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Pulmonary vasodilation has the potential to overcome the cycle of hypoxia and acidosis, improving outcome in these infants. Oxygen and inhaled nitric oxide represent the foundation of therapy. Tertiary pulmonary vasodilators represent a greater challenge, selecting between therapies that include prostanoids, sildenafil, and milrinone. Variable levels of evidence exist for each agent. Thorough review of available data informing efficacy and adverse effects contributes to the development of an informed approach to neonates with refractory PPHN.<\/jats:p>","DOI":"10.1891\/0730-0832.36.3.160","type":"journal-article","created":{"date-parts":[[2017,5,12]],"date-time":"2017-05-12T03:25:53Z","timestamp":1494559553000},"page":"160-170","source":"Crossref","is-referenced-by-count":3,"title":["Treatment of Persistent Pulmonary Hypertension of the Newborn: Use of Pulmonary Vasodilators in Term 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