{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T02:49:05Z","timestamp":1750301345432},"reference-count":23,"publisher":"Springer Publishing Company","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatal Network"],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:p>Jaundice caused by hemolysis continues to challenge practitioners caring for infants in the NICU. Bilirubin levels can rise quickly in the first days of life, and interventions must be prompt to prevent side effects related to hyperbilirubinemia. Conventional treatments such as hydration and phototherapy are common, but new studies suggest that use of intravenous immunoglobulin (IVIG) as an additional treatment may prevent the need for exchange transfusion in some babies. This article presents a case study of an infant with blood-type incompatibility treated successfully with multiple doses of IVIG, discusses the pathophysiology and clinical presentation of hemolytic jaundice, and reviews current management strategies for this disease.<\/jats:p>","DOI":"10.1891\/0730-0832.24.6.17","type":"journal-article","created":{"date-parts":[[2011,11,16]],"date-time":"2011-11-16T14:50:01Z","timestamp":1321455001000},"page":"17-24","source":"Crossref","is-referenced-by-count":13,"title":["Intravenous Immunoglobulin in the Management of Hemolytic Disease of the Newborn"],"prefix":"10.1891","volume":"24","author":[{"given":"Cynthia","family":"Mundy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"793","published-online":{"date-parts":[[2005,11,1]]},"reference":[{"issue":"3","key":"1","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/S0029-7844(02)02180-4","article-title":"Management of rhesus alloimmunization in pregnancy.","volume":"100","author":"KJ. Moise","year":"2002","journal-title":"Obstetrics and Gynecology"},{"key":"2","unstructured":"Mollison PL, Engelfreit CP, and Contreras M. 1993. <i>Blood Transfusion in Clinical Medicine<\/i>, 9th ed. Oxford: Blackwell Scientific Publications."},{"key":"3","unstructured":"McKenzie S. 2005. Anemia. In <i>Intensive Care of the Fetus and Neonate<\/i>, 2nd ed., Spitzer AR, ed. 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In <i>Pathophysiology: The Biologic Basis for Disease in Adults and Children<\/i>, 3rd ed., McCance KL, and Huether SE, eds. St. Louis: Mosby-Year Book, 940\u2013943."},{"key":"8","unstructured":"Ware RE, and Rosse WF. 1998. Autoimmune hemolytic anemia. In <i>Nathan and Oski's Hematology of Infancy and Childhood<\/i>, 5th ed., Nathan DG, and Orkin SH, eds. Philadelphia: WB Saunders, 502\u2013503, 623."},{"key":"9","unstructured":"Watson RL. 1999. Gastrointestinal disorders. In <i>Core Curriculum for Neonatal Intensive Care Nursing<\/i>, 2nd ed., Deacon J, and O'Neill P, eds. Philadelphia: WB Saunders, 281\u2013290."},{"issue":"1","key":"10","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1542\/peds.114.1.297","article-title":"Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation.","volume":"114","year":"2004","journal-title":"Pediatrics"},{"issue":"4","key":"11","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1542\/peds.95.4.468","article-title":"Direct comparison of Sn-mesoporphyrin, an inhibitor of bilirubin production, and phototherapy in controlling hyperbilirubinemia in term and near-term newborns.","volume":"95","author":"A Kappas","year":"1995","journal-title":"Pediatrics"},{"key":"12","unstructured":"Kappas A, et al. 1994. Control of hyperbilirubinemia in preterm and term newborns by an inhibitor of bilirubin production. In <i>Current Progress in Perinatal Medicine<\/i>, Cosmi EV, and DiRenzo GC, eds. 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Mononuclear phagocytes in immune defense. In <i>Immunology<\/i>, 6th ed., Roitt I, Brostoff J, and Male D, eds. St. Louis: Mosby, 155\u2013156."},{"issue":"8316","key":"17","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S0140-6736(83)91738-5","article-title":"High-dose intravenous IgG in adults with autoimmune thrombocytopenia.","volume":"321","author":"A Newland","year":"1983","journal-title":"Lancet"},{"key":"18","unstructured":"Bayer Corporation. 2004. Immune globulin intravenous (human), 10%. Bayer product insert. Retrieved April 1, 2005, f rom <a target=\"_blank\" href='http:\/\/www.univgraph.com\/bayer\/inserts\/gamimune10s-D.pdf'>http:\/\/www.univgraph.com\/bayer\/inser ts\/ gamimune10s-D.pdf<\/a>"},{"issue":"2","key":"19","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1651-2227.1991.tb11828.x","article-title":"High-dose intravenous gamma globulin therapy for neonatal immune haemolytic jaundice due to blood group incompatibility.","volume":"80","author":"K Sato","year":"1991","journal-title":"Acta Paediatrica Scandinavica"},{"issue":"1","key":"20","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0022-3476(05)82551-X","article-title":"High-dose intravenous immune globulin therapy for hyperbilirubinemia caused by Rh hemolytic disease.","volume":"121","author":"J Rubo","year":"1992","journal-title":"The Journal of Pediatrics"},{"issue":"3","key":"21","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1515\/jpme.1993.21.3.183","article-title":"Intravenous immunoglobulin therapy in neonatal immune hemolytic jaundice.","volume":"21","author":"Z Ergaz","year":"1993","journal-title":"Journal of Perinatal Medicine"},{"issue":"11","key":"22","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1111\/j.1651-2227.1996.tb13924.x","article-title":"Intravenous immune globulin in neonatal immune hemolytic disease: Does it reduce hemolysis?","volume":"85","author":"C Hammerman","year":"1996","journal-title":"Acta Paediatrica"},{"key":"23","doi-asserted-by":"crossref","unstructured":"Alcock G, and Liley H. 2003. Immunoglobulin infusion for isoimmune hemolytic jaundice in neonates. Retrieved December 13, 2003, from <a target=\"_blank\" href='http:\/\/www.nichd.nih.gov\/cochraneneonatal\/Alcock\/Alcock.htm'>http:\/\/www.nichd.nih.gov\/cochraneneonatal\/ Alcock\/Alcock.htm<\/a>","DOI":"10.1002\/14651858.CD003313"}],"container-title":["Neonatal Network"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1891\/0730-0832.24.6.17","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T19:29:41Z","timestamp":1639682981000},"score":1,"resource":{"primary":{"URL":"http:\/\/connect.springerpub.com\/lookup\/doi\/10.1891\/0730-0832.24.6.17"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11]]},"references-count":23,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2005,11,1]]},"published-print":{"date-parts":[[2005,11]]}},"alternative-id":["10.1891\/0730-0832.24.6.17"],"URL":"https:\/\/doi.org\/10.1891\/0730-0832.24.6.17","relation":{},"ISSN":["0730-0832","1539-2880"],"issn-type":[{"value":"0730-0832","type":"print"},{"value":"1539-2880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,11]]}}}