{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T02:15:31Z","timestamp":1717380931185},"reference-count":0,"publisher":"RCVS Knowledge","issue":"1","license":[{"start":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T00:00:00Z","timestamp":1641945600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["VE"],"abstract":"<jats:p>PICO question&#x0D;\nDoes treatment with a non-steroidal anti-inflammatory drug (NSAID) with supplementation of marine-derived\u00a0 omega-3 fatty acids (n-3FAs) compared to the NSAID alone, result in an increased ability to exert force by the osteoarthritic limb(s) of dogs or alleviate other measures of osteoarthritis?&#x0D;\n\u00a0&#x0D;\nClinical bottom line&#x0D;\nCategory of research question&#x0D;\nTreatment&#x0D;\nThe number and type of study designs reviewed&#x0D;\nTwo prospective, block-randomised, clinical trials&#x0D;\nStrength of evidence&#x0D;\nNone&#x0D;\nOutcomes reported&#x0D;\nKwananocha et al. (2016) investigated administration of carprofen supplemented with marine-derived n-3 FAs, to carprofen alone, administered over 4 weeks. Vijarnsorn et al. (2019) investigated administration of firocoxib supplemented with n-3FA, to firocoxib alone, for 4 weeks.\u00a0 There were no statistical differences between treatment groups at week 2 and week 4 post-treatment for either study. Both studies also reported orthopaedic assessment score (OAS) based on scoring the extent of patient lameness and pain in the affected joint. There were no statistical changes in OASs between treatment groups at week 2 or week 4 post-treatment for either study&#x0D;\nConclusion&#x0D;\nThere is no evidence that marine-derived n-3 FAs provide additional benefit when used as adjunctive agents with NSAIDs for the treatment of canine osteoarthritis&#x0D;\n\u00a0&#x0D;\nHow to apply this evidence in practice&#x0D;\nThe application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient\u2019s circumstances and owners\u2019 values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.&#x0D;\nKnowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.&#x0D;\n\u00a0&#x0D;\n <\/jats:p>","DOI":"10.18849\/ve.v7i1.527","type":"journal-article","created":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T12:43:35Z","timestamp":1641991415000},"source":"Crossref","is-referenced-by-count":1,"title":["Comparison of the effect of marine-derived omega-3 fatty acids (n-3 FAs) as an adjunct to a non-steroidal inflammatory drug (NSAID) therapy vs NSAID therapy alone, for dogs with osteoarthritis"],"prefix":"10.18849","volume":"7","author":[{"given":"Lok Yee Stephanie","family":"Wong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merran","family":"Govendir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"8083","published-online":{"date-parts":[[2022,1,12]]},"container-title":["Veterinary Evidence"],"original-title":[],"link":[{"URL":"https:\/\/veterinaryevidence.org\/index.php\/ve\/article\/download\/527\/689","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/veterinaryevidence.org\/index.php\/ve\/article\/download\/527\/689","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T12:43:36Z","timestamp":1641991416000},"score":1,"resource":{"primary":{"URL":"https:\/\/veterinaryevidence.org\/index.php\/ve\/article\/view\/527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,12]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,1,7]]}},"URL":"https:\/\/doi.org\/10.18849\/ve.v7i1.527","relation":{},"ISSN":["2396-9776"],"issn-type":[{"value":"2396-9776","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,12]]}}}