{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:04:06Z","timestamp":1790841846850,"version":"4.1.0"},"reference-count":135,"publisher":"Impact Journals, LLC","issue":"23","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2016,6,7]]},"DOI":"10.18632\/oncotarget.8986","type":"journal-article","created":{"date-parts":[[2016,4,26]],"date-time":"2016-04-26T00:01:18Z","timestamp":1461628878000},"page":"33960-33982","source":"Crossref","is-referenced-by-count":23,"title":["Cyclic AMP efflux inhibitors as potential therapeutic agents for leukemia"],"prefix":"10.18632","volume":"7","author":[{"given":"Dominique R.","family":"Perez","sequence":"first","affiliation":[{"name":"University of New Mexico Comprehensive Cancer Center, Albuquerque, NM, USA"},{"name":"University of New Mexico Center for Molecular Discovery, Albuquerque, NM, USA"},{"name":"Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yelena","family":"Smagley","sequence":"additional","affiliation":[{"name":"University of New Mexico Comprehensive Cancer Center, Albuquerque, NM, USA"},{"name":"University of New Mexico Center for Molecular Discovery, Albuquerque, NM, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Garcia","sequence":"additional","affiliation":[{"name":"University of New Mexico Comprehensive Cancer Center, Albuquerque, NM, USA"},{"name":"University of New Mexico Center for Molecular Discovery, Albuquerque, NM, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark B.","family":"Carter","sequence":"additional","affiliation":[{"name":"University of New Mexico Comprehensive Cancer Center, Albuquerque, NM, USA"},{"name":"University of New Mexico Center for Molecular Discovery, Albuquerque, NM, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Evangelisti","sequence":"additional","affiliation":[{"name":"University of New Mexico Comprehensive Cancer Center, Albuquerque, NM, USA"},{"name":"University of New Mexico Center for Molecular Discovery, Albuquerque, NM, USA"},{"name":"Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ksenia","family":"Matlawska-Wasowska","sequence":"additional","affiliation":[{"name":"University of New Mexico Comprehensive Cancer Center, Albuquerque, NM, USA"},{"name":"Department of Pediatrics, University of New Mexico Health Sciences Center, Albuquerque, NM, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart S.","family":"Winter","sequence":"additional","affiliation":[{"name":"University of New Mexico Comprehensive Cancer Center, Albuquerque, NM, USA"},{"name":"Department of Pediatrics, University of New Mexico Health Sciences Center, Albuquerque, NM, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry A.","family":"Sklar","sequence":"additional","affiliation":[{"name":"University of New Mexico Comprehensive Cancer Center, Albuquerque, NM, USA"},{"name":"University of New Mexico Center for Molecular Discovery, Albuquerque, NM, USA"},{"name":"Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Chigaev","sequence":"additional","affiliation":[{"name":"University of New Mexico Comprehensive Cancer Center, Albuquerque, NM, USA"},{"name":"University of New Mexico Center for Molecular Discovery, Albuquerque, NM, USA"},{"name":"Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2016,4,25]]},"reference":[{"key":"1","first-page":"646","volume-title":"Cell","volume":"144","author":"Weinberg","year":"2011"},{"key":"2","doi-asserted-by":"crossref","first-page":"e237","DOI":"10.1038\/cddis.2011.124","article-title":"Cyclic AMP induces IPC leukemia cell apoptosisCRE-and CDK-dependent Bim transcription","volume":"2","author":"D\u00f8skeland","year":"2011","journal-title":"Cell Death Dis"},{"key":"3","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.1748-1716.2011.02273.x","article-title":"Cyclic AMP is both a pro-apoptotic and anti-apoptotic second messenger","volume":"204","author":"Zambon","year":"2012","journal-title":"Acta Physiol (Oxf)"},{"issue":"Pt 5","key":"4","first-page":"637","article-title":"cAMP increasing agents attenuate the generation of apoptosis by etoposide in promonocytic leukemia cells","volume":"111","author":"Aller","year":"1998","journal-title":"J Cell Sci"},{"key":"5","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1085\/jgp.201311083","article-title":"Cyclic AMP compartments and signaling specificity: role of cyclic nucleotide phosphodiesterases","volume":"143","author":"Richter","year":"2014","journal-title":"J Gen Physiol"},{"key":"6","first-page":"937","volume-title":"Expert Opin Ther Targets","volume":"17","author":"Insel","year":"2013"},{"issue":"Pt 1","key":"7","first-page":"3363","article-title":"Multiple apoptotic death types triggered through activation of separate pathways by cAMP and inhibitors of protein phosphatases in one (IPC leukemia) cell line","volume":"107","author":"D\u00f8skeland","year":"1994","journal-title":"J Cell Sci"},{"key":"8","first-page":"323","volume-title":"Cancer Lett","volume":"335","author":"Blomhoff","year":"2013"},{"key":"9","doi-asserted-by":"crossref","first-page":"20858","DOI":"10.1074\/jbc.M310643200","article-title":"The pro-apoptotic protein Bim is a convergence point for cAMP\/protein kinase A- and glucocorticoid-promoted apoptosis of lymphoid cells","volume":"279","author":"Insel","year":"2004","journal-title":"J Biol Chem"},{"key":"10","first-page":"199","article-title":"Mechanism of lymphoma cell death induced by cyclic AMP","volume":"81","author":"Tomkins","year":"1975","journal-title":"Am J Pathol"},{"key":"11","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1124\/jpet.113.207449","article-title":"Development of a high-throughput screening paradigm for the discovery of small-molecule modulators of adenylyl cyclase: identification of an adenylyl cyclase 2 inhibitor","volume":"347","author":"Watts","year":"2013","journal-title":"J Pharmacol Exp Ther"},{"key":"12","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1042\/BJ20051368","article-title":"Cyclic nucleotide phosphodiesterases as targets for treatment of haematological malignancies","volume":"393","author":"Epstein","year":"2006","journal-title":"Biochem J"},{"key":"13","doi-asserted-by":"crossref","first-page":"5400","DOI":"10.4049\/jimmunol.0804255","article-title":"Chronic lymphocytic leukemia and B and T cells differ in their response to cyclic nucleotide phosphodiesterase inhibitors","volume":"182","author":"Lerner","year":"2009","journal-title":"J Immunol"},{"key":"14","first-page":"95","article-title":"Cyclic adenosine monophosphate signal pathway in targeted therapy of lymphoma","volume":"123","author":"Wang","year":"2010","journal-title":"Chin Med J (Engl)"},{"key":"15","first-page":"3222","article-title":"Relationship between the levels of cyclic cytidine 3\u2032:5\u2032 cyclic adenosine 3\u2032:5\u2032-monophosphate in urines and leukocytes and the type of human leukemias","volume":"41","author":"Scavennec","year":"1981","journal-title":"Cancer Res"},{"key":"16","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1182\/blood.V61.3.429.429","article-title":"Plasma and urine cyclic nucleotide levels in patients with acute and chronic leukemia","volume":"61","author":"Polli","year":"1983","journal-title":"Blood"},{"key":"17","doi-asserted-by":"crossref","first-page":"33260","DOI":"10.1074\/jbc.M111.268979","article-title":"Increased expression of the pro-apoptotic protein BIM, a mechanism for cAMP\/protein kinase A (PKA)-induced apoptosis of immature T cells","volume":"286","author":"Insel","year":"2011","journal-title":"J Biol Chem"},{"key":"18","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/(SICI)1097-4652(199907)180:1<71::AID-JCP8>3.0.CO;2-N","article-title":"Activation of the cAMP signaling pathway increases apoptosis in human B- precursor cells and is associated with downregulation of Mcl-1 expression","volume":"180","author":"Smeland","year":"1999","journal-title":"J Cell Physiol"},{"key":"19","doi-asserted-by":"crossref","first-page":"6979","DOI":"10.1074\/jbc.M110.166868","article-title":"Multidrug resistance protein 4 (MRP4\/ABCC4) regulates cAMP cellular levels and controls human leukemia cell proliferation and differentiation","volume":"286","author":"Davio","year":"2011","journal-title":"J Biol Chem"},{"key":"20","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.tips.2008.01.006","article-title":"Multidrug resistance protein 4 (MRP4\/ABCC4): a versatile efflux transporter for drugs and signalling molecules","volume":"29","author":"Masereeuw","year":"2008","journal-title":"Trends Pharmacol Sci"},{"key":"21","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1471-2172-9-26","article-title":"Galphas-coupled receptor signaling actively down-regulates alpha4beta1-integrin affinity: a possible mechanism for cell de-adhesion","volume":"9","author":"Sklar","year":"2008","journal-title":"BMC Immunol"},{"key":"22","first-page":"28","volume-title":"BMC Immunol","volume":"12","author":"Sklar","year":"2011"},{"key":"23","doi-asserted-by":"crossref","first-page":"14760","DOI":"10.1074\/jbc.M900925200","article-title":"Soluble adenylyl cyclase controls mitochondria-dependent apoptosis in coronary endothelial cells","volume":"284","author":"Ladilov","year":"2009","journal-title":"J Biol Chem"},{"key":"24","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/clpt.2012.44","article-title":"The UCSF-FDA TransPortal: a public drug transporter database","volume":"92","author":"Giacomini","year":"2012","journal-title":"Clin Pharmacol Ther"},{"key":"25","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s00424-006-0054-9","article-title":"Multidrug resistance-associated proteins 3, 4, and 5","volume":"453","author":"van de Wetering","year":"2007","journal-title":"Pflugers Arch"},{"key":"26","doi-asserted-by":"crossref","first-page":"524","DOI":"10.3892\/etm.2012.627","article-title":"Expression levels of multidrug resistance-associated protein 4 (MRP4) in human leukemia and lymphoma cell lines, and the inhibitory effects of the MRP-specific inhibitor MK-571 on methotrexate distribution in rats","volume":"4","author":"Umehara","year":"2012","journal-title":"Exp Ther Med"},{"key":"27","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1002\/ijc.24207","article-title":"Hematopoietic stem cell differentiation affects expression and function of MRP4 (ABCC4), a transport protein for signaling molecules and drugs","volume":"124","author":"Ritter","year":"2009","journal-title":"Int J Cancer"},{"key":"28","first-page":"64","volume-title":"Nat Rev Mol Cell Biol","volume":"14","author":"Baumann","year":"2013"},{"key":"29","first-page":"4","volume-title":"Cancer Lett","volume":"338","author":"Guzman","year":"2013"},{"key":"30","doi-asserted-by":"crossref","first-page":"3226","DOI":"10.1111\/j.1742-4658.2011.08235.x","article-title":"Multidrug resistance proteins (MRPs\/ABCCs) in cancer chemotherapy and genetic diseases","volume":"278","author":"Tiwari","year":"2011","journal-title":"FEBS J"},{"key":"31","first-page":"4346","volume-title":"Bioorg Med Chem Lett","volume":"19","author":"Crooks","year":"2009"},{"key":"32","doi-asserted-by":"crossref","first-page":"3823","DOI":"10.1007\/s00018-011-0757-8","article-title":"Cyclic AMP: a selective modulator of NF-\u03baB action","volume":"68","author":"Haegeman","year":"2011","journal-title":"Cell Mol Life Sci"},{"key":"33","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1517\/14728220802602349","article-title":"Protein kinase A as a biological target in cancer therapy","volume":"13","author":"Illiano","year":"2009","journal-title":"Expert Opin Ther Targets"},{"key":"34","first-page":"117","volume-title":"Expert Opin Investig Drugs","volume":"19","author":"Schermuly","year":"2010"},{"key":"35","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1084\/jem.20021129","article-title":"activation of cAMP signaling induces growth arrest and differentiation in acute promyelocytic leukemia","volume":"196","author":"Lallemand-Breitenbach","year":"2002","journal-title":"J Exp Med"},{"key":"36","unstructured":"Propper, Saunders, Salisbury, Long, Byrne, Braybrooke, Dowsett, Taylor, Talbot, Ganesan, Harris. Phase I Study of the Novel Cyclic AMP (cAMP) Analogue 8-Chloro- cAMP in Patients with Cancer : Toxicity, Hormonal, and Immunological Effects. 1999; 5:1682\u20139."},{"key":"37","doi-asserted-by":"crossref","unstructured":"Schwede, Maronde, Genieser, Jastorff. Cyclic nucleotide analogs as biochemical tools and prospective drugs. 2000; 87:199\u2013226.","DOI":"10.1016\/S0163-7258(00)00051-6"},{"key":"38","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1186\/2193-1801-3-732","article-title":"Overexpression of MRP4 (ABCC4) and MRP5 (ABCC5) confer resistance to the nucleoside analogs cytarabine and troxacitabine, but not gemcitabine","volume":"3","author":"Peters","year":"2014","journal-title":"Springerplus"},{"key":"39","first-page":"201","volume-title":"Drug Transporters","author":"Kim","year":"2011"},{"key":"40","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1517\/17425255.2012.680885","article-title":"The role of transporters in the toxicity of nucleoside and nucleotide analogs","volume":"8","author":"Lewis","year":"2012","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"41","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0092-8674(82)90087-3","article-title":"Introduction of macromolecules into cultured mammalian cells by osmotic lysis of pinocytic vesicles","volume":"29","author":"Rechsteiner","year":"1982","journal-title":"Cell"},{"key":"42","first-page":"55","article-title":"Integrin and Cell Adhesion Molecules","volume":"757","author":"Sklar","year":"2012","journal-title":"Methods Mol Biol"},{"key":"43","doi-asserted-by":"crossref","first-page":"15213","DOI":"10.1074\/jbc.272.24.15213","article-title":"Desensitization of N -Formylpeptide Receptor-mediated Activation Is Dependent upon Receptor Phosphorylation Desensitization of N -Formylpeptide Receptor-mediated Activation Is Dependent upon Receptor Phosphorylation","volume":"272","author":"Prossnitz","year":"1997","journal-title":"J Biol Chem"},{"key":"44","first-page":"2646","volume-title":"Biochim Biophys Acta - Mol Basis Dis","volume":"1842","author":"Appukuttan","year":"2014"},{"key":"45","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1002\/stem.1597","article-title":"Concise review: leukemia stem cells in personalized medicine","volume":"32","author":"Allan","year":"2014","journal-title":"Stem Cells"},{"key":"46","first-page":"330","volume-title":"Clin Lymphoma Myeloma Leuk","volume":"12","author":"Minden","year":"2012"},{"key":"47","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1158\/1940-6207.CAPR-10-0020","article-title":"Cryptotanshinone inhibits cancer cell proliferation by suppressing Mammalian target of rapamycin-mediated cyclin D1 expression and Rb phosphorylation","volume":"3","author":"Huang","year":"2010","journal-title":"Cancer Prev Res (Phila)"},{"key":"48","doi-asserted-by":"crossref","first-page":"4427","DOI":"10.1182\/blood-2007-05-090621","article-title":"An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells","volume":"110","author":"Hassane","year":"2007","journal-title":"Blood"},{"key":"49","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.toxlet.2008.09.018","article-title":"Mechanism of patulin-induced apoptosis in human leukemia cells (HL-60)","volume":"183","author":"Liu","year":"2008","journal-title":"Toxicol Lett"},{"key":"50","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1038\/sj.leu.2403749","article-title":"Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations","volume":"19","author":"Fioretos","year":"2005","journal-title":"Leukemia"},{"key":"51","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.taap.2004.12.006","article-title":"Activation of ERK mitogen-activated protein kinase in human cells by the mycotoxin patulin","volume":"207","author":"Liu","year":"2005","journal-title":"Toxicol Appl Pharmacol"},{"key":"52","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1177\/1087057111414893","article-title":"Complementary cell-based high-throughput screens identify novel modulators of the unfolded protein response","volume":"16","author":"Schultz","year":"2011","journal-title":"J Biomol Screen"},{"key":"53","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.18632\/oncotarget.707","article-title":"High-Throughput Chemical Screens Identify Disulfiram as an Inhibitor of Human Glioblastoma Stem Cells Abstract","volume":"3","author":"Foltz","year":"2012","journal-title":"Oncotarget"},{"key":"54","first-page":"196","volume-title":"Toxicol Lett","volume":"205","author":"Kikuchi","year":"2011"},{"key":"55","first-page":"4097","volume-title":"Food Chem Toxicol","volume":"50","author":"Baird a","year":"2012"},{"key":"56","first-page":"83","volume-title":"Toxicol","volume":"23","author":"O'Neill","year":"2009"},{"key":"57","first-page":"943","volume-title":"Cell Signal","volume":"24","author":"Kim","year":"2012"},{"key":"58","first-page":"340","article-title":"Induction of oxidative stress response by the mycotoxin patulin in mammalian cells","volume":"95","author":"Su","year":"2007","journal-title":"Toxicol Sci"},{"key":"59","first-page":"390","volume-title":"Toxicon","volume":"55","author":"Zhong","year":"2010"},{"key":"60","doi-asserted-by":"crossref","first-page":"135","DOI":"10.4161\/cbt.22952","article-title":"Parthenolide reduces the frequency of ABCB5-positive cells and clonogenic capacity of melanoma cells from anchorage independent melanospheres","volume":"14","author":"Sztiller-Sikorska","year":"2013","journal-title":"Cancer Biol Ther"},{"key":"61","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1111\/j.1476-5381.2010.00749.x","article-title":"Cell context-dependent activities of parthenolide in primary and metastatic melanoma cells","volume":"160","author":"Wozniak","year":"2010","journal-title":"Br J Pharmacol"},{"key":"62","doi-asserted-by":"crossref","first-page":"5617","DOI":"10.4049\/jimmunol.163.10.5617","article-title":"The antiinflammatory sesquiterpene lactone parthenolide inhibits NF-kappa B by targeting the I kappa B kinase complex","volume":"163","author":"Schmitz","year":"1999","journal-title":"J Immunol"},{"key":"63","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/S1074-5521(01)00049-7","article-title":"The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinase","volume":"8","author":"Crews","year":"2001","journal-title":"Chem Biol"},{"key":"64","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.1365-2141.2010.08319.x","article-title":"The NF (Nuclear factor)-\u03baB inhibitor parthenolide interacts with histone deacetylase inhibitors to induce MKK7\/JNK1-dependent apoptosis in human acute myeloid leukaemia cells","volume":"151","author":"Grant","year":"2010","journal-title":"Br J Haematol"},{"key":"65","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1038\/sj.leu.2404230","article-title":"The sesquiterpene lactone parthenolide induces selective apoptosis of B-chronic lymphocytic leukemia cells","volume":"20","author":"Wickremasinghe","year":"2006","journal-title":"Leukemia"},{"key":"66","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s10549-007-9798-y","article-title":"NF-kappaB pathway inhibitors preferentially inhibit breast cancer stem-like cells","volume":"111","author":"Zhang","year":"2008","journal-title":"Breast Cancer Res Treat"},{"key":"67","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1111\/j.1582-4934.2008.00360.x","article-title":"Dihydroartemisinin induces apoptosis and sensitizes human ovarian cancer cells to carboplatin therapy","volume":"13","author":"Wang","year":"2009","journal-title":"J Cell Mol Med"},{"key":"68","doi-asserted-by":"crossref","first-page":"10854","DOI":"10.1158\/0008-5472.CAN-05-1216","article-title":"Dihydroartemisinin is cytotoxic to papillomavirus-expressing epithelial cellsand","volume":"65","author":"Schlegel","year":"2005","journal-title":"Cancer Res"},{"key":"69","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1016\/j.bcp.2004.08.021","article-title":"Inhibition of angiogenesisand growth of Kaposi's sarcoma xenograft tumors by the anti-malarial artesunate","volume":"68","author":"Efferth","year":"2004","journal-title":"Biochem Pharmacol"},{"key":"70","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1097\/CAD.0b013e328350e8ac","article-title":"Artesunate induces G0\/G1 cell cycle arrest and iron-mediated mitochondrial apoptosis in A431 human epidermoid carcinoma cells","volume":"23","author":"Zhou","year":"2012","journal-title":"Anticancer Drugs"},{"key":"71","doi-asserted-by":"crossref","first-page":"e20550","DOI":"10.1371\/journal.pone.0020550","article-title":"Development of resistance towards artesunate in MDA-MB-231 human breast cancer cells","volume":"6","author":"Efferth","year":"2011","journal-title":"PLoS One"},{"key":"72","doi-asserted-by":"crossref","first-page":"6587","DOI":"10.1074\/jbc.M110.210047","article-title":"Artesunate activates mitochondrial apoptosis in breast cancer cellsiron-catalyzed lysosomal reactive oxygen species production","volume":"286","author":"Brady","year":"2011","journal-title":"J Biol Chem"},{"key":"73","doi-asserted-by":"crossref","first-page":"5519","DOI":"10.1158\/1078-0432.CCR-08-0197","article-title":"Experimental therapy of hepatoma with artemisinin and its derivatives:andactivity, chemosensitization, and mechanisms of action","volume":"14","author":"Wang","year":"2008","journal-title":"Clin Cancer Res"},{"key":"74","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1007\/s00280-009-1095-5","article-title":"Artesunate induces oncosis-like cell deathand has antitumor activity against pancreatic cancer xenografts","volume":"65","author":"Ji","year":"2010","journal-title":"Cancer Chemother Pharmacol"},{"key":"75","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.bcp.2009.04.014","article-title":"Gene expression profiling identifies novel key players involved in the cytotoxic effect of Artesunate on pancreatic cancer cells","volume":"78","author":"Hoheisel","year":"2009","journal-title":"Biochem Pharmacol"},{"key":"76","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s12185-010-0697-3","article-title":"Artesunate inhibiting angiogenesis induced by human myeloma RPMI8226 cells","volume":"92","author":"Pan","year":"2010","journal-title":"Int J Hematol"},{"key":"77","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1006\/bcmd.2002.0492","article-title":"Activity of drugs from traditional chinese medicine toward sensitive and MDR1- or MRP1-overexpressing multidrug-resistant human CCRF-CEM leukemia cells","volume":"28","author":"Davey","year":"2002","journal-title":"Blood Cells, Mol Dis"},{"key":"78","doi-asserted-by":"crossref","first-page":"e693","DOI":"10.1371\/journal.pone.0000693","article-title":"Artesunate induces ROS-mediated apoptosis in doxorubicin-resistant T leukemia cells","volume":"2","author":"Li-Weber","year":"2007","journal-title":"PLoS One"},{"key":"79","first-page":"337","article-title":"Effects of artesunate on cytokinesis and G\/M cell cycle progression of tumour cells and budding yeast","volume":"7","author":"Efferth","year":"2010","journal-title":"Cancer Genomics Proteomics"},{"key":"80","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.vph.2007.05.002","article-title":"Artesunate inhibits angiogenesis and downregulates vascular endothelial growth factor expression in chronic myeloid leukemia K562 cells","volume":"47","author":"Li","year":"2007","journal-title":"Vascul Pharmacol"},{"key":"81","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2008.08.027","article-title":"Differential sensitivity of colorectal cancer cell lines to artesunate is associated with expression of beta-catenin and E-cadherin","volume":"588","author":"Sun","year":"2008","journal-title":"Eur J Pharmacol"},{"key":"82","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.bcp.2009.08.013","article-title":"Anti-cancer effects of artesunate in a panel of chemoresistant neuroblastoma cell lines","volume":"79","author":"Breitling","year":"2010","journal-title":"Biochem Pharmacol"},{"key":"83","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1002\/ijc.25315","article-title":"First evidence that the antimalarial drug artesunate inhibits invasion andmetastasis in lung cancer by targeting essential extracellular proteases","volume":"127","author":"Allgayer","year":"2010","journal-title":"Int J Cancer"},{"key":"84","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1631\/jzus.B1000373","article-title":"Artesunate inhibits growth and induces apoptosis in human osteosarcoma HOS cell lineand","volume":"12","author":"Li","year":"2011","journal-title":"J Zhejiang Univ Sci B"},{"key":"85","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1111\/j.1745-7254.2007.00612.x","article-title":"Dihydroartemisinin is an inhibitor of ovarian cancer cell growth","volume":"28","author":"Fan","year":"2007","journal-title":"Acta Pharmacol Sin"},{"key":"86","doi-asserted-by":"crossref","first-page":"e42703","DOI":"10.1371\/journal.pone.0042703","article-title":"Dihydroartemisinin exerts its anticancer activity through depleting cellular irontransferrin receptor-1","volume":"7","author":"Wang","year":"2012","journal-title":"PLoS One"},{"key":"87","first-page":"1278","volume-title":"Biochem Pharmacol","volume":"83","author":"Lai","year":"2012"},{"key":"88","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1007\/s10637-011-9676-7","article-title":"The redox antimalarial dihydroartemisinin targets human metastatic melanoma cells but not primary melanocytes with induction of NOXA-dependent apoptosis","volume":"30","author":"Wondrak","year":"2012","journal-title":"Invest New Drugs"},{"key":"89","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1097\/CAD.0b013e3283212ade","article-title":"Dihydroartemisinin inhibits growth of pancreatic cancer cellsand","volume":"20","author":"Sun","year":"2009","journal-title":"Anticancer Drugs"},{"key":"90","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1007\/s00432-009-0731-0","article-title":"Growth inhibitory effects of dihydroartemisinin on pancreatic cancer cells: involvement of cell cycle arrest and inactivation of nuclear factor-kappaB","volume":"136","author":"Xue","year":"2010","journal-title":"J Cancer Res Clin Oncol"},{"key":"91","doi-asserted-by":"crossref","first-page":"e37222","DOI":"10.1371\/journal.pone.0037222","article-title":"Dihydroartemisinin enhances Apo2L\/TRAIL-mediated apoptosis in pancreatic cancer cellsROS-mediated up-regulation of death receptor 5","volume":"7","author":"Sun","year":"2012","journal-title":"PLoS One"},{"key":"92","first-page":"99","volume-title":"Cancer Lett","volume":"293","author":"Sun","year":"2010"},{"key":"93","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1007\/s00280-011-1643-7","article-title":"Dihydroartemisinin inhibits angiogenesis in pancreatic cancer by targeting the NF-\u03baB pathway","volume":"68","author":"Bai","year":"2011","journal-title":"Cancer Chemother Pharmacol"},{"key":"94","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/s12253-012-9508-x","article-title":"Dihydroarteminsin-induced apoptosis is not dependent on the translocation of Bim to the endoplasmic reticulum in human lung adenocarcinoma cells","volume":"18","author":"Qu","year":"2012","journal-title":"Pathol Oncol Res"},{"key":"95","first-page":"046028","article-title":"Single-cell analysis of dihydroartemisinin-induced apoptosis through reactive oxygen species-mediated caspase-8 activation and mitochondrial pathway in ASTC-a-1 cells using fluorescence imaging techniques","volume":"15","author":"Li","year":"2013","journal-title":"J Biomed Opt"},{"key":"96","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s00280-009-1129-z","article-title":"Dihydroartemisinin improves the efficiency of chemotherapeutics in lung carcinomasand inhibits murine Lewis lung carcinoma cell line growth","volume":"66","author":"Lou","year":"2010","journal-title":"Cancer Chemother Pharmacol"},{"key":"97","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s10495-011-0580-6","article-title":"Interruption of the MEK\/ERK signaling cascade promotes dihydroartemisinin-induced apoptosisand","volume":"16","author":"Shi","year":"2011","journal-title":"Apoptosis"},{"key":"98","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1158\/1535-7163.MCT-10-0051","article-title":"Dihydroartemisinin induces apoptosis by a Bak-dependent intrinsic pathway","volume":"9","author":"Jendrossek","year":"2010","journal-title":"Mol Cancer Ther"},{"key":"99","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s00280-005-0002-y","article-title":"Dihydroartemisinin downregulates vascular endothelial growth factor expression and induces apoptosis in chronic myeloid leukemia K562 cells","volume":"57","author":"Wu","year":"2006","journal-title":"Cancer Chemother Pharmacol"},{"key":"100","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.4161\/cbt.7.7.6035","article-title":"Dihydroartemisinin induces apoptosis in HL-60 leukemia cells dependent of iron and p38 mitogen-activated protein kinase activation but independent of reactive oxygen species","volume":"7","author":"Ding","year":"2008","journal-title":"Cancer Biol Ther"},{"key":"101","first-page":"103","volume-title":"FEBS Open Bio","volume":"2","author":"Zhou","year":"2012"},{"key":"102","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1097\/01.cad.0000224443.85834.32","article-title":"Dihydroartemisinin inhibits angiogenesis induced by multiple myeloma RPMI8226 cells under hypoxic conditionsdownregulation of vascular endothelial growth factor expression and suppression of vascular endothelial growth factor secretion","volume":"17","author":"Lee","year":"2006","journal-title":"Anticancer Drugs"},{"key":"103","doi-asserted-by":"crossref","first-page":"819","DOI":"10.4161\/cbt.9.10.11552","article-title":"Dihydroartemisinin upregulates death receptor 5 expression and cooperates with TRAIL to induce apoptosis in human prostate cancer cells","volume":"9","author":"Huang","year":"2010","journal-title":"Cancer Biol Ther"},{"key":"104","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1211\/jpp.59.6.0011","article-title":"Dihydroartemisinin exerts cytotoxic effects and inhibits hypoxia inducible factor-1alpha activation in C6 glioma cells","volume":"59","author":"Wei","year":"2007","journal-title":"J Pharm Pharmacol"},{"key":"105","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s11010-011-0716-6","article-title":"Anti-tumor effects of dihydroartemisinin on human osteosarcoma","volume":"351","author":"Ma","year":"2011","journal-title":"Mol Cell Biochem"},{"key":"106","doi-asserted-by":"crossref","first-page":"34181","DOI":"10.1074\/jbc.M113.472563","article-title":"The antiparasitic clioquinol induces apoptosis in leukemia and myeloma cells by inhibiting histone deacetylase activity","volume":"288","author":"Mao","year":"2013","journal-title":"J Biol Chem"},{"key":"107","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/leu.2008.232","article-title":"Clioquinol inhibits the proteasome and displays preclinical activity in leukemia and myeloma","volume":"23","author":"Schimmer","year":"2009","journal-title":"Leukemia"},{"key":"108","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1158\/0008-5472.CAN-04-3577","article-title":"Anticancer activity of the antibiotic clioquinol","volume":"65","author":"Lind","year":"2005","journal-title":"Cancer Res"},{"key":"109","doi-asserted-by":"crossref","first-page":"R897","DOI":"10.1186\/bcr1322","article-title":"Clioquinol and pyrrolidine dithiocarbamate complex with copper to form proteasome inhibitors and apoptosis inducers in human breast cancer cells","volume":"7","author":"Dou","year":"2005","journal-title":"Breast Cancer Res"},{"key":"110","first-page":"2739","article-title":"Clioquinol suppresses cyclin D1 gene expression through transcriptional and post-transcriptional mechanisms","volume":"31","author":"Ding","year":"2011","journal-title":"Anticancer Res"},{"key":"111","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1124\/jpet.107.130377","article-title":"Clioquinol promotes cancer cell toxicity through tumor necrosis factor alpha release from macrophages","volume":"324","author":"White","year":"2008","journal-title":"J Pharmacol Exp Ther"},{"key":"112","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1042\/BJ20081421","article-title":"Clioquinol targets zinc to lysosomes in human cancer cells","volume":"417","author":"Ding","year":"2009","journal-title":"Biochem J"},{"key":"113","first-page":"2087","article-title":"Clioquinol independently targets NF-kappaB and lysosome pathways in human cancer cells","volume":"30","author":"Ding","year":"2010","journal-title":"Anticancer Res"},{"key":"114","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1158\/0008-5472.CAN-06-3546","article-title":"Clioquinol, a therapeutic agent for Alzheimer's disease, has proteasome-inhibitory, androgen receptor-suppressing, apoptosis-inducing, and antitumor activities in human prostate cancer cells and xenografts","volume":"67","author":"Dou","year":"2007","journal-title":"Cancer Res"},{"key":"115","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s11010-012-1338-3","article-title":"Cryptotanshinone induces cell cycle arrest and apoptosis of multidrug resistant human chronic myeloid leukemia cells by inhibiting the activity of eukaryotic initiation factor 4E","volume":"368","author":"Chen","year":"2012","journal-title":"Mol Cell Biochem"},{"key":"116","first-page":"805639","article-title":"Apoptosis induced by tanshinone IIA and cryptotanshinone is mediated by distinct JAK\/STAT3\/5 and SHP1\/2 signaling in chronic myeloid leukemia K562 Cells","volume":"2013","author":"Kim","year":"2013","journal-title":"Evid Based Complement Alternat Med"},{"key":"117","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1158\/0008-5472.CAN-08-2575","article-title":"Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells","volume":"69","author":"Kwon","year":"2009","journal-title":"Cancer Res"},{"key":"118","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1002\/ijc.27343","article-title":"Cryptotanshinone down-regulates androgen receptor signaling by modulating lysine-specific demethylase 1 function","volume":"131","author":"Kang","year":"2012","journal-title":"Int J Cancer"},{"key":"119","first-page":"485","article-title":"Tanshinone I effectively induces apoptosis in estrogen receptor- positive (MCF-7) and estrogen receptor-negative (MDA-MB-231) breast cancer cells","volume":"33","author":"Kim","year":"2008","journal-title":"Int J Oncol"},{"key":"120","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s00280-010-1440-8","article-title":"Cryptotanshinone has diverse effects on cell cycle events in melanoma cell lines with different metastatic capacity","volume":"68","author":"Lu","year":"2011","journal-title":"Cancer Chemother Pharmacol"},{"key":"121","doi-asserted-by":"crossref","first-page":"29923","DOI":"10.1074\/jbc.M113.483909","article-title":"The herbal compound cryptotanshinone restores sensitivity in cancer cells that are resistant to the tumor necrosis factor-related apoptosis-inducing ligand","volume":"288","author":"Yu","year":"2013","journal-title":"J Biol Chem"},{"key":"122","doi-asserted-by":"crossref","first-page":"6758","DOI":"10.3390\/molecules16086758","article-title":"Parthenolide induces apoptosis and cell cycle arrest of human 5637 bladder cancer cells","volume":"16","author":"Xie","year":"2011","journal-title":"Molecules"},{"key":"123","first-page":"1307","article-title":"Parthenolide treatment activates stress signaling proteins in high-risk acute lymphoblastic leukemia cells with chromosomal translocation t(4; 11)","volume":"37","author":"Ducore","year":"2010","journal-title":"Int J Oncol"},{"key":"124","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1158\/1078-0432.CCR-06-1559","article-title":"Parthenolide, a natural inhibitor of Nuclear Factor-kappaB, inhibits lung colonization of murine osteosarcoma cells","volume":"13","author":"Myoui","year":"2007","journal-title":"Clin Cancer Res"},{"key":"125","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/1756-9966-29-108","article-title":"Parthenolide induces proliferation inhibition and apoptosis of pancreatic cancer cells","volume":"29","author":"Huang","year":"2010","journal-title":"J Exp Clin Cancer Res"},{"key":"126","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1097\/CAD.0b013e328356cad9","article-title":"Sesquiterpene lactones as drugs with multiple targets in cancer treatment: focus on parthenolide","volume":"23","author":"D'Herde","year":"2012","journal-title":"Anticancer Drugs"},{"key":"127","first-page":"26","volume-title":"J Inflamm (Lond)","volume":"8","author":"Bonfield","year":"2011"},{"key":"128","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1007\/s10753-011-9346-0","article-title":"Parthenolide, a sesquiterpene lactone, expresses multiple anti-cancer and anti-inflammatory activities","volume":"35","author":"Sillanp\u00e4\u00e4","year":"2012","journal-title":"Inflammation"},{"key":"129","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1124\/mol.64.2.382","article-title":"Molecular modes of action of artesunate in tumor cell lines","volume":"64","author":"Funk","year":"2003","journal-title":"Mol Pharmacol"},{"key":"130","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.niox.2008.04.008","article-title":"Effect of artemisinins and other endoperoxides on nitric oxide-related signaling pathway in RAW 264. 7 mouse macrophage cells","volume":"19","author":"Efferth","year":"2008","journal-title":"Nitric Oxide"},{"key":"131","doi-asserted-by":"crossref","first-page":"e20932","DOI":"10.1371\/journal.pone.0020932","article-title":"Anti-malarial drug artesunate attenuates experimental allergic asthmainhibition of the phosphoinositide 3-kinase\/Akt pathway","volume":"6","author":"Wong","year":"2011","journal-title":"PLoS One"},{"key":"132","first-page":"192","volume-title":"Toxicol Appl Pharmacol","volume":"234","author":"Das","year":"2009"},{"key":"133","doi-asserted-by":"crossref","first-page":"e822","DOI":"10.1038\/cddis.2013.349","article-title":"Patulin induces pro-survival functionsautophagy inhibition and p62 accumulation","volume":"4","author":"Hu","year":"2013","journal-title":"Cell Death Dis"},{"key":"134","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1159\/000354437","article-title":"Patulin-induced suicidal erythrocyte death","volume":"32","author":"Lang","year":"2013","journal-title":"Cell Physiol Biochem"},{"key":"135","doi-asserted-by":"crossref","first-page":"3548","DOI":"10.1016\/j.fct.2011.12.022","article-title":"DNA damage in organs of mice treated acutely with patulin, a known mycotoxin","volume":"50","author":"Rosa","year":"2012","journal-title":"Food Chem Toxicol"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.8986","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T15:37:37Z","timestamp":1692286657000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.8986"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,25]]},"references-count":135,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2016,6,7]]}},"alternative-id":["8986","27129155"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.8986","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,25]]}}}