{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T22:35:12Z","timestamp":1765233312590,"version":"3.40.5"},"reference-count":0,"publisher":"RCVS Knowledge","issue":"2","license":[{"start":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T00:00:00Z","timestamp":1650499200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["VE"],"abstract":"<jats:p>PICO question\r\nIn adult dairy cows with ovarian follicular cysts, does treatment with gonadotropin-releasing hormone (GnRH) compared to human chorionic gonadotropin (hCG) result in a more rapid return to cyclicity?\r\n\u00a0\r\nClinical bottom line\r\nCategory of research question\r\nTreatment\r\nThe number and type of study designs reviewed\r\nThe publications consisted of six non-blinded randomised comparative or controlled trials\r\nStrength of evidence\r\nWeak\r\nOutcomes reported\r\nRecovery time, clinical cure, and interval to conception were consistently evaluated. Many studies also evaluated other fertility parameters such as first estrus or first treatment conception, overall pregnancy and conception risks, and breedings per conception\r\nConclusion\r\nAt this time, there is insufficient evidence to suggest whether GnRH or hCG is more efficacious for treating ovarian follicular cysts in dairy cattle. Ultimately, further research is essential to elucidate which treatment results in a more rapid return to cyclicity for dairy cattle afflicted with cystic ovarian follicles\r\n\u00a0\r\nHow to apply this evidence in practice\r\nThe application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient\u2019s circumstances and owners\u2019 values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.\r\nKnowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.\r\n\u00a0\r\n <\/jats:p>","DOI":"10.18849\/ve.v7i2.509","type":"journal-article","created":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T08:43:33Z","timestamp":1650530613000},"source":"Crossref","is-referenced-by-count":2,"title":["A comparison of gonadotropin-releasing hormone and human chorionic gonadotropin in dairy cows with ovarian follicular cysts"],"prefix":"10.18849","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0472-5319","authenticated-orcid":false,"given":"Kathryn","family":"Kesler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace","family":"Longcore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2498-4855","authenticated-orcid":false,"given":"Alex","family":"Russell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"8083","published-online":{"date-parts":[[2022,4,21]]},"container-title":["Veterinary Evidence"],"original-title":[],"link":[{"URL":"https:\/\/veterinaryevidence.org\/index.php\/ve\/article\/download\/509\/737","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/veterinaryevidence.org\/index.php\/ve\/article\/download\/509\/737","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T08:43:34Z","timestamp":1650530614000},"score":1,"resource":{"primary":{"URL":"https:\/\/veterinaryevidence.org\/index.php\/ve\/article\/view\/509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,21]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,4,7]]}},"URL":"https:\/\/doi.org\/10.18849\/ve.v7i2.509","relation":{},"ISSN":["2396-9776"],"issn-type":[{"type":"electronic","value":"2396-9776"}],"subject":[],"published":{"date-parts":[[2022,4,21]]}}}