{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:09:43Z","timestamp":1791266983748,"version":"4.1.0"},"reference-count":18,"publisher":"Springer Publishing Company","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatal Network"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To compare the effects of morphine and methadone on length of hospital stay (LOS) or treatment (LOT) and adverse effects in infants with neonatal abstinence syndrome (NAS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Systematic review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Sample<\/jats:title><jats:p>PubMed, Google Scholar, Cochrane library, CINAHL, IPA, American Academy of Pediatrics, and clinicaltrials.gov were systematically searched to identify randomized controlled trials (RCTs) and observational studies. comparing morphine and methadone for NAS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Outcomes<\/jats:title><jats:p>LOS, LOT, adverse effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One RCT, two cohort studies, and two chart reviews met inclusion criteria. Each had a low risk of bias. LOS ranged from 12.08 to 36 days with morphine and 21 to 44.23 days with methadone. LOT ranged from 7.46 to 22.9 days (morphine) and 13.9 to 38.08 days (methadone). Adverse effects were not reported. Clinical evidence comparing morphine to methadone for NAS treatment is limited and conflicting. A recommendation for one over the other cannot be made based on these outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1891\/0730-0832.37.6.365","type":"journal-article","created":{"date-parts":[[2018,11,21]],"date-time":"2018-11-21T09:53:45Z","timestamp":1542794025000},"page":"365-371","source":"Crossref","is-referenced-by-count":6,"title":["Morphine and Methadone for Neonatal Abstinence Syndrome: A Systematic Review"],"prefix":"10.1891","volume":"37","author":[{"given":"Lindsay","family":"Slowiczek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren J.","family":"Hein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zara","family":"Risoldi Cochrane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J.","family":"Gregory","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"793","published-online":{"date-parts":[[2018,11,1]]},"reference":[{"key":"2019091816152498000_37.6.365.1","unstructured":"Centers for Disease Control and Prevention, National Center for Injury Prevention and Control. Annual Surveillance Report of Drug-Related Risks and Outcomes: United States, 2017. Washington, DC: U.S. Department of Health and Human Services. https:\/\/www.cdc.gov\/drugoverdose\/pdf\/pubs\/2017-cdc-drug-surveillance-report.pdf."},{"key":"2019091816152498000_37.6.365.2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000208"},{"key":"2019091816152498000_37.6.365.3","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6531a2"},{"key":"2019091816152498000_37.6.365.4","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-3212"},{"key":"2019091816152498000_37.6.365.5","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-4-200908180-00136"},{"key":"2019091816152498000_37.6.365.6","unstructured":"Higgins JPT , Altman DG , Sterne JAC . Assessing risk of bias in included studies. version 5.2.0 (updated June 2017), Cochrane. In: Higgins JPT , Churchill R , Chandler J , Cumpston MS , eds. Cochrane hand book for systematic reviews of interventions; 2017. https:\/\/www.training.cochrane.org\/handbook."},{"key":"2019091816152498000_37.6.365.7","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-010-9491-z"},{"key":"2019091816152498000_37.6.365.8","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2017.0212"},{"key":"2019091816152498000_37.6.365.9","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14096"},{"key":"2019091816152498000_37.6.365.10","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-017-3470-x"},{"key":"2019091816152498000_37.6.365.11","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2014.194"},{"key":"2019091816152498000_37.6.365.12","doi-asserted-by":"publisher","DOI":"10.2146\/sp150025"},{"key":"2019091816152498000_37.6.365.13","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-4036"},{"key":"2019091816152498000_37.6.365.14","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2014.114"},{"key":"2019091816152498000_37.6.365.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.adnc.2005.06.003"},{"key":"2019091816152498000_37.6.365.16","doi-asserted-by":"publisher","DOI":"10.1097\/ADM.0000000000000308"},{"key":"2019091816152498000_37.6.365.17","unstructured":"Tufts Medical Center. Improving outcomes in neonatal abstinence syndrome. 2017. Available from https:\/\/clinicaltrials.gov\/show\/NCT01958476 . Published October 9, 2013. Updated September 12, 2018."},{"key":"2019091816152498000_37.6.365.18","unstructured":"University of New Mexico. Morphine versus methadone for opiate exposed infants with neonatal abstinence syndrome. 2017. Available from https:\/\/clinicaltrials.gov\/show\/NCT02851303 . Published August 1, 2016. Updated July 26, 2017."}],"container-title":["Neonatal Network"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1891\/0730-0832.37.6.365","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T23:15:46Z","timestamp":1568848546000},"score":1,"resource":{"primary":{"URL":"http:\/\/connect.springerpub.com\/lookup\/doi\/10.1891\/0730-0832.37.6.365"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":18,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2018,11,1]]},"published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1891\/0730-0832.37.6.365"],"URL":"https:\/\/doi.org\/10.1891\/0730-0832.37.6.365","relation":{},"ISSN":["0730-0832","1539-2880"],"issn-type":[{"value":"0730-0832","type":"print"},{"value":"1539-2880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11]]}}}