{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T09:51:49Z","timestamp":1765533109043,"version":"3.48.0"},"reference-count":56,"publisher":"Institute of Cytology and Genetics, SB RAS","issue":"7","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/vavilov.elpub.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vestn. VOGiS"],"abstract":"<jats:p>\u00a0 \u00a0Reconstruction and analysis of gene networks regulating biological processes are among the modern methodo\u00adlogical approaches for studying complex biological systems that ensure the vital activity of organisms. Thermoregulation is an important evolutionary acquisition of warm\u00adblooded animals. Multiple physiological systems (nervous, cardiovas\u00ad cular, endocrine, respiratory, muscular, etc.) are involved in this process, maintaining stable body temperature despite changes in ambient temperature.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>\u00a0 \u00a0This study aims<\/jats:bold>\n                    \u00a0to perform a computer reconstruction of the human thermoregulation gene network and present the results in the Termo_Reg_Human 1.0 knowledge base.\n                  <\/jats:p>\n                  <jats:p>\u00a0 \u00a0The gene network was reconstructed using the ANDSystem software and information system, designed for the automated extraction of knowledge and facts from scientific publications and biomedical databases based on machine learning and artificial intelligence methods. The Termo_Reg_Human 1.0 knowledge base (https:\/\/www.sysbio.ru\/ThermoReg_Human\/) contains information about the hu\u00adman thermoregulation gene network, including a description of 469 genes, 473 proteins, and 265 microRNAs important for its functioning, interactions between these objects, and the evolutionary characteristics of the genes. Using the AND-Visio software tool (a module of AND-System), each gene, protein, and microRNA involved in the thermoregulation of the hu\u00adman body was prioritized according to its functional significance, i. e., the number of interactions with other objects in the reconstructed gene network. It was found that the key objects with the largest number of functional interactions in the human thermoregulation gene network included the UCP1, VEGFA, PPARG and DDIT3 genes; STAT3, JUN, VEGFA, TLR4 and TNFA proteins; and the microRNAs hsa\u00admir\u00ad335 and hsa\u00admir\u00ad26b. We revealed that the set of 469 human genes from the network was enriched with genes whose ancestral forms originated at an early evolutionary stage (Unicellular organisms, the root of the phylostratigraphic tree) and at the stage of Vertebrata divergence.<\/jats:p>","DOI":"10.18699\/vjgb-25-106","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T09:47:15Z","timestamp":1765532835000},"page":"1009-1019","source":"Crossref","is-referenced-by-count":0,"title":["The gene network and knowledge base on human thermoregulation"],"prefix":"10.18699","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8588-6511","authenticated-orcid":true,"given":"E. V.","family":"Ignatieva","sequence":"first","affiliation":[{"name":"Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9433-8341","authenticated-orcid":true,"given":"P. S.","family":"Demenkov","sequence":"additional","affiliation":[{"name":"Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4359-6089","authenticated-orcid":true,"given":"A. G.","family":"Bogomolov","sequence":"additional","affiliation":[{"name":"Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4369-356X","authenticated-orcid":true,"given":"R. A.","family":"Ivanov","sequence":"additional","affiliation":[{"name":"Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3138-381X","authenticated-orcid":true,"given":"S. A.","family":"Lashin","sequence":"additional","affiliation":[{"name":"Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences; Novosibirsk State University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. D.","family":"Mikhailova","sequence":"additional","affiliation":[{"name":"Novosibirsk State University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. E.","family":"Alekseeva","sequence":"additional","affiliation":[{"name":"Novosibirsk State University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1947-5554","authenticated-orcid":true,"given":"N. 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