{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T17:49:28Z","timestamp":1778608168524,"version":"3.51.4"},"reference-count":12,"publisher":"Springer Publishing Company","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatal Network"],"published-print":{"date-parts":[[2000,12]]},"abstract":"<jats:p>Apnea of prematurity is a common problem of the premature infant under 30 weeks gestation. Theophylline and caffeine, two methylxanthines, are widely used to treat this condition. The drugs are equally effective in preventing apnea in the premature infant. Caffeine citrate has many advantages over theophylline, however, including once-aday dosing, more predictable plasma concentrations, earlier onset of action, and minimal side effects. Caffeine is therefore the initial drug of choice for apnea of prematurity.<\/jats:p>","DOI":"10.1891\/0730-0832.19.8.33","type":"journal-article","created":{"date-parts":[[2012,5,8]],"date-time":"2012-05-08T03:45:07Z","timestamp":1336448707000},"page":"33-36","source":"Crossref","is-referenced-by-count":17,"title":["Theophylline or Caffeine: Which Is Best for Apnea of Prematurity?"],"prefix":"10.1891","volume":"19","author":[{"given":"Barbara","family":"Gannon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"793","published-online":{"date-parts":[[2000,12,1]]},"reference":[{"issue":"1","key":"1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0031-3955(16)33965-7","article-title":"Pharmacologic considerations in the therapy of neonatal apnea","volume":"28","author":"JV Aranda","year":"1981","journal-title":"Pediatric Clinics of North America"},{"key":"2","first-page":"374","volume-title":"Manual of Neonatal Care","author":"A. Stark","year":"1998"},{"key":"3","first-page":"213","article-title":"Respiratory therapy: General considerations","volume-title":"Neonatal Respiratory Diseases","author":"JM. Adams","year":"1998"},{"issue":"4","key":"4","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1136\/adc.67.4_Spec_No.425","article-title":"Caffeine or theophylline for neonatal apnoea?","volume":"67","author":"JE Scanlon","year":"1992","journal-title":"Archives of Disease in Childhood"},{"issue":"4","key":"5","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1111\/j.1651-2227.1995.tb13649.x","article-title":"Aminophylline versus caffeine citrate for apnea and bradycardia prophylaxis in premature neonates","volume":"84","author":"PB Larsen","year":"1995","journal-title":"Acta Paediatrica"},{"issue":"4","key":"6","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/S0022-3476(87)80569-3","article-title":"Theophylline versus caffeine: Comparative effects in treatment of idiopathic apnea in the preterm infant","volume":"110","author":"A Bairam","year":"1987","journal-title":"Journal of Pediatrics"},{"issue":"2","key":"7","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0378-3732(97)00038-6","article-title":"Comparative effects of theophylline and caffeine on respiratory function of prematurely born infants","volume":"50","author":"B Laubscher","year":"1998","journal-title":"Early Human Development"},{"key":"8","first-page":"144","author":"T Young","year":"1997"},{"key":"9","first-page":"119","volume-title":"Drug Therapy in Infants","author":"R. Roberts","year":"1984"},{"issue":"1","key":"10","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0095-5108(18)31165-5","article-title":"Methylxanthines in apnea of prematurity","volume":"6","author":"JV Aranda","year":"1979","journal-title":"Clinics in Perinatology"},{"issue":"7","key":"11","first-page":"698","article-title":"Comparative efficacy of theophylline and caffeine in the treatment of idiopathic apnea in premature infants","volume":"139","author":"C Brouard","year":"1985","journal-title":"American Journal of the Diseases of Children"},{"issue":"5","key":"12","first-page":"37","article-title":"Caffeine citrate in the NICU","volume":"7","author":"E. Flood","year":"1989","journal-title":"Neonatal Network"}],"container-title":["Neonatal Network"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1891\/0730-0832.19.8.33","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T15:09:09Z","timestamp":1568819349000},"score":1,"resource":{"primary":{"URL":"http:\/\/connect.springerpub.com\/lookup\/doi\/10.1891\/0730-0832.19.8.33"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,12]]},"references-count":12,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2000,12,1]]},"published-print":{"date-parts":[[2000,12]]}},"alternative-id":["10.1891\/0730-0832.19.8.33"],"URL":"https:\/\/doi.org\/10.1891\/0730-0832.19.8.33","relation":{},"ISSN":["0730-0832","1539-2880"],"issn-type":[{"value":"0730-0832","type":"print"},{"value":"1539-2880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,12]]}}}