{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T15:43:02Z","timestamp":1769269382195,"version":"3.49.0"},"reference-count":21,"publisher":"Impact Journals, LLC","issue":"20","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2016,5,17]]},"DOI":"10.18632\/oncotarget.8833","type":"journal-article","created":{"date-parts":[[2016,4,19]],"date-time":"2016-04-19T14:50:21Z","timestamp":1461077421000},"page":"29359-29370","source":"Crossref","is-referenced-by-count":24,"title":["Wip1 suppresses ovarian cancer metastasis through the ATM\/AKT\/Snail mediated signaling"],"prefix":"10.18632","volume":"7","author":[{"given":"Sheng","family":"Yin","sequence":"first","affiliation":[{"name":"Department of Gynecological Oncology, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai 200032, China"},{"name":"Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai 200032, China"},{"name":"Ovarian Cancer Program, Division of Gynecologic Oncology, Department of Gynecology and Obstetrics, Zhongshan Hospital, Fudan University, Shanghai 200032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gynecological Oncology, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai 200032, China"},{"name":"Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai 200032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, The Fifth People's Hospital of Shanghai Fudan University, Shanghai 200240, China"},{"name":"Central Laboratory, The Fifth People's Hospital of Shanghai Fudan University, Shanghai 200240, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai 200032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai 200032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingming","family":"Liu","sequence":"additional","affiliation":[{"name":"Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai 200032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zihao","family":"Qi","sequence":"additional","affiliation":[{"name":"Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai 200032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiao","family":"Meng","sequence":"additional","affiliation":[{"name":"Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai 200032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting-Yan","family":"Shi","sequence":"additional","affiliation":[{"name":"Ovarian Cancer Program, Division of Gynecologic Oncology, Department of Gynecology and Obstetrics, Zhongshan Hospital, Fudan University, Shanghai 200032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gong","family":"Yang","sequence":"additional","affiliation":[{"name":"Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai 200032, China"},{"name":"Department of Gynecology and Obstetrics, The Fifth People's Hospital of Shanghai Fudan University, Shanghai 200240, China"},{"name":"Central Laboratory, The Fifth People's Hospital of Shanghai Fudan University, Shanghai 200240, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongyu","family":"Zang","sequence":"additional","affiliation":[{"name":"Ovarian Cancer Program, Division of Gynecologic Oncology, Department of Gynecology and Obstetrics, Zhongshan Hospital, Fudan University, Shanghai 200032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2016,4,18]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3322\/caac.20107","article-title":"Global cancer statistics","volume":"61","author":"Forman","year":"2011","journal-title":"CA Cancer J Clin"},{"key":"2","doi-asserted-by":"crossref","first-page":"252","DOI":"10.3322\/caac.21235","article-title":"Cancer treatment and survivorship statistics, 2014","volume":"64","author":"Jemal","year":"2014","journal-title":"CA Cancer J Clin"},{"key":"3","doi-asserted-by":"crossref","first-page":"6048","DOI":"10.1073\/pnas.94.12.6048","article-title":"Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner","volume":"94","author":"Appella","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.4161\/cc.9.11.11810","article-title":"Dephosphorylation of gamma-H2AX by WIP1: an important homeostatic regulatory event in DNA repair and cell cycle control","volume":"9","author":"Donehower","year":"2010","journal-title":"Cell cycle"},{"key":"5","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.molcel.2006.07.010","article-title":"Wip1 phosphatase modulates ATM-dependent signaling pathways","volume":"23","author":"Bulavin","year":"2006","journal-title":"Mol Cell"},{"key":"6","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/ng894","article-title":"Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity","volume":"31","author":"Appella","year":"2002","journal-title":"Nat Genet"},{"key":"7","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1182\/blood-2012-05-432674","article-title":"Phosphatase Wip1 negatively regulates neutrophil development through p38 MAPK-STAT1","volume":"121","author":"Zhao","year":"2013","journal-title":"Blood"},{"key":"8","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.4049\/jimmunol.1300656","article-title":"Phosphatase Wip1 negatively regulates neutrophil migration and inflammation","volume":"192","author":"Zhao","year":"2014","journal-title":"J Immunol"},{"key":"9","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.yexcr.2015.09.020","article-title":"Wip1 knockout inhibits the proliferation and enhances the migration of bone marrow mesenchymal stem cells","volume":"334","author":"Li","year":"2015","journal-title":"Exp Cell Res"},{"key":"10","doi-asserted-by":"publisher","first-page":"9031","DOI":"10.18632\/oncotarget.3320","article-title":"WIP1 stimulates migration and invasion of salivary adenoid cystic carcinoma by inducing MMP-9 and VEGF-C","volume":"6","author":"Liang","year":"2015","journal-title":"Oncotarget"},{"key":"11","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1038\/onc.2014.37","article-title":"The WIP1 oncogene promotes progression and invasion of aggressive medulloblastoma variants","volume":"34","author":"Castellino","year":"2015","journal-title":"Oncogene"},{"key":"12","doi-asserted-by":"crossref","first-page":"2991","DOI":"10.4161\/cc.7.19.6784","article-title":"Metastasis and AKT activation","volume":"7","author":"Pardee","year":"2008","journal-title":"Cell cycle"},{"key":"13","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/35000034","article-title":"The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells","volume":"2","author":"Garcia De Herreros","year":"2000","journal-title":"Nat Cell Biol"},{"key":"14","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/ncb1173","article-title":"Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition","volume":"6","author":"Hung","year":"2004","journal-title":"Nat Cell Biol"},{"key":"15","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1038\/sj.onc.1210729","article-title":"A chemical inhibitor of PPM1D that selectively kills cells overexpressing PPM1D","volume":"27","author":"Ashworth","year":"2008","journal-title":"Oncogene"},{"key":"16","doi-asserted-by":"crossref","first-page":"6517","DOI":"10.1093\/emboj\/19.23.6517","article-title":"p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation","volume":"19","author":"Imai","year":"2000","journal-title":"EMBO J"},{"key":"17","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.4161\/cc.19901","article-title":"Wip1 sensitizes p53-negative tumors to apoptosis by regulating the Bax\/Bcl-xL ratio","volume":"11","author":"Demidov","year":"2012","journal-title":"Cell cycle"},{"key":"18","doi-asserted-by":"crossref","first-page":"4029","DOI":"10.1074\/jbc.M410344200","article-title":"Full activation of PKB\/Akt in response to insulin or ionizing radiation is mediated through ATM","volume":"280","author":"Sanchez-Prieto","year":"2005","journal-title":"J Biol Chem"},{"key":"19","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1158\/1535-7163.MCT-08-1189","article-title":"The ATM inhibitor KU-55933 suppresses cell proliferation and induces apoptosis by blocking Akt in cancer cells with overactivated Akt","volume":"9","author":"Yang","year":"2010","journal-title":"Mol Cancer Ther"},{"key":"20","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/nature11725","article-title":"Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer","volume":"493","author":"Warren-Perry","year":"2013","journal-title":"Nature"},{"key":"21","doi-asserted-by":"publisher","first-page":"6670","DOI":"10.18632\/oncotarget.3118","article-title":"Fibrillin-1, induced by Aurora-A but inhibited by BRCA2, promotes ovarian cancer metastasis","volume":"6","author":"Yang","year":"2015","journal-title":"Oncotarget"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.8833","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T20:13:00Z","timestamp":1589227980000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.8833"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,18]]},"references-count":21,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2016,5,17]]}},"alternative-id":["8833","27121065"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.8833","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,18]]}}}