{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T16:19:27Z","timestamp":1779898767639,"version":"3.53.1"},"reference-count":21,"publisher":"Springer Publishing Company","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatal Network"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:p>Extracorporeal membrane oxygenation (ECMO), a technique for providing life support to patients with cardiac and\/or respiratory dysfunction, allows the heart and lungs to \u201crest.\u201d The neonatal respiratory population has been a major benefactor of ECMO since 1982. Its use for neonatal respiratory disease increased dramatically until the past few years, when the number of neonatal respiratory ECMO cases began a downward trend. Fewer patients with persistent pulmonary hypertension of the newborn (PPHN), meconium aspiration syndrome, respiratory distress syndrome, or sepsis are requiring ECMO support as frequently as in the past. Many attribute this decline to the newer respiratory therapies\u2014mainly, surfactant, high-frequency oscillatory ventilation, and inhaled nitric oxide. Neonates who continue to require ECMO today are sicker than the historic norm and have more complicated and lengthy ECMO runs. Patients with congenital diaphragmatic hernia, PPHN, and sepsis remain the most consistent in their representation among ECMO recipients within this author\u2019s institution, suggesting that the newer respiratory therapies have not had the same impact on these patients\u2019 needs for ECMO support. Better guidelines for determining which patients would benefit from earlier inititation of ECMO are needed.<\/jats:p>","DOI":"10.1891\/0730-0832.25.4.229","type":"journal-article","created":{"date-parts":[[2011,11,16]],"date-time":"2011-11-16T14:38:35Z","timestamp":1321454315000},"page":"229-238","source":"Crossref","is-referenced-by-count":29,"title":["Neonatal ECMO: Current Controversies and Trends"],"prefix":"10.1891","volume":"25","author":[{"given":"Jesse","family":"Ford","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"793","published-online":{"date-parts":[[2006,7,1]]},"reference":[{"issue":"2","key":"1","first-page":"425","article-title":"Extracorporeal membrane oxygenation for newborn respiratory failure: Forty-five cases.","volume":"92","author":"RH Bartlett","year":"1982","journal-title":"Surgery"},{"issue":"8","key":"2","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/S0022-3468(96)90099-8","article-title":"ECMO in evolution: The impact of changing patient demographics and alternative therapies on ECMO.","volume":"31","author":"JM Wilson","year":"1996","journal-title":"Journal of Pediatric Surgery"},{"issue":"2","key":"3","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0022-3468(98)90464-X","article-title":"Percutaneous access for venovenous extracorporeal life support in neonates.","volume":"33","author":"CA Reickert","year":"1998","journal-title":"Journal of Pediatric Surgery"},{"issue":"10","key":"4","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1097\/00003246-199610000-00013","article-title":"A comparison of venovenous and venoarterial extracorporeal membrane oxygenation in the treatment of neonatal respiratory failure.","volume":"24","author":"GR Knight","year":"1996","journal-title":"Critical Care Medicine"},{"issue":"4","key":"5","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1542\/peds.78.4.699","article-title":"Intracranial hemorrhage during extracorporeal membrane oxygenation in neonates.","volume":"78","author":"RE Cilley","year":"1986","journal-title":"Pediatrics"},{"issue":"7","key":"6","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1055\/s-2000-13449","article-title":"ECMO in the newborn.","volume":"17","author":"ES Kim","year":"2000","journal-title":"American Journal of Perinatology"},{"key":"7","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1007\/s001340000603","article-title":"Do we need new indications for ECMO in neonates pretreated with high-frequency ventilation and\/or inhaled nitric oxide?","volume":"26","author":"H K\u00f6ssel","year":"2000","journal-title":"Intensive Care Medicine"},{"key":"8","doi-asserted-by":"crossref","unstructured":"Roy BJ, et al. 2000. The changing demographics of neonatal extracorporeal membrane oxygenation patients reported to the Extracorporeal Life Support Organization (ELSO) Registry. <i>Pediatrics<\/i> 106(6): 1334\u20131338.","DOI":"10.1542\/peds.106.6.1334"},{"issue":"6","key":"9","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1542\/peds.106.6.1339","article-title":"Decreased use of neonatal extracorporeal membrane oxygenation (ECMO): How new treatment modalities have affected ECMO utilization.","volume":"106","author":"SR Hintz","year":"2000","journal-title":"Pediatrics"},{"issue":"5","key":"10","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1053\/jpsu.2002.32257","article-title":"The impact of changing neonatal respiratory management on extracorporeal membrane oxygenation utilization.","volume":"37","author":"TT Hui","year":"2002","journal-title":"Journal of Pediatric 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