{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T10:06:56Z","timestamp":1787652416858,"version":"build-2736575974"},"reference-count":190,"publisher":"Impact Journals, LLC","issue":"30","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2016,7,26]]},"DOI":"10.18632\/oncotarget.9195","type":"journal-article","created":{"date-parts":[[2016,5,6]],"date-time":"2016-05-06T20:09:34Z","timestamp":1462565374000},"page":"48788-48812","source":"Crossref","is-referenced-by-count":57,"title":["Targeted inhibition of STATs and IRFs as a potential treatment strategy in cardiovascular disease"],"prefix":"10.18632","volume":"7","author":[{"given":"Malgorzata","family":"Szelag","sequence":"first","affiliation":[{"name":"Department of Human Molecular Genetics, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Piaszyk-Borychowska","sequence":"additional","affiliation":[{"name":"Department of Human Molecular Genetics, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martyna","family":"Plens-Galaska","sequence":"additional","affiliation":[{"name":"Department of Human Molecular Genetics, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Wesoly","sequence":"additional","affiliation":[{"name":"Laboratory of High Throughput Technologies, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans A.R.","family":"Bluyssen","sequence":"additional","affiliation":[{"name":"Department of Human Molecular Genetics, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2016,5,5]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"e442","DOI":"10.1371\/journal.pmed.0030442","article-title":"Projections of global mortality and burden of disease from 2002 to 2030","volume":"3","author":"Loncar","year":"2006","journal-title":"PLoS medicine"},{"key":"2","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.cytogfr.2011.06.003","article-title":"STAT1 as a novel therapeutical target in pro-atherogenic signal integration of IFNgamma, TLR4 and IL-6 in vascular disease","volume":"22","author":"Bluyssen","year":"2011","journal-title":"Cytokine & growth factor reviews"},{"key":"3","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1097\/00003246-200107001-00011","article-title":"The endothelium in sepsis: source of and a target for inflammation","volume":"29","author":"Zeerleder","year":"2001","journal-title":"Critical care medicine"},{"key":"4","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/35025203","article-title":"Atherosclerosis","volume":"407","author":"Lusis","year":"2000","journal-title":"Nature"},{"key":"5","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1161\/CIRCULATIONAHA.113.005015","article-title":"Contribution of intimal smooth muscle cells to cholesterol accumulation and macrophage-like cells in human atherosclerosis","volume":"129","author":"Francis","year":"2014","journal-title":"Circulation"},{"key":"6","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1161\/01.ATV.0000245830.29764.84","article-title":"T cells in atherogenesis: for better or for worse?","volume":"26","author":"Hansson","year":"2006","journal-title":"Arteriosclerosis, thrombosis, and vascular biology"},{"key":"7","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.atherosclerosis.2004.04.027","article-title":"Emergence of dendritic cells in rupture-prone regions of vulnerable carotid plaques","volume":"176","author":"Garlichs","year":"2004","journal-title":"Atherosclerosis"},{"key":"8","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1369\/jhc.4B6570.2005","article-title":"Co-accumulation of dendritic cells and natural killer T cells within rupture-prone regions in human atherosclerotic plaques","volume":"53","author":"Lord","year":"2005","journal-title":"The journal of histochemistry and cytochemistry"},{"key":"9","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/nature01323","article-title":"Inflammation in atherosclerosis","volume":"420","author":"Libby","year":"2002","journal-title":"Nature"},{"key":"10","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1146\/annurev.pathol.1.110304.100100","article-title":"Inflammation and atherosclerosis","volume":"1","author":"Soderberg-Naucler","year":"2006","journal-title":"Annual review of pathology"},{"key":"11","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/nrm909","article-title":"Stats: transcriptional control and biological impact","volume":"3","author":"Darnell","year":"2002","journal-title":"Nature reviews Molecular cell biology"},{"key":"12","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1146\/annurev.immunol.26.021607.090400","article-title":"The IRF family transcription factors in immunity and oncogenesis","volume":"26","author":"Taniguchi","year":"2008","journal-title":"Annual review of immunology"},{"key":"13","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.vph.2005.08.021","article-title":"JANUS under stress--role of JAK\/STAT signaling pathway in vascular diseases","volume":"43","author":"Schieffer","year":"2005","journal-title":"Vascular pharmacology"},{"key":"14","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1161\/HYPERTENSIONAHA.113.02795","article-title":"Interferon regulatory factors in heart: stress response beyond inflammation","volume":"63","author":"Wang","year":"2014","journal-title":"Hypertension"},{"key":"15","doi-asserted-by":"crossref","first-page":"6675","DOI":"10.1074\/jbc.M001748200","article-title":"DNA binding specificity of different STAT proteins. Comparison of in vitro specificity with natural target sites","volume":"276","author":"Bucher","year":"2001","journal-title":"The Journal of biological chemistry"},{"key":"16","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1093\/nar\/gks1085","article-title":"STAT1:DNA sequence-dependent binding modulation by phosphorylation, protein:protein interactions and small-molecule inhibition","volume":"41","author":"Reich","year":"2013","journal-title":"Nucleic acids research"},{"key":"17","doi-asserted-by":"crossref","first-page":"6806","DOI":"10.1073\/pnas.90.14.6806","article-title":"Induction of the Ly-6A\/E gene by interferon alpha\/beta and gamma requires a DNA element to which a tyrosine-phosphorylated 91-kDa protein binds","volume":"90","author":"Bothwell","year":"1993","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"18","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1101\/gad.9.8.984","article-title":"A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain","volume":"9","author":"Darnell","year":"1995","journal-title":"Genes & development"},{"key":"19","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1126\/science.8397445","article-title":"A common nuclear signal transduction pathway activated by growth factor and cytokine receptors","volume":"261","author":"Gilman","year":"1993","journal-title":"Science"},{"key":"20","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1126\/science.8140422","article-title":"Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6","volume":"264","author":"Darnell","year":"1994","journal-title":"Science"},{"key":"21","doi-asserted-by":"crossref","first-page":"3899","DOI":"10.1073\/pnas.87.10.3899","article-title":"Lesion-induced increase in nerve growth factor mRNA is mediated by c-fos","volume":"87","author":"Thoenen","year":"1990","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"22","doi-asserted-by":"crossref","first-page":"4138","DOI":"10.1073\/pnas.0534764100","article-title":"Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth","volume":"100","author":"Grandis","year":"2003","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"23","doi-asserted-by":"crossref","first-page":"3942","DOI":"10.1128\/MCB.22.11.3942-3957.2002","article-title":"A novel interferon regulatory factor (IRF), IRF-10, has a unique role in immune defense and is induced by the v-Rel oncoprotein","volume":"22","author":"Bose","year":"2002","journal-title":"Molecular and cellular biology"},{"key":"24","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/34224","article-title":"Structure of IRF-1 with bound DNA reveals determinants of interferon regulation","volume":"391","author":"Aggarwal","year":"1998","journal-title":"Nature"},{"key":"25","doi-asserted-by":"crossref","first-page":"13063","DOI":"10.1074\/jbc.270.22.13063","article-title":"Functional domain analysis of interferon consensus sequence binding protein (ICSBP) and its association with interferon regulatory factors","volume":"270","author":"Levi","year":"1995","journal-title":"The Journal of biological chemistry"},{"key":"26","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1126\/science.8197455","article-title":"Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins","volume":"264","author":"Stark","year":"1994","journal-title":"Science"},{"key":"27","doi-asserted-by":"crossref","first-page":"9785","DOI":"10.1074\/jbc.272.15.9785","article-title":"Phosphorylation events modulate the ability of interferon consensus sequence binding protein to interact with interferon regulatory factors and to bind DNA","volume":"272","author":"Levi","year":"1997","journal-title":"The Journal of biological chemistry"},{"key":"28","doi-asserted-by":"crossref","first-page":"6468","DOI":"10.4049\/jimmunol.163.12.6468","article-title":"Protein-protein and DNA-protein interactions affect the activity of lymphoid-specific IFN regulatory factors","volume":"163","author":"Levi","year":"1999","journal-title":"Journal of immunology"},{"key":"29","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S1074-7613(00)80527-0","article-title":"The interferon regulatory transcription factor IRF-1 controls positive and negative selection of CD8+ thymocytes","volume":"7","author":"Mak","year":"1997","journal-title":"Immunity"},{"key":"30","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1023\/A:1006850009017","article-title":"A role for casein kinase II phosphorylation in the regulation of IRF-1 transcriptional activity","volume":"191","author":"Hiscott","year":"1999","journal-title":"Molecular and cellular biochemistry"},{"key":"31","doi-asserted-by":"crossref","first-page":"39081","DOI":"10.1074\/jbc.M004900200","article-title":"Interaction between interferon consensus sequence-binding protein and COP9\/signalosome subunit CSN2 (Trip15). A possible link between interferon regulatory factor signaling and the COP9\/signalosome","volume":"275","author":"Levi","year":"2000","journal-title":"The Journal of biological chemistry"},{"key":"32","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/(SICI)1097-4644(19970801)66:2<175::AID-JCB5>3.0.CO;2-N","article-title":"Phosphorylation of the oncogenic transcription factor interferon regulatory factor 2 (IRF2) in vitro and in vivo","volume":"66","author":"Stein","year":"1997","journal-title":"Journal of cellular biochemistry"},{"key":"33","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1128\/MCB.01866-07","article-title":"Interferon regulatory factor 6 promotes cell cycle arrest and is regulated by the proteasome in a cell cycle-dependent manner","volume":"28","author":"Hendrix","year":"2008","journal-title":"Molecular and cellular biology"},{"key":"34","doi-asserted-by":"crossref","first-page":"3280","DOI":"10.1172\/JCI42856","article-title":"Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice","volume":"120","author":"Pernis","year":"2010","journal-title":"The Journal of clinical investigation"},{"key":"35","doi-asserted-by":"crossref","first-page":"17432","DOI":"10.1073\/pnas.1418399111","article-title":"Protein kinase IKKbeta-catalyzed phosphorylation of IRF5 at Ser462 induces its dimerization and nuclear translocation in myeloid cells","volume":"111","author":"Cohen","year":"2014","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"36","doi-asserted-by":"crossref","first-page":"3103","DOI":"10.1161\/hc5001.100631","article-title":"Toll-like receptor-4 is expressed by macrophages in murine and human lipid-rich atherosclerotic plaques and upregulated by oxidized LDL","volume":"104","author":"Arditi","year":"2001","journal-title":"Circulation"},{"key":"37","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1161\/CIRCULATIONAHA.104.498865","article-title":"Expansion of circulating Toll-like receptor 4-positive monocytes in patients with acute coronary syndrome","volume":"111","author":"Koglin","year":"2005","journal-title":"Circulation"},{"key":"38","doi-asserted-by":"crossref","first-page":"10679","DOI":"10.1073\/pnas.0403249101","article-title":"Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E","volume":"101","author":"Arditi","year":"2004","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"39","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.2337\/db06-1491","article-title":"Metabolic endotoxemia initiates obesity and insulin resistance","volume":"56","author":"Ferrieres","year":"2007","journal-title":"Diabetes"},{"key":"40","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1093\/ajcn\/87.5.1219","article-title":"Energy intake is associated with endotoxemia in apparently healthy men","volume":"87","author":"Ferrieres","year":"2008","journal-title":"Am J Clin Nutr"},{"key":"41","doi-asserted-by":"crossref","first-page":"431","DOI":"10.2215\/CJN.03600807","article-title":"Endotoxemia is related to systemic inflammation and atherosclerosis in peritoneal dialysis patients","volume":"3","author":"Li","year":"2008","journal-title":"Clin J Am Soc Nephrol"},{"key":"42","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.biochi.2010.04.016","article-title":"Complex links between dietary lipids, endogenous endotoxins and metabolic inflammation","volume":"93","author":"Michalski","year":"2011","journal-title":"Biochimie"},{"key":"43","first-page":"61","article-title":"TLR4 antagonist reduces early-stage atherosclerosis in diabetic apolipoprotein E-deficient mice","volume":"216","author":"Huang","year":"2013","journal-title":"J Endocrinol"},{"key":"44","first-page":"393946","article-title":"The expression and functions of toll-like receptors in atherosclerosis","volume":"2010","author":"Monaco","year":"2010","journal-title":"Mediators Inflamm"},{"key":"45","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1161\/ATVBAHA.110.218669","article-title":"High-mobility group box protein 1 neutralization reduces development of diet-induced atherosclerosis in apolipoprotein e-deficient mice","volume":"31","author":"Bobik","year":"2011","journal-title":"Arteriosclerosis, thrombosis, and vascular biology"},{"key":"46","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1159\/000191413","article-title":"The roles of Toll-like receptors in atherosclerosis","volume":"1","author":"Erridge","year":"2009","journal-title":"Journal of innate immunity"},{"key":"47","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors","volume":"11","author":"Akira","year":"2010","journal-title":"Nature immunology"},{"key":"48","doi-asserted-by":"crossref","first-page":"20059","DOI":"10.1074\/jbc.R700016200","article-title":"JAK-STAT signaling: from interferons to cytokines","volume":"282","author":"Decker","year":"2007","journal-title":"The Journal of biological chemistry"},{"key":"49","doi-asserted-by":"crossref","first-page":"27","DOI":"10.18388\/abp.2007_3266","article-title":"STAT activation and differential complex formation dictate selectivity of interferon responses","volume":"54","author":"Bluyssen","year":"2007","journal-title":"Acta biochimica Polonica"},{"key":"50","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.cytogfr.2008.11.003","article-title":"Interferon gamma: a master regulator of atherosclerosis","volume":"20","author":"Ramji","year":"2009","journal-title":"Cytokine & growth factor reviews"},{"key":"51","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.ejim.2003.08.010","article-title":"Low-dose interferon-alpha accelerates atherosclerosis in an LDL receptor-deficient mouse model","volume":"14","author":"Harats","year":"2003","journal-title":"Eur J Intern Med"},{"key":"52","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.cmet.2010.06.008","article-title":"Myeloid type I interferon signaling promotes atherosclerosis by stimulating macrophage recruitment to lesions","volume":"12","author":"de Winther","year":"2010","journal-title":"Cell metabolism"},{"key":"53","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1097\/MOL.0b013e328344780b","article-title":"Catching up with important players in atherosclerosis: type I interferons and neutrophils","volume":"22","author":"Weber","year":"2011","journal-title":"Current opinion in lipidology"},{"key":"54","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/35003221","article-title":"Interferon-gamma elicits arteriosclerosis in the absence of leukocytes","volume":"403","author":"Pober","year":"2000","journal-title":"Nature"},{"key":"55","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s00011-005-1377-2","article-title":"Gamma interferon: a central mediator in atherosclerosis","volume":"54","author":"Zuckerman","year":"2005","journal-title":"Inflammation research"},{"key":"56","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1160\/TH09-05-0297","article-title":"How much is too much? Interleukin-6 and its signalling in atherosclerosis","volume":"102","author":"Schieffer","year":"2009","journal-title":"Thromb Haemost"},{"key":"57","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1161\/01.ATV.19.10.2364","article-title":"Interleukin-6 exacerbates early atherosclerosis in mice","volume":"19","author":"Tracy","year":"1999","journal-title":"Arteriosclerosis, thrombosis, and vascular biology"},{"key":"58","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1161\/01.CIR.101.15.1767","article-title":"Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men","volume":"101","author":"Hennekens","year":"2000","journal-title":"Circulation"},{"key":"59","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1161\/ATVBAHA.107.153080","article-title":"IL-6 deficiency protects against angiotensin II induced endothelial dysfunction and hypertrophy","volume":"27","author":"Didion","year":"2007","journal-title":"Arteriosclerosis, thrombosis, and vascular biology"},{"key":"60","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.atherosclerosis.2011.09.015","article-title":"A pilot study of endothelial dysfunction and aortic stiffness after interleukin-6 receptor inhibition in rheumatoid arthritis","volume":"219","author":"Sfikakis","year":"2011","journal-title":"Atherosclerosis"},{"key":"61","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1101\/gad.3.9.1362","article-title":"Cytoplasmic activation of ISGF3, the positive regulator of interferon-alpha-stimulated transcription, reconstituted in vitro","volume":"3","author":"Darnell","year":"1989","journal-title":"Genes & development"},{"key":"62","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1128\/MCB.14.3.1657","article-title":"The signalling pathways of interleukin-6 and gamma interferon converge by the activation of different transcription factors which bind to common responsive DNA elements","volume":"14","author":"Horn","year":"1994","journal-title":"Molecular and cellular biology"},{"key":"63","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1002\/j.1460-2075.1995.tb07128.x","article-title":"A major role for the protein tyrosine kinase JAK1 in the JAK\/STAT signal transduction pathway in response to interleukin-6","volume":"14","author":"Kerr","year":"1995","journal-title":"EMBO J"},{"key":"64","doi-asserted-by":"crossref","first-page":"5790","DOI":"10.1074\/jbc.271.10.5790","article-title":"Formation of STAT1-STAT2 heterodimers and their role in the activation of IRF-1 gene transcription by interferon-alpha","volume":"271","author":"Stark","year":"1996","journal-title":"The Journal of biological chemistry"},{"key":"65","doi-asserted-by":"crossref","first-page":"241","DOI":"10.4161\/jkst.22469","article-title":"STAT1 as a central mediator of IFNgamma and TLR4 signal integration in vascular dysfunction","volume":"1","author":"Bluyssen","year":"2012","journal-title":"Jak-Stat"},{"key":"66","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1189\/jlb.69.6.1036","article-title":"Different Toll-like receptor agonists induce distinct macrophage responses","volume":"69","author":"Fenton","year":"2001","journal-title":"Journal of leukocyte biology"},{"key":"67","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/nri1684","article-title":"The yin and yang of type I interferon activity in bacterial infection","volume":"5","author":"Stockinger","year":"2005","journal-title":"Nature reviews Immunology"},{"key":"68","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/nri2079","article-title":"The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling","volume":"7","author":"Bowie","year":"2007","journal-title":"Nature reviews Immunology"},{"key":"69","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.immuni.2006.08.009","article-title":"Type I interferon [corrected] gene induction by the interferon regulatory factor family of transcription factors","volume":"25","author":"Taniguchi","year":"2006","journal-title":"Immunity"},{"key":"70","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.imbio.2006.05.007","article-title":"Signal integration between IFNgamma and TLR signalling pathways in macrophages","volume":"211","author":"Hume","year":"2006","journal-title":"Immunobiology"},{"key":"71","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1189\/jlb.1206763","article-title":"Crosstalk among Jak-STAT, Toll-like receptor, and ITAM-dependent pathways in macrophage activation","volume":"82","author":"Ivashkiv","year":"2007","journal-title":"Journal of leukocyte biology"},{"key":"72","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1600-065X.2008.00707.x","article-title":"Regulation of interferon and Toll-like receptor signaling during macrophage activation by opposing feedforward and feedback inhibition mechanisms","volume":"226","author":"Ivashkiv","year":"2008","journal-title":"Immunological reviews"},{"key":"73","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.immuni.2009.09.002","article-title":"Cross-regulation of signaling pathways by interferon-gamma: implications for immune responses and autoimmune diseases","volume":"31","author":"Ivashkiv","year":"2009","journal-title":"Immunity"},{"key":"74","doi-asserted-by":"crossref","first-page":"e113318","DOI":"10.1371\/journal.pone.0113318","article-title":"STAT1-dependent signal integration between IFNgamma and TLR4 in vascular cells reflect pro-atherogenic responses in human atherosclerosis","volume":"9","author":"Bluyssen","year":"2014","journal-title":"PloS one"},{"key":"75","doi-asserted-by":"crossref","first-page":"5235","DOI":"10.4049\/jimmunol.154.10.5235","article-title":"The interferon-stimulated response element and a kappa B site mediate synergistic induction of murine IP-10 gene transcription by IFN-gamma and TNF-alpha","volume":"154","author":"Hamilton","year":"1995","journal-title":"Journal of immunology"},{"key":"76","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1096\/fasebj.9.10.7542214","article-title":"Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers","volume":"9","author":"Maniatis","year":"1995","journal-title":"FASEB J"},{"key":"77","doi-asserted-by":"crossref","first-page":"253","DOI":"10.4049\/jimmunol.178.1.253","article-title":"Multiple NF-kappaB and IFN regulatory factor family transcription factors regulate CCL19 gene expression in human monocyte-derived dendritic cells","volume":"178","author":"Julkunen","year":"2007","journal-title":"Journal of immunology"},{"key":"78","doi-asserted-by":"crossref","first-page":"19188","DOI":"10.1074\/jbc.M602059200","article-title":"Interferon regulatory factor 8 regulates RANTES gene transcription in cooperation with interferon regulatory factor-1, NF-kappaB, and PU. 1","volume":"281","author":"Ma","year":"2006","journal-title":"The Journal of biological chemistry"},{"key":"79","doi-asserted-by":"crossref","first-page":"4346","DOI":"10.1093\/nar\/25.21.4346","article-title":"Convergence of TNFalpha and IFNgamma signalling pathways through synergistic induction of IRF-1\/ISGF-2 is mediated by a composite GAS\/kappaB promoter element","volume":"25","author":"Pine","year":"1997","journal-title":"Nucleic acids research"},{"key":"80","doi-asserted-by":"crossref","first-page":"17247","DOI":"10.1074\/jbc.271.29.17247","article-title":"Cooperative role of interferon regulatory factor 1 and p91 (STAT1) response elements in interferon-gamma-inducible expression of human indoleamine 2,3-dioxygenase gene","volume":"271","author":"Gupta","year":"1996","journal-title":"The Journal of biological chemistry"},{"key":"81","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/sj.gene.6364035","article-title":"Regulation of murine Tap1 and Lmp2 genes in macrophages by interferon gamma is mediated by STAT1 and IRF-1","volume":"5","author":"Celada","year":"2004","journal-title":"Genes and immunity"},{"key":"82","doi-asserted-by":"crossref","first-page":"26167","DOI":"10.1074\/jbc.M113.477950","article-title":"Constitutive activation of signal transducer and activator of transcription 3 (STAT3) and nuclear factor kappaB signaling in glioblastoma cancer stem cells regulates the Notch pathway","volume":"288","author":"Pfeffer","year":"2013","journal-title":"The Journal of biological chemistry"},{"key":"83","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/nrc2734","article-title":"STATs in cancer inflammation and immunity: a leading role for STAT3","volume":"9","author":"Jove","year":"2009","journal-title":"Nature reviews Cancer"},{"key":"84","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cytogfr.2009.11.005","article-title":"Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer","volume":"21","author":"Karin","year":"2010","journal-title":"Cytokine & growth factor reviews"},{"key":"85","doi-asserted-by":"crossref","first-page":"5144","DOI":"10.1038\/onc.2012.546","article-title":"Essential role of cooperative NF-kappaB and Stat3 recruitment to ICAM-1 intronic consensus elements in the regulation of radiation-induced invasion and migration in glioma","volume":"32","author":"Rao","year":"2013","journal-title":"Oncogene"},{"key":"86","doi-asserted-by":"crossref","first-page":"14313","DOI":"10.3390\/ijms150814313","article-title":"Data mining of atherosclerotic plaque transcriptomes predicts STAT1-dependent inflammatory signal integration in vascular disease","volume":"15","author":"Bluyssen","year":"2014","journal-title":"International journal of molecular sciences"},{"key":"87","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.1161\/CIRCULATIONAHA.107.696922","article-title":"Signal transducer and activator of transcription 1 is required for optimal foam cell formation and atherosclerotic lesion development","volume":"115","author":"Chisolm","year":"2007","journal-title":"Circulation"},{"key":"88","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1161\/CIRCULATIONAHA.107.711275","article-title":"Signal transducer and activator of transcription-1 is critical for apoptosis in macrophages subjected to endoplasmic reticulum stress in vitro and in advanced atherosclerotic lesions in vivo","volume":"117","author":"Tabas","year":"2008","journal-title":"Circulation"},{"key":"89","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.atherosclerosis.2014.02.029","article-title":"Modulation of vascular smooth muscle cell phenotype by STAT-1 and STAT-3","volume":"234","author":"Wijelath","year":"2014","journal-title":"Atherosclerosis"},{"key":"90","doi-asserted-by":"crossref","first-page":"H2935","DOI":"10.1152\/ajpheart.00887.2006","article-title":"Fludarabine prevents smooth muscle proliferation in vitro and neointimal hyperplasia in vivo through specific inhibition of STAT-1 activation","volume":"292","author":"Indolfi","year":"2007","journal-title":"American journal of physiology Heart and circulatory physiology"},{"key":"91","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1161\/ATVBAHA.109.193896","article-title":"Jak\/STAT signaling pathway regulates nox1 and nox4-based NADPH oxidase in human aortic smooth muscle cells","volume":"30","author":"Simionescu","year":"2010","journal-title":"Arteriosclerosis, thrombosis, and vascular biology"},{"key":"92","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.atherosclerosis.2013.12.043","article-title":"Genetic manipulation of the ApoF\/Stat2 locus supports an important role for type I interferon signaling in atherosclerosis","volume":"233","author":"Rader","year":"2014","journal-title":"Atherosclerosis"},{"key":"93","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/cvr\/cvv103","article-title":"Emerging translational approaches to target STAT3 signalling and its impact on vascular disease","volume":"106","author":"Sedding","year":"2015","journal-title":"Cardiovascular research"},{"key":"94","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.3390\/ijms9112253","article-title":"Pravastatin prevents aortic atherosclerosis via modulation of signal transduction and activation of transcription 3 (STAT3) to attenuate interleukin-6 (IL-6) action in ApoE knockout mice","volume":"9","author":"Li","year":"2008","journal-title":"International journal of molecular sciences"},{"key":"95","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1161\/01.ATV.0000168428.96177.24","article-title":"Signal transducer and activator of transcription 3alpha and specificity protein 1 interact to upregulate intercellular adhesion molecule-1 in ischemic-reperfused myocardium and vascular endothelium","volume":"25","author":"Becker","year":"2005","journal-title":"Arteriosclerosis, thrombosis, and vascular biology"},{"key":"96","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.atherosclerosis.2011.04.023","article-title":"Anti-inflammatory, anti-proliferative and anti-atherosclerotic effects of quercetin in human in vitro and in vivo models","volume":"218","author":"Kooistra","year":"2011","journal-title":"Atherosclerosis"},{"key":"97","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1093\/hmg\/ddg018","article-title":"A central role of interferon regulatory factor-1 for the limitation of neointimal hyperplasia","volume":"12","author":"Neumann","year":"2003","journal-title":"Human molecular genetics"},{"key":"98","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1161\/HYPERTENSIONAHA.114.03229","article-title":"Interferon regulatory factor 1 is required for cardiac remodeling in response to pressure overload","volume":"64","author":"Li","year":"2014","journal-title":"Hypertension"},{"key":"99","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1161\/CIRCULATIONAHA.106.603431","article-title":"Toll-like receptor 4 is involved in brain damage and inflammation after experimental stroke","volume":"115","author":"Lizasoain","year":"2007","journal-title":"Circulation"},{"key":"100","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1128\/MCB.01070-13","article-title":"Interferon regulatory factor 8 modulates phenotypic switching of smooth muscle cells by regulating the activity of myocardin","volume":"34","author":"Li","year":"2014","journal-title":"Molecular and cellular biology"},{"key":"101","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1161\/ATVBAHA.111.236539","article-title":"Hematopoietic interferon regulatory factor 8-deficiency accelerates atherosclerosis in mice","volume":"32","author":"Zernecke","year":"2012","journal-title":"Arteriosclerosis, thrombosis, and vascular biology"},{"key":"102","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1161\/CIRCGENETICS.113.000044","article-title":"Coronary heart disease in systemic lupus erythematosus is associated with interferon regulatory factor-8 gene variants","volume":"6","author":"Syvanen","year":"2013","journal-title":"Circulation Cardiovascular genetics"},{"key":"103","doi-asserted-by":"crossref","first-page":"e8852","DOI":"10.1371\/journal.pone.0008852","article-title":"Macrophage plasticity in experimental atherosclerosis","volume":"5","author":"Caligiuri","year":"2010","journal-title":"PloS one"},{"key":"104","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/ni.2304","article-title":"Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization","volume":"13","author":"Hu","year":"2012","journal-title":"Nature immunology"},{"key":"105","doi-asserted-by":"crossref","first-page":"3303","DOI":"10.1038\/ncomms4303","article-title":"IRF8 suppresses pathological cardiac remodelling by inhibiting calcineurin signalling","volume":"5","author":"Li","year":"2014","journal-title":"Nature communications"},{"key":"106","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/nrd4088","article-title":"Therapeutic modulators of STAT signalling for human diseases","volume":"12","author":"Turkson","year":"2013","journal-title":"Nature reviews Drug discovery"},{"key":"107","doi-asserted-by":"crossref","first-page":"239","DOI":"10.4155\/tde.13.152","article-title":"Cancer therapy using oligonucleotide-based STAT3 inhibitors: will they deliver?","volume":"5","author":"Nechaev","year":"2014","journal-title":"Therapeutic delivery"},{"key":"108","doi-asserted-by":"crossref","first-page":"135","DOI":"10.2174\/1389203716666151102103706","article-title":"Advances in peptidic and peptidomimetic-based approaches to inhibit STAT signaling in human diseases","volume":"17","author":"Bluyssen","year":"2016","journal-title":"Curr Protein Pept Sci"},{"key":"109","doi-asserted-by":"crossref","first-page":"6613","DOI":"10.1038\/sj.onc.1204086","article-title":"STAT proteins: novel molecular targets for cancer drug discovery","volume":"19","author":"Jove","year":"2000","journal-title":"Oncogene"},{"key":"110","doi-asserted-by":"crossref","first-page":"4700","DOI":"10.1073\/pnas.0409894102","article-title":"A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells","volume":"102","author":"Lin","year":"2005","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"111","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/jid.2010.255","article-title":"Stat3 as a therapeutic target for the treatment of psoriasis: a clinical feasibility study with STA-21, a Stat3 inhibitor","volume":"131","author":"Sano","year":"2011","journal-title":"J Invest Dermatol"},{"key":"112","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1002\/art.38305","article-title":"STA-21, a promising STAT-3 inhibitor that reciprocally regulates Th17 and Treg cells, inhibits osteoclastogenesis in mice and humans and alleviates autoimmune inflammation in an experimental model of rheumatoid arthritis","volume":"66","author":"Cho","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"113","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.chembiol.2006.09.018","article-title":"Stattic: a small-molecule inhibitor of STAT3 activation and dimerization","volume":"13","author":"Berg","year":"2006","journal-title":"Chem Biol"},{"key":"114","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1161\/HYPERTENSIONAHA.111.00299","article-title":"Small-molecule inhibitors of signal transducer and activator of transcription 3 protect against angiotensin II-induced vascular dysfunction and hypertension","volume":"61","author":"Faraci","year":"2013","journal-title":"Hypertension"},{"key":"115","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1002\/ijc.28429","article-title":"STAT3 inhibition sensitizes colorectal cancer to chemoradiotherapy in vitro and in vivo","volume":"134","author":"Grade","year":"2014","journal-title":"Int J Cancer"},{"key":"116","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1021\/ml1000273","article-title":"Identification of a New Series of STAT3 Inhibitors by Virtual Screening","volume":"1","author":"Akiyama","year":"2010","journal-title":"ACS Med Chem Lett"},{"key":"117","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.3892\/ijo.2011.957","article-title":"Antitumor activity of a novel small molecule STAT3 inhibitor against a human lymphoma cell line with high STAT3 activation","volume":"38","author":"Akiyama","year":"2011","journal-title":"International journal of oncology"},{"key":"118","doi-asserted-by":"crossref","first-page":"607","DOI":"10.4143\/crt.2014.249","article-title":"Phase I Study of OPB-31121, an Oral STAT3 Inhibitor, in Patients with Advanced Solid Tumors","volume":"47","author":"Bang","year":"2015","journal-title":"Cancer Res Treat"},{"key":"119","doi-asserted-by":"crossref","first-page":"e166","DOI":"10.1038\/bcj.2013.63","article-title":"A novel STAT inhibitor, OPB-31121, has a significant antitumor effect on leukemia with STAT-addictive oncokinases","volume":"3","author":"Naoe","year":"2013","journal-title":"Blood Cancer J"},{"key":"120","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.canlet.2013.02.010","article-title":"OPB-31121, a novel small molecular inhibitor, disrupts the JAK2\/STAT3 pathway and exhibits an antitumor activity in gastric cancer cells","volume":"335","author":"Bang","year":"2013","journal-title":"Cancer Lett"},{"key":"121","doi-asserted-by":"crossref","first-page":"513","DOI":"10.7164\/antibiotics.56.513","article-title":"TMC-264, a novel inhibitor of STAT6 activation produced by Phoma sp. TC 1674","volume":"56","author":"Ohnuki","year":"2003","journal-title":"J Antibiot (Tokyo)"},{"key":"122","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1164\/rccm.200410-1420OC","article-title":"Niflumic acid suppresses interleukin-13-induced asthma phenotypes","volume":"173","author":"Nakanishi","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"123","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1002\/cbic.200700701","article-title":"Discovery of chromone-based inhibitors of the transcription factor STAT5","volume":"9","author":"Berg","year":"2008","journal-title":"Chembiochem"},{"key":"124","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1165\/rcmb.2008-0163OC","article-title":"A novel STAT6 inhibitor AS1517499 ameliorates antigen-induced bronchial hypercontractility in mice","volume":"41","author":"Misawa","year":"2009","journal-title":"Am J Respir Cell Mol Biol"},{"key":"125","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1440-1681.2008.05067.x","article-title":"Pravastatin attenuates interferon-gamma action via modulation of STAT1 to prevent aortic atherosclerosis in apolipoprotein E-knockout mice","volume":"36","author":"Sun","year":"2009","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"126","doi-asserted-by":"crossref","first-page":"714","DOI":"10.3109\/08923973.2011.564185","article-title":"Immunomodulatory effect of water extract of cinnamon on anti-CD3-induced cytokine responses and p38, JNK, ERK1\/2, and STAT4 activation","volume":"33","author":"Kang","year":"2011","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"127","doi-asserted-by":"crossref","first-page":"3421","DOI":"10.1182\/blood-2009-11-255232","article-title":"The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors","volume":"117","author":"Frank","year":"2011","journal-title":"Blood"},{"key":"128","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1038\/leu.2011.338","article-title":"Dual inhibition of Jak2 and STAT5 enhances killing of myeloproliferative neoplasia cells","volume":"26","author":"Frank","year":"2012","journal-title":"Leukemia"},{"key":"129","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.bbrc.2009.03.046","article-title":"Capsaicin inhibits the IL-6\/STAT3 pathway by depleting intracellular gp130 pools through endoplasmic reticulum stress","volume":"382","author":"Park","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"130","doi-asserted-by":"crossref","first-page":"e37960","DOI":"10.1371\/journal.pone.0037960","article-title":"Curcumin blocks small cell lung cancer cells migration, invasion, angiogenesis, cell cycle and neoplasia through Janus kinase-STAT3 signalling pathway","volume":"7","author":"Li","year":"2012","journal-title":"PloS one"},{"key":"131","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1158\/0008-5472.CAN-08-2575","article-title":"Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells","volume":"69","author":"Kwon","year":"2009","journal-title":"Cancer research"},{"key":"132","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/mnfr.200800148","article-title":"Resveratrol addiction: to die or not to die","volume":"53","author":"Aggarwal","year":"2009","journal-title":"Molecular nutrition & food research"},{"key":"133","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.1016\/j.bmcl.2009.04.083","article-title":"Natural product inhibitors of protein-protein interactions mediated by Src-family SH2 domains","volume":"19","author":"Berg","year":"2009","journal-title":"Bioorg Med Chem Lett"},{"key":"134","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s12263-012-0281-y","article-title":"Dietary compounds as potent inhibitors of the signal transducers and activators of transcription (STAT) 3 regulatory network","volume":"7","author":"Diederich","year":"2012","journal-title":"Genes & nutrition"},{"key":"135","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2174\/156800907780006922","article-title":"Small molecule inhibitors of Stat3 signaling pathway","volume":"7","author":"Neamati","year":"2007","journal-title":"Current cancer drug targets"},{"key":"136","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.carres.2010.07.019","article-title":"A combined theoretical and spectroscopic study of 4,6-di-O-acetyl-2,3-dideoxy-D-erythro-hex-2-enopyranosyl sulfamide: a novel glycosyl carbonic anhydrase IX inhibitor","volume":"346","author":"Colinas","year":"2011","journal-title":"Carbohydr Res"},{"key":"137","doi-asserted-by":"crossref","first-page":"6645","DOI":"10.1021\/jm300207s","article-title":"Small molecule inhibitors of signal transducer and activator of transcription 3 (Stat3) protein","volume":"55","author":"Neamati","year":"2012","journal-title":"Journal of medicinal chemistry"},{"key":"138","doi-asserted-by":"crossref","first-page":"e0116688","DOI":"10.1371\/journal.pone.0116688","article-title":"Identification of STAT1 and STAT3 specific inhibitors using comparative virtual screening and docking validation","volume":"10","author":"Bluyssen","year":"2015","journal-title":"PloS one"},{"key":"139","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1593\/neo.91196","article-title":"A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells","volume":"12","author":"Lin","year":"2010","journal-title":"Neoplasia"},{"key":"140","doi-asserted-by":"crossref","first-page":"e40724","DOI":"10.1371\/journal.pone.0040724","article-title":"Structurally modified curcumin analogs inhibit STAT3 phosphorylation and promote apoptosis of human renal cell carcinoma and melanoma cell lines","volume":"7","author":"Lesinski","year":"2012","journal-title":"PloS one"},{"key":"141","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/j.1471-4159.2011.07594.x","article-title":"Resveratrol mitigates lipopolysaccharide- and Abeta-mediated microglial inflammation by inhibiting the TLR4\/NF-kappaB\/STAT signaling cascade","volume":"120","author":"Marambaud","year":"2012","journal-title":"Journal of neurochemistry"},{"key":"142","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.ejphar.2013.10.055","article-title":"In silico simulations of STAT1 and STAT3 inhibitors predict SH2 domain cross-binding specificity","volume":"720","author":"Bluyssen","year":"2013","journal-title":"European journal of pharmacology"},{"key":"143","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1046\/j.1365-2443.2001.00426.x","article-title":"Induction of IRF-3\/\u22127 kinase and NF-kappaB in response to double-stranded RNA and virus infection: common and unique pathways","volume":"6","author":"Fujita","year":"2001","journal-title":"Genes Cells"},{"key":"144","doi-asserted-by":"crossref","first-page":"3174","DOI":"10.1128\/JVI.79.5.3174-3178.2005","article-title":"Interferon regulatory factor 3-independent double-stranded RNA-induced inhibition of hepatitis C virus replicons in human embryonic kidney 293 cells","volume":"79","author":"Kukolj","year":"2005","journal-title":"J Virol"},{"key":"145","doi-asserted-by":"crossref","first-page":"6430","DOI":"10.1128\/JVI.00044-06","article-title":"Reverse genetic generation of recombinant Zaire Ebola viruses containing disrupted IRF-3 inhibitory domains results in attenuated virus growth in vitro and higher levels of IRF-3 activation without inhibiting viral transcription or replication","volume":"80","author":"Nichol","year":"2006","journal-title":"J Virol"},{"key":"146","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s13578-015-0007-0","article-title":"Division of labor between IRF1 and IRF2 in regulating different stages of transcriptional activation in cellular antiviral activities","volume":"5","author":"Zhao","year":"2015","journal-title":"Cell Biosci"},{"key":"147","first-page":"175","article-title":"siRNA targeting the IRF2 transcription factor inhibits leukaemic cell growth","volume":"33","author":"Dolnikov","year":"2008","journal-title":"International journal of oncology"},{"key":"148","doi-asserted-by":"crossref","first-page":"R111","DOI":"10.1186\/bcr3053","article-title":"Loss of interferon regulatory factor 5 (IRF5) expression in human ductal carcinoma correlates with disease stage and contributes to metastasis","volume":"13","author":"Barnes","year":"2011","journal-title":"Breast Cancer Res"},{"key":"149","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1038\/leu.2015.124","article-title":"Selective targeting of IRF4 by synthetic microRNA-125b-5p mimics induces anti-multiple myeloma activity in vitro and in vivo","volume":"29","author":"Tassone","year":"2015","journal-title":"Leukemia"},{"key":"150","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1007\/s10875-011-9576-9","article-title":"A benzamide-linked small molecule HS-Cf inhibits TNF-alpha-induced interferon regulatory factor-1 in porcine chondrocytes: a potential disease-modifying drug for osteoarthritis therapeutics","volume":"31","author":"Ho","year":"2011","journal-title":"J Clin Immunol"},{"key":"151","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.febslet.2012.01.016","article-title":"LY294002 inhibits TLR3\/4-mediated IFN-beta production via inhibition of IRF3 activation with a PI3K-independent mechanism","volume":"586","author":"Gao","year":"2012","journal-title":"FEBS Lett"},{"key":"152","doi-asserted-by":"crossref","first-page":"3431","DOI":"10.4049\/jimmunol.1100580","article-title":"Simvastatin inhibits IFN regulatory factor 4 expression and Th17 cell differentiation in CD4+ T cells derived from patients with multiple sclerosis","volume":"187","author":"Markovic-Plese","year":"2011","journal-title":"Journal of immunology"},{"key":"153","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1097\/00024382-200405000-00012","article-title":"Inhibition of lipopolysaccharide-induced interferon regulatory factor 3 activation and protection from septic shock by hydroxystilbenes","volume":"21","author":"David","year":"2004","journal-title":"Shock"},{"key":"154","doi-asserted-by":"crossref","first-page":"7113","DOI":"10.1128\/JVI.77.12.7113-7119.2003","article-title":"Impairment of interferon-induced IRF-7 gene expression due to inhibition of ISGF3 formation by trichostatin A","volume":"77","author":"Civas","year":"2003","journal-title":"J Virol"},{"key":"155","doi-asserted-by":"crossref","first-page":"15208","DOI":"10.1074\/jbc.M611907200","article-title":"Minocycline down-regulates MHC II expression in microglia and macrophages through inhibition of IRF-1 and protein kinase C (PKC)alpha\/betaII","volume":"282","author":"Duncan","year":"2007","journal-title":"The Journal of biological chemistry"},{"key":"156","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0969-2126(98)00050-1","article-title":"Solution structure of the IRF-2 DNA-binding domain: a novel subgroup of the winged helix-turn-helix family","volume":"6","author":"Kyogoku","year":"1998","journal-title":"Structure"},{"key":"157","doi-asserted-by":"crossref","first-page":"5028","DOI":"10.1093\/emboj\/18.18.5028","article-title":"Crystal structure of an IRF-DNA complex reveals novel DNA recognition and cooperative binding to a tandem repeat of core sequences","volume":"18","author":"Hakoshima","year":"1999","journal-title":"Embo Journal"},{"key":"158","article-title":"Solution structure of the IRF domain of human interferon regulator factors 4","author":"Yokoyama","year":"2006","journal-title":"Protein Data Bank"},{"key":"159","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.molcel.2007.04.022","article-title":"Structure of IRF-3 bound to the PRDIII-I regulatory element of the human interferon-beta enhancer","volume":"26","author":"Aggarwal","year":"2007","journal-title":"Mol Cell"},{"key":"160","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1006\/jmbi.1993.1626","article-title":"Comparative protein modelling by satisfaction of spatial restraints","volume":"234","author":"Blundell","year":"1993","journal-title":"Journal of molecular biology"},{"key":"161","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1021\/ja026939x","article-title":"HADDOCK: a protein-protein docking approach based on biochemical or biophysical information","volume":"125","author":"Bonvin","year":"2003","journal-title":"J Am Chem Soc"},{"key":"162","article-title":"CAVS - Novel in silico selection strategy of specific STAT inhibitory compounds","author":"Bluyssen","year":"2014","journal-title":"J Comp Science"},{"key":"163","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1056\/NEJMoa1110556","article-title":"JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis","volume":"366","author":"Barosi","year":"2012","journal-title":"N Engl J Med"},{"key":"164","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1111\/j.1365-2133.2012.11168.x","article-title":"Efficacy and safety of tofacitinib, an oral Janus kinase inhibitor, in the treatment of psoriasis: a Phase 2b randomized placebo-controlled dose-ranging study","volume":"167","author":"Harness","year":"2012","journal-title":"Br J Dermatol"},{"key":"165","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1056\/NEJMoa1112168","article-title":"Tofacitinib, an oral Janus kinase inhibitor, in active ulcerative colitis","volume":"367","author":"Study","year":"2012","journal-title":"N Engl J Med"},{"key":"166","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1056\/NEJMoa1310476","article-title":"Tofacitinib versus methotrexate in rheumatoid arthritis","volume":"370","author":"Investigators","year":"2014","journal-title":"N Engl J Med"},{"key":"167","doi-asserted-by":"crossref","first-page":"837","DOI":"10.3899\/jrheum.130683","article-title":"Safety and efficacy of tofacitinib, an oral janus kinase inhibitor, for the treatment of rheumatoid arthritis in open-label, longterm extension studies","volume":"41","author":"Riese","year":"2014","journal-title":"J Rheumatol"},{"key":"168","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1161\/01.CIR.0000043244.13596.20","article-title":"Fluvastatin enhances the inhibitory effects of a selective angiotensin II type 1 receptor blocker, valsartan, on vascular neointimal formation","volume":"107","author":"Iwai","year":"2003","journal-title":"Circulation"},{"key":"169","doi-asserted-by":"crossref","first-page":"H1291","DOI":"10.1152\/ajpheart.00181.2007","article-title":"Angiotensin II and endothelin-1 augment the vascular complications of diabetes via JAK2 activation","volume":"293","author":"Marrero","year":"2007","journal-title":"American journal of physiology Heart and circulatory physiology"},{"key":"170","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.ejim.2006.12.007","article-title":"STAT1 and STAT3 as intracellular regulators of vascular remodeling","volume":"18","author":"Szarejko","year":"2007","journal-title":"European Journal of Internal Medicine"},{"key":"171","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1139\/y11-105","article-title":"Losartan inhibits STAT1 activation and protects human glomerular mesangial cells from angiotensin II induced premature senescence","volume":"90","author":"Wang","year":"2012","journal-title":"Canadian journal of physiology and pharmacology"},{"key":"172","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s11010-011-1197-3","article-title":"STAT1 mediates cellular senescence induced by angiotensin II and H(2)O(2) in human glomerular mesangial cells","volume":"365","author":"Wang","year":"2012","journal-title":"Molecular and cellular biochemistry"},{"key":"173","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1158\/1940-6207.CAPR-11-0247","article-title":"Curcumin induces the differentiation of myeloid-derived suppressor cells and inhibits their interaction with cancer cells and related tumor growth","volume":"5","author":"Yang","year":"2012","journal-title":"Cancer prevention research"},{"key":"174","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1093\/carcin\/bgq167","article-title":"Cucurbitacin E, a tetracyclic triterpenes compound from Chinese medicine, inhibits tumor angiogenesis through VEGFR2-mediated Jak2-STAT3 signaling pathway","volume":"31","author":"Liu","year":"2010","journal-title":"Carcinogenesis"},{"key":"175","doi-asserted-by":"crossref","first-page":"3236","DOI":"10.1038\/sj.onc.1208470","article-title":"Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity","volume":"24","author":"Sebti","year":"2005","journal-title":"Oncogene"},{"key":"176","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/1471-2407-11-112","article-title":"The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines","volume":"11","author":"London","year":"2011","journal-title":"BMC cancer"},{"key":"177","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1007\/s10637-011-9645-1","article-title":"Small molecules, LLL12 and FLLL32, inhibit STAT3 and exhibit potent growth suppressive activity in osteosarcoma cells and tumor growth in mice","volume":"30","author":"Lin","year":"2012","journal-title":"Investigational new drugs"},{"key":"178","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.intimp.2009.09.009","article-title":"Evaluation of anti-leukemia effect of resveratrol by modulating STAT3 signaling","volume":"10","author":"Ye","year":"2010","journal-title":"International immunopharmacology"},{"key":"179","doi-asserted-by":"crossref","first-page":"5426","DOI":"10.1158\/1078-0432.CCR-09-0287","article-title":"Humanized anti-interleukin-6 receptor antibody suppresses tumor angiogenesis and in vivo growth of human oral squamous cell carcinoma","volume":"15","author":"Ando","year":"2009","journal-title":"Clin Cancer Res"},{"key":"180","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.cyto.2013.04.027","article-title":"Selective JAK\/STAT3 signalling regulates transcription of colony stimulating factor-2 and -3 in Concanavalin-A-activated mesenchymal stromal cells","volume":"63","author":"Annabi","year":"2013","journal-title":"Cytokine"},{"key":"181","doi-asserted-by":"crossref","first-page":"6601","DOI":"10.1158\/0008-5472.CAN-11-1217","article-title":"Antiangiogenic and antimetastatic activity of JAK inhibitor AZD1480","volume":"71","author":"Jove","year":"2011","journal-title":"Cancer research"},{"key":"182","doi-asserted-by":"crossref","first-page":"e335","DOI":"10.1038\/bcj.2015.63","article-title":"A phase 2 randomized dose-ranging study of the JAK2-selective inhibitor fedratinib (SAR302503) in patients with myelofibrosis","volume":"5","author":"Talpaz","year":"2015","journal-title":"Blood Cancer J"},{"key":"183","doi-asserted-by":"crossref","first-page":"e81819","DOI":"10.1371\/journal.pone.0081819","article-title":"STAT3 oligonucleotide inhibits tumor angiogenesis in preclinical models of squamous cell carcinoma","volume":"9","author":"Kim","year":"2014","journal-title":"PloS one"},{"key":"184","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s00395-012-0261-9","article-title":"Inhibition of STAT3 signaling prevents vascular smooth muscle cell proliferation and neointima formation","volume":"107","author":"Sedding","year":"2012","journal-title":"Basic Res Cardiol"},{"key":"185","doi-asserted-by":"crossref","first-page":"755","DOI":"10.3892\/ol.2014.1795","article-title":"Effects of AG490 and S3I-201 on regulation of the JAK\/STAT3 signaling pathway in relation to angiogenesis in TRAIL-resistant prostate cancer cells","volume":"7","author":"Sozen","year":"2014","journal-title":"Oncol Lett"},{"key":"186","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1002\/jcc.21720","article-title":"Web servers and services for electrostatics calculations with APBS and PDB2PQR","volume":"32","author":"Baker","year":"2011","journal-title":"Journal of computational chemistry"},{"key":"187","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1021\/jm020406h","article-title":"Surflex: fully automatic flexible molecular docking using a molecular similarity-based search engine","volume":"46","author":"Jain","year":"2003","journal-title":"Journal of medicinal chemistry"},{"key":"188","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.1093\/nar\/gkg557","article-title":"GeneSilico protein structure prediction meta-server","volume":"31","author":"Bujnicki","year":"2003","journal-title":"Nucleic acids research"},{"key":"189","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S0168-9525(00)02024-2","article-title":"EMBOSS: the European Molecular Biology Open Software Suite","volume":"16","author":"Bleasby","year":"2000","journal-title":"Trends Genet"},{"key":"190","doi-asserted-by":"crossref","first-page":"W235","DOI":"10.1093\/nar\/gkp287","article-title":"3D-DART: a DNA structure modelling server","volume":"37","author":"Bonvin","year":"2009","journal-title":"Nucleic acids research"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.9195","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T23:30:24Z","timestamp":1692315024000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.9195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,5]]},"references-count":190,"journal-issue":{"issue":"30","published-print":{"date-parts":[[2016,7,26]]}},"alternative-id":["9195","27166190"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.9195","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,5]]}}}