{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:24:08Z","timestamp":1791908648209,"version":"4.3.4"},"reference-count":0,"publisher":"Ethnicity and Disease Inc","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ethn Dis"],"abstract":"<jats:p>The burden of Alzheimer\u2019s disease and related dementias (ADRD) has increased substantially in the United States, particu\u00adlarly in health disparity populations. Little is known about the epidemiology of ADRD in American Indian (AI) adults, although they have a high prevalence of ADRD risk factors including hypertension, diabetes, obesity, and smoking. Using electronic health records from a large health care organization during 2016-18, we describe characteristics of AI patients aged \u226555 years with and without an ADRD diagnosis, assess ADRD risk factors and contrast findings with results from age- and sex-matched non- Hispanic White (NHW) patients. To identify factors associated with ADRD diagnoses, we estimated population-averaged prevalence rate ratios to approximate relative risk (RR) using generalized estimating equations models adjusted for age, sex, and marital and rural residency status. The age-adjusted prevalence of ADRD diagnosis was 6.6% of AI patients, compared with 4.4% in NHW patients. Patient age and diagnosis of hy\u00adpertension, depression, hyperlipidemia, or diabetes were significantly associated with higher risk of ADRD diagnosis in AIs (RR range: 1.1-2.8) whereas female sex or being married\/having a partner were associated with lower risk of ADRD diagnosis (each RR=.7). ADRD risk factors were generally similar between AI and NHW patients, except for sex and marital status. However, the adjusted risk of ADRD was approxi\u00admately 49% higher in AI patients. To our knowledge, our study is the first to examine ADRD diagnoses and comorbidities in AIs across a large geographical region in south\u00adwest United States. Future efforts to confirm our findings in diverse AI communities are warranted. Ethn Dis. 2020;30(4):671-680; doi:10.18865\/ed.30.4.671<\/jats:p>","DOI":"10.18865\/ed.30.4.671","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T16:00:13Z","timestamp":1600963213000},"page":"671-680","source":"Crossref","is-referenced-by-count":21,"title":["Risk Factors for Alzheimer\u2019s Disease and Related Dementia Diagnoses in American Indians"],"prefix":"10.18865","volume":"30","author":[{"given":"Cara L.","family":"Carty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn","family":"Noonan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemma","family":"Muller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Don","family":"Saner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric M.","family":"Reiman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dedra","family":"Buchwald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronny A.","family":"Bell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lonnie A.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"18154","published-online":{"date-parts":[[2020,9,24]]},"container-title":["Ethnicity &amp; Disease"],"original-title":[],"link":[{"URL":"https:\/\/www.ethndis.org\/edonline\/index.php\/ethndis\/article\/viewFile\/1265\/1975","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ethndis.org\/edonline\/index.php\/ethndis\/article\/viewFile\/1265\/2038","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ethndis.org\/edonline\/index.php\/ethndis\/article\/download\/1265\/1975","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T16:14:21Z","timestamp":1600964061000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ethndis.org\/edonline\/index.php\/ethndis\/article\/view\/1265"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,24]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,9,24]]}},"URL":"https:\/\/doi.org\/10.18865\/ed.30.4.671","relation":{},"ISSN":["1945-0826","1049-510X"],"issn-type":[{"value":"1945-0826","type":"electronic"},{"value":"1049-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9,24]]}}}