{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T19:08:44Z","timestamp":1775934524322,"version":"3.50.1"},"reference-count":79,"publisher":"Impact Journals, LLC","issue":"19","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2016,5,10]]},"DOI":"10.18632\/oncotarget.8853","type":"journal-article","created":{"date-parts":[[2016,4,20]],"date-time":"2016-04-20T12:56:17Z","timestamp":1461156977000},"page":"26992-27006","source":"Crossref","is-referenced-by-count":12,"title":["Dysregulation of peritoneal cavity B1a cells and murine primary biliary cholangitis"],"prefix":"10.18632","volume":"7","author":[{"given":"Yan-Qing","family":"Yang","sequence":"first","affiliation":[{"name":"Liver Immunology Laboratory, Institute of Immunology and The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Yang","sequence":"additional","affiliation":[{"name":"Liver Immunology Laboratory, Institute of Immunology and The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Yao","sequence":"additional","affiliation":[{"name":"Liver Immunology Laboratory, Institute of Immunology and The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Di","family":"Ma","sequence":"additional","affiliation":[{"name":"Liver Immunology Laboratory, Institute of Immunology and The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin-Hu","family":"Wang","sequence":"additional","affiliation":[{"name":"Liver Immunology Laboratory, Institute of Immunology and The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Li","sequence":"additional","affiliation":[{"name":"Liver Immunology Laboratory, Institute of Immunology and The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingfa","family":"Wu","sequence":"additional","affiliation":[{"name":"The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Eric","family":"Gershwin","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, CA, United States of America"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe-Xiong","family":"Lian","sequence":"additional","affiliation":[{"name":"Liver Immunology Laboratory, Institute of Immunology and The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, China"},{"name":"Innovation Center for Cell Signaling Network, Hefei National Laboratory for Physical Sciences at Microscale, Hefei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2016,4,20]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s12016-015-8484-9","article-title":"Unmet challenges in immune-mediated hepatobiliary diseases","volume":"48","author":"Gershwin","year":"2015","journal-title":"Clin Rev Allergy Immunol"},{"key":"2","doi-asserted-by":"crossref","first-page":"3525","DOI":"10.4049\/jimmunol.138.10.3525","article-title":"Identification and specificity of a cDNA encoding the 70 kd mitochondrial antigen recognized in primary biliary cirrhosis","volume":"138","author":"Coppel","year":"1987","journal-title":"J Immunol"},{"key":"3","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1056\/NEJMra043898","article-title":"Primary biliary cirrhosis","volume":"353","author":"Gershwin","year":"2005","journal-title":"N Engl J Med"},{"key":"4","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1002\/hep.27725","article-title":"Chemokine (C-X-C motif) ligand 13 promotes intrahepatic chemokine (C-X-C motif) receptor 5+ lymphocyte homing and aberrant B-cell immune responses in primary biliary cirrhosis","volume":"61","author":"Hou","year":"2015","journal-title":"Hepatology"},{"key":"5","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1002\/hep.28122","article-title":"Natural killer cells regulate T cell immune responses in primary biliary cirrhosis","volume":"62","author":"Akashi","year":"2015","journal-title":"Hepatology"},{"key":"6","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/hep.27306","article-title":"CXCR5+ CD4+ T follicular helper cells participate in the pathogenesis of primary biliary cirrhosis","volume":"61","author":"Li","year":"2015","journal-title":"Hepatology"},{"key":"7","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1002\/hep.27313","article-title":"Ongoing activation of autoantigen-specific B cells in primary biliary cirrhosis","volume":"60","author":"Gershwin","year":"2014","journal-title":"Hepatology"},{"key":"8","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jaut.2014.01.034","article-title":"Murine autoimmune cholangitis requires two hits: cytotoxic KLRG1(+) CD8 effector cells and defective T regulatory cells","volume":"50","author":"Ridgway","year":"2014","journal-title":"J Autoimmun"},{"key":"9","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/cei.12581","article-title":"Immunological potential of cytotoxic T lymphocyte antigen 4 immunoglobulin in murine autoimmune cholangitis","volume":"180","author":"Gershwin","year":"2015","journal-title":"Clin Exp Immunol"},{"key":"10","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jaut.2015.01.011","article-title":"Systems biologic analysis of T regulatory cells genetic pathways in murine primary biliary cirrhosis","volume":"59","author":"Lian","year":"2015","journal-title":"Journal of autoimmunity"},{"key":"11","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jaut.2015.09.002","article-title":"Successful treatment of murine autoimmune cholangitis by parabiosis: Implications for hematopoietic therapy","volume":"66","author":"Lian","year":"2016","journal-title":"J Autoimmun"},{"key":"12","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jaut.2014.02.009","article-title":"Distinct from its canonical effects, deletion of IL-12p40 induces cholangitis and fibrosis in interleukin-2Ralpha(\u2212\/\u2212) mice","volume":"51","author":"Lian","year":"2014","journal-title":"Journal of autoimmunity"},{"key":"13","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.cellimm.2011.01.005","article-title":"B cells promote hepatic inflammation, biliary cyst formation, and salivary gland inflammation in the NOD. c3c4 model of autoimmune cholangitis","volume":"268","author":"Gershwin","year":"2011","journal-title":"Cellular immunology"},{"key":"14","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1002\/hep.23238","article-title":"B-cell depletion with anti-CD20 ameliorates autoimmune cholangitis but exacerbates colitis in transforming growth factor-beta receptor II dominant negative mice","volume":"50","author":"Gershwin","year":"2009","journal-title":"Hepatology"},{"key":"15","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1053\/j.gastro.2008.11.035","article-title":"B cells suppress the inflammatory response in a mouse model of primary biliary cirrhosis","volume":"136","author":"Lian","year":"2009","journal-title":"Gastroenterology"},{"key":"16","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1002\/hep.24044","article-title":"B cell depletion therapy exacerbates murine primary biliary cirrhosis","volume":"53","author":"Gershwin","year":"2011","journal-title":"Hepatology"},{"key":"17","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/nri2901","article-title":"The double life of a B-1 cell: self-reactivity selects for protective effector functions","volume":"11","author":"Baumgarth","year":"2011","journal-title":"Nature reviews Immunology"},{"key":"18","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1182\/blood-2008-02-078071","article-title":"B lymphocytes: how they develop and function","volume":"112","author":"Tedder","year":"2008","journal-title":"Blood"},{"key":"19","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.immuni.2015.04.005","article-title":"Regulatory B cells: origin, phenotype, and function","volume":"42","author":"Mauri","year":"2015","journal-title":"Immunity"},{"key":"20","doi-asserted-by":"crossref","first-page":"705","DOI":"10.4049\/jimmunol.176.2.705","article-title":"A case for regulatory B cells","volume":"176","author":"Bhan","year":"2006","journal-title":"Journal of immunology"},{"key":"21","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/cmi.2012.60","article-title":"Regulatory B cells in autoimmune diseases","volume":"10","author":"Lu","year":"2013","journal-title":"Cellular & molecular immunology"},{"key":"22","doi-asserted-by":"crossref","first-page":"2780","DOI":"10.4049\/jimmunol.1300649","article-title":"Peritoneal cavity regulatory B cells (B10 cells) modulate IFN-gamma+CD4+ T cell numbers during colitis development in mice","volume":"191","author":"Tedder","year":"2013","journal-title":"Journal of immunology"},{"key":"23","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/nature12979","article-title":"IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases","volume":"507","author":"Miyazaki","year":"2014","journal-title":"Nature"},{"key":"24","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1002\/hep.28001","article-title":"B cells expressing CD11b effectively inhibit CD4+ T-cell responses and ameliorate experimental autoimmune hepatitis in mice","volume":"62","author":"Chu","year":"2015","journal-title":"Hepatology"},{"key":"25","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1084\/jem.192.2.271","article-title":"B-1 and B-2 cell-derived immunoglobulin M antibodies are nonredundant components of the protective response to influenza virus infection","volume":"192","author":"Chen","year":"2000","journal-title":"The Journal of experimental medicine"},{"key":"26","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1084\/jem.188.12.2381","article-title":"A critical role of natural immunoglobulin M in immediate defense against systemic bacterial infection","volume":"188","author":"Chen","year":"1998","journal-title":"The Journal of experimental medicine"},{"key":"27","first-page":"6","article-title":"A CD25(\u2212) positive population of activated B1 cells expresses LIFR and responds to LIF","volume":"2","author":"Rothstein","year":"2011","journal-title":"Frontiers in immunology"},{"key":"28","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/cmi.2012.63","article-title":"Regulatory functions of innate-like B cells","volume":"10","author":"Zhang","year":"2013","journal-title":"Cellular and Molecular Immunology"},{"key":"29","doi-asserted-by":"crossref","unstructured":"Wang, Shin, Abbasi, Jain, Kovalchuk, Beaty, Chen, Gonzalez-Garcia, Morse. Expression of plasma cell alloantigen 1 defines layered development of B-1a B-cell subsets with distinct innate-like functions. Proceedings of the National Academy of Sciences of the United States of America. 2012. 109:pp. 20077\u201320082.","DOI":"10.1073\/pnas.1212428109"},{"key":"30","doi-asserted-by":"crossref","first-page":"e88869","DOI":"10.1371\/journal.pone.0088869","article-title":"Activated peritoneal cavity B-1a cells possess regulatory B cell properties","volume":"9","author":"Broere","year":"2014","journal-title":"PloS one"},{"key":"31","doi-asserted-by":"crossref","first-page":"4637","DOI":"10.4049\/jimmunol.0901719","article-title":"CD22 expression mediates the regulatory functions of peritoneal B-1a cells during the remission phase of contact hypersensitivity reactions","volume":"184","author":"Fujimoto","year":"2010","journal-title":"Journal of immunology"},{"key":"32","doi-asserted-by":"crossref","first-page":"123","DOI":"10.2119\/molmed.2011.00333","article-title":"Multiple mechanisms of immune suppression by B lymphocytes","volume":"18","author":"Lundy","year":"2012","journal-title":"Molecular medicine"},{"key":"33","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1749-6632.2009.05137.x","article-title":"B10 cells and regulatory B cells balance immune responses during inflammation, autoimmunity, and cancer","volume":"1183","author":"Tedder","year":"2010","journal-title":"Annals of the New York Academy of Sciences"},{"key":"34","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1093\/intimm\/dxn031","article-title":"Regulatory role of B-1 B cells in chronic colitis","volume":"20","author":"Bhan","year":"2008","journal-title":"International immunology"},{"key":"35","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/cmi.2012.63","article-title":"Regulatory functions of innate-like B cells","volume":"10","author":"Zhang","year":"2013","journal-title":"Cellular & molecular immunology"},{"key":"36","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/cmi.2014.56","article-title":"A B-1a cell subset induces Foxp3(\u2212) T cells with regulatory activity through an IL-10-independent pathway","volume":"12","author":"Chiang","year":"2015","journal-title":"Cellular & molecular immunology"},{"key":"37","doi-asserted-by":"crossref","first-page":"P86","DOI":"10.1186\/1546-0096-12-S1-P86","article-title":"Regulatory B cell Il-10 production is diminished in juvenile dermatomyositis","volume":"12","author":"Nistala","year":"2014","journal-title":"Pediatric Rheumatology"},{"key":"38","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/j.1600-0609.2012.01778.x","article-title":"High Ki-67 expression in diffuse large B-cell lymphoma patients with non-germinal center subtype indicates limited survival benefit from R-CHOP therapy","volume":"88","author":"Guan","year":"2012","journal-title":"European journal of haematology"},{"key":"39","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1600-065X.2008.00652.x","article-title":"Regulation of B-cell entry into the cell cycle","volume":"224","author":"Clark","year":"2008","journal-title":"Immunological reviews"},{"key":"40","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1146\/annurev-immunol-020711-074934","article-title":"Immune regulatory function of B cells","volume":"30","author":"Bosma","year":"2012","journal-title":"Annual review of immunology"},{"key":"41","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1600-065X.2008.00661.x","article-title":"Regulatory B cells as inhibitors of immune responses and inflammation","volume":"224","author":"Tedder","year":"2008","journal-title":"Immunological reviews"},{"key":"42","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1002\/eji.1830220314","article-title":"Ly-1 B (B-1) cells are the main source of B cell-derived interleukin 10","volume":"22","author":"Howard","year":"1992","journal-title":"European journal of immunology"},{"key":"43","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/imr.12176","article-title":"B10 cell regulation of health and disease","volume":"259","author":"Tedder","year":"2014","journal-title":"Immunological reviews"},{"key":"44","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.immuni.2014.10.016","article-title":"Interleukin-10-producing plasmablasts exert regulatory function in autoimmune inflammation","volume":"41","author":"Baba","year":"2014","journal-title":"Immunity"},{"key":"45","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1038\/ni.1791","article-title":"Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis","volume":"10","author":"Kronenberg","year":"2009","journal-title":"Nature immunology"},{"key":"46","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.immuni.2008.02.017","article-title":"Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces","volume":"28","author":"Rudensky","year":"2008","journal-title":"Immunity"},{"key":"47","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1146\/annurev-immunol-031210-101312","article-title":"Regulation and functions of the IL-10 family of cytokines in inflammation and disease","volume":"29","author":"Hymowitz","year":"2011","journal-title":"Annual review of immunology"},{"key":"48","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1084\/jem.174.3.561","article-title":"CTLA-4 is a second receptor for the B cell activation antigen B7","volume":"174","author":"Ledbetter","year":"1991","journal-title":"The Journal of experimental medicine"},{"key":"49","doi-asserted-by":"crossref","first-page":"5","DOI":"10.4103\/2319-4170.151150","article-title":"Immune checkpoint blockade therapy: the 2014 Tang Prize in Biopharmaceutical Science","volume":"38","author":"Shen","year":"2015","journal-title":"Biomedical journal"},{"key":"50","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1146\/annurev.immunol.24.021605.090535","article-title":"A molecular perspective of CTLA-4 function","volume":"24","author":"Madrenas","year":"2006","journal-title":"Annual review of immunology"},{"key":"51","doi-asserted-by":"crossref","first-page":"5155","DOI":"10.1182\/blood-2011-11-388918","article-title":"Basis of CTLA-4 function in regulatory and conventional CD4(+) T cells","volume":"119","author":"Singer","year":"2012","journal-title":"Blood"},{"key":"52","doi-asserted-by":"crossref","unstructured":"Verhagen, Genolet, Britton, Stevenson, Sabatos-Peyton, Dyson, Luescher, Wraith. CTLA-4 controls the thymic development of both conventional and regulatory T cells through modulation of the TCR repertoire. Proceedings of the National Academy of Sciences of the United States of America. 2013. 110:pp. E221\u2013230.","DOI":"10.1073\/pnas.1208573110"},{"key":"53","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1084\/jem.20082492","article-title":"Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies","volume":"206","author":"Allison","year":"2009","journal-title":"The Journal of experimental medicine"},{"key":"54","doi-asserted-by":"crossref","first-page":"7316","DOI":"10.4049\/jimmunol.179.11.7316","article-title":"A new role of CTLA-4 on B cells in thymus-dependent immune responses in vivo","volume":"179","author":"Brunner-Weinzierl","year":"2007","journal-title":"Journal of immunology"},{"key":"55","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1046\/j.1365-2249.2001.01575.x","article-title":"Increased expression of CTLA-4 (CD152) by T and B lymphocytes in Wegener's granulomatosis","volume":"126","author":"Broker","year":"2001","journal-title":"Clinical and experimental immunology"},{"key":"56","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.4049\/jimmunol.155.4.1776","article-title":"Activated T cells can induce high levels of CTLA-4 expression on B cells","volume":"155","author":"van Lier","year":"1995","journal-title":"Journal of immunology"},{"key":"57","doi-asserted-by":"crossref","unstructured":"Baumgarth, Jager, Herman, Herzenberg. CD4+ T cells derived from B cell-deficient mice inhibit the establishment of peripheral B cell pools. Proceedings of the National Academy of Sciences of the United States of America. 2000. 97:pp. 4766\u20134771.","DOI":"10.1073\/pnas.97.9.4766"},{"key":"58","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.cytogfr.2009.02.004","article-title":"Interferon-gamma: a historical perspective","volume":"20","author":"Matthys","year":"2009","journal-title":"Cytokine Growth Factor Rev"},{"key":"59","doi-asserted-by":"crossref","first-page":"5200","DOI":"10.1182\/blood-2010-05-284547","article-title":"IL-21 induces death of marginal zone B cells during chronic inflammation","volume":"116","author":"Kopf","year":"2010","journal-title":"Blood"},{"key":"60","doi-asserted-by":"crossref","first-page":"4111","DOI":"10.4049\/jimmunol.170.8.4111","article-title":"IL-21 induces the apoptosis of resting and activated primary B cells","volume":"170","author":"Grusby","year":"2003","journal-title":"Journal of immunology"},{"key":"61","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/s10875-008-9264-6","article-title":"CD72, a coreceptor with both positive and negative effects on B lymphocyte development and function","volume":"29","author":"Bondada","year":"2009","journal-title":"Journal of clinical immunology"},{"key":"62","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1034\/j.1600-065X.2000.00608.x","article-title":"CD72, a negative regulator of B-cell responsiveness","volume":"176","author":"Pan","year":"2000","journal-title":"Immunological reviews"},{"key":"63","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S1074-7613(00)80124-7","article-title":"CD72-deficient mice reveal nonredundant roles of CD72 in B cell development and activation","volume":"11","author":"Parnes","year":"1999","journal-title":"Immunity"},{"key":"64","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/S0960-9822(07)00421-6","article-title":"The B-cell transmembrane protein CD72 binds to and is an in vivo substrate of the protein tyrosine phosphatase SHP-1","volume":"8","author":"Hozumi","year":"1998","journal-title":"Current biology"},{"key":"65","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1146\/annurev.immunol.26.021607.090357","article-title":"The biology of interleukin-2","volume":"26","author":"Malek","year":"2008","journal-title":"Annual review of immunology"},{"key":"66","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1111\/j.1365-3083.2006.01832.x","article-title":"B-cell CD25 expression in murine primary and secondary lymphoid tissue","volume":"64","author":"Brisslert","year":"2006","journal-title":"Scand J Immunol"},{"key":"67","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1365-3083.2010.02380.x","article-title":"Functional characterization of murine CD25 expressing B cells","volume":"71","author":"Brisslert","year":"2010","journal-title":"Scand J Immunol"},{"key":"68","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1111\/j.1365-2567.2006.02331.x","article-title":"Phenotypic and functional characterization of human CD25+ B cells","volume":"117","author":"Tarkowski","year":"2006","journal-title":"Immunology"},{"key":"69","first-page":"481948","article-title":"Phenotype and function of CD25-expressing B lymphocytes isolated from human umbilical cord blood","volume":"2011","author":"Brisslert","year":"2011","journal-title":"Clinical & developmental immunology"},{"key":"70","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1182\/blood-2009-03-212886","article-title":"Activated human B cells: stimulatory or tolerogenic antigen-presenting cells?","volume":"114","author":"von Bergwelt-Baildon","year":"2009","journal-title":"Blood"},{"key":"71","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.autrev.2011.11.018","article-title":"Human CD19(+)CD25(high) B regulatory cells suppress proliferation of CD4(+) T cells and enhance Foxp3 and CTLA-4 expression in T-regulatory cells","volume":"11","author":"Toubi","year":"2012","journal-title":"Autoimmunity reviews"},{"key":"72","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.4049\/jimmunol.177.3.1655","article-title":"Anti-mitochondrial antibodies and primary biliary cirrhosis in TGF-beta receptor II dominant-negative mice","volume":"177","author":"Gershwin","year":"2006","journal-title":"Journal of immunology"},{"key":"73","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.jaut.2013.07.008","article-title":"STAT3-mediated attenuation of CCl-induced mouse liver fibrosis by the protein kinase inhibitor sorafenib","volume":"46","author":"Lian","year":"2013","journal-title":"Journal of autoimmunity"},{"key":"74","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1002\/hep.22226","article-title":"Adoptive transfer of CD8(+) T cells from transforming growth factor beta receptor type II (dominant negative form) induces autoimmune cholangitis in mice","volume":"47","author":"Gershwin","year":"2008","journal-title":"Hepatology"},{"key":"75","doi-asserted-by":"publisher","DOI":"10.3791\/1488","article-title":"Isolation of mouse peritoneal cavity cells","author":"Dittel","year":"2010","journal-title":"J Vis Exp"},{"key":"76","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1002\/eji.201141519","article-title":"Novel functions of murine B1 cells: active phagocytic and microbicidal abilities","volume":"42","author":"Liu","year":"2012","journal-title":"European journal of immunology"},{"key":"77","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1002\/hep.23132","article-title":"Deletion of interleukin-12p40 suppresses autoimmune cholangitis in dominant negative transforming growth factor beta receptor type II mice","volume":"50","author":"Gershwin","year":"2009","journal-title":"Hepatology"},{"key":"78","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1172\/JCI0214698","article-title":"Quantitative and functional analysis of PDC-E2-specific autoreactive cytotoxic T lymphocytes in primary biliary cirrhosis","volume":"109","author":"Gershwin","year":"2002","journal-title":"Journal of Clinical Investigation"},{"key":"79","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.1002\/eji.201344183","article-title":"Molecular signatures and transcriptional regulatory networks of human immature decidual NK and mature peripheral NK cells","volume":"44","author":"Wei","year":"2014","journal-title":"European journal of immunology"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.8853","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T18:23:52Z","timestamp":1692296632000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.8853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,20]]},"references-count":79,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2016,5,10]]}},"alternative-id":["8853","27105495"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.8853","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,20]]}}}