{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T11:16:55Z","timestamp":1701256615749},"reference-count":35,"publisher":"Impact Journals, LLC","issue":"21","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2016,5,24]]},"DOI":"10.18632\/oncotarget.8948","type":"journal-article","created":{"date-parts":[[2016,4,23]],"date-time":"2016-04-23T09:42:27Z","timestamp":1461404547000},"page":"31429-31439","source":"Crossref","is-referenced-by-count":7,"title":["Multiple analyses of large-scale genome-wide association study highlight new risk pathways in lumbar spine bone mineral density"],"prefix":"10.18632","volume":"7","author":[{"given":"Jinsong","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Trauma and Emergency Surgeon, The Second Affiliated Hospital, Harbin Medical University, Harbin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guiyou","family":"Liu","sequence":"additional","affiliation":[{"name":"Genome Analysis Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keshen","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China"},{"name":"Stroke Center, Neurology & Neurosurgery Division, The Clinical Medicine Research Institute & The First Affiliated Hospital, Jinan University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2016,4,23]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/nrg3228","article-title":"Genetics of osteoporosis from genome-wide association studies: advances and challenges","volume":"13","author":"Spector","year":"2012","journal-title":"Nat Rev Genet"},{"key":"2","doi-asserted-by":"crossref","first-page":"e1000806","DOI":"10.1371\/journal.pgen.1000806","article-title":"Genome-wide association study identifies ALDH7A1 as a novel susceptibility gene for osteoporosis","volume":"6","author":"Xu","year":"2010","journal-title":"PLoS Genet"},{"key":"3","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/ng.2249","article-title":"Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture","volume":"44","author":"Vandenput","year":"2012","journal-title":"Nat Genet"},{"key":"4","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nature14878","article-title":"Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture","volume":"526","author":"Nielson","year":"2015","journal-title":"Nature"},{"key":"5","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/j.1471-4159.2011.07547.x","article-title":"Cell adhesion molecules contribute to Alzheimer's disease: multiple pathway analyses of two genome-wide association studies","volume":"120","author":"Chen","year":"2012","journal-title":"J Neurochem"},{"key":"6","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.neurobiolaging.2013.10.084","article-title":"Cardiovascular disease contributes to Alzheimer's disease: evidence from large-scale genome-wide association studies","volume":"35","author":"Li","year":"2014","journal-title":"Neurobiol Aging"},{"issue":"2904","key":"7","first-page":"e2901","article-title":"Cell adhesion molecule pathway genes are regulated by cis-regulatory SNPs and show significantly altered expression in Alzheimer's disease brains","volume":"36","author":"Li","year":"2015","journal-title":"Neurobiol Aging"},{"key":"8","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1007\/s12035-014-8884-5","article-title":"Integrating Genome-Wide Association Study and Brain Expression Data Highlights Cell Adhesion Molecules and Purine Metabolism in Alzheimer's Disease","volume":"52","author":"Liu","year":"2015","journal-title":"Mol Neurobiol"},{"key":"9","doi-asserted-by":"crossref","first-page":"3494","DOI":"10.1093\/hmg\/ddr248","article-title":"Pathway-driven gene stability selection of two rheumatoid arthritis GWAS identifies and validates new susceptibility genes in receptor mediated signalling pathways","volume":"20","author":"Coin","year":"2011","journal-title":"Hum Mol Genet"},{"key":"10","doi-asserted-by":"crossref","first-page":"e75951","DOI":"10.1371\/journal.pone.0075951","article-title":"Measles contributes to rheumatoid arthritis: evidence from pathway and network analyses of genome-wide association studies","volume":"8","author":"Li","year":"2013","journal-title":"PLoS One"},{"key":"11","doi-asserted-by":"crossref","first-page":"13025","DOI":"10.1038\/srep13025","article-title":"Pathway analysis of body mass index genome-wide association study highlights risk pathways in cardiovascular disease","volume":"5","author":"Liu","year":"2015","journal-title":"Sci Rep"},{"key":"12","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1002\/jbmr.36","article-title":"Pathway-based genome-wide association analysis identified the importance of regulation-of-autophagy pathway for ultradistal radius BMD","volume":"25","author":"Deng","year":"2010","journal-title":"J Bone Miner Res"},{"key":"13","doi-asserted-by":"crossref","first-page":"8099","DOI":"10.1007\/s11033-012-1657-1","article-title":"Pathway analysis of genome-wide association study for bone mineral density","volume":"39","author":"Song","year":"2012","journal-title":"Mol Biol Rep"},{"key":"14","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s00439-009-0676-z","article-title":"Strategies and issues in the detection of pathway enrichment in genome-wide association studies","volume":"126","author":"Prince","year":"2009","journal-title":"Hum Genet"},{"key":"15","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1002\/gepi.20636","article-title":"Evaluation of an approximation method for assessment of overall significance of multiple-dependent tests in a genomewide association study","volume":"35","author":"O'Donovan","year":"2011","journal-title":"Genet Epidemiol"},{"key":"16","first-page":"4","article-title":"Wnt signaling in bone development and disease: making stronger bone with Wnts","author":"Yang","year":"2012","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"17","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s00223-009-9256-4","article-title":"Polymorphisms of the WNT10B gene, bone mineral density, and fractures in postmenopausal women","volume":"85","author":"Riancho","year":"2009","journal-title":"Calcif Tissue Int"},{"key":"18","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1056\/NEJMoa0801197","article-title":"Multiple genetic loci for bone mineral density and fractures","volume":"358","author":"Kong","year":"2008","journal-title":"N Engl J Med"},{"key":"19","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/nrg2884","article-title":"Analysing biological pathways in genome-wide association studies","volume":"11","author":"Hakonarson","year":"2010","journal-title":"Nat Rev Genet"},{"key":"20","doi-asserted-by":"crossref","first-page":"2762","DOI":"10.1093\/bioinformatics\/btp448","article-title":"The SNP ratio test: pathway analysis of genome-wide association datasets","volume":"25","author":"Corvin","year":"2009","journal-title":"Bioinformatics"},{"key":"21","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1086\/522374","article-title":"Pathway-based approaches for analysis of genomewide association studies","volume":"81","author":"Bucan","year":"2007","journal-title":"Am J Hum Genet"},{"key":"22","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.ajhg.2010.04.014","article-title":"Insights into colon cancer etiology via a regularized approach to gene set analysis of GWAS data","volume":"86","author":"Hsu","year":"2010","journal-title":"Am J Hum Genet"},{"key":"23","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"Sham","year":"2007","journal-title":"Am J Hum Genet"},{"key":"24","first-page":"6","article-title":"Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traits","author":"Altshuler","year":"2010","journal-title":"PLoS Genet"},{"key":"25","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s00439-011-0956-2","article-title":"Genetic analysis of biological pathway data through genomic randomization","volume":"129","author":"Haines","year":"2011","journal-title":"Hum Genet"},{"key":"26","doi-asserted-by":"crossref","first-page":"W741","DOI":"10.1093\/nar\/gki475","article-title":"WebGestalt: an integrated system for exploring gene sets in various biological contexts","volume":"33","author":"Snoddy","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"27","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1136\/ard.2003.016253","article-title":"Bone mineral density in patients with rheumatoid arthritis: relation between disease severity and low bone mineral density","volume":"63","author":"Lems","year":"2004","journal-title":"Ann Rheum Dis"},{"key":"28","doi-asserted-by":"crossref","unstructured":"Heidari, Firouzjahi, Mirghssemi, Heidar, Hakimi, Hajian-Tilaki. Relationship between bone mineral density and duration of rheumatoid arthritis Indian Journal of Rheumatology. 2015; 10:10\u201315.","DOI":"10.1016\/j.injr.2014.09.002"},{"key":"29","doi-asserted-by":"crossref","first-page":"e14073","DOI":"10.1371\/journal.pone.0014073","article-title":"TGF-beta1 as possible link between loss of bone mineral density and chronic inflammation","volume":"5","author":"Nussler","year":"2010","journal-title":"PLoS One"},{"key":"30","doi-asserted-by":"crossref","first-page":"272","DOI":"10.7150\/ijbs.2929","article-title":"TGF-beta and BMP signaling in osteoblast differentiation and bone formation","volume":"8","author":"Li","year":"2012","journal-title":"Int J Biol Sci"},{"key":"31","doi-asserted-by":"crossref","first-page":"10619","DOI":"10.1073\/pnas.0701421104","article-title":"Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis","volume":"104","author":"Paralkar","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"32","doi-asserted-by":"crossref","first-page":"698","DOI":"10.3109\/1354750X.2011.629373","article-title":"Bone mineral density and genetic markers involved in three connected pathways (focal adhesion, actin cytoskeleton regulation and cell cycle): the CUMAGAS-BMD information system","volume":"16","author":"Karachalios","year":"2011","journal-title":"Biomarkers"},{"key":"33","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.2337\/diacare.22.7.1196","article-title":"Bone mineral density in patients with type 1 and type 2 diabetes","volume":"22","author":"Ronnemaa","year":"1999","journal-title":"Diabetes Care"},{"key":"34","first-page":"174186","article-title":"Type 1 diabetes and osteoporosis: from molecular pathways to bone phenotype","volume":"2015","author":"Fraser","year":"2015","journal-title":"J Osteoporos"},{"key":"35","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/1471-2156-14-107","article-title":"Conditional testing of multiple variants associated with bone mineral density in the FLNB gene region suggests that they represent a single association signal","volume":"14","author":"Wilson","year":"2013","journal-title":"BMC Genet"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.8948","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T20:41:43Z","timestamp":1589229703000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.8948"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,23]]},"references-count":35,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2016,5,24]]}},"alternative-id":["8948","27119226"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.8948","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,23]]}}}