{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T22:41:36Z","timestamp":1785364896823,"version":"3.55.0"},"reference-count":75,"publisher":"Impact Journals, LLC","issue":"25","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2016,6,21]]},"DOI":"10.18632\/oncotarget.9353","type":"journal-article","created":{"date-parts":[[2016,5,13]],"date-time":"2016-05-13T21:59:48Z","timestamp":1463176788000},"page":"37906-37919","source":"Crossref","is-referenced-by-count":8,"title":["Identification of polycystic ovary syndrome potential drug targets based on pathobiological similarity in the protein-protein interaction network"],"prefix":"10.18632","volume":"7","author":[{"given":"Hao","family":"Huang","sequence":"first","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuehan","family":"He","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan","family":"Li","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqing","family":"Wei","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiran","family":"Li","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiqiang","family":"Xie","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yahui","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Jiang","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binbin","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Lv","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiming","family":"He","sequence":"additional","affiliation":[{"name":"Institute of Opto-electronics, Harbin Institute of Technology, Harbin, Heilongjiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2016,5,13]]},"reference":[{"key":"1","first-page":"19","article-title":"Polycystic ovary syndrome and impact on health","volume":"16","author":"Merchant","year":"2011","journal-title":"MEFS"},{"key":"2","first-page":"2015","article-title":"Polycystic Ovary Syndrome: Important Underrecognised Cardiometabolic Risk Factor in Reproductive-Age Women","author":"Ougouag","year":"2015","journal-title":"Int J Endocrinol"},{"key":"3","first-page":"12","article-title":"Anthropometric and biochemical characteristics of polycystic ovarian syndrome in South Indian women using AES-2006 criteria","author":"Hasan","year":"2014","journal-title":"Int J Endocrinol Metab"},{"key":"4","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/0002-8703(91)90434-J","article-title":"Insulin resistance and compensatory hyperinsulinemia: role in hypertension, dyslipidemia, and coronary heart disease","volume":"121","author":"Reaven","year":"1991","journal-title":"American heart journal"},{"key":"5","doi-asserted-by":"crossref","first-page":"s72","DOI":"10.7861\/clinmedicine.15-6-s72","article-title":"Polycystic ovary syndrome: insight into pathogenesis and a common association with insulin resistance","volume":"15","author":"Franks","year":"2015","journal-title":"Clin Med (Lond)"},{"key":"6","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1002\/ajhb.20937","article-title":"Type 2 diabetes, cardiovascular disease, and the evolutionary paradox of the polycystic ovary syndrome: a fertility first hypothesis","volume":"21","author":"Prentice","year":"2009","journal-title":"Am J Hum Biol"},{"key":"7","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1046\/j.1365-2265.2000.00884.x","article-title":"The prevalence of polycystic ovaries in women with type 2 diabetes mellitus","volume":"52","author":"Conway","year":"2000","journal-title":"Clin Endocrinol (Oxf)"},{"key":"8","doi-asserted-by":"crossref","first-page":"147","DOI":"10.2217\/WHE.11.94","article-title":"The link between polycystic ovary syndrome and both Type 1 and Type 2 diabetes mellitus: what do we know today?","volume":"8","author":"Franks","year":"2012","journal-title":"Women's Health"},{"key":"9","doi-asserted-by":"crossref","first-page":"1257601","DOI":"10.1126\/science.1257601","article-title":"Uncovering disease-disease relationships through the incomplete interactome","volume":"347","author":"Barab\u00e1si","year":"2015","journal-title":"Science"},{"key":"10","doi-asserted-by":"crossref","first-page":"D668","DOI":"10.1093\/nar\/gkj067","article-title":"DrugBank: a comprehensive resource fordrug discovery and exploration","volume":"34","author":"Woolsey","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"11","doi-asserted-by":"crossref","first-page":"3835","DOI":"10.1210\/jc.2003-031737","article-title":"Effect of the insulin sensitizer pioglitazone on insulin resistance, hyperandrogenism, and ovulatory dysfunction in women with polycystic ovary syndrome","volume":"89","author":"Keller","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"12","doi-asserted-by":"crossref","first-page":"5535","DOI":"10.1210\/jc.2004-0150","article-title":"Pancreatic islets from type 2 diabetic patients have functional defects and increased apoptosis that are ameliorated by metformin","volume":"89","author":"Mosca","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"13","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.2337\/diab.45.12.1661","article-title":"Thiazolidinediones in the treatment of insulin resistance and type II diabetes","volume":"45","author":"Olefsky","year":"1996","journal-title":"Diabetes"},{"key":"14","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.fertnstert.2005.12.067","article-title":"Effect of pioglitazone on glucose metabolism and luteinizing hormone secretion in women with polycystic ovary syndrome","volume":"86","author":"Henriksen","year":"2006","journal-title":"Fertility and sterility"},{"key":"15","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/nrd2195","article-title":"A robustness-based approach to systems-oriented drug design","volume":"5","author":"Kitano","year":"2007","journal-title":"Nat Rev Drug Discov"},{"key":"16","doi-asserted-by":"publisher","first-page":"8071","DOI":"10.18632\/oncotarget.3513","article-title":"Systems biology network-based discovery of a small molecule activator BL-AD008 targeting AMPK\/ZIPK and inducing apoptosis in cervical cancer","volume":"6","author":"Huang","year":"2015","journal-title":"Oncotarget"},{"key":"17","doi-asserted-by":"publisher","first-page":"13088","DOI":"10.18632\/oncotarget.3743","article-title":"Identification of novel genes that regulate androgen receptor signaling and growth of androgen-deprived prostate cancer cells","volume":"6","author":"Ding","year":"2015","journal-title":"Oncotarget"},{"key":"18","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1194\/jlr.R600022-JLR200","article-title":"Thematic review series: systems biology approaches to metabolic and cardiovascular disorders. Lipidomics: a global approach to lipid analysis in biological systems","volume":"47","author":"Watson","year":"2006","journal-title":"J Lipid Res"},{"key":"19","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1089\/omi.2015.0088","article-title":"Tissue-specific molecular biomarker signatures of type 2 diabetes: an integrative analysis of transcriptomics and protein-protein interaction data","volume":"19","author":"Arga","year":"2015","journal-title":"OMICS"},{"key":"20","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1161\/CIRCGENETICS.114.000676","article-title":"Shared molecular pathways and gene networks for cardiovascular disease and type 2 diabetes mellitus in women across diverse ethnicities","volume":"7","author":"Liu","year":"2014","journal-title":"Circ Cardiovasc Genet"},{"key":"21","first-page":"17","article-title":"Protein-protein interaction networks (PPI) and complex diseases","volume":"7","author":"Peyvandi","year":"2014","journal-title":"Gastroenterol Hepatol Bed Bench"},{"key":"22","doi-asserted-by":"crossref","first-page":"3026","DOI":"10.1039\/c3mb70289h","article-title":"Cancer-related marketing centrality motifs acting as pivot units in the human signaling network and mediating cross-talk between biological pathways","volume":"9","author":"Li","year":"2013","journal-title":"Mol Biosyst"},{"key":"23","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1752-0509-8-6","article-title":"Protein interaction networks as metric spaces: a novel perspective on distribution of hubs","volume":"8","author":"Mwambene","year":"2014","journal-title":"BMC Syst Biol"},{"key":"24","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jsbmb.2008.03.031","article-title":"estrogen metabolism in proliferative endometria from untreated women with polycystic ovarian syndrome with and without endometrial hyperplasia","volume":"110","author":"Vega","year":"2008","journal-title":"J Steroid Biochem Mol Biol"},{"key":"25","first-page":"2014","article-title":"Polycystic ovary syndrome, insulin resistance, and obesity: navigating the pathophysiologic labyrinth","author":"Berm\u00fadez","year":"2014","journal-title":"Int J Reprod Med"},{"key":"26","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nrendo.2010.217","article-title":"Polycystic ovary syndrome: etiology, pathogenesis and diagnosis","volume":"7","author":"Azziz","year":"2011","journal-title":"Nat Rev Endocrinol"},{"key":"27","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.1210\/en.2007-0248","article-title":"Female mice haploinsufficient for an inactivated androgen receptor (AR) exhibit age-dependent defects that resemble the AR null phenotype of dysfunctional late follicle development, ovulation, and fertility","volume":"148","author":"Handelsman","year":"2007","journal-title":"Endocrinology"},{"key":"28","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1093\/humrep\/17.10.2573","article-title":"Maternal serum androgens in pregnant women with polycystic ovarian syndrome: possible implications in prenatal androgenization","volume":"17","author":"Recabarren","year":"2002","journal-title":"Human Reproduction"},{"key":"29","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/j.1365-2265.2007.02764.x","article-title":"Metabolic characteristics of women with polycystic ovaries and oligo-amenorrhoea but normal androgen levels: implications for the management of polycystic ovary syndrome","volume":"66","author":"Franks","year":"2007","journal-title":"Clinical endocrinology"},{"key":"30","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1210\/mend.13.6.0308","article-title":"Regulation of angiogenic growth factors in the female reproductive tract by estrogens and progestins","volume":"13","author":"Stancel","year":"1999","journal-title":"Mol Endocrinol"},{"key":"31","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.mce.2011.09.026","article-title":"Estrogen dependent signaling in reproductive tissues-a role for estrogen receptors and estrogen related receptors","volume":"348","author":"Saunders","year":"2012","journal-title":"Mol Cell Endocrinol"},{"key":"32","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1093\/nar\/29.14.2905","article-title":"Estrogen receptor interaction with estrogen response elements","volume":"29","author":"Klinge","year":"2001","journal-title":"Nucleic Acids Res"},{"key":"33","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1210\/me.2002-0398","article-title":"Characterization of the hypothalamic-pituitary-gonadal axis in estrogen receptor (ER) null mice reveals hypergonadism and endocrine sex reversal in females lacking ER\u03b1 but not ER\u03b2","volume":"17","author":"Korach","year":"2003","journal-title":"Molecular Endocrinology"},{"key":"34","doi-asserted-by":"crossref","first-page":"505","DOI":"10.3109\/09513590.2011.649811","article-title":"The importance of ER\u03b1 and ER\u03b2 gene polymorphisms in PCOS","volume":"28","author":"Agathocles","year":"2012","journal-title":"Gynecol Endocrinol"},{"key":"35","doi-asserted-by":"crossref","first-page":"5532","DOI":"10.1210\/jc.2002-020323","article-title":"Estrogen receptor \u03b1 and \u03b2 expression in theca and granulosa cells from women with polycystic ovary syndrome","volume":"87","author":"Magoffin","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"36","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1210\/jcem.86.5.7463","article-title":"Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia","volume":"86","author":"Tataranni","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"37","first-page":"774","article-title":"Insulin Resistance and the Polycystic Ovary Syndrome: Mechanism and Implications for Pathogenesis 1","volume":"18","author":"Dunaif","year":"1997","journal-title":"Endocr Rev"},{"key":"38","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.2337\/db06-1017","article-title":"Association of the Estrogen Receptor-\u03b1 Gene With the Metabolic Syndrome and Its Component Traits in African-American Families The Insulin Resistance Atherosclerosis Family Study","volume":"56","author":"Sale","year":"2007","journal-title":"Diabetes"},{"key":"39","doi-asserted-by":"crossref","first-page":"E765","DOI":"10.1210\/jc.2011-2377","article-title":"Abnormal expression of genes involved in inflammation, lipid metabolism, and Wnt signaling in the adipose tissue of polycystic ovary syndrome","volume":"97","author":"Azziz","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"40","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1530\/eje.1.02187","article-title":"Oxidised low-density lipoprotein concentration-early marker of an altered lipid metabolism in young women with PCOS","volume":"155","author":"Mili\u0107","year":"2006","journal-title":"Eur J Endocrinol"},{"key":"41","first-page":"2","article-title":"Serum lipoprotein (a) and lipid profile in polycystic ovarian syndrome","author":"Alur","year":"2015","journal-title":"JCSR"},{"key":"42","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nrm2391","article-title":"Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes","volume":"9","author":"Czech","year":"2008","journal-title":"Nat Rev Mol Cell Biol"},{"key":"43","first-page":"261","article-title":"Effects of adiposity on plasma lipid response to reductions in dietary saturated fatty acids and cholesterol","volume":"2","author":"Kris-Etherton","year":"2011","journal-title":"Methods Mol Biol"},{"key":"44","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jri.2004.01.010","article-title":"The molecular signature of polycystic ovary syndrome (PCOS) theca cells defined by gene expression profiling","volume":"63","author":"Strauss","year":"2004","journal-title":"J Reprod Immunol"},{"key":"45","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/S0015-0282(16)56212-8","article-title":"The influence of luteinizing hormone and insulin on sex steroids and sex hormone-binding globulin in the polycystic ovarian syndrome","volume":"60","author":"Judd","year":"1993","journal-title":"Fertility and sterility"},{"key":"46","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.tem.2007.07.004","article-title":"Pathophysiology and types of dyslipidemia in PCOS","volume":"18","author":"Chrousos","year":"2007","journal-title":"Trends Endocrinol Metab"},{"key":"47","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1146\/annurev.med.53.082901.104018","article-title":"The mechanisms of action of PPARs","volume":"53","author":"Moller","year":"2002","journal-title":"Annu Rev Med"},{"key":"48","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.bbadis.2004.11.011","article-title":"Roles of PPAR delta in lipid absorption and metabolism: a new target for the treatment of type 2 diabetes","volume":"1740","author":"Grimaldi","year":"2005","journal-title":"Biochim Biophys Acta"},{"key":"49","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1142\/S0192415X15500172","article-title":"Chrysanthemum Promotes Adipocyte Differentiation, Adiponectin Secretion and Glucose Uptake","volume":"43","author":"Kobayashi-Hattori","year":"2015","journal-title":"Am J Chin Med"},{"key":"50","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s00592-012-0383-4","article-title":"Polycystic ovary syndrome is not associated with genetic variants that mark risk of type 2 diabetes","volume":"50","author":"Welt","year":"2013","journal-title":"Acta Diabetol"},{"key":"51","doi-asserted-by":"crossref","first-page":"P1","DOI":"10.1530\/EJE-14-0253","article-title":"The polycystic ovary syndrome: a position statement from the European Society of Endocrinology","volume":"171","author":"Pasquali","year":"2014","journal-title":"Eur J Endocrinol"},{"key":"52","doi-asserted-by":"crossref","first-page":"e2466","DOI":"10.1371\/journal.pone.0002466","article-title":"Pioglitazone enhances mitochondrial biogenesis and ribosomal protein biosynthesis in skeletal muscle in polycystic ovary syndrome","volume":"3","author":"Hojlund","year":"2008","journal-title":"PLoS One"},{"key":"53","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/ncpendmet0787","article-title":"Drug insight: insulin-sensitizing drugs in the treatment of polycystic ovary syndrome\u2014a reappraisal","volume":"4","author":"Dunaif","year":"2008","journal-title":"Nat Rev Endocrinol"},{"key":"54","doi-asserted-by":"crossref","first-page":"197","DOI":"10.2174\/1389557013407034","article-title":"Pharmaceutical target identification by gene expression analysis","volume":"1","author":"Walker","year":"2001","journal-title":"Mini Rev Med Chem"},{"key":"55","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1055\/s-2008-1058085","article-title":"Increased low grade inflammatory serum markers in patients with Polycystic ovary syndrome (PCOS) and their relationship to PPARgamma gene variants","volume":"116","author":"Muller-Wieland","year":"2008","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"56","first-page":"772","article-title":"Insulin resistance is attenuated in women with polycystic ovary syndrome with the Pro12Ala polymorphism in the PPAR\u03b3 gene","volume":"87","author":"Ehrmann","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"57","doi-asserted-by":"crossref","first-page":"3621","DOI":"10.1210\/jc.2003-030328","article-title":"Glucose metabolism and insulin resistance in women with polycystic ovary syndrome during therapy with oral contraceptives containing cyproterone acetate or desogestrel","volume":"88","author":"Volpe","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"58","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/BF03351061","article-title":"Serum prostate specific antigen levels in women with polycystic ovary syndrome and the effect of flutamide+ desogestrel\/ethinyl estradiol combination","volume":"27","author":"Bahceci","year":"2004","journal-title":"J Endocrinol Invest"},{"key":"59","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.fertnstert.2007.02.062","article-title":"Clomiphene citrate or letrozole for ovulation induction in women with polycystic ovarian syndrome: a prospective randomized trial","volume":"92","author":"Abulatta","year":"2009","journal-title":"Fertility and sterility"},{"key":"60","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1056\/NEJMoa063971","article-title":"Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome","volume":"356","author":"Cataldo","year":"2007","journal-title":"N Engl J Med"},{"key":"61","doi-asserted-by":"crossref","first-page":"4068","DOI":"10.1210\/jc.2005-0110","article-title":"Prospective parallel randomized, double-blind, double-dummy controlled clinical trial comparing clomiphene citrate and metformin as the first-line treatment for ovulation induction in nonobese anovulatory women with polycystic ovary syndrome","volume":"90","author":"Zullo","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"62","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/0092-8674(95)90201-5","article-title":"Steroid hormone receptors: many actors in search of a plot","volume":"83","author":"Sch\u00fctz","year":"1995","journal-title":"Cell"},{"key":"63","doi-asserted-by":"crossref","first-page":"26380","DOI":"10.1074\/jbc.M300688200","article-title":"The molecular phenotype of polycystic ovary syndrome (PCOS) theca cells and new candidate PCOS genes defined by microarray analysis","volume":"278","author":"Strauss","year":"2003","journal-title":"J Biol Chem"},{"key":"64","first-page":"207","article-title":"Tamoxifen versus letrozole in combination with clomiphene citrate to stimulate ovulation in clomiphene-resistant PCOS women","volume":"5","author":"El Shaer","year":"2015","journal-title":"EBWHJ"},{"key":"65","first-page":"6","article-title":"iMiRNA-SSF: Improving the Identification of MicroRNA Precursors by Combining Negative Sets with Different Distributions","author":"Liu","year":"2016","journal-title":"Sci Rep"},{"key":"66","doi-asserted-by":"crossref","first-page":"D767","DOI":"10.1093\/nar\/gkn892","article-title":"Human protein reference database\u20142009 update","volume":"37","author":"Venugopal","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"67","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/nar\/30.1.207","article-title":"Gene Expression Omnibus: NCBI gene expression and hybridization array data repository","volume":"30","author":"Lash","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"68","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/ng0504-431","article-title":"The genetic association database","volume":"36","author":"Wang","year":"2004","journal-title":"Nat Genet"},{"key":"69","doi-asserted-by":"crossref","first-page":"D940","DOI":"10.1093\/nar\/gkr972","article-title":"Disease Ontology: a backbone for disease semantic integration","volume":"40","author":"Kibbe","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"70","first-page":"D514","article-title":"Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic disorders","volume":"33","author":"McKusick","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"71","first-page":"1","article-title":"A cluster algorithm for graphs. Report-Information systems","author":"Van Dongen","year":"2000","journal-title":"CWI"},{"key":"72","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Hochberg","year":"1995","journal-title":"J R Stat Soc Series B Stat Methodol"},{"key":"73","doi-asserted-by":"crossref","first-page":"e0149183","DOI":"10.1371\/journal.pone.0149183","article-title":"Single Gene Prognostic Biomarkers in Ovarian Cancer: A Meta-Analysis","volume":"11","author":"Leyland-Jones","year":"2016","journal-title":"PloS one"},{"key":"74","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1093\/bioinformatics\/btu654","article-title":"An alternative approach to multiple testing for methylation QTL mapping reduces the proportion of falsely identified CpGs","volume":"31","author":"van Zwet","year":"2015","journal-title":"Bioinformatics"},{"key":"75","unstructured":"Witten, Frank. Data Mining: Practical machine learning tools and techniques. 2005."}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.9353","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,16]],"date-time":"2024-06-16T11:00:04Z","timestamp":1718535604000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.9353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,13]]},"references-count":75,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2016,6,21]]}},"alternative-id":["9353","27191267"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.9353","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,13]]}}}