{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:49:34Z","timestamp":1792097374687,"version":"4.4.0"},"reference-count":19,"publisher":"Springer Publishing Company","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatal Network"],"published-print":{"date-parts":[[2001,6]]},"abstract":"<jats:p>Arthrogryposis multiplex congenita (AMC) is a term that is used to describe the presence of multiple joint contractures at birth. AMC can be seen singularly or in conjunction with other abnormalities. Historically, the term<jats:italic>arthrogryposis<\/jats:italic>was used as a disease diagnosis, but it is now clear that AMC is not a disease entity but a syndrome, involving a manifestation of many fetal and neonatal disorders of the neuromuscular system. Its etiology is multifocal, and there is a wide variation in the degree to which muscles and joints are affected. Early identification and implementation of a plan of therapy are essential. The purpose of this article is to provide an overview of the AMC syndrome, specifically, clinical features, etiology, diagnosis, therapeutic interventions, family support, and outcomes.<\/jats:p>","DOI":"10.1891\/0730-0832.20.4.13","type":"journal-article","created":{"date-parts":[[2012,5,8]],"date-time":"2012-05-08T07:46:02Z","timestamp":1336463162000},"page":"13-20","source":"Crossref","is-referenced-by-count":21,"title":["Arthrogryposis Multiplex Congenita"],"prefix":"10.1891","volume":"20","author":[{"given":"Pat","family":"O\u2019Flaherty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"793","published-online":{"date-parts":[[2001,6,1]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1001\/jama.1923.02650180025009","article-title":"Arthrogryposis multiplex congenita","volume":"81","author":"WG. Stern","year":"1923","journal-title":"JAMA"},{"issue":"1","key":"2","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1055\/s-2008-1059546","article-title":"Arthrogryposis multiplex congenita: Review with comment","volume":"14","author":"G Hageman","year":"1983","journal-title":"Neuropediatrics"},{"issue":"4","key":"3","first-page":"44","article-title":"Genetic aspects of arthrogryposis","volume":"194","author":"J. Hall","year":"1985","journal-title":"Clinical Orthopaedics and Related Research"},{"issue":"4","key":"4","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1055\/s-2008-1071489","article-title":"Arthrogryposis multiplex congenita: Feeding, language, and other health problems","volume":"21","author":"RD. Robinson","year":"1990","journal-title":"Neuropediatrics"},{"issue":"7","key":"5","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0387-7604(98)00037-0","article-title":"Arthrogryposis multiplex congenita","volume":"20","author":"N. Gordon","year":"1998","journal-title":"Brain and Development"},{"key":"6","first-page":"356","volume-title":"The Developing Human: Clinically Oriented Embryology","author":"KL Moore","year":"1998"},{"issue":"8","key":"7","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1542\/peds.72.6.857","article-title":"Fetal akinesia deformation sequence: An animal model","volume":"72","author":"AC. Moessinger","year":"1983","journal-title":"Pediatrics"},{"issue":"2","key":"8","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/tera.1420250214","article-title":"Concepts of multiple congenital contractures in man and animals","volume":"25","author":"CA. Swinyard","year":"1982","journal-title":"Teratology"},{"issue":"3","key":"9","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1097\/01202412-199707000-00002","article-title":"Arthrogryposis multiplex congenita: Etiology, genetics, classification, diagnostic approach, and general aspects","volume":"6","author":"J. Hall","year":"1997","journal-title":"Journal of Pediatric Orthopedics"},{"key":"10","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1097\/00003086-198504000-00004","article-title":"The etiology of arthrogryposis (multiple congenital contracture)","volume":"194","author":"CA. Swinyard","year":"1985","journal-title":"Clinical Orthopaedics"},{"key":"11","first-page":"781","article-title":"Arthrogryposis","volume-title":"Principles & Practice of Medical Genetics","author":"J. Hall","year":"1983"},{"issue":"3","key":"12","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0387-7604(96)00557-8","article-title":"The spectrum of arthrogryposis in 33 Chinese children","volume":"19","author":"V. Wong","year":"1997","journal-title":"Brain and Development"},{"issue":"240","key":"13","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1136\/adc.45.240.277","article-title":"Arthrogryposis following treatment of maternal tetanus with muscle relaxants","volume":"45","author":"RH. Jago","year":"1970","journal-title":"Archives of Disease in Childhood"},{"key":"14","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1097\/00003086-198504000-00005","article-title":"Neuropathologic aspects of arthrogryposis multiplex congenita","volume":"194","author":"BQ. Banker","year":"1985","journal-title":"Clinical Orthopaedics"},{"issue":"7","key":"15","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/S0046-8177(86)80177-0","article-title":"Arthrogryposis multiplex congenita: Spectrum of pathologic changes","volume":"17","author":"BQ. Banker","year":"1986","journal-title":"Human Pathology"},{"issue":"6 part 1","key":"16","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/S0022-3476(87)80225-1","article-title":"Prenatal diagnosis of arthrogryposis multiplex congenita","volume":"111","author":"R. Bendon","year":"1987","journal-title":"Journal of Pediatrics"},{"issue":"4","key":"17","first-page":"115","article-title":"Arthrogryposis multiplex congenita: A long-term follow-up study","volume":"194","author":"W Carlson","year":"1985","journal-title":"Clinical Orthopaedics and Related Research"},{"issue":"4","key":"18","first-page":"104","article-title":"Arthrogryposis: Pediatric review and habilitative aspects","volume":"194","author":"G. Hahn","year":"1985","journal-title":"Clinical Orthopaediatrics and Related Research"},{"issue":"3","key":"19","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/01202412-199707000-00003","article-title":"Arthrogryposis multiplex congenita: Perinatal and electromyographic findings, disability, and psychosocial outcome","volume":"6","author":"J. Sodergard","year":"1997","journal-title":"Journal of Pediatric Orthopedics"}],"container-title":["Neonatal Network"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1891\/0730-0832.20.4.13","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,15]],"date-time":"2022-01-15T04:04:22Z","timestamp":1642219462000},"score":1,"resource":{"primary":{"URL":"http:\/\/connect.springerpub.com\/lookup\/doi\/10.1891\/0730-0832.20.4.13"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,6]]},"references-count":19,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2001,6,1]]},"published-print":{"date-parts":[[2001,6]]}},"alternative-id":["10.1891\/0730-0832.20.4.13"],"URL":"https:\/\/doi.org\/10.1891\/0730-0832.20.4.13","relation":{},"ISSN":["0730-0832","1539-2880"],"issn-type":[{"value":"0730-0832","type":"print"},{"value":"1539-2880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,6]]}}}