","year":"2011","journal-title":"Cells Tissues Organs"},{"issue":"6","key":"165","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.cellsig.2010.10.015","article-title":"Transforming growth factor-beta and the hallmarks of cancer","volume":"23","author":"Schiemann","year":"2011","journal-title":"Cell Signal"},{"issue":"49","key":"166","doi-asserted-by":"crossref","first-page":"6485","DOI":"10.1038\/onc.2010.377","article-title":"Transforming growth factor-beta-induced epithelial-mesenchymal transition facilitates epidermal growth factor-dependent breast cancer progression","volume":"29","author":"Schiemann","year":"2010","journal-title":"Oncogene"},{"issue":"2","key":"167","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s10911-010-9181-1","article-title":"The pathophysiology of epithelial-mesenchymal transition induced by transforming growth factor-beta in normal and malignant mammary epithelial cells","volume":"15","author":"Schiemann","year":"2010","journal-title":"Journal of mammary gland biology and neoplasia"},{"issue":"1","key":"168","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1517\/13543780903382609","article-title":"Targeting the transforming growth factor-beta signaling pathway in human cancer","volume":"19","author":"Datta","year":"2010","journal-title":"Expert Opin Investig Drugs"},{"issue":"3","key":"169","first-page":"271","article-title":"Hedgehog signaling, epithelial-to-mesenchymal transition and miRNA (review)","volume":"22","author":"Katoh","year":"2008","journal-title":"Int J Mol Med"},{"issue":"5933","key":"170","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1126\/science.1171362","article-title":"Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer","volume":"324","author":"Ireland-Zecchini","year":"2009","journal-title":"Science"},{"issue":"2","key":"171","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.3390\/cancers3021513","article-title":"Epidermal Growth Factor Receptor in Pancreatic Cancer","volume":"3","author":"Siriwardena","year":"2011","journal-title":"Cancers"},{"issue":"5","key":"172","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s10620-012-2036-4","article-title":"Suppression of the epidermal growth factor receptor inhibits epithelial-mesenchymal transition in human pancreatic cancer PANC-1 cells","volume":"57","author":"Yang","year":"2012","journal-title":"Dig Dis Sci"},{"issue":"10","key":"173","doi-asserted-by":"crossref","first-page":"e26815","DOI":"10.1371\/journal.pone.0026815","article-title":"DeltaNp63alpha-mediated induction of epidermal growth factor receptor promotes pancreatic cancer cell growth and chemoresistance","volume":"6","author":"Korc","year":"2011","journal-title":"PLoS One"},{"issue":"10","key":"174","doi-asserted-by":"crossref","first-page":"e46891","DOI":"10.1371\/journal.pone.0046891","article-title":"EGFR inhibition abrogates leiomyosarcoma cell chemoresistance through inactivation of survival pathways and impairment of CSC potential","volume":"7","author":"Eramo","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"175","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.radonc.2011.05.042","article-title":"Epithelial-mesenchymal-transition induced by EGFR activation interferes with cell migration and response to irradiation and cetuximab in head and neck cancer cells","volume":"101","author":"Tinhofer","year":"2011","journal-title":"Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology"},{"key":"176","first-page":"419","article-title":"Treatment of pancreatic cancer with epidermal growth factor receptor-targeted therapy","volume":"3","author":"Burtness","year":"2009","journal-title":"Biologics : targets & therapy"},{"issue":"2","key":"177","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.bbcan.2009.03.002","article-title":"Epithelial-mesenchymal transition in cancer metastasis: Mechanisms, markers and strategies to overcome drug resistance in the clinic","volume":"1796","author":"Pintzas","year":"2009","journal-title":"Biochimica et Biophysica Acta (BBA) - Reviews on Cancer"},{"issue":"5","key":"178","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.cell.2009.11.007","article-title":"Epithelial-mesenchymal transitions in development and disease","volume":"139","author":"Nieto","year":"2009","journal-title":"Cell"},{"issue":"14","key":"179","doi-asserted-by":"crossref","first-page":"8018","DOI":"10.1073\/pnas.131209798","article-title":"Expression and functional significance of VE-cadherin in aggressive human melanoma cells: role in vasculogenic mimicry","volume":"98","author":"Seftor","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"180","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1038\/oncsis.2013.16","article-title":"MUC1 induces drug resistance in pancreatic cancer cells via upregulation of multidrug resistance genes","volume":"2","author":"Mukherjee","year":"2013","journal-title":"Oncogenesis"},{"issue":"3","key":"181","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ccr.2005.02.013","article-title":"Smoldering and polarized inflammation in the initiation and promotion of malignant disease","volume":"7","author":"Mantovani","year":"2005","journal-title":"Cancer Cell"},{"issue":"6917","key":"182","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature01322","article-title":"Inflammation and cancer","volume":"420","author":"Werb","year":"2002","journal-title":"Nature"},{"issue":"7092","key":"183","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nature04870","article-title":"Nuclear factor-kappaB in cancer development and progression","volume":"441","author":"Karin","year":"2006","journal-title":"Nature"},{"issue":"6","key":"184","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/mc.20217","article-title":"NF-kappaB and cancer: mechanisms and targets","volume":"45","author":"Karin","year":"2006","journal-title":"Mol Carcinog"},{"key":"185","first-page":"133","article-title":"Tracking the road from inflammation to cancer: the critical role of IkappaB kinase (IKK)","volume":"102","author":"Karin","year":"2006","journal-title":"Harvey lectures"},{"issue":"4","key":"186","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.cell.2006.02.016","article-title":"Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer","volume":"124","author":"Nizet","year":"2006","journal-title":"Cell"},{"issue":"5564","key":"187","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1126\/science.1067100","article-title":"Matrix metalloproteinase inhibitors and cancer: trials and tribulations","volume":"295","author":"Matrisian","year":"2002","journal-title":"Science"},{"issue":"10","key":"188","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/nri1703","article-title":"NF-kappaB: linking inflammation and immunity to cancer development and progression","volume":"5","author":"Greten","year":"2005","journal-title":"Nat Rev Immunol"},{"issue":"6","key":"189","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1084\/jem.193.6.727","article-title":"Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy","volume":"193","author":"Pollard","year":"2001","journal-title":"J Exp Med"},{"issue":"23","key":"190","doi-asserted-by":"crossref","first-page":"11238","DOI":"10.1158\/0008-5472.CAN-06-1278","article-title":"Macrophages regulate the angiogenic switch in a mouse model of breast cancer","volume":"66","author":"Pollard","year":"2006","journal-title":"Cancer Res"},{"issue":"12","key":"191","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.it.2004.09.015","article-title":"The chemokine system in diverse forms of macrophage activation and polarization","volume":"25","author":"Locati","year":"2004","journal-title":"Trends in immunology"},{"issue":"11","key":"192","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S1471-4906(02)02302-5","article-title":"Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes","volume":"23","author":"Sica","year":"2002","journal-title":"Trends in immunology"},{"issue":"5","key":"193","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1182\/blood-2005-01-0428","article-title":"A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-kappaB and enhanced IRF-3\/STAT1 activation)","volume":"107","author":"Sica","year":"2006","journal-title":"Blood"},{"issue":"23","key":"194","doi-asserted-by":"crossref","first-page":"11432","DOI":"10.1158\/0008-5472.CAN-06-1867","article-title":"p50 nuclear factor-kappaB overexpression in tumor-associated macrophages inhibits M1 inflammatory responses and antitumor resistance","volume":"66","author":"Sica","year":"2006","journal-title":"Cancer Res"},{"issue":"10","key":"195","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/nri1936","article-title":"Cancer despite immunosurveillance: immunoselection and immunosubversion","volume":"6","author":"Kroemer","year":"2006","journal-title":"Nat Rev Immunol"},{"issue":"4","key":"196","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1084\/jem.183.4.1323","article-title":"The altered tumoricidal capacity of macrophages isolated from tumor-bearing mice is related to reduce expression of the inducible nitric oxide synthase gene","volume":"183","author":"Lopez","year":"1996","journal-title":"J Exp Med"},{"issue":"2","key":"197","doi-asserted-by":"crossref","first-page":"762","DOI":"10.4049\/jimmunol.164.2.762","article-title":"Autocrine production of IL-10 mediates defective IL-12 production and NF-kappa B activation in tumor-associated macrophages","volume":"164","author":"Mantovani","year":"2000","journal-title":"J Immunol"},{"issue":"1","key":"198","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/(SICI)1097-0215(19990702)82:1<12::AID-IJC3>3.0.CO;2-O","article-title":"Microglial\/macrophage expression of interleukin 10 in human glioblastomas","volume":"82","author":"Tonn","year":"1999","journal-title":"Int J Cancer"},{"issue":"1","key":"199","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/nrc1256","article-title":"Tumour-educated macrophages promote tumour progression and metastasis","volume":"4","author":"Pollard","year":"2004","journal-title":"Nat Rev Cancer"},{"issue":"2","key":"200","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1158\/0008-5472.CAN-05-4005","article-title":"Distinct role of macrophages in different tumor microenvironments","volume":"66","author":"Pollard","year":"2006","journal-title":"Cancer Res"},{"issue":"4","key":"201","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.4049\/jimmunol.180.4.2011","article-title":"Plasticity of macrophage function during tumor progression: regulation by distinct molecular mechanisms","volume":"180","author":"Lewis","year":"2008","journal-title":"J Immunol"},{"issue":"10","key":"202","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.cellbi.2007.03.023","article-title":"Zinc-finger transcription factor snail accelerates survival, migration and expression of matrix metalloproteinase-2 in human bone mesenchymal stem cells","volume":"31","author":"Mao","year":"2007","journal-title":"Cell biology international"},{"issue":"10","key":"203","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/35036374","article-title":"Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis","volume":"2","author":"Hanahan","year":"2000","journal-title":"Nat Cell Biol"},{"issue":"6","key":"204","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.1158\/0008-5472.CAN-08-4312","article-title":"Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway","volume":"69","author":"Sarkar","year":"2009","journal-title":"Cancer Res"},{"issue":"3","key":"205","first-page":"1355","article-title":"Expression of matrix metalloproteinases (MMPs) in primary human breast cancer: MMP-9 as a potential biomarker for cancer invasion and metastasis","volume":"34","author":"Al-Qahtani","year":"2014","journal-title":"Anticancer Res"},{"key":"206","article-title":"Transcriptional factor Snail controls tumor neovascularization, growth and metastasis in mouse model of human ovarian carcinoma","volume":"3","author":"Szewczuk","year":"2014","journal-title":"Clinical and Translational Medicine"},{"issue":"6","key":"207","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1177\/548.6505","article-title":"Triple-negative breast cancer: current state of the art","volume":"96","author":"Crispino","year":"2010","journal-title":"Tumori"},{"issue":"7","key":"208","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S1050-1738(03)00142-7","article-title":"Controlling the angiogenic switch: a balance between two distinct TGF-b receptor signaling pathways","volume":"13","author":"Valdimarsdottir","year":"2003","journal-title":"Trends in cardiovascular medicine"},{"issue":"2","key":"209","first-page":"711","article-title":"An angiogenic switch in macrophages involving synergy between Toll-like receptors 2, 4, 7, and 9 and adenosine A(2A) receptors","volume":"163","author":"Leibovich","year":"2003","journal-title":"AmJPathol"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.8396","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T09:11:53Z","timestamp":1718442713000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.8396"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,27]]},"references-count":209,"journal-issue":{"issue":"26","published-print":{"date-parts":[[2016,6,28]]}},"alternative-id":["8396","27029067"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.8396","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,27]]}}}