{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T14:06:29Z","timestamp":1789653989289,"version":"4.0.0"},"reference-count":0,"publisher":"RCVS Knowledge","issue":"3","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["VE"],"abstract":"<jats:p>Question\nIn cats with eosinophilic airway inflammation does cyproheptadine compared with no treatment result in a reduction in severity of clinical signs?\n\u00a0\nClinical bottom line\nThe category of research question was:\nTreatment.\nThe number and type of study designs that were critically appraised were:\nFour studies were evaluated: the first was a randomised, blinded, placebo-controlled, crossover study, the second was a randomised crossover study, the third was a non-randomised, controlled study, and the fourth a non-randomised, controlled study.\nCritical appraisal of the selected papers meeting the inclusion criteria collectively provide zero\/weak\/moderate\/strong evidence in terms of their experimental design and implementation:\nModerate.\nThe outcomes reported are summarised as follows\u2026\nIn two of the four studies it was found that cyproheptadine was not useful in resolving the symptoms of feline airway inflammation. The third study showed that the concentration of cyproheptadine that completely blocked contractile effects of serotonin did not successfully cause a significant effect on contraction caused by muscarinic stimulation. The fourth study provided evidence that cyproheptadine could reduce serotonin-induced bronchoconstriction.\nIn view of the strength of evidence and the outcomes from the studies the following conclusion is made\u2026\nThere is no current evidence to support that cyproheptadine monotherapy has any immediate benefit over no treatment for feline eosinophilic airway inflammation, and its use is not supported for this indication.<\/jats:p>","DOI":"10.18849\/ve.v11i3.747","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T13:52:57Z","timestamp":1789653177000},"source":"Crossref","is-referenced-by-count":0,"title":["The Effectiveness of Cyproheptadine as a Treatment Option for Cats with Eosinophilic Airway Inflammation"],"prefix":"10.18849","volume":"11","author":[{"given":"Jillian","family":"Seeman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5562-5521","authenticated-orcid":false,"given":"Rachael","family":"Kreisler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6039-1529","authenticated-orcid":false,"given":"Jeffery","family":"Norris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"8083","published-online":{"date-parts":[[2026,9,17]]},"container-title":["Veterinary Evidence"],"original-title":[],"link":[{"URL":"https:\/\/veterinaryevidence.org\/index.php\/ve\/article\/download\/747\/1229","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/veterinaryevidence.org\/index.php\/ve\/article\/download\/747\/1229","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T13:52:58Z","timestamp":1789653178000},"score":1,"resource":{"primary":{"URL":"https:\/\/veterinaryevidence.org\/index.php\/ve\/article\/view\/747"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,17]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,7,6]]}},"URL":"https:\/\/doi.org\/10.18849\/ve.v11i3.747","relation":{},"ISSN":["2396-9776"],"issn-type":[{"value":"2396-9776","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,17]]}}}