{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:36:43Z","timestamp":1760132203707},"reference-count":61,"publisher":"Springer Publishing Company","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatal Network"],"published-print":{"date-parts":[[2001,3]]},"abstract":"<jats:p>Management of congenital diaphragmatic hernia has changed dramatically over the past couple of decades. Until the early 1980s, it was felt that the abdominal contents should be returned to the abdomen as soon as possible to allow the lungs to expand. It is now known that it is not the defect that causes respiratory distress, but the infant\u2019s hypoplastic lungs and accompanying pulmonary hypertension. Advances in treatment and technology have contributed to changes in management. Ultrasonography now allows for early prenatal detection. Prenatal treatment modalities include<jats:italic>in utero<\/jats:italic>tracheal ligation and maternal antenatal steroids. Postnatal modalities have expanded to include permissive hypercapnia, high-frequency ventilation, inhaled nitric oxide, pharmacologic support, exogenous surfactant, and extracorporeal membrane oxygenation. Liquid ventilation and lobar lung transplantation have also been tried. In spite of these advances, the overall survival rate remains about 63 percent.<\/jats:p>","DOI":"10.1891\/0730-0832.20.2.5","type":"journal-article","created":{"date-parts":[[2012,5,8]],"date-time":"2012-05-08T07:43:18Z","timestamp":1336462998000},"page":"5-15","source":"Crossref","is-referenced-by-count":4,"title":["Current and Emerging Treatment for Congenital Diaphragmatic Hernia"],"prefix":"10.1891","volume":"20","author":[{"given":"Jeanne","family":"Braby","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"793","published-online":{"date-parts":[[2001,3,1]]},"reference":[{"issue":"7","key":"1","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/S0022-3468(98)90522-X","article-title":"Current surgical management of congenital diaphragmatic hernia: A report from the Congenital Diaphragmatic Hernia Study Group","volume":"33","author":"RH Clark","year":"1998","journal-title":"Journal of Pediatric Surgery"},{"issue":"4","key":"2","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0095-5108(18)30200-8","article-title":"Toward understanding the developmental anatomy of congenital diaphragmatic hernia","volume":"23","author":"D Kluth","year":"1996","journal-title":"Clinics in Perinatology"},{"issue":"4","key":"3","first-page":"381","article-title":"Challenges in nursing: Infants with congenital diaphragmatic hernia","volume":"21","author":"PA Kent","year":"1992","journal-title":"Heart & Lung"},{"issue":"4","key":"4","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/S0095-5108(18)30212-4","article-title":"In utero management of congenital diaphragmatic hernia","volume":"23","author":"GB Mychaliska","year":"1996","journal-title":"Clinics in Perinatology"},{"issue":"4","key":"5","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S0095-5108(18)30201-X","article-title":"Congenital diaphragmatic hernia epidemiology and outcome","volume":"23","author":"MR Langham","year":"1996","journal-title":"Clinics in Perinatology"},{"issue":"3","key":"6","first-page":"465","article-title":"In utero therapy and ethical considerations","volume":"23","author":"MG Neerhof","year":"1996","journal-title":"Clinics in Perinatology"},{"issue":"1","key":"7","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0045-9380(98)80058-3","article-title":"Congenital diaphragmatic hernia from the womb to childhood","volume":"28","author":"DW Thibeault","year":"1998","journal-title":"Current Problems in Pediatrics"},{"key":"8","first-page":"291","article-title":"Management of infants with congenital diaphragmatic hernia with ECMO","volume-title":"ECMO Extracorporeal Cardiopulmonary SupportCritical Care","author":"CW Breaux","year":"1995"},{"issue":"4","key":"9","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0095-5108(18)30202-1","article-title":"Etiologic and genetic factors in congenital diaphragmatic hernia","volume":"23","author":"D Tibboel","year":"1996","journal-title":"Clinics in Perinatology"},{"issue":"8","key":"10","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/0022-3468(94)90290-9","article-title":"Congenital diaphragmatic hernia and associated anomalies: Their incidence, identification, and impact on prognosis","volume":"29","author":"DO Fauza","year":"1994","journal-title":"Journal of Pediatric Surgery"},{"issue":"4","key":"11","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/S0095-5108(18)30203-3","article-title":"Prenatal diagnosis of congenital diaphragmatic hernia with predictors of mortality","volume":"23","author":"DT Wilcox","year":"1996","journal-title":"Clinics in Perinatology"},{"issue":"1","key":"12","doi-asserted-by":"crossref","DOI":"10.1136\/fn.79.1.F1","article-title":"Management of congenital diaphragmatic hernia","volume":"79","author":"CF Davis","year":"1998","journal-title":"Archives of Disease in Childhood: Fetal and Neonatal Edition"},{"issue":"6","key":"13","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/0022-3468(94)90378-6","article-title":"Antenatal diagnosis of isolated congenital diaphragmatic hernia is not an indicator of outcome","volume":"29","author":"JM Wilson","year":"1994","journal-title":"Journal of Pediatric Surgery"},{"key":"14","doi-asserted-by":"crossref","unstructured":"Levine AH. 1991. 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