{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:21:15Z","timestamp":1780636875703,"version":"3.54.1"},"reference-count":31,"publisher":"Springer Publishing Company","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatal Network"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:p>Meconium aspiration syndrome (MAS) is one of the most common conditions associated with aspiration during the newborn period. MAS can be defined as respiratory distress in a neonate born through meconium-stained amniotic fluid (MSAF) with symptoms that cannot otherwise be explained. It can be characterized by early onset of respiratory distress in term and near-term infants delivered through MSAF. Early presentation includes respiratory symptoms such as respiratory distress, poor lung compliance, hypoxemia, and radiographic findings of hyperinflation and patchy opacifications. This article discusses the pathophysiology of MAS, historical and current prevention strategies, current management strategies, and prognoses for infants born through MSAF.<\/jats:p>","DOI":"10.1891\/0730-0832.27.2.81","type":"journal-article","created":{"date-parts":[[2011,11,16]],"date-time":"2011-11-16T14:42:56Z","timestamp":1321454576000},"page":"81-87","source":"Crossref","is-referenced-by-count":9,"title":["Meconium Aspiration Syndrome"],"prefix":"10.1891","volume":"27","author":[{"given":"Jeanne Ray","family":"Wiedemann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Saugstad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Barnes-Powell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Duran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"793","published-online":{"date-parts":[[2008,3,1]]},"reference":[{"key":"1","unstructured":"Clark, D. A., & Clark, M. B. (2004). Meconium Aspiration Syndrome. Retrieved March 15, 2006, from <a target=\"_blank\" href='http:\/\/www.emedicine.com\/PED\/topic768.htm'>http:\/\/www.emedicine.com\/PED\/ topic768.htm<\/a>"},{"key":"2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.clp.2005.11.014","article-title":"Intrapartum and postdelivery management of infants born to mothers with meconium-stained amniotic fluid: Evidence-based recommendations.","volume":"33","author":"S. Velaphi","year":"2006","journal-title":"Clinics in Perinatology"},{"key":"3","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1053\/siny.2001.0051","article-title":"Handling the meconium-stained infant.","volume":"6","author":"T. Wiswell","year":"2001","journal-title":"Seminars in Neonatology"},{"key":"4","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1067\/mob.2001.116828","article-title":"Severe meconium aspiration syndrome is not caused by aspiration of meconium.","volume":"186","author":"A Ghidini","year":"2001","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"5","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.clp.2004.03.020","article-title":"Controversies in the treatment of meconium aspiration syndrome.","volume":"31","author":"S. Gelfand","year":"2004","journal-title":"Clinics of Perinatology"},{"key":"6","unstructured":"Lee, J. S., Stark, A. R. (2004). Meconium aspiration. In J. P. Cloherty, E. C. Eichenwald, & A. R. Stark (Eds.), <i>Manual of neonatal care.<\/i> (5th ed., pp. 402\u2013406). Philadelphia: Lippincott Williams & Wilkins,"},{"key":"7","unstructured":"Whitsett, J. A., Rice, W. R., Warner, B. B., Wert, S. E., & Pryhuber, G. S. (2005). Acute respiratory disorders. In <i>Avery's neonatology: Pathophysiology and management of the newborn<\/i> (6th ed., pp. 553\u2013577). Philadelphia: Lippincott Williams & Wilkins."},{"key":"8","article-title":"Respiratory distress.","volume-title":"Core curriculum for neonatal intensive care","author":"K Zukowsky","year":"2004"},{"key":"9","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/S0022-3476(74)80358-6","article-title":"Meconium aspiration in infants\u2014A prospective study.","volume":"85","author":"G. Gregory","year":"1974","journal-title":"The Journal of Pediatrics"},{"key":"10","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/0002-9378(75)90585-2","article-title":"Tracheal suction in meconium aspiration.","volume":"122","author":"P. Ting","year":"1975","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"11","first-page":"349","article-title":"Combined obstetric and pediatric approach to prevent meconium aspiration syndrome.","volume":"71","author":"B. Carson","year":"1976","journal-title":"Journal of Obstetrics and Gynecology"},{"issue":"2","key":"12","article-title":"Summary of major changes to the 2005 AAP\/AHA emergency cardiovascular care guidelines for neonatal resuscitation: Translating evidence-based guidelines to the NRP.","volume":"15","author":"Association American Heart","year":"2005","journal-title":"NRP Instructor Update"},{"key":"13","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/S0031-3955(16)38618-7","article-title":"Meconium staining and the meconium aspiration syndrome.","volume":"40","author":"T. Wiswell","year":"1993","journal-title":"Pediatric Clinics of North America"},{"key":"14","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0002-9378(92)91856-6","article-title":"Meconium aspiration syndrome: Reflections on a murky subject.","volume":"166","author":"V. Katz","year":"1992","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"15","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0031-3955(05)70025-0","article-title":"Meconium-stained amniotic fluid and the meconium aspiration syndrome: An update.","volume":"4","author":"G. Cleary","year":"1998","journal-title":"Pediatric Clinics of North America"},{"key":"16","doi-asserted-by":"crossref","DOI":"10.1542\/peds.103.4.e56","article-title":"An advisory statement from the Pediatric Working Group of the International Liaison Committee on Resuscitation.","volume":"103","author":"J. Kattwinkel","year":"1999","journal-title":"Pediatrics"},{"key":"17","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1542\/peds.2006-0219","article-title":"2005 American Heart Association (AHA) guidelines for cardiopulmonary resuscitation (CPR) and emergency cardiovascular care (ECC) of pediatric and neonatal patients: Pediatric basic life support.","volume":"117","author":"Association American Heart","year":"2006","journal-title":"Pediatrics"},{"issue":"3","key":"18","article-title":"International guidelines for neonatal resuscitation: An excerpt from the Guidelines 2000 for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care: International Consensus on Science. Contributors and reviewers for the Neonatal Resuscitation Guidelines.","volume":"106","author":"S. Niermeyer","year":"2000","journal-title":"Pediatrics"},{"key":"19","unstructured":"International Liaison Committee on Resusitation. (2005) Intermational consensus conference on cardiopulmonary resusitation and emergency cardiovascular care: Part 7: Neonatal resusitation. <i>Circulation<\/i>, 112, III-91\u2013III-99."},{"key":"20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clp.2005.11.004","article-title":"Delivery room resuscitation past, present, and the future.","volume":"33","author":"J. Perlman","year":"2006","journal-title":"Clinics of Perinatology"},{"key":"21","doi-asserted-by":"crossref","unstructured":"Hofmeyr, G. (2002). Amnioinfusion for meconium-stained liquor in labour. <i>Cochrane Database of Systematic Reviews, 1<\/i>, CD000014.","DOI":"10.1002\/14651858.CD000014"},{"key":"22","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1056\/NEJMoa050223","article-title":"Amnioinfusion for the prevention of meconium aspiration syndrome.","volume":"353","author":"W. Fraser","year":"2005","journal-title":"The New England Journal of Medicine"},{"issue":"9434","key":"23","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0140-6736(04)16852-9","article-title":"Oropharyngeal and nasopharyngeal suctioning of meconium-stained neonates before delivery of their shoulders: Multicentre, randomised controlled trial.","volume":"364","author":"N. Vain","year":"2004","journal-title":"Lancet"},{"key":"24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1542\/peds.105.1.1","article-title":"Delivery room management of the apparently vigorous meconium-stained neonate: Results of the multicenter, international collaborative trial.","volume":"105","author":"T. Wiswell","year":"2000","journal-title":"Pediatrics"},{"key":"25","doi-asserted-by":"crossref","unstructured":"Halliday, H. L., & Sweet, D. (2001). Endotracheal intubation at birth for preventing morbidity and mortality in vigorous, meconium-stained infants born at term. <i>Cochrane Database of Systematic Reviews, 1<\/i>, CD0005000.","DOI":"10.1002\/14651858.CD000500"},{"key":"26","first-page":"288","article-title":"Neonatal resuscitation.","volume":"48","author":"T. Wiswell","year":"2003","journal-title":"Respiratory Care"},{"key":"27","unstructured":"Kattwinkel, J. (2006). <i>Textbook of neonatal resusitation<\/i>, (5th ed., pp. 1-1\u20132-26). Elk Grove Village, Illinois: AAD\/AHA."},{"key":"28","first-page":"586","article-title":"Comparison of high-frequency flow interruption ventilation and hyperventilation in persistent pulmonary hypertension of the newborn.","volume":"46","author":"K. Jirapaet","year":"2001","journal-title":"Respiratory Care"},{"key":"29","unstructured":"Soll, R. F., & Dargaville, P. (2007). Surfactant for meconium aspiration syndrome in full term infants. <i>Cochrane Database of Systematic Reviews, 2<\/i>, CD002054."},{"key":"30","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1542\/peds.97.1.48","article-title":"Surfactant replacement therapy for meconium aspiration syndrome.","volume":"97","author":"R. Findlay","year":"1996","journal-title":"Pediatrics"},{"key":"31","doi-asserted-by":"crossref","unstructured":"Cullen, A. B., Wolfson, M. R., & Shaffer, T. H. (2002). Impact of mechanical ventilation on the developing airway. Retrieved October 10, 2006, from <a target=\"_blank\" href='http:\/\/www.neoreviews.com'>http:\/\/www.neoreviews.com<\/a>","DOI":"10.1542\/neo.3-7-e137"}],"container-title":["Neonatal Network"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1891\/0730-0832.27.2.81","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T19:27:45Z","timestamp":1639682865000},"score":1,"resource":{"primary":{"URL":"http:\/\/connect.springerpub.com\/lookup\/doi\/10.1891\/0730-0832.27.2.81"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":31,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2008,3,1]]},"published-print":{"date-parts":[[2008,3]]}},"alternative-id":["10.1891\/0730-0832.27.2.81"],"URL":"https:\/\/doi.org\/10.1891\/0730-0832.27.2.81","relation":{},"ISSN":["0730-0832","1539-2880"],"issn-type":[{"value":"0730-0832","type":"print"},{"value":"1539-2880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3]]}}}