{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T16:38:09Z","timestamp":1782319089782,"version":"3.54.5"},"reference-count":52,"publisher":"Institute of Cytology and Genetics, SB RAS","issue":"8","license":[{"start":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T00:00:00Z","timestamp":1768089600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/vavilov.elpub.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vestn. VOGiS"],"abstract":"<jats:p>\n                    Rhesus macaques (\n                    <jats:italic>Macaca mulatta<\/jats:italic>\n                    ) are the most common non-human primates living in captivity. The use of rhesus macaques as model objects is determined, first of all, by their phylogenetic and physiological closeness to humans, and, as a consequence, the possibility of extrapolating the obtained results to humans. Currently, it is known that a number of biochemical changes occur under various physiological conditions, including at the transcriptomic level. The real-time polymerase chain reaction is a widely used universal method for gene expression analysis. Carrying out such studies always requires a preliminary selection of \u201chousekeeping genes\u201d (HKGs) \u2013 genes necessary for the implementation of basic functions in the cell and stably expressed in different cell types and under different conditions. At present, there are only two systematic studies on the search for HKGs in the rhesus macaque brain, and therefore in this work a search and systematization of HKGs for this species were carried out. As a result, two panels of promising HKGs for\n                    <jats:italic>M. mulatta<\/jats:italic>\n                    were formed: an extended panel, consisting of 56 genes, and a small panel, consisting of 8 genes:\n                    <jats:italic>ARHGDIA, CYB5R1, NDUFA7, RRAGA, TTC1, UBA6, VPS72,<\/jats:italic>\n                    and\n                    <jats:italic>YWHAH<\/jats:italic>\n                    . Both panels of potential HKGs do not have pseudogenes in macaques or humans, are characterized by stable and sufficient expression in the brain of rhesus macaques and can be used to analyze expression not only in the brain but also in peripheral blood. However, it should be noted that the data have not been experimentally verified and require verification in laboratory conditions.\u00a0\n                  <\/jats:p>","DOI":"10.18699\/vjgb-25-138","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T08:51:50Z","timestamp":1769071910000},"page":"1318-1324","source":"Crossref","is-referenced-by-count":1,"title":["A housekeeping gene search to analyze expression changes of individual genes in Macaca mulatta"],"prefix":"10.18699","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1274-2901","authenticated-orcid":true,"given":"M. V.","family":"Shulskaya","sequence":"first","affiliation":[{"name":"National Research Center \u201cKurchatov Institute\u201d"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6200-4491","authenticated-orcid":true,"given":"A. Kh.","family":"Alieva","sequence":"additional","affiliation":[{"name":"National Research Center \u201cKurchatov Institute\u201d"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2781-2649","authenticated-orcid":true,"given":"I. R.","family":"Kumakov","sequence":"additional","affiliation":[{"name":"National Research Center \u201cKurchatov Institute\u201d"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4544-6183","authenticated-orcid":true,"given":"M. I.","family":"Shadrina","sequence":"additional","affiliation":[{"name":"National Research Center \u201cKurchatov Institute\u201d"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3530-0655","authenticated-orcid":true,"given":"P. A.","family":"Slominsky","sequence":"additional","affiliation":[{"name":"National Research Center \u201cKurchatov Institute\u201d"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7950","published-online":{"date-parts":[[2026,1,11]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Abbott D.H., Rogers J., Dumesic D.A., Levine J.E. Naturally occurring and experimentally induced rhesus macaque models for polycystic ovary syndrome: translational gateways to clinical application. Med Sci (Basel). 2019;7(12):107. doi 10.3390\/medsci7120107","DOI":"10.3390\/medsci7120107"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Ahn K., Huh J.W., Park S.J., Kim D.S., Ha H.S., Kim Y.J., Lee J.R., Chang K.T., Kim H.S. Selection of internal reference genes for SYBR green qRT-PCR studies of rhesus monkey (Macaca mulatta) tissues. BMC Mol Biol. 2008;9:78. doi 10.1186\/1471-2199-9-78","DOI":"10.1186\/1471-2199-9-78"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Brammer D.W., Gillespie P.J., Tian M., Young D., Raveendran M., Williams L.E., Gagea M., \u2026 Pasqualini R., Arap W., Rogers J., Abee C.R., Gelovani J.G. MLH1-rheMac hereditary nonpolyposis colorectal cancer syndrome in rhesus macaques. Proc Natl Acad Sci USA. 2018;115(11):2806-2811. doi 10.1073\/pnas.1722106115","DOI":"10.1073\/pnas.1722106115"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Cai J., Li T., Huang B., Cheng H., Ding H., Dong W., Xiao M., Liu L., Wang Z. The use of laser microdissection in the identification of suitable reference genes for normalization of quantitative real-timePCR in human FFPE epithelial ovarian tissue samples. PLoS One. 2014;9(4):e95974. doi 10.1371\/journal.pone.0095974","DOI":"10.1371\/journal.pone.0095974"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Cai X.B., Wu K.C., Zhang X., Lv J.N., Jin G.H., Xiang L., Chen J., Huang X.F., Pan D., Lu B., Lu F., Qu J., Jin Z.B. Whole-exome sequencing identified ARL2 as a novel candidate gene for MRCS (microcornea, rod-cone dystrophy, cataract, and posterior staphyloma) syndrome. Clin Genet. 2019;96(1):61-71. doi 10.1111\/cge.13541","DOI":"10.1111\/cge.13541"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Chen F., Wang J., Zhang S., Chen M., Zhang X., Wu Z. Overexpression of SSR2 promotes proliferation of liver cancer cells and predicts prognosis of patients with hepatocellular carcinoma. J Cell Mol Med. 2022;26(11):3169-3182. doi 10.1111\/jcmm.17314","DOI":"10.1111\/jcmm.17314"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Colman R.J. Non-human primates as a model for aging. Biochim Biophys Acta Mol Basis Dis. 2018;1864(9):2733-2741. doi 10.1016\/j.bbadis.2017.07.008","DOI":"10.1016\/j.bbadis.2017.07.008"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"de Kok J.B., Roelofs R.W., Giesendorf B.A., Pennings J.L., Waas E.T., Feuth T., Swinkels D.W., Span P.N. Normalization of gene expression measurements in tumor tissues: comparison of 13 endogenous control genes. Lab Invest. 2005;85(1):154-159. doi 10.1038\/labinvest.3700208","DOI":"10.1038\/labinvest.3700208"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Deycmar S., Gomes B., Charo J., Ceppi M., Cline J.M. Spontaneous, naturally occurring cancers in non-human primates as a translational model for cancer immunotherapy. J Immunother Cancer. 2023; 11(1):e005514. doi 10.1136\/jitc-2022-005514","DOI":"10.1136\/jitc-2022-005514"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Dheda K., Huggett J.F., Chang J.S., Kim L.U., Bustin S.A., John son M.A., Rook G.A., Zumla A. The implications of using aninap propriate reference gene for real-time reverse transcription PCR data normalization. Anal Biochem. 2005;344(1):141-143. doi 10.1016\/j.ab.2005.05.022","DOI":"10.1016\/j.ab.2005.05.022"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Doss-Pepe E.W., Stenroos E.S., Johnson W.G., Madura K. Ataxin-3 interactions with rad23 and valosin-containing protein and its associations with ubiquitin chains and the proteasome are consistent with a role in ubiquitin-mediated proteolysis. Mol Cell Biol. 2003;23(18): 6469-6483. doi 10.1128\/MCB.23.18.6469-6483.2003","DOI":"10.1128\/MCB.23.18.6469-6483.2003"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Eghlidi D.H., Urbanski H.F. Effects of age and estradiol on gene ex pression in the rhesus macaque hypothalamus. Neuroendocrinology. 2015;101(3):236-245. doi 10.1159\/000381063","DOI":"10.1159\/000381063"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Esmaeilzadeh E., Biglari S., Mosallaei M., Khorshid H.R.K., Vahidnezhad H., Tabatabaiefar M.A. A novel homozygote pathogenic variant in the DIAPH1 gene associated with seizures, cortical blindness, and microcephaly syndrome (SCBMS): report of a family and literature review. Mol Genet Genomic Med. 2024;12(11):e70031. doi 10.1002\/mgg3.70031","DOI":"10.1002\/mgg3.70031"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Fernandez-Moreira D., Ugalde C., Smeets R., Rodenburg R.J., Lopez Laso E., Ruiz-Falco M.L., Briones P., Martin M.A., Smeitink J.A., Arenas J. X-linked NDUFA1 gene mutations associated with mitochondrial encephalomyopathy. Ann Neurol. 2007;61(1):73-83. doi 10.1002\/ana.21036","DOI":"10.1002\/ana.21036"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Georgiou M., Ali N., Yang E., Grewal P.S., Rotsos T., Pontikos N., Robson A.G., Michaelides M. Extending the phenotypic spectrum of PRPF8, PRPH2, RP1 and RPGR, and the genotypic spectrum of early-onset severe retinal dystrophy. Orphanet J Rare Dis. 2021; 16(1):128. doi 10.1186\/s13023-021-01759-8","DOI":"10.1186\/s13023-021-01759-8"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Kaya I., Nilsson A., Lupt\u00e1kov\u00e1 D., He Y., Vallianatou T., Bj\u00e4rterot P., Svenningsson P., Bezard E., Andr\u00e9n P.E. Spatial lipidomicsreveals brain region-specific changes of sulfatides in an experimental MPTP Parkinson\u2019s disease primate model. NPJ Parkinsons Dis. 2023;9(1): 118. doi 10.1038\/s41531-023-00558-1","DOI":"10.1038\/s41531-023-00558-1"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Li Y., Singh J., Varghese R., Zhang Y., Fatanmi O.O., Cheema A.K., Singh V.K. Transcriptome of rhesus macaque (Macaca mulatta) exposed to total-body irradiation. Sci Rep. 2021;11(1):6295. doi 10.1038\/s41598-021-85669-6","DOI":"10.1038\/s41598-021-85669-6"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Liang N., Zhong R., Hou X., Zhao G., Ma S., Cheng G., Liu X. Ataxia telangiectasia mutated (ATM) participates in the regulation of ionizing radiation-induced cell death via MAPK14 in lung cancer H1299 cells. Cell Prolif. 2015;48(5):561-572. doi 10.1111\/cpr.12203","DOI":"10.1111\/cpr.12203"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Liu D.X., Gilbert M.H., Wang X., Didier P.J., Shields C.L., Lackner A.A. Coats-like retinopathy in a Young Indian Rhesus Macaque (Macaca mulatta). J Med Primatol. 2015;44(2):108-112. doi 10.1111\/jmp.12166","DOI":"10.1111\/jmp.12166"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Loeffler D.A., Klaver A.C., Coffey M.P., Aasly J.O., LeWitt P.A. Age related decrease in heat shock 70-kDa protein 8 in cerebrospinal fluid is associated with increased oxidative stress. Front Aging Neurosci. 2016;8:178. doi 10.3389\/fnagi.2016.00178","DOI":"10.3389\/fnagi.2016.00178"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Lomniczi A., Garcia-Rudaz C., Ramakrishnan R., Wilmot B., Khouangsathiene S., Ferguson B., Dissen G.A., Ojeda S.R. A single-nucleotide polymorphism in the EAP1 gene is associated with amenorrhea\/oligomenorrhea in nonhuman primates. Endocrinology. 2012; 153(1):339-349. doi 10.1210\/en.2011-1540","DOI":"10.1210\/en.2011-1540"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Majewski M., Ostheim P., Gluzman-Poltorak Z., Vainstein V., Basile L., Sch\u00fcle S., Haimerl M., Stroszczynski C., Port M., Abend M. Gene expression changes in male and female rhesus macaque 60 days after irradiation. PLoS One. 2021;16(7):e0254344. doi 10.1371\/journal.pone.0254344","DOI":"10.1371\/journal.pone.0254344"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Maniv I., Sarji M., Bdarneh A., Feldman A., Ankawa R., Koren E., Magid-Gold I., \u2026 Michaelson D., Van Leeuwen F.W., Verheijen B.M., Fuchs Y., Glickman M.H. Altered ubiquitin signaling induces Alzheimer\u2019s disease-like hallmarks in a three-dimensional human neural cell culture model. Nat Commun. 2023;14(1):5922. doi 10.1038\/s41467-023-41545-7","DOI":"10.1038\/s41467-023-41545-7"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"McBride J.L., Neuringer M., Ferguson B., Kohama S.G., Tagge I.J., Zweig R.C., Renner L.M., \u2026 Sherman L.S., Domire J.S., Ducore R.M., Colgin L.M., Lewis A.D. Discovery of a CLN7 model of Batten disease in non-human primates. Neurobiol Dis. 2018;119: 65-78. doi 10.1016\/j.nbd.2018.07.013","DOI":"10.1016\/j.nbd.2018.07.013"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Mishra S., Bernal C., Silvano M., Anand S., Ruiz i Altaba A. The protein secretion modulator TMED9 drives CNIH4\/TGF\u03b1\/GLI signaling opposing TMED3-WNT-TCF to promote colon cancer metastases. Oncogene. 2019;38(29):5817-5837. doi 10.1038\/s41388-019-0845-z","DOI":"10.1038\/s41388-019-0845-z"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Moshiri A., Chen R., Kim S., Harris R.A., Li Y., Raveendran M., Davis S., \u2026 Gopalakrishna K.N., Boyd K., Artemyev N.O., Rogers J., Thomasy S.M. A nonhuman primate model of inherited retinal disease. J Clin Invest. 2019;129(2):863-874. doi 10.1172\/JCI123980","DOI":"10.1172\/JCI123980"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Nair H.B., Baker R., Owston M.A., Escalona R., Dick E.J., Vandeberg J.L., Nickisch K.J. An efficient model of human endometriosis by induced unopposedestrogenicity in baboons. Oncotarget. 2016; 7(10):10857-10869. doi 10.18632\/oncotarget.7516","DOI":"10.18632\/oncotarget.7516"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Noriega N.C., Kohama S.G., Urbanski H.F. Microarray analysis of relative gene expression stability for selection of internal reference genes in the rhesus macaque brain. BMC Mol Biol. 2010;11:47. doi 10.1186\/1471-2199-11-47","DOI":"10.1186\/1471-2199-11-47"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Paschalis E.P., Gamsjaeger S., Condon K., Klaushofer K., Burr D. Estrogen depletion alters mineralization regulation mechanisms in an ovariectomized monkey animal model. Bone. 2019;120:279-284. doi 10.1016\/j.bone.2018.11.004","DOI":"10.1016\/j.bone.2018.11.004"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"Patterson M.M., Jackson L.R., Brooks M.B., Catalfamo J.L. Type-3 von willebrand\u2019s disease in a rhesus monkey (Macaca mulatta). Comp Med. 2002;52(4):368-371 Peterson S.M., Mcgill T.J., Puthussery T., Stoddard J., Renner L., Lewis A.D., Colgin L.M.A., Gayet J., Wang X., Prongay K., Cullin C., Dozier B.L., Ferguson B., Neuringer M. Bardet-Biedl Syndrome in rhesus macaques: a nonhuman primate model of retinitis pigmentosa. Exp Eye Res. 2019;189:107825. doi 10.1016\/j.exer.2019.107825","DOI":"10.1016\/j.exer.2019.107825"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"Peterson S.M., Watowich M.M., Renner L.M., Martin S., Offenberg E., Lea A., Montague M.J., Higham J.P., Snyder-Mackler N., Neu ringer M., Ferguson B. Genetic variants in melanogenesis proteins TYRP1 and TYR are associated with the golden rhesus macaque phenotype. G3 (Bethesda). 2023;13(10):jkad168. doi 10.1093\/g3journal\/jkad168","DOI":"10.1093\/g3journal\/jkad168"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Poirier K., Hubert L., Viot G., Rio M., Billuart P., Besmond C., Bienvenu T. CSNK2B splice site mutations in patients cause intellectualdisability with or without myoclonic epilepsy. Hum Mutat. 2017; 38(8):932-941. doi 10.1002\/humu.23270","DOI":"10.1002\/humu.23270"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Ramsk\u00f6ld D., Wang E.T., Burge C.B., Sandberg R. An abundance of ubiquitously expressed genes revealed by tissue transcriptome sequence data. PLoS Comput Biol. 2009;5(12):e1000598. doi 10.1371\/journal.pcbi.1000598","DOI":"10.1371\/journal.pcbi.1000598"},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"Robinson A.A., Abraham C.R., Rosene D.L. Candidate molecular pathways of white matter vulnerability in the brain of normal agingrhesus monkeys. GeroScience. 2018;40(1):31-47. doi 10.1007\/s11357-018-0006-2","DOI":"10.1007\/s11357-018-0006-2"},{"key":"ref35","doi-asserted-by":"crossref","unstructured":"Serrano-Lorenzo P., Rabasa M., Esteban J., Hidalgo Mayoral I., Dom\u00ednguez-Gonz\u00e1lez C., Blanco-Echevarr\u00eda A., Garrido-Moraga R., Lucia A., Bl\u00e1zquez A., Rubio J.C., Palma-Milla C., Arenas J., Mar t\u00edn M.A. Clinical, biochemical, and molecular characterization of two families with novel mutations in the LDHA gene (GSD XI). Genes (Basel). 2022;13(10):1835. doi 10.3390\/genes13101835","DOI":"10.3390\/genes13101835"},{"key":"ref36","doi-asserted-by":"crossref","unstructured":"Sherman L.S., Su W., Johnson A.L., Peterson S.M., Cullin C., Lavin der T., Ferguson B., Lewis A.D. A novel non-human primate model of Pelizaeus-Merzbacher disease. Neurobiol Dis. 2021;158:105465. doi 10.1016\/j.nbd.2021.105465","DOI":"10.1016\/j.nbd.2021.105465"},{"key":"ref37","doi-asserted-by":"crossref","unstructured":"Silver N., Cotroneo E., Proctor G., Osailan S., Paterson K.L., Carpenter G.H. Selection of housekeeping genes for gene expression studies in the adult rat submandibular gland under normal, inflamed, atrophic and regenerative states. BMC Mol Biol. 2008;9:64. doi 10.1186\/1471-2199-9-64","DOI":"10.1186\/1471-2199-9-64"},{"key":"ref38","doi-asserted-by":"crossref","unstructured":"Singh K.K., Krawczak M., Dawson W.W., Schmidtke J. Association of HTRA1 and ARMS2 gene variation with drusen formation in rhesus macaques. Exp Eye Res. 2009;88(3):479-482. doi 10.1016\/j.exer.2008.10.019","DOI":"10.1016\/j.exer.2008.10.019"},{"key":"ref39","doi-asserted-by":"crossref","unstructured":"Smith A.C., Mears A.J., Bunker R., Ahmed A., Mackenzie M., Schwartzentruber J.A., Beaulieu C.L., Ferretti E., Majewski J., Bul man D.E., Celik F.C., Boycott K.M., Graham G.E. Mutations in the enzyme glutathione peroxidase 4 cause Sedaghatian-type spondy lometaphyseal dysplasia. J Med Genet. 2014;51(7):470-474. doi 10.1136\/jmedgenet-2013-102218","DOI":"10.1136\/jmedgenet-2013-102218"},{"key":"ref40","doi-asserted-by":"crossref","unstructured":"Stevanin G., Fujigasaki H., Lebre A.S., Camuzat A., Jeannequin C., Dode C., Takahashi J., San C., Bellance R., Brice A., Durr A. Huntington\u2019s disease-like phenotype due to trinucleotide repeat expansions in the TBP and JPH3 genes. Brain. 2003;126:1599-1603. doi 10.1093\/brain\/awg155","DOI":"10.1093\/brain\/awg155"},{"key":"ref41","doi-asserted-by":"crossref","unstructured":"Sun Y., Yang X., Liu M., Tang H. B4GALT3 up-regulation by miR-27a contributes to the oncogenic activity in human cervical cancer cells. Cancer Lett. 2016;375(2):284-292. doi 10.1016\/j.canlet.2016.03.016","DOI":"10.1016\/j.canlet.2016.03.016"},{"key":"ref42","doi-asserted-by":"crossref","unstructured":"Tanackovic G., Ransijn A., Thibault P., Abou Elela S., Klinck R., Ber son E.L., Chabot B., Rivolta C. PRPF mutations are associated with generalized defects in spliceosome formation and pre-mRNA splicing in patients with retinitis pigmentosa. Hum Mol Genet. 2011;20: 2116-2130. doi 10.1093\/hmg\/ddr094","DOI":"10.1093\/hmg\/ddr094"},{"key":"ref43","doi-asserted-by":"crossref","unstructured":"Tanaka M., Fujikawa R., Sekiguchi T., Hernandez J., Johnson O.T., Tanaka D., Kumafuji K., \u2026 Hattori K., Mashimo T., Kuwamura M., Gestwicki J.E., Kuramoto T. A missense mutation in the Hspa8 gene encoding heat shock cognate protein 70 causes neuroaxonal dystro phy in rats. Front Neurosci. 2024;18:1263724. doi 10.3389\/fnins.2024.1263724","DOI":"10.3389\/fnins.2024.1263724"},{"key":"ref44","doi-asserted-by":"crossref","unstructured":"Tu Z., Wang L., Xu M., Zhou X., Chen T., Sun F. Further understanding human disease genes by comparing with housekeeping genes and other genes. BMC Genomics. 2006;7:31. doi 10.1186\/1471-2164-7-31","DOI":"10.1186\/1471-2164-7-31"},{"key":"ref45","doi-asserted-by":"crossref","unstructured":"Tutar Y. Pseudogenes. Comp Funct Genomics. 2012;2012:424526. doi 10.1155\/2012\/424526","DOI":"10.1155\/2012\/424526"},{"key":"ref46","doi-asserted-by":"crossref","unstructured":"Ueda Y., Slabaugh T.L., Walker A.L., Ontiveros E.S., Sosa P.M., Rea der R., Roberts J.A., Stern J.A. Heart rate and heart rate variability of rhesus macaques (Macaca mulatta) affected by left ventricular hypertrophy. Front Vet Sci. 2019;6:1. doi 10.3389\/fvets.2019.00001","DOI":"10.3389\/fvets.2019.00001"},{"key":"ref47","doi-asserted-by":"crossref","unstructured":"Vandesompele J., De Preter K., Pattyn F., Poppe B., Van Roy N., De Paepe A., Speleman F. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 2002;3(7):research0034. doi 10.1186\/gb-2002-3-7-research0034","DOI":"10.1186\/gb-2002-3-7-research0034"},{"key":"ref48","doi-asserted-by":"crossref","unstructured":"Wang H., Wang Y., Tan P., Liu Y., Zhou S., Ma W. Prognostic value and anti-tumor immunity role of TMED9 in pan-cancer: a bioinformatics study. Transl Cancer Res. 2024;13(10):5429-5445. doi 10.21037\/tcr-24-258","DOI":"10.21037\/tcr-24-258"},{"key":"ref49","doi-asserted-by":"crossref","unstructured":"Wei H., Zhang Y., Jia Y., Chen X., Niu T., Chatterjee A., He P., Hou G. Heat shock protein 90: biological functions, diseases, and therapeutic targets. MedComm. 2024;5(2):e470. doi 10.1002\/mco2.470","DOI":"10.1002\/mco2.470"},{"key":"ref50","doi-asserted-by":"crossref","unstructured":"Zhang D., Liu X., Xu X., Xu J., Yi Z., Shan B., Liu B. HPCAL1 pro motes glioblastoma proliferation via activation of Wnt\/\u03b2-catenin signalling pathway. J Cell Mol Med. 2019;23:3108-3117. doi 10.1111\/jcmm.14083","DOI":"10.1111\/jcmm.14083"},{"key":"ref51","doi-asserted-by":"crossref","unstructured":"Zhang Y.B., Zheng S.F., Ma L.J., Lin P., Shang-Guan H.C., Lin Y.X., Kang D.Z., Yao P.S. Elevated hexose-6-phosphate dehydrogenase regulated by OSMR-AS1\/hsa-miR-516b-5p axis correlates with poor prognosis and dendritic cells infiltration of glioblastoma. Brain Sci. 2022;12(8):1012. doi 10.3390\/brainsci12081012","DOI":"10.3390\/brainsci12081012"},{"key":"ref52","doi-asserted-by":"crossref","unstructured":"Z\u00fchlke C., Hellenbroich Y., Dalski A., Kononowa N., Hagenah J., Vieregge P., Riess O., Klein C., Schwinger E. Different types of repeat expansion in the TATA-binding protein gene are associated with a new form of inherited ataxia. 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