{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:58:21Z","timestamp":1773273501285,"version":"3.50.1"},"reference-count":49,"publisher":"Springer Publishing Company","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatal Network"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:p>Retinopathy of prematurity (ROP) continues to be a significant complication in preterm neonates despite advances in neonatal care. Very low birth weight and extremely low birth weight infants continue to suffer from the sequelae of premature birth, including ROP. Controversy and uncertainty surround prevention of ROP. Possible preventive strategies include the use or restriction of oxygen therapy; steroid therapy; changes in blood transfusion protocols; reduced exposure of the retina to light; and administration of nutritional factors, indomethacin, and D-penicillamine. This article reviews recent studies that have proved or disproved the effectiveness of these preventive measures. It also identifies the implications of the study results for clinical practice and makes recommendations for future research.<\/jats:p>","DOI":"10.1891\/0730-0832.25.6.393","type":"journal-article","created":{"date-parts":[[2011,11,16]],"date-time":"2011-11-16T14:32:22Z","timestamp":1321453942000},"page":"393-403","source":"Crossref","is-referenced-by-count":23,"title":["Evidence-Based Review of Retinopathy of Prematurity Prevention in VLBW and ELBW Infants"],"prefix":"10.1891","volume":"25","author":[{"given":"AnnMarie","family":"DiBiasie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"793","published-online":{"date-parts":[[2006,11,1]]},"reference":[{"issue":"4","key":"1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.2165\/00128072-200103040-00003","article-title":"The management of retinopathy of prematurity.","volume":"3","author":"J. Reynolds","year":"2001","journal-title":"Pediatric Drugs"},{"key":"2","doi-asserted-by":"crossref","unstructured":"Phelps D, and Watts J. 2001. Early light reduction for preventing retinopathy of prematurity in very low birth weight infants. <i>Cochrane Database of Systematic Reviews<\/i> 1: CD000122.","DOI":"10.1002\/14651858.CD000122"},{"issue":"6","key":"3","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1053\/siny.2001.0079","article-title":"Retinopathy of prematurity: Causation.","volume":"6","author":"J McColm","year":"2001","journal-title":"Seminars in Neonatology"},{"issue":"2","key":"4","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1542\/peds.111.2.339","article-title":"Can changes in clinical practice decrease the incidence of severe retinopathy of prematurity in very low birth weight infants?","volume":"111","author":"L Chow","year":"2003","journal-title":"Pediatrics"},{"issue":"6","key":"5","first-page":"434","article-title":"Supplemental oxygen may decrease progression of prethreshold disease to threshold retinopathy of prematurity.","volume":"17","author":"M Gaynon","year":"1997","journal-title":"Journal of Perinatology"},{"key":"6","doi-asserted-by":"crossref","unstructured":"Lloyd J, et al. 2003. Supplemental oxygen for the treatment of prethreshold retinopathy of prematurity. <i>Cochrane Database of Systematic Reviews<\/i> 2: CD003482.","DOI":"10.1002\/14651858.CD003482"},{"issue":"1","key":"7","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1006\/taap.2002.9387","article-title":"Oxygen toxicity in premature infants.","volume":"181","author":"B Weinberger","year":"2002","journal-title":"Toxicology and Applied Pharmacology"},{"issue":"2","key":"8","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3928\/0191-3913-20000301-06","article-title":"Relationship between serum inositol concentration and development of retinopathy of prematurity: A prospective study.","volume":"37","author":"C Friedman","year":"2000","journal-title":"Journal of Pediatric Ophthalmology and Strabismus"},{"key":"9","unstructured":"Vannucci RC, and Palmer C. 2002. Hypoxia-ischemia: neuropathology, pathogenesis, and management. In <i>Neonatal-Perinatal Medicine: Diseases of the Fetus and Infant.<\/i> 7th ed. Vol. 2. Fanaroff A, and Martin R. eds. St. Louis: Mosby, 847\u2013867."},{"issue":"1","key":"10","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1542\/peds.74.1.127","article-title":"An international Classification of retinopathy of prematurity.","volume":"74","year":"1984","journal-title":"Pediatrics"},{"issue":"7","key":"11","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1001\/archopht.1987.01060070042025","article-title":"An international Classification of retinopathy of prematurity. 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Organization of a systematic review for the Cochrane Neonatal Review Group. Retrieved October 20, 2003, from <a target=\"_blank\" href='http:\/\/cochrane.mcmaster.ca\/neonatal\/'>http:\/\/cochrane.mcmaster.ca\/neonatal\/<\/a>"},{"issue":"5","key":"21","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1053\/siny.2002.0130","article-title":"Giving small babies oxygen: 50 years of uncertainty.","volume":"7","author":"W Tin","year":"2002","journal-title":"Seminars in Neonatology"},{"issue":"2","key":"22","article-title":"Pulse oximetry, severe retinopathy, and outcome at one year in babies of less than 28 weeks gestation.","volume":"84","author":"W Tin","year":"2001","journal-title":"Archives of Disease in Childhood. 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D-penicillamine for preventing retinopathy of prematurity in preterm infants. <i>Cochrane Database of Systematic Reviews<\/i> 3: CD001073."},{"issue":"3","key":"48","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1542\/peds.104.3.514","article-title":"The effect of blood transfusion protocol on retinopathy of prematurity: A prospective, randomized study.","volume":"104","author":"S Brooks","year":"1999","journal-title":"Pediatrics"},{"issue":"1","key":"49","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/sj.jp.7200511","article-title":"The effect of anemia on retinopathy of prematurity in extremely low birth weight infants.","volume":"21","author":"J Englert","year":"2001","journal-title":"Journal of Perinatology"}],"container-title":["Neonatal Network"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1891\/0730-0832.25.6.393","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T19:25:02Z","timestamp":1639682702000},"score":1,"resource":{"primary":{"URL":"http:\/\/connect.springerpub.com\/lookup\/doi\/10.1891\/0730-0832.25.6.393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11]]},"references-count":49,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2006,11,1]]},"published-print":{"date-parts":[[2006,11]]}},"alternative-id":["10.1891\/0730-0832.25.6.393"],"URL":"https:\/\/doi.org\/10.1891\/0730-0832.25.6.393","relation":{},"ISSN":["0730-0832","1539-2880"],"issn-type":[{"value":"0730-0832","type":"print"},{"value":"1539-2880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11]]}}}