{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:33:14Z","timestamp":1792647194001,"version":"4.5.0"},"reference-count":31,"publisher":"Springer Publishing Company","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatal Network"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>Despite comprehensive antenatal screening recommendations and inexpensive treatment, congenital syphilis has long been and continues to be a public health concern, causing substantial morbidity and adverse outcomes. The following article reviews syphilis etiology and presentation, clinical disease, laboratory diagnosis, and treatment of congenital syphilis. A case will be presented describing a 31-week male infant exposed to infectious syphilis <jats:italic>in utero<\/jats:italic>. The neonate presented with classic signs of infection at birth. After initial serology testing of the infant, appropriate treatment was commenced. The infant received crystalline penicillin G for a period of ten days in consultation with pediatric infectious disease specialists. As expected, the infant\u2019s rapid plasma reagin (RPR) titers declined by three and six months of age. An interdisciplinary approach provided safe and optimal care for this infant. He was discharged, stable, and thriving at 38 weeks corrected age. Long-term multidisciplinary management and follow-up were arranged.<\/jats:p>","DOI":"10.1891\/0730-0832.30.5.320","type":"journal-article","created":{"date-parts":[[2011,11,16]],"date-time":"2011-11-16T09:46:08Z","timestamp":1321436768000},"page":"320-328","source":"Crossref","is-referenced-by-count":14,"title":["Resurgence of Congenital Syphilis: Diagnosis and Treatment"],"prefix":"10.1891","volume":"30","author":[{"given":"Tara","family":"Follett","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise F.","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"793","published-online":{"date-parts":[[2011,1,1]]},"reference":[{"issue":"2","key":"2019091812454392000_30.5.320.1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1128\/CMR.12.2.187","article-title":"Syphilis: Review with emphasis on clinical, epidemiologic, and some biologic features","volume":"12","year":"1999","journal-title":"Clinical Microbiology Reviews"},{"key":"2019091812454392000_30.5.320.2","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/952493"},{"issue":"14","key":"2019091812454392000_30.5.320.3","first-page":"413","article-title":"Congenital syphilis\u2014United States, 2003\u20132008","volume":"59","author":"Centers for Disease Control and Prevention","year":"2010","journal-title":"Morbidity and Mortality Weekly Report"},{"issue":"1","key":"2019091812454392000_30.5.320.4","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/0891-5245(92)90060-H","article-title":"Congenital syphilis: Old disease, new resurgence","volume":"6","year":"1992","journal-title":"Journal of Pediatric Health Care"},{"issue":"6","key":"2019091812454392000_30.5.320.5","first-page":"424","article-title":"The prevention and management of congenital syphilis: An overview and recommendations","volume":"82","year":"2004","journal-title":"Bulletin of the World Health Organization"},{"key":"2019091812454392000_30.5.320.6","first-page":"126","article-title":"Congenital syphilis","volume":"76","year":"1998","journal-title":"Bulletin of the World Health Organization"},{"issue":"6","key":"2019091812454392000_30.5.320.7","first-page":"417","article-title":"Antenatal syphilis control: People, programmes, policies and politics","volume":"82","year":"2004","journal-title":"Bulletin of the World Health Organization"},{"key":"2019091812454392000_30.5.320.8","unstructured":"World Health Organization. (2007). The global elimination of congenital syphilis: Rationale and strategy for action. Retrieved from http:\/\/whqlibdoc.who.int\/publications\/2007\/9789241595858_eng.pdf"},{"key":"2019091812454392000_30.5.320.9","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001143"},{"key":"2019091812454392000_30.5.320.10","unstructured":"Centers for Disease Control and Prevention. (2007). Syphilis\u2014CDC fact sheet. Retrieved from http:\/\/www.cdc.gov\/std\/syphilis\/STDFact-Syphilis.htm"},{"key":"2019091812454392000_30.5.320.11","unstructured":"Centers for Disease Control and Prevention. (2011). Syphilis profiles 2009\u2014United States. Retrieved from http:\/\/www.cdc.gov\/std\/syphilis2009\/Syphilis-2009-All-Profiles.pdf"},{"key":"2019091812454392000_30.5.320.12","unstructured":"Public Health Agency of Canada. (2010). Syphilis. Canadian guidelines on sexually transmitted infections. 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An old disease, a contemporary perinatal problem","volume":"21","year":"1992","journal-title":"Journal of Obstetric, Gynecologic, and Neonatal Nursing"},{"issue":"6","key":"2019091812454392000_30.5.320.17","first-page":"433","article-title":"Maternal syphilis: Pathophysiology and treatment","volume":"82","year":"2004","journal-title":"Bulletin of the World Health Organization"},{"issue":"1","key":"2019091812454392000_30.5.320.18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/CMR.8.1.1","article-title":"Laboratory diagnosis and interpretation of tests for syphilis","volume":"8","year":"1995","journal-title":"Clinical Microbiology Reviews"},{"issue":"6","key":"2019091812454392000_30.5.320.19","first-page":"439","article-title":"Diagnostic tools for preventing and managing maternal and congenital syphilis: An overview","volume":"82","year":"2004","journal-title":"Bulletin of the World Health Organization"},{"key":"2019091812454392000_30.5.320.20","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-010-0900-8"},{"key":"2019091812454392000_30.5.320.21","doi-asserted-by":"publisher","DOI":"10.1086\/500406"},{"key":"2019091812454392000_30.5.320.22","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2008.04.042"},{"key":"2019091812454392000_30.5.320.23","unstructured":"American Academy of Pediatrics. 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Baltimore, MD: Lippincott Williams & Wilkins."},{"key":"2019091812454392000_30.5.320.31","first-page":"822","volume-title":"Neonatal-perinatal medicine","volume":"Vols. 1\u20132","year":"2010"}],"container-title":["Neonatal Network"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1891\/0730-0832.30.5.320","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T15:45:37Z","timestamp":1568821537000},"score":1,"resource":{"primary":{"URL":"http:\/\/connect.springerpub.com\/lookup\/doi\/10.1891\/0730-0832.30.5.320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":31,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2011,1,1]]},"published-print":{"date-parts":[[2011]]}},"alternative-id":["10.1891\/0730-0832.30.5.320"],"URL":"https:\/\/doi.org\/10.1891\/0730-0832.30.5.320","relation":{},"ISSN":["0730-0832","1539-2880"],"issn-type":[{"value":"0730-0832","type":"print"},{"value":"1539-2880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}