{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:59:21Z","timestamp":1770512361708,"version":"3.49.0"},"reference-count":42,"publisher":"Springer Publishing Company","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatal Network"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:title>A<jats:sc>BSTRACT<\/jats:sc><\/jats:title><jats:p>Newborns, and especially premature newborns, are at significant risk for developing hypotension in the first week or two after birth. The etiology of hypotension in the newborn may vary, but the very low birth weight and extremely low birth weight preterm infants are less likely to respond to conventional cardiovascular support when they develop hypotension. This article reviews the least conventional treatment using hydrocortisone for hypotension that is refractory to conventional volume replacement and\/or vasopressor medications with the underlying assumption that sick and premature newborns have a relative or measured adrenal insufficiency. The addition of hydrocortisone in the treatment of hypotension in the newborn is becoming more common but is not universally advocated. However, the supportive evidence is growing, and, as reviewed, use of hydrocortisone requires judicious and cautious regard.<\/jats:p>","DOI":"10.1891\/0730-0832.34.1.46","type":"journal-article","created":{"date-parts":[[2015,8,6]],"date-time":"2015-08-06T23:45:27Z","timestamp":1438904727000},"page":"46-51","source":"Crossref","is-referenced-by-count":16,"title":["Hydrocortisone for Treatment of Hypotension in the Newborn"],"prefix":"10.1891","volume":"34","author":[{"given":"Patricia J.","family":"Johnson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"793","published-online":{"date-parts":[[2015,1,1]]},"reference":[{"key":"2019091814251530000_34.1.46.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2014.06.009"},{"key":"2019091814251530000_34.1.46.2","doi-asserted-by":"publisher","DOI":"10.1136\/fn.88.6.F450"},{"key":"2019091814251530000_34.1.46.3","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7210563"},{"key":"2019091814251530000_34.1.46.4","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211211"},{"key":"2019091814251530000_34.1.46.5","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211193"},{"key":"2019091814251530000_34.1.46.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2010.04.002"},{"key":"2019091814251530000_34.1.46.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2005.04.035"},{"key":"2019091814251530000_34.1.46.8","unstructured":"Adcock LM . Etiology, clinical manifestations, and evaluation of neonatal shock. UpToDate Web site. http:\/\/www.uptodate.com\/contents\/etiology-clinical-manifestations-and-evaluation-of-neonatal-shock. Updated July 18, 2014. Accessed May 30, 2014."},{"key":"2019091814251530000_34.1.46.9","doi-asserted-by":"publisher","DOI":"10.1542\/neo.8-1-e32"},{"key":"2019091814251530000_34.1.46.10","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211225"},{"key":"2019091814251530000_34.1.46.11","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2009.126"},{"key":"2019091814251530000_34.1.46.12","doi-asserted-by":"crossref","unstructured":"McClean CW , Cayabyab RG , Noori S , Seri I . Cerebral circulation and hypotension in the premature infant: Diagnosis and treatment. In: Perlman JM , Polin RA , eds. Neonatology Questions and Controversies: Neurology. Philadelphia, PA: Saunders\/Elsevier; 2008:3\u201326.","DOI":"10.1016\/B978-1-4160-3157-4.10002-1"},{"key":"2019091814251530000_34.1.46.13","unstructured":"Vargo L , Seri I . The Management of Hypotension in the Very-Low-Birth-Weight Infant: Guideline for Practice. Glenview, IL: National Association of Neonatal Nurse Practitioners; 2011."},{"key":"2019091814251530000_34.1.46.14","first-page":"152","article-title":"Hypotension in the neonate","volume":"3","year":"2002","journal-title":"NeoReviews"},{"key":"2019091814251530000_34.1.46.15","doi-asserted-by":"publisher","DOI":"10.1053\/siny.2000.0034"},{"key":"2019091814251530000_34.1.46.16","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1038\/sj.jp.7211464","article-title":"Management of hypotension and low systemic blood flow in the very low birth weight neonate during the first postnatal week","volume":"26","year":"2006","journal-title":"J Perinatol"},{"key":"2019091814251530000_34.1.46.17","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-3782(99)00038-9"},{"key":"2019091814251530000_34.1.46.18","doi-asserted-by":"publisher","DOI":"10.1542\/neo.5-3-e109"},{"key":"2019091814251530000_34.1.46.19","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-2057"},{"key":"2019091814251530000_34.1.46.20","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211774"},{"key":"2019091814251530000_34.1.46.21","doi-asserted-by":"crossref","first-page":"e22","DOI":"10.1542\/neo.5-1-e22","article-title":"Pharmacology review: the use of dobutamine in the treatment of neonatal cardiovascular compromise","volume":"5","year":"2004","journal-title":"NeoReviews"},{"key":"2019091814251530000_34.1.46.22","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2002.021972"},{"key":"2019091814251530000_34.1.46.23","doi-asserted-by":"crossref","unstructured":"Ibrahim H , Sinha IP , Subhear NV . Corticosteroids for treating hypotension in preterm infants. Cochrane Database Syst Rev. 2011;(12):CD003662.","DOI":"10.1002\/14651858.CD003662.pub4"},{"key":"2019091814251530000_34.1.46.24","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1542\/peds.92.5.715","article-title":"Glucocorticoid-responsive hypotension in extremely low birth weight newborns","volume":"92","year":"1993","journal-title":"Pediatrics"},{"key":"2019091814251530000_34.1.46.25","doi-asserted-by":"publisher","DOI":"10.1542\/peds.107.5.1070"},{"key":"2019091814251530000_34.1.46.26","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2008.16"},{"key":"2019091814251530000_34.1.46.27","doi-asserted-by":"publisher","DOI":"10.1136\/fn.81.3.F171"},{"key":"2019091814251530000_34.1.46.28","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2009.24"},{"key":"2019091814251530000_34.1.46.29","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31817603ba"},{"key":"2019091814251530000_34.1.46.30","doi-asserted-by":"crossref","unstructured":"Barrett EJ . The adrenal gland. In: Boron WF , Boulpaep EL , eds. Medical Physiology. 2nd ed. Philadelphia, PA: Saunders; 2012:1057\u20131073.","DOI":"10.1016\/B978-1-4160-3115-4.50053-6"},{"key":"2019091814251530000_34.1.46.31","doi-asserted-by":"crossref","unstructured":"Stewart PM , Krone NP . The adrenal cortex. In: Melmed S , Polonsky KS , Larsen PR , Kronenberg HM , Williams , eds. Williams Textbook of Endocrinology. 12th ed. Philadelphia, PA: Saunders; 2011:479\u2013544.","DOI":"10.1016\/B978-1-4377-0324-5.00015-8"},{"key":"2019091814251530000_34.1.46.32","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.4.9901075"},{"key":"2019091814251530000_34.1.46.33","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-0661"},{"key":"2019091814251530000_34.1.46.34","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2008.190"},{"key":"2019091814251530000_34.1.46.35","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-0869"},{"key":"2019091814251530000_34.1.46.36","unstructured":"Lexicomp Online. Hydrocortisone (systemic) pediatric and neonatal Lexi-drugs. http:\/\/online.lexi.com\/lco\/action\/doc\/retrieve\/docid\/pdh_f\/2892255. Accessed July 2, 2014."},{"key":"2019091814251530000_34.1.46.37","unstructured":"Stokowski LA . Controversies in using steroids: from fetus to newborn. Medscape Multispecialty Web site. http:\/\/www.medscape.org\/viewarticle\/481188. Published 2004. Accessed October 1, 2014."},{"key":"2019091814251530000_34.1.46.38","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1542\/peds.95.5.682","article-title":"Invasive fungal dermatitis in the \u22651000-gram neonate","volume":"95","year":"1995","journal-title":"Pediatrics"},{"key":"2019091814251530000_34.1.46.39","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7210699"},{"key":"2019091814251530000_34.1.46.40","first-page":"315642","article-title":"Postnatal corticosteroids for prevention and treatment of chronic lung disease in the preterm newborn","volume":"2012","year":"2012","journal-title":"Int J Pediatr"},{"key":"2019091814251530000_34.1.46.41","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-3158"},{"key":"2019091814251530000_34.1.46.42","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-2252"}],"container-title":["Neonatal Network"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1891\/0730-0832.34.1.46","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T01:36:09Z","timestamp":1653010569000},"score":1,"resource":{"primary":{"URL":"http:\/\/connect.springerpub.com\/lookup\/doi\/10.1891\/0730-0832.34.1.46"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":42,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,1,1]]},"published-print":{"date-parts":[[2015]]}},"alternative-id":["10.1891\/0730-0832.34.1.46"],"URL":"https:\/\/doi.org\/10.1891\/0730-0832.34.1.46","relation":{},"ISSN":["0730-0832","1539-2880"],"issn-type":[{"value":"0730-0832","type":"print"},{"value":"1539-2880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}