{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:03:36Z","timestamp":1786986216080,"version":"build-2736575974"},"reference-count":0,"publisher":"RCVS Knowledge","issue":"2","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["VE"],"abstract":"<jats:p>PICO Question\nIn dogs with osteoarthritis, does grapiprant compared to no grapiprant result in a reduction in osteoarthritic pain?\n\u00a0\nClinical bottom line\nCategory of research\nTreatment.\nNumber and type of study designs reviewed\nTwo randomised controlled trials.\nStrength of evidence\nWeak.\nOutcomes reported\nOne study found that dogs with osteoarthritis given grapiprant were found to have significant clinical improvement in both owner assessed outcomes (treatment successes, pain interference scores, pain severity scores) and veterinarian assessed outcomes (total orthopaedic scores) when compared to a placebo. The second study of dogs with acute induced arthritis found no significant differences in vertical force ratios or veterinarian assessed visual lameness scores between dogs administered grapiprant and the control group.\nConclusion\nThese studies find that grapiprant reduces the impact of osteoarthritic pain on activities of daily living and orthopaedic scores in dogs but does not improve lameness associated with acute, severe osteoarthritic pain. Given the limited and inconsistent evidence, further appropriate studies are required to determine the efficacy of grapiprant in managing osteoarthritic pain in dogs.<\/jats:p>","DOI":"10.18849\/ve.v11i2.732","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T14:41:50Z","timestamp":1776177710000},"source":"Crossref","is-referenced-by-count":1,"title":["Does grapiprant reduce osteoarthritic pain in dogs?"],"prefix":"10.18849","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6360-6825","authenticated-orcid":false,"given":"Grace","family":"Olding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3595-0500","authenticated-orcid":false,"given":"Merran","family":"Govendir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"8083","published-online":{"date-parts":[[2026,4,14]]},"container-title":["Veterinary Evidence"],"original-title":[],"link":[{"URL":"https:\/\/veterinaryevidence.org\/index.php\/ve\/article\/download\/732\/1191","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/veterinaryevidence.org\/index.php\/ve\/article\/download\/732\/1192","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/veterinaryevidence.org\/index.php\/ve\/article\/download\/732\/1192","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T14:41:51Z","timestamp":1776177711000},"score":1,"resource":{"primary":{"URL":"https:\/\/veterinaryevidence.org\/index.php\/ve\/article\/view\/732"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,14]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,4,14]]}},"URL":"https:\/\/doi.org\/10.18849\/ve.v11i2.732","relation":{},"ISSN":["2396-9776"],"issn-type":[{"value":"2396-9776","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,14]]}}}