{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:41:11Z","timestamp":1760550071423},"reference-count":102,"publisher":"Impact Journals, LLC","issue":"23","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2016,6,7]]},"DOI":"10.18632\/oncotarget.9591","type":"journal-article","created":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T01:27:31Z","timestamp":1464226051000},"page":"33722-33743","source":"Crossref","is-referenced-by-count":18,"title":["Use of estetrol with other steroids for attenuation of neonatal hypoxic-Ischemic brain injury: to combine or not to combine?"],"prefix":"10.18632","volume":"7","author":[{"given":"Ekaterine","family":"Tskitishvili","sequence":"first","affiliation":[{"name":"Laboratory of Development Biology and Tumor, GIGA-Cancer, Department of Obstetrics and Gynecology\/Department of Clinical Sciences, University of Liege, Liege 1, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christel","family":"Pequeux","sequence":"additional","affiliation":[{"name":"Laboratory of Development Biology and Tumor, GIGA-Cancer, Department of Obstetrics and Gynecology\/Department of Clinical Sciences, University of Liege, Liege 1, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carine","family":"Munaut","sequence":"additional","affiliation":[{"name":"Laboratory of Development Biology and Tumor, GIGA-Cancer, Department of Obstetrics and Gynecology\/Department of Clinical Sciences, University of Liege, Liege 1, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renaud","family":"Viellevoye","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Department of Pediatrics, University of Liege, Liege 1, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Nisolle","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Liege, Liege1, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnes","family":"No\u00ebl","sequence":"additional","affiliation":[{"name":"Laboratory of Development Biology and Tumor, GIGA-Cancer, Department of Obstetrics and Gynecology\/Department of Clinical Sciences, University of Liege, Liege 1, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Michel","family":"Foidart","sequence":"additional","affiliation":[{"name":"Laboratory of Development Biology and Tumor, GIGA-Cancer, Department of Obstetrics and Gynecology\/Department of Clinical Sciences, University of Liege, Liege 1, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2016,5,26]]},"reference":[{"issue":"4","key":"1","doi-asserted-by":"publisher","first-page":"e952","DOI":"10.1542\/peds.2013-0511","article-title":"Antepartum and intrapartum factors preceding neonatal hypoxic-ischemic encephalopathy","volume":"132","author":"Cowan","year":"2013","journal-title":"Pediatrics"},{"issue":"19","key":"2","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1056\/NEJMra041996","article-title":"Neonatal brain injury","volume":"351","author":"Ferriero","year":"2004","journal-title":"N Engl J Med"},{"issue":"4","key":"3","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/S0095-5108(02)00059-3","article-title":"Pathogenesis of hypoxic-ischemic cerebral injury in the term infant: current concepts","volume":"29","author":"Barks","year":"2002","journal-title":"Clin Perinatol"},{"key":"4","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.expneurol.2009.06.007","article-title":"Protein ubiquitination in postsynaptic densities after hypoxia in rat neostriatum is blocked by hypothermia","volume":"219","author":"Coirini","year":"2009","journal-title":"Exp Neurol"},{"issue":"4","key":"5","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1016\/0896-6273(95)90186-8","article-title":"Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function","volume":"15","author":"Nicotera","year":"1995","journal-title":"Neuron"},{"issue":"1","key":"6","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/S1474-4422(08)70294-1","article-title":"Perinatal brain injury: from pathogenesis to neuroprotection","volume":"7","author":"Volpe","year":"2001","journal-title":"Ment Retard Dev Disabil Res Rev"},{"issue":"1","key":"7","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1152\/physrev.00029.2006","article-title":"Nitric oxide and peroxynitrite in health and disease","volume":"87","author":"Liaudet","year":"2007","journal-title":"Physiol Rev"},{"issue":"2","key":"8","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1097\/01.wco.0000218229.73678.a8","article-title":"Perinatal brain injury and regulation of transcription","volume":"19","author":"Huang","year":"2006","journal-title":"Curr Opin Neurol"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2015.09.011","article-title":"Perinatal brain damage: The term infant","author":"Groenendaal","year":"2015","journal-title":"Neurobiol Dis"},{"key":"10","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/S0140-6736(05)17946-X","article-title":"Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicenter randomised trial","volume":"65","author":"Gunn","year":"2005","journal-title":"Lancet"},{"issue":"15","key":"11","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1056\/NEJMcps050929","article-title":"Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy","volume":"353","author":"Duara","year":"2005","journal-title":"N Engl J Med"},{"key":"12","doi-asserted-by":"publisher","first-page":"e222","DOI":"10.1016\/j.jpeds.2010.02.016","article-title":"Serial MRI and neurodevelopmental outcome in 9- to 10-year old children with neonatal encephalopathy","volume":"157","author":"de Vries","year":"2010","journal-title":"J Pediatr"},{"key":"13","volume-title":"Neonatal Neural Rescue: A Clinical Guide","author":"Gunn","year":"2013"},{"issue":"1","key":"14","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1006\/EXNR.1994.1147","article-title":"Progesterone facilitates cognitive recovery and reduces secondary neuronal loss caused by cortical contusion injury in male rats","volume":"129","author":"Stein","year":"1994","journal-title":"Exp Neurol"},{"key":"15","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/nm0498-447","article-title":"Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides","volume":"4","author":"Buxbaum","year":"1998","journal-title":"Nat Med"},{"issue":"1","key":"16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0006-8993(93a91526-X","article-title":"Progesterone protects against lipid peroxidation following traumatic brain injury in rats","volume":"31","author":"Stein","year":"1997","journal-title":"Mol Chem Neuropathol"},{"issue":"5","key":"17","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1089\/neu.2000.17.367","article-title":"Gender differences in acute CNS trauma and stroke: neuroprotective effects of estrogen and progesterone","volume":"17","author":"Hall","year":"2000","journal-title":"J Neurotrauma"},{"key":"18","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/S0301-0082(00)00025-3","article-title":"Neuroprotection by estradiol","volume":"63","author":"DonCarlos","year":"2001","journal-title":"Prog Neurobiol"},{"issue":"7","key":"19","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/S0166-2236(00)01821-X","article-title":"Brain damage, sex hormones and recovery: a new role for progesterone and estrogen?\u201d","volume":"24","author":"Stein","year":"2001","journal-title":"Trends Neurosci"},{"key":"20","first-page":"141","article-title":"The role of the estrogen in neuroprotection: implications for neurodegenerative diseases","volume":"24","author":"Stefano","year":"2003","journal-title":"Neuro Endocrinol Lett"},{"key":"21","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1001\/archneur.61.6.886","article-title":"Postmenopausal estrogen use affects risk for Parkinson disease","volume":"61","author":"Wooten","year":"2004","journal-title":"Arch Neurol"},{"key":"22","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.steroids.2007.02.003","article-title":"Neurotrophic and neuroprotective actions of estrogen: basic mechanisms and clinical implications","volume":"72","author":"Khan","year":"2007","journal-title":"Steroids"},{"key":"23","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/S0079-6123(09)17516-7","article-title":"Estrogen and testosterone therapies in multiple sclerosis","volume":"175","author":"Voskuhl","year":"2009","journal-title":"Prog Brain Res"},{"key":"24","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.yfrne.2009.04.007","article-title":"Neuroprotective effects of estrogens following ischemic stroke","volume":"30","author":"Wise","year":"2009","journal-title":"Front Neuroendocrinol"},{"key":"25","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1111\/j.1749-6632.2009.05360.x.","article-title":"Physiological low dose of estrogen-protected neurons in experimental spinal cord injury","volume":"1199","author":"Banik","year":"2010","journal-title":"Ann N Y Acad Sci"},{"key":"26","doi-asserted-by":"publisher","first-page":"2441","DOI":"10.1002\/jnr.21370","article-title":"Progesterone increases brain-derived neurotrophic factor expression and protects against glutamate toxicity in a mitogen-activated protein kinase- and phosphoinositide-3 kinase-dependent manner in cerebral cortical explants","volume":"85","author":"Singh","year":"2007","journal-title":"J Neurosci Res"},{"key":"27","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1097\/00001756-200205070-00018","article-title":"Impact of progestins on estradiol potentiation of the glutamate calcium response","volume":"13","author":"Brinton","year":"2002","journal-title":"Neuroreport"},{"key":"28","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1210\/endo.143.1.8582","article-title":"Impact of progestins on estrogen-induced neuroprotection: synergy by progesterone and 19-norprogesterone and antagonism by medroxyprogesterone acetate","volume":"143","author":"Brinton","year":"2002","journal-title":"Endocrinology"},{"key":"29","doi-asserted-by":"publisher","first-page":"10506","DOI":"10.1073\/pnas.1334098100","article-title":"Divergent impact of progesterone and medroxyprogesterone acetate (Provera) on nuclear mitogen-activated protein kinase signaling","volume":"100","author":"Brinton","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"30","doi-asserted-by":"publisher","first-page":"1836","DOI":"10.1046\/j.1471-4159.1996.66051836.x","article-title":"Estrogens attenuate and corticosterone exacerbates excitotoxicity, oxidative injury, and amyloid beta-peptide toxicity in hippocampal neurons","volume":"66","author":"Mattson","year":"1996","journal-title":"J Neurochem"},{"issue":"2","key":"31","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.yhbeh.2012.06.003.","article-title":"Progesterone and neuroprotection","volume":"63","author":"Su","year":"2013","journal-title":"Horm Behav"},{"key":"32","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.jsbmb.2008.03.027","article-title":"Estetrol: A unique steroid in human pregnancy","volume":"110","author":"Coeling Bennink","year":"2008","journal-title":"J Steroid Biochem Mol Biol"},{"key":"33","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.expneurol.2014.07.015","article-title":"Estetrol attenuates neonatal hypoxic-ischemic brain injury","volume":"261","author":"Foidart","year":"2014","journal-title":"Exp Neurol"},{"key":"34","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.jsbmb.2014.04.011","article-title":"Effect of estetrol administration on brain and serum allopregnanolone in intact and ovariectomized rats","volume":"143","author":"Genazzani","year":"2014","journal-title":"J Steroid Biochem Mol Biol"},{"key":"35","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.steroids.2015.01.003","article-title":"Effect of estetrol on Beta-Endorphin level in female rats","volume":"95","author":"Genazzani","year":"2015","journal-title":"Steroids"},{"issue":"10","key":"36","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.15252\/emmm.201404112.","article-title":"The uterine and vascular actions of estetrol delineate a distinctive profile of estrogen receptor \u03b1 modulation, uncoupling nuclear and membrane activation","volume":"6","author":"Adlanmerini","year":"2014","journal-title":"EMBO Mol. Med"},{"key":"37","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.ejphar.2004.11.039","article-title":"Estrogen attenuates hypoxic-ischemic brain injury in neonatal rats","volume":"507","author":"LeBlanc","year":"2005","journal-title":"Eur J Pharmacol"},{"issue":"2","key":"38","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.expneurol.2007.08.020","article-title":"17beta-estradiol protects the neonatal brain from hypoxia-ischemia","volume":"208","author":"Levison","year":"2007","journal-title":"Exp Neurol"},{"issue":"9","key":"39","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1002\/jnr.22023","article-title":"17Beta-estradiol protects against hypoxic\/ischemic white matter damage in the neonatal rat brain","volume":"87","author":"Rosenberg","year":"2009","journal-title":"J Neurisci Res"},{"issue":"1","key":"40","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.expneurol.2011.10.004","article-title":"Progesterone and allopregnanolone exacerbate hypoxic-ischemic brain injury in immature rats","volume":"233","author":"Ikeda","year":"2012","journal-title":"Exp Neurol"},{"issue":"4","key":"41","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.3892\/etm.2014.1858","article-title":"Progesterone alleviates hypoxic-ischemic brain injury via the Akt\/GSK-3\u03b2 signaling pathway","volume":"8","author":"Wang","year":"2014","journal-title":"Exp Ther Med"},{"key":"42","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1159\/000085978","article-title":"Perinatal Hypoxic-Ischemic Brain Damage: Evolution of an Animal Model","volume":"27","author":"Vanucci","year":"2005","journal-title":"Dev Neurosci"},{"issue":"3","key":"43","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1210\/jc.2011-2612","article-title":"Neurodevelopmental follow-up at five years corrected age of extremely low birth weight infants after postnatal replacement of 17\u03b2-estradiol and progesterone","volume":"97","author":"Pohlandt","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"44","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1111\/j.1365-2826.2009.01903.x","article-title":"Combined 17beta-oestradiol and progesterone treatment prevents neuronal cell injury in cortical but not midbrain neurones or neuroblastoma cells","volume":"21","author":"Kipp","year":"2009","journal-title":"J Neuroendocrinol"},{"key":"45","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1016\/j.steroids.2009.02.011","article-title":"Oestrogen and progestins differently prevent glutamate toxicity in cortical neurons depending on prior hormonal exposure via the induction of neural nitric oxide synthase","volume":"74","author":"Simoncini","year":"2009","journal-title":"Steroids"},{"key":"46","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1111\/j.1460-9568.2008.06591.x","article-title":"Progesterone reverses 17beta-estradiol-mediated neuroprotection and BDNF induction in cultured hippocampal slices","volume":"29","author":"Baudry","year":"2009","journal-title":"Eur J Neurosci"},{"key":"47","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1111\/j.1471-4159.2010.07038.x","article-title":"Progesterone inhibits estrogen-mediated neuroprotection against excitotoxicity by down-regulating estrogen receptor-beta","volume":"115","author":"Baudry","year":"2010","journal-title":"J Neurochem"},{"key":"48","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.neulet.2008.09.010","article-title":"Progesterone blocks estrogen neuroprotection from kainate in middle-aged female rats","volume":"445","author":"Pike","year":"2008","journal-title":"Neurosci Lett"},{"key":"49","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1111\/j.1365-2826.2008.01801.x","article-title":"Progesterone a ttenuates oestrogen neuroprotection via downregulation of oestrogen receptor expression in cultured neurones","volume":"21","author":"Pike","year":"2009","journal-title":"J Neuroendocrinol"},{"key":"50","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.brainres.2006.03.127","article-title":"Progestins inhibit the neuroprotective effects of estrogen in rat hippocampus","volume":"1099","author":"Pike","year":"2006","journal-title":"Brain Res"},{"key":"51","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.brainres.2010.11.090","article-title":"Estrogen protection against mitochondrial toxin-induced cell death in hippocampal neurons: antagonism by progesterone","volume":"1379","author":"Brinton","year":"2011","journal-title":"Brain Res"},{"issue":"3","key":"52","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1542\/peds.2007-1673","article-title":"National Institute of Child Health and Human Development Research Network Neonatal Elevated temperature after hypoxic-ischemic encephalopathy: risk factor for adverse outcomes","volume":"122","author":"Poole","year":"2008","journal-title":"Pediatrics"},{"issue":"2","key":"53","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1038\/nrn2252","article-title":"Development of the human cerebral cortex: Boulder Committee revisited","volume":"9","author":"Rakic","year":"2008","journal-title":"Nat Rev Neurosci"},{"key":"54","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/S0169-328X(02)0054-2","article-title":"E strogen receptor b (ERb) protein levels in neurons depend on estrogen receptor a (ERa) gene expression and on its ligand in a brain region-specific manner","volume":"110","author":"Ogawa","year":"2003","journal-title":"Molec Brain Res"},{"key":"55","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/cne.1376","article-title":"Quantitative analysis of ER alpha and GAD colocalization in the hippocampus of the adult female rat","volume":"440","author":"Woolley","year":"2001","journal-title":"J Comp Neurol"},{"key":"56","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/S0306-4522(00)00242-6","article-title":"Evidence for novel estrogen binding sites in the rat hippocampus","volume":"99","author":"Merchenthaler","year":"2000","journal-title":"Neuroscience"},{"key":"57","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/0169-328X(94)00284-L","article-title":"Estrogen receptor mRNA alterations in the developing rat hippocampus","volume":"30","author":"Handa","year":"1995","journal-title":"Brain Res Mol Brain Res"},{"key":"58","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/S0165-3806(01)00171-7","article-title":"Localization of estrogen receptor alpha (ER-alpha) in pyramidal neurons of the developing rat hippocampus","volume":"128","author":"Handa","year":"2001","journal-title":"Brain Res Dev Brain Res"},{"key":"59","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/0165-3806(93)90069-M","article-title":"The ontogeny of estrogen receptors in heterochronic hippocampal and neocortical transplants demonstrates an intrinsic developmental program","volume":"75","author":"Handa","year":"1993","journal-title":"Brain Res Dev Brain Res"},{"key":"60","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/neu.1025","article-title":"Sex differences in progesterone receptor immunoreactivity in neonatal mouse brain depend on estrogen receptor a expression","volume":"47","author":"Merchenthaler","year":"2001","journal-title":"J Neurobiol"},{"key":"61","doi-asserted-by":"publisher","first-page":"3076","DOI":"10.1210\/en.2005-1177","article-title":"Differential modulation of estrogen receptors (ERs) in ischemic brain injury: a role for ER{alpha} in estradiol-mediated protection against delayed cell death","volume":"147","author":"Wise","year":"2006","journal-title":"Endocrinology"},{"issue":"4","key":"62","doi-asserted-by":"publisher","first-page":"1952","DOI":"10.1073\/pnas.98.4.1952","article-title":"Estrogen receptor alpha, not beta, is a critical link in estradiol-mediated protection against brain injury","volume":"98","author":"Wise","year":"2001","journal-title":"Proc Nat Acad Sci USA"},{"key":"63","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1016\/j.bbagen.2009","article-title":"Actions of estrogens on glial cells: implications for neuroprotection","volume":"1800","author":"Garcia-Segura","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"64","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.exger.2006.06.032","article-title":"Role of astrocytes in estrogen-mediated neuroprotection","volume":"42","author":"Brann","year":"2007","journal-title":"Exp Gerontol"},{"key":"65","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.yfrne.2008.04.001","article-title":"Estrogen anti-inflammatory activity in brain: a therapeutic opportunity for menopause and neurodegenerative diseases","volume":"29","author":"Maggi","year":"2008","journal-title":"Front Neuroendocrinol"},{"key":"66","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.mcn.2008.06.001","article-title":"Estradiol facilitates neurite maintenance by a Src\/Ras\/ERK signalling pathway","volume":"39","author":"Rodr\u00edguez-Alvarez","year":"2008","journal-title":"Mol Cell Neurosci"},{"key":"67","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.steroids.2007.10.011","article-title":"Mechanistic Insights into the Direct Antioxidant Effects of Estrogens","volume":"66","author":"Simpkins","year":"2006","journal-title":"Drug Dev Res"},{"key":"68","doi-asserted-by":"publisher","first-page":"297","DOI":"10.2174\/1568007043337193","article-title":"Mitochondria as therapeutic targets of estrogen action in the central nervous system","volume":"3","author":"Brinton","year":"2004","journal-title":"Curr Drug Targets CNS Neurol Disorders"},{"key":"69","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1471-2202-7-74","article-title":"Estrogen protects neuronal cells from amyloid beta-induced apoptosis via regulation of mitochondrial proteins and function","author":"Brinton","year":"2006","journal-title":"BMC Neurosci"},{"key":"70","doi-asserted-by":"publisher","first-page":"14069","DOI":"10.1523\/JNEUROSCI.4391-07.2007","article-title":"Estradiol in vivo regulation of brain mitochondrial proteome","volume":"27","author":"Brinton","year":"2007","journal-title":"J Neurosci"},{"key":"71","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.tins.2008.07.003","article-title":"The healthy cell bias of estrogen action: mitochondrial bioenergetics and neurological implications","volume":"31","author":"Brinton","year":"2008","journal-title":"Trends Neurosci"},{"key":"72","doi-asserted-by":"publisher","first-page":"3167","DOI":"10.1210\/en.2007-1227","article-title":"Progesterone and estrogen regulate oxidative metabolism in brain mitochondria","volume":"149","author":"Nilsen","year":"2008","journal-title":"Endocrinology"},{"key":"73","doi-asserted-by":"publisher","first-page":"1504","DOI":"10.1016\/j.addr.2008.06.003","article-title":"Estrogen regulation of glucose metabolism and mitochondrial function: therapeutic implications for prevention of Alzheimer's disease","volume":"60","author":"Brinton","year":"2008","journal-title":"Adv Drug Deliv Rev"},{"key":"74","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1161\/01.STR.31.1.161","article-title":"Neuroprotective effects of female gonadal steroids in reproductively senescent female rats","volume":"31","author":"Miller","year":"2000","journal-title":"Stroke"},{"key":"75","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/S0166-2236(00)01581-2","article-title":"Mechanisms of programmed cell death in the developing brain","volume":"23","author":"Rakic","year":"2000","journal-title":"Trends Neurosci"},{"key":"76","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1523\/JNEUROSCI.21-01-00169.2001","article-title":"Bcl-X(L)-caspase-9 interactions in the developing nervous system: evidence for multiple death pathways","volume":"21","author":"Roth","year":"2001","journal-title":"J Neurosci"},{"key":"77","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1210\/en.2002-220899","article-title":"Estrogen activation of cyclic adenosine 5Vmonophosphate response element-mediated transcription requires the extracellularly regulated kinase\/mitogen-activated protein kinase pathway","volume":"144","author":"Dorsa","year":"2003","journal-title":"Endocrinology"},{"key":"78","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1016\/j.expneurol.2005.01.009","article-title":"Progesterone suppresses the inflammatory response and nitric oxide synthase-2 expression following cerebral ischemia","volume":"193","author":"Murphy","year":"2005","journal-title":"Exp Neurol"},{"key":"79","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.branres.2004.02.022","article-title":"Effects of progesterone on the inflammatory response to brain injury in the rat","volume":"1008","author":"Stein","year":"2004","journal-title":"Brain Res"},{"key":"80","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1002\/syn.20915","article-title":"Progesterone influences postischemic synaptogenesis in the CA1 region of the hippocampus in rats","volume":"65","author":"Zhu","year":"2011","journal-title":"Synapse"},{"key":"81","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.jsbmb.2005.01.016","article-title":"Progesterone neuroprotection in spinal cord trauma involves up-regulation of brain-derived neurotrophic factor in motoneurons","author":"De Nicola","year":"2005","journal-title":"J Steroid Biochem"},{"key":"82","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1089\/neu.2006.23.181","article-title":"Progesterone increases the expression of myelin basic protein and the number of cells showing NG2 immunostaining in the lesioned spinal cord","volume":"23","author":"De Nicola","year":"2006","journal-title":"J Neurotrauma"},{"key":"83","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.molbrainres.2004.10.047","article-title":"Gonadal steroids regulate GABAA receptor subunit mRNA expression in NT2-Neurons","volume":"138","author":"Greenfield","year":"2005","journal-title":"Brain Res Mol Brain Res"},{"key":"84","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1016\/j.neuroscience.2005.07.034","article-title":"Signaling mechanisms in progesteroneneurotransmitter interactions","volume":"138","author":"Mani","year":"2006","journal-title":"Neuroscience"},{"key":"85","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.brainres.2005.05.004","article-title":"Progesterone treatment inhibits the inflammatory agents that accompany traumatic brain injury","volume":"049","author":"Hoffman","year":"2005","journal-title":"Brain Res"},{"key":"86","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1002\/cne.21427","article-title":"Distribution of progesterone receptor immunoreactivity in the fetal and neonatal rat forebrain","volume":"504","author":"Wagner","year":"2007","journal-title":"J Comp Neurol"},{"issue":"5","key":"87","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1093\/cercor\/bhp165","article-title":"Ontogeny of progesterone receptor expression in the subplate of fetal and neonatal rat cortex","volume":"20","author":"Wagner C","year":"2010","journal-title":"Cereb Cortex"},{"issue":"1","key":"88","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1530\/JOE-14-0549","article-title":"Estetrol is a weak estrogen antagonizing estradiol-dependent mammary gland proliferation","volume":"224","author":"Foidart","year":"2015","journal-title":"J Endocrinol"},{"key":"89","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1159\/000054580","article-title":"Progesterone prevents estradiol-induced dendritic spine formation in cultured hippocampal neurons","volume":"72","author":"Segal","year":"2000","journal-title":"Neuroendocrinology"},{"key":"90","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/0531-5565(94)90022-1","article-title":"Estradiol and progesterone regulate neuronal structure and synaptic connectivity in adult as well as developing brain","volume":"29","author":"Woolley","year":"1994","journal-title":"Exp Gerontol"},{"key":"91","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1002\/cne.903360210","article-title":"Roles of estradiol and progesterone in regulation of hippocampal dendritic spine density during the estrous cycle in the rat","volume":"336","author":"McEwen","year":"1993","journal-title":"J Comp Neurol"},{"issue":"18","key":"92","doi-asserted-by":"publisher","first-page":"11946","DOI":"10.1073\/pnas.182296499","article-title":"Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo","volume":"99","author":"Greenberg","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"93","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1096\/fj.02-0515com","article-title":"Vascular endothelial growth factor promotes proliferation of cortical neuron precursors by regulating E2F expression","volume":"17","author":"Greenberg","year":"2003","journal-title":"FASEB J"},{"issue":"1","key":"94","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/S0165-3806(99)00125-X","article-title":"Neuronal VEGF expression correlates with angiogenesis in postnatal developing rat brain","volume":"119","author":"Ment","year":"2000","journal-title":"Brain Res Dev Brain Res"},{"issue":"3","key":"95","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.06.025","article-title":"Glial fibrillary acidic protein as a biomarker for neonatal hypoxic-ischemic encephalopathy treated with whole-body cooling","volume":"205","author":"Graham","year":"2011","journal-title":"Am J Obstet Gynecol"},{"issue":"3","key":"96","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1097\/PCC.0b013e3182720642","article-title":"Serum Biomarkers of MRI Brain Injury in Neonatal Hypoxic Ischemic Encephalopathy Treated With Whole-Body Hypothermia: A Pilot Study","volume":"14","author":"Johnston","year":"2013","journal-title":"Pediatr Crit Care Med"},{"issue":"6","key":"97","doi-asserted-by":"publisher","first-page":"463","DOI":"10.3109\/13625187.2015.1068934","article-title":"Unique effects on hepatic function, lipid metabolism, bone and growth endocrine parameters of estetrol in combined oral contraceptives","volume":"20","author":"Coelingh Bennink","year":"2015","journal-title":"Eur J Contracept Reprod Health Care"},{"issue":"5","key":"98","doi-asserted-by":"publisher","first-page":"2406","DOI":"10.1038\/nprot.2006.356","article-title":"Culuring hippocampal neurons","volume":"1","author":"Banker","year":"2006","journal-title":"Nat Protoc"},{"issue":"9","key":"99","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1038\/nprot.2012.099","article-title":"Culturing pyramidal neurons from the early postnatal mouse hippocampus and cortex","volume":"7","author":"Arikkath","year":"2012","journal-title":"Nat Protoc"},{"key":"100","doi-asserted-by":"crossref","first-page":"F3","DOI":"10.1136\/fn.74.1.F3","article-title":"Posthypoxic cooling of neonatal rats provides protection against brain injury","volume":"74","author":"Kjellmer","year":"1996","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"101","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1203\/00006450-199310000-00029","article-title":"Influence of mild hypothermia on hypoxic-ischemic brain damage in the immature rat","volume":"34","author":"Vannucci","year":"1993","journal-title":"Pediatr Res"},{"key":"102","volume-title":"The rat brain in stereotaxic coordinates","author":"Watson","year":"2007","edition":"6"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.9591","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T21:40:31Z","timestamp":1589233231000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.9591"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,26]]},"references-count":102,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2016,6,7]]}},"alternative-id":["9591","27231853"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.9591","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,26]]}}}