{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T05:19:04Z","timestamp":1777439944455,"version":"3.51.4"},"reference-count":29,"publisher":"Springer Publishing Company","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatal Network"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:p>Gestational alloimmune liver disease (GALD) is initiated by maternal antibodies that attack fetal hepatocytes. The fetal  immune response to the antibodies causes liver damage. The incidence of GALD is four per 100,000 live births in the United States. Frequently, liver injury leads to fetal loss or neonatal demise; nonetheless, the presentation of GALD has a wide range of severity. Survival rates have increased from 20 to 80 percent changes in treatment and understanding of GALD. Current treatment is focused on supportive care with intravenous immunoglobulin (IVIG) and exchange transfusions. Mortality risk is positively associated with the timing of diagnosis. Although there has been an increase in understanding this disease, the discovery of the specific alloantigen is still needed. Relevant embryology, pathophysiology, clinical manifestations, diagnosis, medical treatment, and prognosis are discussed to aid health care professionals in the early identification and treatment for the neonate and family unit.<\/jats:p>","DOI":"10.1891\/0730-0832.37.5.271","type":"journal-article","created":{"date-parts":[[2018,9,12]],"date-time":"2018-09-12T17:08:18Z","timestamp":1536772098000},"page":"271-280","source":"Crossref","is-referenced-by-count":15,"title":["Gestational Alloimmune Liver Disease: A Case Study"],"prefix":"10.1891","volume":"37","author":[{"given":"Oksana","family":"Kasko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erica","family":"Klose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ganapathy","family":"Rama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Desi","family":"Newberry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Jnah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"793","published-online":{"date-parts":[[2018,9,1]]},"reference":[{"key":"2019091816140626000_37.5.271.1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001569"},{"key":"2019091816140626000_37.5.271.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.01.010"},{"key":"2019091816140626000_37.5.271.3","doi-asserted-by":"publisher","DOI":"10.2350\/12-02-1155-OA.1"},{"key":"2019091816140626000_37.5.271.4","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-0568"},{"key":"2019091816140626000_37.5.271.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jceh.2013.10.004"},{"key":"2019091816140626000_37.5.271.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2014.09.030"},{"key":"2019091816140626000_37.5.271.7","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.13090"},{"issue":"5","key":"2019091816140626000_37.5.271.8","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1111\/hepr.12381","article-title":"Neonatal liver failure owing to gestational alloimmune liver disease without iron overload: gestational alloimmune liver disease in neonate","volume":"45","year":"2015","journal-title":"Hepatol Res"},{"key":"2019091816140626000_37.5.271.9","doi-asserted-by":"publisher","DOI":"10.1002\/pd.3887"},{"key":"2019091816140626000_37.5.271.10","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1329901"},{"key":"2019091816140626000_37.5.271.11","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2012.9"},{"key":"2019091816140626000_37.5.271.12","doi-asserted-by":"publisher","DOI":"10.3233\/NPM-1577113"},{"key":"2019091816140626000_37.5.271.13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2005.00357.x"},{"key":"2019091816140626000_37.5.271.14","doi-asserted-by":"publisher","DOI":"10.1542\/neo.17-3-e154"},{"key":"2019091816140626000_37.5.271.15","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4232"},{"key":"2019091816140626000_37.5.271.16","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/7432859"},{"key":"2019091816140626000_37.5.271.17","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcpc1404334"},{"issue":"12","key":"2019091816140626000_37.5.271.18","first-page":"1274","article-title":"Neonatal hemochromatosis. Case series from Bahrain","volume":"34","year":"2013","journal-title":"Saudi Med J"},{"key":"2019091816140626000_37.5.271.19","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/650916"},{"key":"2019091816140626000_37.5.271.20","doi-asserted-by":"publisher","DOI":"10.1002\/lt.24433"},{"key":"2019091816140626000_37.5.271.21","unstructured":"Diab Y , Luchtman-Jones L . Hematologic and oncologic problems in the fetus and neonate. In: Martin RJ , Fanaroff AA , Walsh MC , eds. Neonatal-Perinatal Medicine: Diseases of the Fetus and Infant. 10th ed. Philadelphia, PA: Elsevier Saunders; 2015:1294\u20131343."},{"key":"2019091816140626000_37.5.271.22","unstructured":"Diehl-Jones W , Fraser D . Hematologic disorders. In: Verklan MT , Walden M , eds. Core Curriculum for Neonatal Intensive Care Nursing. 5th ed. St. Louis, MO: Elsevier Saunders; 2015:662\u2013688."},{"key":"2019091816140626000_37.5.271.23","unstructured":"Moore KL , Persaud TVN , Torchia MG . The Developing Human: Clinically Oriented Embryology. 10th ed. Philadelphia, PA: Elsevier; 2016."},{"key":"2019091816140626000_37.5.271.24","unstructured":"Benjamin JT , Mezu-Ndubuisi OJ , Maheshwari A . Developmental immunology. In: Martin RJ , Fanaroff AA , Walsh MC , eds. Neonatal-Perinatal Medicine: Diseases of the Fetus and Infant. 10th ed. Philadelphia, PA: Elsevier Saunders; 2015:696\u2013733."},{"key":"2019091816140626000_37.5.271.25","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.306"},{"key":"2019091816140626000_37.5.271.26","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12418"},{"key":"2019091816140626000_37.5.271.27","doi-asserted-by":"publisher","DOI":"10.5152\/dir.2015.15094"},{"key":"2019091816140626000_37.5.271.28","unstructured":"Taketomo CK , Hodding JH , Kraus DM . Pediatric & Neonatal Dosage Handbook. 23rd ed. Hudson, OH: Wolters Kluwer Clinical Drug Information, Inc; 2016."},{"key":"2019091816140626000_37.5.271.29","doi-asserted-by":"publisher","DOI":"10.1002\/lt.23709"}],"container-title":["Neonatal Network"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1891\/0730-0832.37.5.271","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T23:14:29Z","timestamp":1568848469000},"score":1,"resource":{"primary":{"URL":"http:\/\/connect.springerpub.com\/lookup\/doi\/10.1891\/0730-0832.37.5.271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":29,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2018,9,1]]},"published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1891\/0730-0832.37.5.271"],"URL":"https:\/\/doi.org\/10.1891\/0730-0832.37.5.271","relation":{},"ISSN":["0730-0832","1539-2880"],"issn-type":[{"value":"0730-0832","type":"print"},{"value":"1539-2880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9]]}}}