{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T11:40:24Z","timestamp":1793014824785,"version":"4.5.0"},"reference-count":41,"publisher":"Impact Journals, LLC","issue":"22","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2016,5,31]]},"DOI":"10.18632\/oncotarget.9051","type":"journal-article","created":{"date-parts":[[2016,4,27]],"date-time":"2016-04-27T08:51:56Z","timestamp":1461747116000},"page":"32785-32795","source":"Crossref","is-referenced-by-count":43,"title":["Loss of PAX8 in high-grade serous ovarian cancer reduces cell survival despite unique modes of action in the fallopian tube and ovarian surface epithelium"],"prefix":"10.18632","volume":"7","author":[{"given":"Laura H.","family":"Rodgers","sequence":"first","affiliation":[{"name":"Department of Medicinal Chemistry and Pharmacognosy, Center for Pharmaceutical Biotechnology, College of Pharmacy, University of Illinois at Chicago, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eoghain\u00edn \u00d3","family":"hAinmhire","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry and Pharmacognosy, Center for Pharmaceutical Biotechnology, College of Pharmacy, University of Illinois at Chicago, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandria N.","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry and Pharmacognosy, Center for Pharmaceutical Biotechnology, College of Pharmacy, University of Illinois at Chicago, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna E.","family":"Burdette","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry and Pharmacognosy, Center for Pharmaceutical Biotechnology, College of Pharmacy, University of Illinois at Chicago, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2016,4,27]]},"reference":[{"key":"1","article-title":"Cancer statistics, 2016","author":"Jemal","year":"2016","journal-title":"CA Cancer J Clin"},{"key":"2","doi-asserted-by":"crossref","first-page":"X16","DOI":"10.1093\/annonc\/mdt463","article-title":"Origin and molecular pathogenesis of ovarian high-grade serous carcinoma","volume":"24","author":"Kurman","year":"2013","journal-title":"Ann Oncol"},{"key":"3","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1155\/2007\/309382","article-title":"Early detection of ovarian cancer","volume":"23","author":"Bast Jr","year":"2007","journal-title":"Dis Markers"},{"key":"4","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1038\/nrg1225","article-title":"Developmental genetics of the female reproductive tract in mammals","volume":"4","author":"Behringer","year":"2003","journal-title":"Nat Rev Genet"},{"key":"5","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.humpath.2015.03.017","article-title":"PAX8 expression in ovarian surface epithelial cells","volume":"46","author":"Lawrenson","year":"2015","journal-title":"Hum Pathol"},{"key":"6","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/modpathol.2011.3","article-title":"PAX 8 expression in non-neoplastic tissues, primary tumors, and metastatic tumors: a comprehensive immunohistochemical study","volume":"24","author":"Truong","year":"2011","journal-title":"Mod Pathol"},{"key":"7","first-page":"17","article-title":"The value of PAX8 and WT1 molecules in ovarian cancer diagnosis","volume":"54","author":"Am\u0103linei","year":"2013","journal-title":"Rom J Morphol Embryol"},{"key":"8","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1097\/PAS.0b013e31816d71ad","article-title":"Expression of pax8 as a useful marker in distinguishing ovarian carcinomas from mammary carcinomas","volume":"32","author":"Soslow","year":"2008","journal-title":"Am J Surg Pathol"},{"key":"9","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1097\/PAS.0b013e318216c112","article-title":"A comprehensive analysis of PAX8 expression in human epithelial tumors","volume":"35","author":"Hornick","year":"2011","journal-title":"Am J Surg Pathol"},{"key":"10","first-page":"567","article-title":"Pax8: a marker for carcinoma of M\u00fcllerian origin in serous effusions","volume":"39","author":"Greenebaum","year":"2011","journal-title":"Diag Cytopathol"},{"key":"11","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.ygyno.2006.08.052","article-title":"Emerging roles for PAX8 in ovarian cancer and endosalpingeal development","volume":"104","author":"McDonald","year":"2007","journal-title":"Gynecol Oncol"},{"key":"12","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1097\/PAS.0b013e3181da7687","article-title":"PAX8 reliably distinguishes ovarian serous tumors from malignant mesothelioma","volume":"34","author":"Hirsch","year":"2010","journal-title":"Am J Surg Pathol"},{"key":"13","first-page":"53","article-title":"A new spontaneously transformed syngeneic model of high-grade serous ovarian cancer with a tumor-initiating cell population","volume":"4","author":"Vanderhyden","year":"2014","journal-title":"Front Oncol"},{"key":"14","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1093\/carcin\/bgt357","article-title":"Loss of LKB1 and PTEN tumor suppressor genes in the ovarian surface epithelium induces papillary serous ovarian cancer","volume":"35","author":"Teixeira","year":"2014","journal-title":"Carcinogenesis"},{"key":"15","article-title":"Pax-8-PPAR-[gamma] fusion protein in thyroid carcinoma","author":"Koenig","year":"2014","journal-title":"Rev Endocrinol"},{"key":"16","doi-asserted-by":"crossref","first-page":"e729","DOI":"10.1038\/cddis.2013.262","article-title":"Pax8 has a critical role in epithelial cell survival and proliferation","volume":"4","author":"Zannini","year":"2013","journal-title":"Cell Death Dis"},{"key":"17","doi-asserted-by":"crossref","first-page":"4824","DOI":"10.1038\/onc.2011.190","article-title":"PAX8 promotes tumor cell growth by transcriptionally regulating E2F1 and stabilizing RB protein","volume":"30","author":"Eccles","year":"2011","journal-title":"Oncogene"},{"key":"18","doi-asserted-by":"crossref","first-page":"12372","DOI":"10.1073\/pnas.1109363108","article-title":"Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer","volume":"108","author":"Mermel","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"19","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1186\/1471-2407-14-292","article-title":"A role for PAX8 in the tumorigenic phenotype of ovarian cancer cells","volume":"14","author":"Zannini","year":"2014","journal-title":"BMC Cancer"},{"key":"20","doi-asserted-by":"crossref","first-page":"6249","DOI":"10.1073\/pnas.96.11.6249","article-title":"E-cadherin induces mesenchymal-to-epithelial transition in human ovarian surface epithelium","volume":"96","author":"Roskelley","year":"1999","journal-title":"Proc Natl Acad Sci"},{"key":"21","doi-asserted-by":"crossref","first-page":"5638","DOI":"10.1002\/j.1460-2075.1995.tb00251.x","article-title":"Loss of p53 function through PAX-mediated transcriptional repression","volume":"14","author":"Gruss","year":"1995","journal-title":"The EMBO journal"},{"key":"22","doi-asserted-by":"crossref","first-page":"3425","DOI":"10.4161\/cc.8.20.9628","article-title":"p53 negatively regulates expression of FoxM1","volume":"8","author":"Gartel","year":"2009","journal-title":"Cell cycle (Georgetown, Tex)"},{"key":"23","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/nature10166","article-title":"Integrated genomic analyses of ovarian carcinoma","volume":"474","author":"Network","year":"2011","journal-title":"Nature"},{"key":"24","first-page":"3211","article-title":"Transcriptional activation of the bcl-2 apoptosis suppressor gene by the paired box transcription factor PAX8","volume":"17","author":"McDonnell","year":"1996","journal-title":"Anticancer Res"},{"key":"25","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/1471-2164-13-147","article-title":"Genome-wide analysis of Pax8 binding provides new insights into thyroid functions","volume":"13","author":"Santisteban","year":"2012","journal-title":"BMC genomics"},{"key":"26","doi-asserted-by":"crossref","first-page":"4824","DOI":"10.1038\/onc.2011.190","article-title":"PAX8 promotes tumor cell growth by transcriptionally regulating E2F1 and stabilizing RB protein","volume":"30","author":"Eccles","year":"2011","journal-title":"Oncogene"},{"key":"27","doi-asserted-by":"crossref","first-page":"4297","DOI":"10.1002\/j.1460-2075.1996.tb00804.x","article-title":"PAX8-mediated activation of the wt1 tumor suppressor gene","volume":"15","author":"Pelletier","year":"1996","journal-title":"Embo J"},{"key":"28","doi-asserted-by":"crossref","first-page":"30678","DOI":"10.1074\/jbc.272.49.30678","article-title":"PAX 8 regulates human WT1 transcription through a novel DNA binding site","volume":"272","author":"Saunders","year":"1997","journal-title":"J Biol Chem"},{"key":"29","doi-asserted-by":"crossref","first-page":"4329","DOI":"10.1158\/0008-5472.CAN-11-0640","article-title":"FoxM1: a master regulator of tumor metastasis","volume":"71","author":"Park","year":"2011","journal-title":"Cancer Res"},{"key":"30","doi-asserted-by":"crossref","first-page":"e23790","DOI":"10.1371\/journal.pone.0023790","article-title":"Aberrant activation of ERK\/FOXM1 signaling cascade triggers the cell migration\/invasion in ovarian cancer cells","volume":"6","author":"Ngan","year":"2011","journal-title":"PloS one"},{"key":"31","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s10549-009-0572-1","article-title":"FoxM1 down-regulation leads to inhibition of proliferation, migration and invasion of breast cancer cells through the modulation of extra-cellular matrix degrading factors","volume":"122","author":"Sarkar","year":"2010","journal-title":"Breast Cancer Res Treat"},{"key":"32","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.1038\/emboj.2009.239","article-title":"FoxM1, a critical regulator of oxidative stress during oncogenesis","volume":"28","author":"Raychaudhuri","year":"2009","journal-title":"EMBO J"},{"key":"33","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1365-2184.2009.00604.x","article-title":"three-dimensional modelling of human ovarian surface epithelial cells","volume":"42","author":"Dafou","year":"2009","journal-title":"Cell Prolif"},{"key":"34","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1002\/ijc.29528","article-title":"Mutant p53 expression in fallopian tube epithelium drives cell migration","volume":"137","author":"Burdette","year":"2015","journal-title":"Int J Cancer"},{"key":"35","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.ygyno.2015.05.040","article-title":"tumor growth of high-grade serous ovarian cancer cell lines","volume":"138","author":"Sharon Stack","year":"2015","journal-title":"Gynecol Oncol"},{"key":"36","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.ygyno.2015.08.017","article-title":"Beyond genomics: Critical evaluation of cell line utility for ovarian cancer research","volume":"139","author":"MacDuffie","year":"2015","journal-title":"Gynecol Oncol"},{"key":"37","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1038\/ncomms3126","article-title":"Evaluating cell lines as tumour models by comparison of genomic profiles","volume":"4","author":"Schultz","year":"2013","journal-title":"Nat Communs"},{"key":"38","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1038\/nprot.2006.179","article-title":"Sulforhodamine B colorimetric assay for cytotoxicity screening","volume":"1","author":"Kirtikara","year":"2006","journal-title":"Nat Protoc"},{"key":"39","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nprot.2007.30","article-title":"scratch assay: a convenient and inexpensive method for analysis of cell migration","volume":"2","author":"Guan","year":"2007","journal-title":"Nat Protoc"},{"key":"40","first-page":"bgt003","article-title":"Early transformative changes in normal ovarian surface epithelium induced by oxidative stress require akt upregulation, DNA damage, and epithelial-stromal interaction","author":"Burdette","year":"2013","journal-title":"Carcinogenesis"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.3985","article-title":"Tumorigenesis and peritoneal colonization from fallopian tube epithelium","author":"Burdette","year":"2015","journal-title":"Oncotarget"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.9051","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T17:14:12Z","timestamp":1589217252000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.9051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,27]]},"references-count":41,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2016,5,31]]}},"alternative-id":["9051","27129161"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.9051","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,27]]}}}