{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:16:14Z","timestamp":1790766974539,"version":"4.1.0"},"reference-count":25,"publisher":"Impact Journals, LLC","issue":"27","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2106,7,5]]},"DOI":"10.18632\/oncotarget.9313","type":"journal-article","created":{"date-parts":[[2016,5,12]],"date-time":"2016-05-12T15:59:18Z","timestamp":1463068758000},"page":"41599-41611","source":"Crossref","is-referenced-by-count":13,"title":["Speed of leukemia development and genetic diversity in xenograft models of T cell acute lymphoblastic leukemia"],"prefix":"10.18632","volume":"7","author":[{"given":"Sandrine","family":"Poglio","sequence":"first","affiliation":[{"name":"Commissariat \u00e0 l'Energie Atomique et aux Energies Alternatives (CEA), DSV-IRCM-SCSR-LSHL, UMR 967, Fontenay-aux-Roses, France"},{"name":"INSERM, U967, Fontenay-aux-Roses, France"},{"name":"Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, UMR 967, Fontenay-aux-Roses, France"},{"name":"Universit\u00e9 Paris-Sud, UMR 967, Fontenay-aux-Roses, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Lewandowski","sequence":"additional","affiliation":[{"name":"INSERM, U967, Fontenay-aux-Roses, France"},{"name":"Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, UMR 967, Fontenay-aux-Roses, France"},{"name":"Universit\u00e9 Paris-Sud, UMR 967, Fontenay-aux-Roses, France"},{"name":"CEA, DSV-IRCM-SCSR-LRTS, UMR 967, Fontenay-aux-Roses, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Calvo","sequence":"additional","affiliation":[{"name":"Commissariat \u00e0 l'Energie Atomique et aux Energies Alternatives (CEA), DSV-IRCM-SCSR-LSHL, UMR 967, Fontenay-aux-Roses, France"},{"name":"INSERM, U967, Fontenay-aux-Roses, France"},{"name":"Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, UMR 967, Fontenay-aux-Roses, France"},{"name":"Universit\u00e9 Paris-Sud, UMR 967, Fontenay-aux-Roses, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Caye","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Diderot, Paris, France"},{"name":"Assistance Publique-H\u00f4pitaux de Paris (AP-HP), D\u00e9partement de G\u00e9n\u00e9tique, UF de G\u00e9n\u00e9tique Mol\u00e9culaire, H\u00f4pital Robert Debr\u00e9 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Gros","sequence":"additional","affiliation":[{"name":"INSERM, UMR1053 Bordeaux Research in Translational Oncology (BaRITOn),Bordeaux, France"},{"name":"Universit\u00e9 de Bordeaux, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elodie","family":"Laharanne","sequence":"additional","affiliation":[{"name":"INSERM, UMR1053 Bordeaux Research in Translational Oncology (BaRITOn),Bordeaux, France"},{"name":"Universit\u00e9 de Bordeaux, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Leblanc","sequence":"additional","affiliation":[{"name":"AP-HP, Service d'h\u00e9matologie P\u00e9diatrique, H\u00f4pital Robert Debr\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Landman-Parker","sequence":"additional","affiliation":[{"name":"AP-HP, Service d'h\u00e9matologie P\u00e9diatrique, H\u00f4pital Armand Trousseau, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Baruchel","sequence":"additional","affiliation":[{"name":"AP-HP, Service d'h\u00e9matologie P\u00e9diatrique, H\u00f4pital Robert Debr\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Soulier","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Diderot, Paris, France"},{"name":"AP-HP, Laboratoire d'H\u00e9matologie, H\u00f4pital Saint-Louis, Paris, France"},{"name":"Team Genome and Cancer, U944 INSERM, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Ballerini","sequence":"additional","affiliation":[{"name":"Commissariat \u00e0 l'Energie Atomique et aux Energies Alternatives (CEA), DSV-IRCM-SCSR-LSHL, UMR 967, Fontenay-aux-Roses, France"},{"name":"INSERM, U967, Fontenay-aux-Roses, France"},{"name":"Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, UMR 967, Fontenay-aux-Roses, France"},{"name":"Universit\u00e9 Paris-Sud, UMR 967, Fontenay-aux-Roses, France"},{"name":"AP-HP, Service d'h\u00e9matologie P\u00e9diatrique, H\u00f4pital Armand Trousseau, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Clappier","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Diderot, Paris, France"},{"name":"AP-HP, Laboratoire d'H\u00e9matologie, H\u00f4pital Saint-Louis, Paris, France"},{"name":"Team Genome and Cancer, U944 INSERM, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Pflumio","sequence":"additional","affiliation":[{"name":"Commissariat \u00e0 l'Energie Atomique et aux Energies Alternatives (CEA), DSV-IRCM-SCSR-LSHL, UMR 967, Fontenay-aux-Roses, France"},{"name":"INSERM, U967, Fontenay-aux-Roses, France"},{"name":"Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, UMR 967, Fontenay-aux-Roses, France"},{"name":"Universit\u00e9 Paris-Sud, UMR 967, Fontenay-aux-Roses, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2016,5,12]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1038\/leu.2010.159","article-title":"Insights into the stem cells of chronic myeloid leukemia","volume":"24","author":"Eaves","year":"2010","journal-title":"Leukemia"},{"key":"2","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/35102167","article-title":"Stem cells, cancer, and cancer stem cells","volume":"414","author":"Weissman","year":"2001","journal-title":"Nature"},{"key":"3","doi-asserted-by":"crossref","first-page":"3398","DOI":"10.1172\/JCI61269","article-title":"The molecular basis of T cell acute lymphoblastic leukemia","volume":"122","author":"Ferrando","year":"2012","journal-title":"The Journal of clinical investigation"},{"key":"4","first-page":"1730","article-title":"NOTCH is a key regulator of human T-cell acute leukemia initiating cell activity","author":"Pflumio","year":"2009","journal-title":"Blood"},{"key":"5","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/nm0797-730","article-title":"Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell","volume":"3","author":"Dick","year":"1997","journal-title":"Nature medicine"},{"key":"6","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1038\/nbt1350","article-title":"Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region","volume":"25","author":"Taniguchi","year":"2007","journal-title":"Nature biotechnology"},{"key":"7","doi-asserted-by":"crossref","first-page":"5268","DOI":"10.1182\/blood-2010-06-292300","article-title":"Leukemia-initiating cells in human T-lymphoblastic leukemia exhibit glucocorticoid resistance","volume":"116","author":"Dick","year":"2010","journal-title":"Blood"},{"key":"8","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1182\/blood-2006-06-030445","article-title":"Characterization of a progenitor cell population in childhood T-cell acute lymphoblastic leukemia","volume":"109","author":"Blair","year":"2007","journal-title":"Blood"},{"key":"9","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1038\/leu.2011.93","article-title":"Expression of CD34 and CD7 on human T-cell acute lymphoblastic leukemia discriminates functionally heterogeneous cell populations","volume":"25","author":"Pflumio","year":"2011","journal-title":"Leukemia"},{"key":"10","doi-asserted-by":"crossref","first-page":"3683","DOI":"10.1242\/jcs.037507","article-title":"Novel functions of the CD34 family","volume":"121","author":"McNagny","year":"2008","journal-title":"Journal of cell science"},{"key":"11","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1084\/jem.20110105","article-title":"Clonal selection in xenografted human T cell acute lymphoblastic leukemia recapitulates gain of malignancy at relapse","volume":"208","author":"Soulier","year":"2011","journal-title":"The Journal of experimental medicine"},{"key":"12","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/leu.2014.317","article-title":"Rapid childhood T-ALL growth in xenograft models correlates with mature phenotype and NF-kappaB pathway activation but not with poor prognosis","volume":"29","author":"Pflumio","year":"2015","journal-title":"Leukemia"},{"key":"13","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.3324\/haematol.2011.045153","article-title":"MLL-ENL leukemia burden initiated in femoral diaphysis and preceded by mature B-cell depletion","volume":"96","author":"Romeo","year":"2011","journal-title":"Haematologica"},{"key":"14","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1128\/MCB.26.1.209-220.2006","article-title":"Notch activation is an early and critical event during T-Cell leukemogenesis in Ikaros-deficient mice","volume":"26","author":"Chan","year":"2006","journal-title":"Molecular and cellular biology"},{"key":"15","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/nature05690","article-title":"Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia","volume":"446","author":"Downing","year":"2007","journal-title":"Nature"},{"key":"16","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.leukres.2009.09.012","article-title":"Genetic inactivation of Ikaros is a rare event in human T-ALL","volume":"34","author":"Kastner","year":"2010","journal-title":"Leukemia research"},{"key":"17","doi-asserted-by":"crossref","first-page":"597","DOI":"10.3324\/haematol.2012.073965","article-title":"Breakpoint-specific multiplex polymerase chain reaction allows the detection of IKZF1 intragenic deletions and minimal residual disease monitoring in B-cell precursor acute lymphoblastic leukemia","volume":"98","author":"Clappier","year":"2013","journal-title":"Haematologica"},{"key":"18","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1126\/science.1164266","article-title":"Genomic analysis of the clonal origins of relapsed acute lymphoblastic leukemia","volume":"322","author":"Downing","year":"2008","journal-title":"Science (New York, NY)"},{"key":"19","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1200\/JCO.2010.30.2877","article-title":"Late recurrence of childhood T-cell acute lymphoblastic leukemia frequently represents a second leukemia rather than a relapse: first evidence for genetic predisposition","volume":"29","author":"Meijerink","year":"2011","journal-title":"Journal of clinical oncology"},{"key":"20","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1002\/emmm.201303286","article-title":"Interleukin-18 produced by bone marrow-derived stromal cells supports T-cell acute leukaemia progression","volume":"6","author":"Ballerini","year":"2014","journal-title":"EMBO molecular medicine"},{"key":"21","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.ccr.2014.01.031","article-title":"Functional heterogeneity of genetically defined subclones in acute myeloid leukemia","volume":"25","author":"Dipersio","year":"2014","journal-title":"Cancer cell"},{"key":"22","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1038\/leu.2010.158","article-title":"AML xenograft efficiency is significantly improved in NOD\/SCID-IL2RG mice constitutively expressing human SCF, GM-CSF and IL-3","volume":"24","author":"Mulloy","year":"2010","journal-title":"Leukemia"},{"key":"23","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1091\/mbc.e11-02-0143","article-title":"cTAGE5 mediates collagen secretion through interaction with TANGO1 at endoplasmic reticulum exit sites","volume":"22","author":"Katada","year":"2011","journal-title":"Molecular biology of the cell"},{"key":"24","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nature13187","article-title":"Tumour cell heterogeneity maintained by cooperating subclones in Wnt-driven mammary cancers","volume":"508","author":"Gunther","year":"2014","journal-title":"Nature"},{"key":"25","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jim.2009.06.008","article-title":"ELDA: extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays","volume":"347","author":"Smyth","year":"2009","journal-title":"Journal of immunological methods"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.9313","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T21:48:43Z","timestamp":1589233723000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.9313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,12]]},"references-count":25,"journal-issue":{"issue":"27","published-print":{"date-parts":[[2106,7,5]]}},"alternative-id":["9313","27191650"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.9313","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,12]]}}}