{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T23:46:19Z","timestamp":1777506379551,"version":"3.51.4"},"reference-count":15,"publisher":"Impact Journals, LLC","issue":"22","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2016,5,31]]},"DOI":"10.18632\/oncotarget.8702","type":"journal-article","created":{"date-parts":[[2016,4,12]],"date-time":"2016-04-12T11:02:11Z","timestamp":1460458931000},"page":"32641-32651","source":"Crossref","is-referenced-by-count":8,"title":["Characterization of selective and potent PI3K\u03b4 inhibitor (PI3KD-IN-015) for B-Cell malignances"],"prefix":"10.18632","volume":"7","author":[{"given":"Xiaochuan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Chemistry, University of Science and Technology of China, Hefei 230036, Anhui, P. R. China"},{"name":"High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei 230031, Anhui, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aoli","family":"Wang","sequence":"additional","affiliation":[{"name":"High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei 230031, Anhui, P. R. China"},{"name":"University of Science and Technology of China, Hefei 230036, Anhui, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofei","family":"Liang","sequence":"additional","affiliation":[{"name":"High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei 230031, Anhui, P. R. China"},{"name":"CHMFL-HCMTC Target Therapy Joint Laboratory, Hefei 230031, Anhui, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Chen","sequence":"additional","affiliation":[{"name":"High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei 230031, Anhui, P. R. China"},{"name":"CHMFL-HCMTC Target Therapy Joint Laboratory, Hefei 230031, Anhui, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juanjuan","family":"Liu","sequence":"additional","affiliation":[{"name":"High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei 230031, Anhui, P. R. China"},{"name":"University of Science and Technology of China, Hefei 230036, Anhui, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Zhao","sequence":"additional","affiliation":[{"name":"High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei 230031, Anhui, P. R. China"},{"name":"CHMFL-HCMTC Target Therapy Joint Laboratory, Hefei 230031, Anhui, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Wu","sequence":"additional","affiliation":[{"name":"High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei 230031, Anhui, P. R. China"},{"name":"University of Science and Technology of China, Hefei 230036, Anhui, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanxin","family":"Deng","sequence":"additional","affiliation":[{"name":"High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei 230031, Anhui, P. R. China"},{"name":"University of Science and Technology of China, Hefei 230036, Anhui, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei 230031, Anhui, P. R. China"},{"name":"CHMFL-HCMTC Target Therapy Joint Laboratory, Hefei 230031, Anhui, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beilei","family":"Wang","sequence":"additional","affiliation":[{"name":"High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei 230031, Anhui, P. R. China"},{"name":"CHMFL-HCMTC Target Therapy Joint Laboratory, Hefei 230031, Anhui, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaxin","family":"Wu","sequence":"additional","affiliation":[{"name":"High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei 230031, Anhui, P. R. China"},{"name":"University of Science and Technology of China, Hefei 230036, Anhui, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feiyang","family":"Liu","sequence":"additional","affiliation":[{"name":"High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei 230031, Anhui, P. R. China"},{"name":"University of Science and Technology of China, Hefei 230036, Anhui, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stacey M.","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophia","family":"Adamia","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard M.","family":"Stone","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilene A.","family":"Galinsky","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer R.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James D.","family":"Griffin","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanchun","family":"Zhang","sequence":"additional","affiliation":[{"name":"CHMFL-HCMTC Target Therapy Joint Laboratory, Hefei 230031, Anhui, P. R. China"},{"name":"Hefei Cosource Medicine Technology Co. LTD., Hefei 230031, Anhui, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teckpeng","family":"Loh","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Science and Technology of China, Hefei 230036, Anhui, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei 230031, Anhui, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenchao","family":"Wang","sequence":"additional","affiliation":[{"name":"High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei 230031, Anhui, P. R. China"},{"name":"CHMFL-HCMTC Target Therapy Joint Laboratory, Hefei 230031, Anhui, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen L.","family":"Weisberg","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei 230031, Anhui, P. R. China"},{"name":"CHMFL-HCMTC Target Therapy Joint Laboratory, Hefei 230031, Anhui, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingsong","family":"Liu","sequence":"additional","affiliation":[{"name":"High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei 230031, Anhui, P. R. China"},{"name":"CHMFL-HCMTC Target Therapy Joint Laboratory, Hefei 230031, Anhui, P. R. China"},{"name":"Hefei Science Center, Chinese Academy of Sciences, Hefei 230031, Anhui, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2016,4,12]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nrm2882","article-title":"The emerging mechanisms of isoform-specific PI3K signalling","volume":"11","author":"Bilanges","year":"2010","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1038\/nrd4204","article-title":"PI3K and cancer: lessons, challenges and opportunities","volume":"13","author":"Rommel","year":"2014","journal-title":"Nat Rev Drug Discov"},{"key":"3","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.4049\/jimmunol.173.4.2236","article-title":"Cutting edge: differential roles for phosphoinositide 3-kinases, p110gamma and p110delta, in lymphocyte chemotaxis and homing","volume":"173","author":"Cyster","year":"2004","journal-title":"J Immunol"},{"key":"4","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1182\/blood-2005-07-3041","article-title":"Key role of the p110delta isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110delta function in B cells","volume":"107","author":"Vanhaesebroeck","year":"2006","journal-title":"Blood"},{"key":"5","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1182\/blood-2010-02-271171","article-title":"Phosphatidylinositol 3-kinase-delta inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals","volume":"116","author":"Johnson","year":"2010","journal-title":"Blood"},{"key":"6","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1158\/2159-8290.CD-11-0249","article-title":"PI3Kdelta inhibitors in cancer: rationale and serendipity merge in the clinic","volume":"1","author":"Rommel","year":"2011","journal-title":"Cancer Discov"},{"key":"7","doi-asserted-by":"crossref","first-page":"6648","DOI":"10.1038\/sj.onc.1209670","article-title":"A selective inhibitor of the p110delta isoform of PI 3-kinase inhibits AML cell proliferation and survival and increases the cytotoxic effects of VP16","volume":"25","author":"Khwaja","year":"2006","journal-title":"Oncogene"},{"key":"8","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.coph.2015.05.017","article-title":"PI3K inhibitors in inflammation, autoimmunity and cancer","volume":"23","author":"Okkenhaug","year":"2015","journal-title":"Curr Opin Pharmacol"},{"key":"9","doi-asserted-by":"crossref","first-page":"3390","DOI":"10.1182\/blood-2013-11-535047","article-title":"Idelalisib, an inhibitor of phosphatidylinositol 3-kinase p110delta, for relapsed\/refractory chronic lymphocytic leukemia","volume":"123","author":"Ulrich","year":"2014","journal-title":"Blood"},{"key":"10","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1056\/NEJMoa1314583","article-title":"PI3Kdelta inhibition by idelalisib in patients with relapsed indolent lymphoma","volume":"370","author":"Johnson","year":"2014","journal-title":"N Engl J Med"},{"key":"11","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1056\/NEJMe1400055","article-title":"Idelalisib--a PI3Kdelta inhibitor for B-cell cancers","volume":"370","author":"Cantley","year":"2014","journal-title":"N Engl J Med"},{"key":"12","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1158\/1535-7163.MCT-08-1200","article-title":"Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941","volume":"8","author":"Saghir","year":"2009","journal-title":"Molecular cancer therapeutics"},{"key":"13","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nbt1068","article-title":"A small molecule-kinase interaction map for clinical kinase inhibitors","volume":"23","author":"Insko","year":"2005","journal-title":"Nature biotechnology"},{"key":"14","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.ccr.2014.02.012","article-title":"PI3Kdelta inhibition hits a sensitive spot in B cell malignancies","volume":"25","author":"Khwaja","year":"2014","journal-title":"Cancer cell"},{"key":"15","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1146\/annurev-pharmtox-010611-134717","article-title":"The PI3K, metabolic, and autophagy networks: interactive partners in cellular health and disease","volume":"53","author":"Abraham","year":"2013","journal-title":"Annu Rev Pharmacol Toxicol"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.8702","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T20:49:01Z","timestamp":1589230141000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.8702"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,12]]},"references-count":15,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2016,5,31]]}},"alternative-id":["8702","27081697"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.8702","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,12]]}}}