{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T13:56:18Z","timestamp":1697378178066},"reference-count":32,"publisher":"Springer Publishing Company","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatal Network"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:p>THE DUCTUS ARTERIOSUS IS a vascular shunt that exists before birth to enable blood flow to bypass the lungs, which are not yet functional, and direct it instead to the systemic circulation and to vital organs such as the kidney and the gastrointestinal (GI) tract. In the term infant, this shunt should start to close within the first few hours after birth; it should close functionally within 72 hours and anatomically within 2 weeks after birth.<jats:sup>1<\/jats:sup> In the preterm infant, functional and subsequent anatomic closure frequently does not take place. Failure of ductal closure occurs in as many as 60 percent of all infants who are less than 28 weeks gestation at birth.<jats:sup>1<\/jats:sup> Causes for patency of the ductus arteriosus in preterm infants include decreased smooth muscle fibers in the duct and continued responsiveness of the ductus arteriosus to prostaglandins produced within it.<\/jats:p>","DOI":"10.1891\/0730-0832.26.3.187","type":"journal-article","created":{"date-parts":[[2011,11,16]],"date-time":"2011-11-16T14:31:48Z","timestamp":1321453908000},"page":"187-195","source":"Crossref","is-referenced-by-count":6,"title":["Safety and Efficacy of Ibuprofen versus Indomethacin for the Treatment of Patent Ductus Arteriosus in the Preterm Infant: Reviewing the Evidence"],"prefix":"10.1891","volume":"26","author":[{"given":"Ann","family":"Donze","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan Renaud","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Bryowsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"793","published-online":{"date-parts":[[2007,5,1]]},"reference":[{"key":"1","unstructured":"Van Overmeire, B., & Chemtob, S. 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Necrotizing enterocolitis and gastrointestinal complications after indomethacin therapy and surgical ligation in premature infants with patent ductus arteriosus. <i>Journal of Perinatology, 23<\/i>, 286\u2013290.","DOI":"10.1038\/sj.jp.7210911"},{"key":"4","doi-asserted-by":"crossref","unstructured":"Van Overmeire, B., Follens, I., Hartmann, S. A., Creten, W., & Van Acker, K. J. (1997). Treatment of patent ductus arteriosus with ibuprofen. <i>Archives of Disease in Childhood. Fetal and Neonatal Edition, 763<\/i>, 179\u2013184.","DOI":"10.1136\/fn.76.3.F179"},{"key":"5","doi-asserted-by":"crossref","unstructured":"Lago, P., Bettiol, E., Salvadori, S., Pitassi, I., Vianello, A., Chiandetti, L., et al. (2002). 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