{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T05:55:52Z","timestamp":1747202152098,"version":"3.40.5"},"reference-count":0,"publisher":"RCVS Knowledge","issue":"2","license":[{"start":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T00:00:00Z","timestamp":1656460800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["VE"],"abstract":"<jats:p>PICO question\r\nIn cats with psychogenic alopecia, is overgrooming reduced by the use of clomipramine compared to untreated cats?\r\n\u00a0\r\nClinical bottom line\r\nCategory of research question\r\nTreatment\r\nThe number and type of study designs reviewed\r\nOne pseudo-randomised controlled study\r\nStrength of evidence\r\nWeak\r\nOutcomes reported\r\nEffect of clomipramine using owner report of number, intensity, and \/ or duration of grooming episodes, owner reported clinical improvement, and veterinary measured alopecia, extent of tissue damage, and hair regrowth\r\nConclusion\r\nThe only controlled study found no evidence that clomipramine alone is effective in reducing grooming episodes, alopecia, or improved hair regrowth. Further\u00a0research with randomised, double blind controlled trials and limitation of confounding factors is required to determine the efficacy of clomipramine alone or in addition to behavioural \/ environmental therapies\r\n\u00a0\r\nHow to apply this evidence in practice\r\nThe application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient\u2019s circumstances and owners\u2019 values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.\r\nKnowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.\r\n\u00a0\r\n <\/jats:p>","DOI":"10.18849\/ve.v7i2.573","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T18:29:35Z","timestamp":1656527375000},"source":"Crossref","is-referenced-by-count":0,"title":["Does treatment with clomipramine reduce cat psychogenic alopecia?"],"prefix":"10.18849","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5841-4340","authenticated-orcid":false,"given":"Anne-Claude","family":"Griesser","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"8083","published-online":{"date-parts":[[2022,6,29]]},"container-title":["Veterinary Evidence"],"original-title":[],"link":[{"URL":"https:\/\/veterinaryevidence.org\/index.php\/ve\/article\/download\/573\/758","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/veterinaryevidence.org\/index.php\/ve\/article\/download\/573\/758","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T18:29:37Z","timestamp":1656527377000},"score":1,"resource":{"primary":{"URL":"https:\/\/veterinaryevidence.org\/index.php\/ve\/article\/view\/573"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,29]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,4,7]]}},"URL":"https:\/\/doi.org\/10.18849\/ve.v7i2.573","relation":{},"ISSN":["2396-9776"],"issn-type":[{"type":"electronic","value":"2396-9776"}],"subject":[],"published":{"date-parts":[[2022,6,29]]}}}