{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:54:19Z","timestamp":1790128459169,"version":"4.0.1"},"reference-count":46,"publisher":"Impact Journals, LLC","issue":"21","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2016,5,24]]},"DOI":"10.18632\/oncotarget.8864","type":"journal-article","created":{"date-parts":[[2016,4,20]],"date-time":"2016-04-20T15:23:13Z","timestamp":1461165793000},"page":"30523-30535","source":"Crossref","is-referenced-by-count":52,"title":["CD30 on extracellular vesicles from malignant Hodgkin cells supports damaging of CD30 ligand-expressing bystander cells with Brentuximab-Vedotin,<i>in vitro<\/i>"],"prefix":"10.18632","volume":"7","author":[{"given":"Hinrich P.","family":"Hansen","sequence":"first","affiliation":[{"name":"Department of Internal Medicine I, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Trad","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University Kiel, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Dams","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Zigrino","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia","family":"Moss","sequence":"additional","affiliation":[{"name":"BioZyme Inc., Apex, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Tator","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisela","family":"Sch\u00f6n","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia C","family":"Grenzi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Bachurski","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Aquino","sequence":"additional","affiliation":[{"name":"Brazilian Biosciences National Laboratory, LNBio, CNPEM, Campinas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horst","family":"D\u00fcrkop","sequence":"additional","affiliation":[{"name":"Pathodiagnostik Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin S","family":"Reiners","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"von Bergwelt-Baildon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hallek","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Gr\u00f6tzinger","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University Kiel, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Engert","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana F Paes","family":"Leme","sequence":"additional","affiliation":[{"name":"Brazilian Biosciences National Laboratory, LNBio, CNPEM, Campinas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke Pogge","family":"von Strandmann","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2016,4,20]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1046\/j.1365-2141.2002.03768.x","article-title":"Mast cell infiltration correlates with poor prognosis in Hodgkin's lymphoma","volume":"119","author":"Enblad","year":"2002","journal-title":"Br J Haematol"},{"key":"2","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1046\/j.1365-2141.2001.02977.x","article-title":"Mast cells express functional CD30 ligand and are the predominant CD30L-positive cells in Hodgkin's disease","volume":"114","author":"Nilsson","year":"2001","journal-title":"Br J Haematol"},{"key":"3","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/ejh.12583","article-title":"Tumour-associated mast cells in classical Hodgkin's lymphoma: correlation with histological subtype, other tumour-infiltrating inflammatory cell subsets and outcome","volume":"96","author":"d'Amore","year":"2016","journal-title":"Eur J Haematol"},{"key":"4","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/hon.2900110404","article-title":"Infiltration of eosinophils in Hodgkin's disease involved lymph nodes predicts prognosis","volume":"11","author":"Glimelius","year":"1993","journal-title":"Hematol Oncol"},{"key":"5","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/path.4306","article-title":"Protrusion-guided extracellular vesicles mediate CD30 trans-signalling in the microenvironment of Hodgkin's lymphoma","volume":"232","author":"Hallek","year":"2014","journal-title":"J Pathol"},{"key":"6","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/eji.1830190125","article-title":"Ki-1 (CD30) antigen is released by Ki-1-positive tumor cellsand. I. Partial characterization of soluble Ki-1 antigen and detection of the antigen in cell culture supernatants and in serum by an enzyme-linked immunosorbent assay","volume":"19","author":"Diamantstein","year":"1989","journal-title":"Eur J Immunol"},{"key":"7","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1158\/0008-5472.CAN-06-2470","article-title":"ADAM10 inhibition of human CD30 shedding increases specificity of targeted immunotherapy","volume":"67","author":"Hansen","year":"2007","journal-title":"Cancer Res"},{"key":"8","doi-asserted-by":"crossref","first-page":"6703","DOI":"10.4049\/jimmunol.165.12.6703","article-title":"CD30 shedding from Karpas 299 lymphoma cells is mediated by TNF-alpha- converting enzyme","volume":"165","author":"Lemke","year":"2000","journal-title":"J Immunol"},{"key":"9","first-page":"114","article-title":"Proteolytically active ADAM10 and ADAM17 carried on membrane microvesicles in human abdominal aortic aneurysms","author":"Liu","year":"2015","journal-title":"Thromb Haemost"},{"key":"10","article-title":"Microenvironmental interactions in classical Hodgkin lymphoma and their role in promoting tumor growth, immune escape and drug resistance","author":"Casagrande","year":"2015","journal-title":"Cancer Lett"},{"key":"11","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1172\/JCI24274","article-title":"Mast cell CD30 ligand is upregulated in cutaneous inflammation and mediates degranulation-independent chemokine secretion","volume":"116","author":"Nilsson","year":"2006","journal-title":"J Clin Invest"},{"key":"12","doi-asserted-by":"crossref","first-page":"3635","DOI":"10.4049\/jimmunol.157.8.3635","article-title":"Reverse signaling via CD30 ligand","volume":"157","author":"Smith","year":"1996","journal-title":"J Immunol"},{"key":"13","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/1521-4141(200201)32:1<163::AID-IMMU163>3.0.CO;2-T","article-title":"Soluble CD30 binds to CD153 with high affinity and blocks transmembrane signaling by CD30","volume":"32","author":"Al-Shamkhani","year":"2002","journal-title":"Eur J Immunol"},{"key":"14","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1200\/JCO.2011.38.0410","article-title":"Results of a pivotal phase II study of brentuximab vedotin for patients with relapsed or refractory Hodgkin's lymphoma","volume":"30","author":"Connors","year":"2012","journal-title":"Journal of clinical oncology"},{"key":"15","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1182\/blood-2003-01-0039","article-title":"cAC10-vcMMAE, an anti-CD30-monomethyl auristatin E conjugate with potent and selective antitumor activity","volume":"102","author":"Siegall","year":"2003","journal-title":"Blood"},{"key":"16","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1158\/1078-0432.CCR-09-2069","article-title":"Intracellular activation of SGN-35, a potent anti-CD30 antibody-drug conjugate","volume":"16","author":"Alley","year":"2010","journal-title":"Clin Cancer Res"},{"key":"17","article-title":"Intratumoral payload release influences the potency and bystander-killing effects of antibody-drug conjugates in preclinical models","author":"Law","year":"2016","journal-title":"Cancer Res"},{"key":"18","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1042\/BJ20090549","article-title":"Active-site determinants of substrate recognition by the metalloproteinases TACE and ADAM10","volume":"424","author":"Turk","year":"2009","journal-title":"Biochem J"},{"key":"19","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1182\/blood-2002-12-3775","article-title":"The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion","volume":"102","author":"Ludwig","year":"2003","journal-title":"Blood"},{"key":"20","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.4049\/jimmunol.139.6.2081","article-title":"Biochemical characterization and biosynthesis of the Ki-1 antigen in Hodgkin-derived and virus-transformed human B and T lymphoid cell lines","volume":"139","author":"Stein","year":"1987","journal-title":"J Immunol"},{"key":"21","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1016\/S0002-9440(10)65522-8","article-title":"Frequent expression of the variant CD30 in human malignant myeloid and lymphoid neoplasms","volume":"155","author":"Watanabe","year":"1999","journal-title":"Am J Pathol"},{"key":"22","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1182\/blood.V88.7.2422.bloodjournal8872422","article-title":"A variant CD30 protein lacking extracellular and transmembrane domains is induced in HL-60 by tetradecanoylphorbol acetate and is expressed in alveolar macrophages","volume":"88","author":"Watanabe","year":"1996","journal-title":"Blood"},{"key":"23","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0022-1759(02)00330-7","article-title":"Production and characterization of clinical grade exosomes derived from dendritic cells","volume":"270","author":"Le Pecq","year":"2002","journal-title":"J Immunol Methods"},{"key":"24","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1038\/sj.bjc.6605238","article-title":"Inflammation and tissue repair markers distinguish the nodular sclerosis and mixed cellularity subtypes of classical Hodgkin's lymphoma","volume":"101","author":"Ernberg","year":"2009","journal-title":"Br J Cancer"},{"key":"25","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1093\/ajcp\/55.3.283","article-title":"Cytochemical identification of monocytes and granulocytes","volume":"55","author":"Crosby","year":"1971","journal-title":"Am J Clin Pathol"},{"key":"26","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/j.1365-2141.1990.tb02664.x","article-title":"Serum levels of soluble CD30 molecule (Ki-1 antigen) in Hodgkin's disease: relationship with disease activity and clinical stage","volume":"75","author":"Stein","year":"1990","journal-title":"Br J Haematol"},{"key":"27","doi-asserted-by":"crossref","first-page":"e7542","DOI":"10.1371\/journal.pone.0007542","article-title":"miR-143 interferes with ERK5 signaling, and abrogates prostate cancer progression in mice","volume":"4","author":"Fajas","year":"2009","journal-title":"PLoS One"},{"key":"28","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/nm.2753","article-title":"Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET","volume":"18","author":"Badal","year":"2012","journal-title":"Nat Med"},{"key":"29","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nature15756","article-title":"Tumour exosome integrins determine organotropic metastasis","volume":"527","author":"Soplop","year":"2015","journal-title":"Nature"},{"key":"30","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.it.2011.05.005","article-title":"ADAM17: a molecular switch to control inflammation and tissue regeneration","volume":"32","author":"Rose-John","year":"2011","journal-title":"Trends Immunol"},{"key":"31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2015.10.003","article-title":"The alpha secretase ADAM10: A metalloprotease with multiple functions in the brain","volume":"135","author":"Lichtenthaler","year":"2015","journal-title":"Prog Neurobiol"},{"key":"32","first-page":"581","article-title":"Membrane vesicles as conveyors of immune responses","volume":"9","author":"Segura","year":"2009","journal-title":"Nature reviews"},{"key":"33","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1038\/ncb1800","article-title":"Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers","volume":"10","author":"Breakefield","year":"2008","journal-title":"Nature cell biology"},{"key":"34","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s11060-015-2051-3","article-title":"Initial evidence that blood-borne microvesicles are biomarkers for recurrence and survival in newly diagnosed glioblastoma patients","volume":"127","author":"Koch","year":"2016","journal-title":"J Neurooncol"},{"key":"35","first-page":"2581","article-title":"Observations on cell lines derived from a patient with Hodgkin's disease","volume":"38","author":"Cuttner","year":"1978","journal-title":"Cancer research"},{"key":"36","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1158\/1078-0432.CCR-13-1024","article-title":"Plasma microRNA are disease response biomarkers in classical Hodgkin lymphoma","volume":"20","author":"Gandhi","year":"2014","journal-title":"Clin Cancer Res"},{"key":"37","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1002\/ijc.20278","article-title":"Metalloproteinase inhibition augments antitumor efficacy of the anti-CD30 immunotoxin Ki-3(scFv)-ETA\u2019 against human lymphomas","volume":"111","author":"Hansen","year":"2004","journal-title":"Int J Cancer"},{"key":"38","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/ijc.2910600419","article-title":"Shedding of the soluble form of CD30 from the Hodgkin-analogous cell line L540 is strongly inhibited by a new CD30-specific antibody (Ki-4)","volume":"60","author":"Lemke","year":"1995","journal-title":"Int J Cancer"},{"key":"39","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s11912-015-0466-9","article-title":"Development and Integration of Antibody-Drug Conjugate in Non-Hodgkin Lymphoma","volume":"17","author":"Forero-Torres","year":"2015","journal-title":"Curr Oncol Rep"},{"key":"40","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1006\/bbrc.1999.0336","article-title":"Expression of CD30 ligand (CD153) on murine activated T cells","volume":"256","author":"Okumura","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"41","doi-asserted-by":"crossref","first-page":"786","DOI":"10.4049\/jimmunol.165.2.786","article-title":"Engagement of CD153 (CD30 ligand) by CD30+ T cells inhibits class switch DNA recombination and antibody production in human IgD+ IgM+ B cells","volume":"165","author":"Casali","year":"2000","journal-title":"J Immunol"},{"key":"42","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/j.leukres.2014.09.007","article-title":"Microvascular density, CD68 and tryptase expression in human diffuse large B-cell lymphoma","volume":"38","author":"Ribatti","year":"2014","journal-title":"Leuk Res"},{"key":"43","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1053\/j.seminhematol.2012.01.003","article-title":"Lymphoproliferative disorders associated with hypereosinophilia","volume":"49","author":"de Leval","year":"2012","journal-title":"Semin Hematol"},{"key":"44","doi-asserted-by":"crossref","first-page":"4231","DOI":"10.4049\/jimmunol.134.6.4231","article-title":"Production and characterization of a monoclonal antibody that binds Reed-Sternberg cells","volume":"134","author":"Fisher","year":"1985","journal-title":"Journal of immunology"},{"key":"45","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1182\/blood.V74.5.1678.1678","article-title":"BER-H2: a new anti-Ki-1 (CD30) monoclonal antibody directed at a formol-resistant epitope","volume":"74","author":"Stein","year":"1989","journal-title":"Blood"},{"key":"46","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1096\/fj.03-0901fje","article-title":"The ectodomain shedding of CD30 is specifically regulated by peptide motifs in its cysteine-rich domains 2 and 5","volume":"18","author":"Engert","year":"2004","journal-title":"Faseb J"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.8864","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T21:44:11Z","timestamp":1718487851000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.8864"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,20]]},"references-count":46,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2016,5,24]]}},"alternative-id":["8864","27105521"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.8864","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,20]]}}}