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Although there are several proposed risk-reduction strategies, one intervention gaining support is the administration of prophylactic enteral probiotics. Regardless of growing evidentiary support and a benign safety profile, neonatal providers have yet to embrace this therapy. This article provides an overview of the proposed benefits of probiotics, focusing on their role as a NEC prevention strategy. A review of several sentinel research studies targeting preterm, VLBW, and ELBW infants is provided. Considerations for ongoing research are reviewed. Finally, two evidence-based NEC prevention probiotics protocols are presented.<\/jats:p>","DOI":"10.1891\/0730-0832.34.2.83","type":"journal-article","created":{"date-parts":[[2015,8,6]],"date-time":"2015-08-06T23:45:27Z","timestamp":1438904727000},"page":"83-101","source":"Crossref","is-referenced-by-count":2,"title":["Probiotics for Preterm Infants: A Premature or Overdue Necrotizing Enterocolitis Prevention Strategy?"],"prefix":"10.1891","volume":"34","author":[{"given":"Sharon","family":"Anderson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"793","published-online":{"date-parts":[[2015,1,1]]},"reference":[{"key":"2019091814251698000_34.2.83.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1005408"},{"key":"2019091814251698000_34.2.83.2","first-page":"2759","article-title":"Strategies to prevent necrotising enterocolitis","volume":"123","year":"2010","journal-title":"Chin Med J (Engl)"},{"key":"2019091814251698000_34.2.83.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2009.02.013"},{"key":"2019091814251698000_34.2.83.4","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.60.050207.092824"},{"key":"2019091814251698000_34.2.83.5","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200868090-00004"},{"key":"2019091814251698000_34.2.83.6","unstructured":"U.S. Department of Health and Human Services, National Institutes of Health, National Institute for Child Health and Human Development Neonatal Research Network. Preterm birth complications: necrotizing enterocolitis. http:\/\/www.nichd.nih.gov\/research\/supported\/Pages\/nrn.aspx. Published October 31, 2013. Accessed May 20, 2014."},{"key":"2019091814251698000_34.2.83.7","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197801000-00001"},{"key":"2019091814251698000_34.2.83.8","unstructured":"Modified Bell\u2019s staging criteria for necrotizing enterocolitis. MedicalCriteria.com Web site. http:\/\/www.medicalcriteria.com\/criteria\/ped_nec.htm. Published October 23, 2010. 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