{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T08:06:02Z","timestamp":1666166762168},"reference-count":13,"publisher":"Springer Publishing Company","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatal Network"],"published-print":{"date-parts":[[2008,9]]},"abstract":"LATE-ONSET SEPSIS AMONG very low birth weight (VLBW) and extremely low birth weight (ELBW) neonates is a troubling occurrence. The most recently published data from the National Nosocomial Infection Surveillance system documents 5.4 umbilical- and central line\u2013related bloodstream infections (BSIs) per 1,000 catheter days in infants weighing between 1,001 and 1,500 g.1<\/jats:sup> For infants weighing 1,000 g or less, the rate is 9.1 infections per 1,000 catheter days. A variety of factors, including prematurity and related relative immunocompromise, altered skin integrity, and multiple invasive procedures, places VLBW and ELBW neonates at risk for infection. Tunneled central catheters or peripherally inserted central catheters (PICCs) clearly add to the risk of infection in these vulnerable patients. In a point prevalence survey of a network of 29 NICUs, researchers found that coagulase-negative Staphylococcus (CoNS) was the causative organism in nearly half (48.3 percent) of the documented bloodstream infections.2<\/jats:sup> Vancomycin prophylaxis is a potential strategy for the prevention of late-onset sepsis associated with CoNS. This column explores the efficacy and safety of this strategy.<\/jats:p>","DOI":"10.1891\/0730-0832.27.5.351","type":"journal-article","created":{"date-parts":[[2011,11,16]],"date-time":"2011-11-16T09:41:41Z","timestamp":1321436501000},"page":"351-354","source":"Crossref","is-referenced-by-count":2,"title":["Vancomycin Prophylaxis for Late-Onset Sepsis in Very Low and Extremely Low Birth Weight Neonates"],"prefix":"10.1891","volume":"27","author":[{"given":"Susan Givens","family":"Bell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"793","published-online":{"date-parts":[[2008,9,1]]},"reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"National Nosocomial Infection Surveillance System. (2004). National Nosocomial Infection Surveillance (NNIS) system report, data summary from January 1992 through June 2004, issued October 2004. American Journal of Infection Control, 32<\/i>, 470\u2013485.","DOI":"10.1016\/j.ajic.2004.10.001"},{"key":"2","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1067\/mpd.2001.119442","article-title":"Prevalence of nosocomial infections in neonatal intensive care unit patients: Results from the first national point-prevalence survey.","volume":"139","author":"A. Sohn","year":"2001","journal-title":"The Journal of Pediatrics"},{"key":"3","doi-asserted-by":"crossref","unstructured":"Craft, A. P., Finer, N. N., & Barrington, K. J. (2000). Vancomycin for prophylaxis against sepsis in preterm neonates. Cochrane Database of Systematic Reviews, CD001971<\/i>. http:\/\/www.nichd.nih.gov\/cochrane\/craft\/craft.htm<\/a>","DOI":"10.1002\/14651858.CD001971"},{"key":"4","doi-asserted-by":"crossref","unstructured":"Garland, J. S., Alex, C. P., Henrickson, K. J., McAuliffe, T. L., & Maki, D. G. (2005). A vancomycin-heparin lock solution for prevention of nosocomial bloodstream infection in critically ill neonates with peripherally inserted central venous catheters: A prospective, randomized trial. Pediatrics, 116<\/i>, e198\u2013e205.","DOI":"10.1542\/peds.2004-2674"},{"key":"5","unstructured":"Centers for Disease Control and Prevention. (2004). 12 steps to prevent antimicrobial resistance among hospitalized children.<\/i> Retrieved May 7, 2007, from http:\/\/www.cdc.gov\/drugresistance\/healthcare\/children\/12Steps_Children.pdf<\/a>"},{"key":"6","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1097\/00006454-199803000-00002","article-title":"Selective use of vancomycin to prevent coagulase negative staphylococcal nosocomial bacteremia in high risk very low birth weight infants.","volume":"17","author":"R. Baier","year":"1998","journal-title":"The Pediatric Infectious Disease Journal"},{"key":"7","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0195-6701(97)90146-8","article-title":"Low dose vancomycin prophylaxis reduces coagulase negative staphylococcal bacteremia in very low birth weight infants.","volume":"37","author":"R. Cooke","year":"1997","journal-title":"The Journal of Hospital Infection"},{"key":"8","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0022-3476(94)70207-1","article-title":"Prevention of gram positive sepsis in infants weighing less than 1500 grams.","volume":"125","author":"M. Kacica","year":"1994","journal-title":"The Journal of Pediatrics"},{"key":"9","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1055\/s-2007-1025215","article-title":"Pr\u00e4ventive antibiotika gabe zur verhinderung nosokomialer septikamien bei sehr kleinen fruhgeborenen (VLBW infants).","volume":"205","author":"J. Moller","year":"1993","journal-title":"Klinische Pediatrics"},{"key":"10","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0022-3476(94)70208-X","article-title":"Prevention of central venous catheter related coagulase negative staphylococcal sepsis in neonates.","volume":"125","author":"P. Spafford","year":"1994","journal-title":"The Journal of Pediatrics"},{"key":"11","first-page":"499","article-title":"Interpreting measures of treatment effect","volume":"59","author":"H. Davies","year":"1998","journal-title":"Hospital Medicine<\/i>"},{"key":"12","unstructured":"Davies, H. T. O. (2001). What are confidence intervals? What is...? Series, 3<\/i>(1), 1\u20138. Retrieved May 16, 2008 from http:\/\/www.evidence-based-medicine.co.uk\/ebmfiles\/WhatareConfInter.pdf<\/a>"},{"key":"13","unstructured":"American College of Physicians-American Society of Internal Medicine. (2001). Primer on statistical significance and P<\/i> values. Effective Clinical Practice, 4<\/i>, 183\u2013184."}],"container-title":["Neonatal Network"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1891\/0730-0832.27.5.351","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T14:14:20Z","timestamp":1568816060000},"score":1,"resource":{"primary":{"URL":"http:\/\/connect.springerpub.com\/lookup\/doi\/10.1891\/0730-0832.27.5.351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9]]},"references-count":13,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2008,9,1]]},"published-print":{"date-parts":[[2008,9]]}},"alternative-id":["10.1891\/0730-0832.27.5.351"],"URL":"https:\/\/doi.org\/10.1891\/0730-0832.27.5.351","relation":{},"ISSN":["0730-0832","1539-2880"],"issn-type":[{"value":"0730-0832","type":"print"},{"value":"1539-2880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,9]]}}}