{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T09:44:10Z","timestamp":1780393450715,"version":"3.54.1"},"reference-count":35,"publisher":"Springer Publishing Company","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatal Network"],"published-print":{"date-parts":[[2019,11,1]]},"abstract":"<jats:p>Congenital chylothorax is defined as an abnormal accumulation of lymphatic fluid in the pleural space. It is a rare condition in the neonate that causes significant respiratory, nutritional, and immunologic problems resulting in a high mortality rate. Presented here is a case of congenital bilateral chylothorax in a preterm infant. Fetal ultrasound at 33 weeks' gestation showed polyhydramnios, bilateral pleural effusions, ascites, and subcutaneous edema. Fetal pleuracentesis was done on the right side with 118 mL of fluid aspirated. This article addresses the management of this difficult disease process, complications, and implications for research of controversial therapies.<\/jats:p>","DOI":"10.1891\/0730-0832.38.6.357","type":"journal-article","created":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T01:15:31Z","timestamp":1573521331000},"page":"357-364","source":"Crossref","is-referenced-by-count":3,"title":["Congenital Chylothorax: Common and Uncommon Findings in an Infant with Chylous Effusions"],"prefix":"10.1891","volume":"38","author":[{"given":"Eileen","family":"DeWitt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Michalczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"793","published-online":{"date-parts":[[2019,11,11]]},"reference":[{"key":"2020060812492719000_38.6.357.1","unstructured":"Light RW . Chylothorax and psuedochylothorax. In: Rhyner S , ed. Pleural Diseases 6th ed. Philadelphia, PA: Wolters Kluwer Lippincott Williams and Wilkins; 2013"},{"key":"2020060812492719000_38.6.357.2","first-page":"53","article-title":"Congenital chylothorax: Current perspectives and trends","volume":"7","year":"2017","journal-title":"Res Rep Neonatol"},{"key":"2020060812492719000_38.6.357.3","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-2072"},{"issue":"4","key":"2020060812492719000_38.6.357.4","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.prrv.2009.06.008","article-title":"Chylothorax: Diagnosis and management in children","volume":"10","year":"2009","journal-title":"Paediatr Respr Rev"},{"key":"2020060812492719000_38.6.357.5","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.12477"},{"key":"2020060812492719000_38.6.357.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2009.08.010"},{"key":"2020060812492719000_38.6.357.7","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2011.648246"},{"key":"2020060812492719000_38.6.357.8","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.21070"},{"key":"2020060812492719000_38.6.357.9","doi-asserted-by":"publisher","DOI":"10.1080\/08035250310007312"},{"key":"2020060812492719000_38.6.357.10","doi-asserted-by":"publisher","DOI":"10.1002\/ped4.12007"},{"key":"2020060812492719000_38.6.357.11","doi-asserted-by":"publisher","DOI":"10.1080\/08035250500477545"},{"key":"2020060812492719000_38.6.357.12","unstructured":"Taeusch HW , Ballard RA , Gleason CA . Avery's Diseases of the Newborn . 8th ed. Philadelphia, PA: Elsevier Saunders; 2005."},{"issue":"1","key":"2020060812492719000_38.6.357.13","doi-asserted-by":"crossref","first-page":"E2","DOI":"10.1542\/neo.15-1-e2","article-title":"Point of care chest ultrasound in the neonatal intensive care unit: An Italian perspective","volume":"15","year":"2014","journal-title":"NeoReviews"},{"issue":"4","key":"2020060812492719000_38.6.357.14","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1097\/MCP.0000000000000285","article-title":"Complications of thoracentesis: Incidence, risk factors, and strategies for prevention","volume":"22","year":"2016","journal-title":"Curr Opin Pulm Med"},{"key":"2020060812492719000_38.6.357.15","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-2977(99)00114-X"},{"issue":"8","key":"2020060812492719000_38.6.357.16","first-page":"E2","article-title":"Idiopathic chylothorax: Pathophysiology, diagnosis, and thoracic duct imaging","volume":"34","year":"2012","journal-title":"Compend Contin Educ Vet"},{"issue":"2","key":"2020060812492719000_38.6.357.17","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.pedneo.2015.07.001","article-title":"Prenatal therapy improves the survival of premature infants with congenital chylothorax","volume":"57","year":"2016","journal-title":"Pediatr Neonatol"},{"key":"2020060812492719000_38.6.357.18","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2000.104287"},{"key":"2020060812492719000_38.6.357.19","first-page":"12","article-title":"Nutritional management of chyle leaks: An update","volume":"94","year":"2011","journal-title":"Pract Gastroenterol Ser"},{"key":"2020060812492719000_38.6.357.20","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.08.008"},{"key":"2020060812492719000_38.6.357.21","unstructured":"Abu-Shaweesh JM . Respiratory disorders in preterm and term infants: Part 5. In: Martin RJ , Fanaroff AA , Walsh MC , eds. Fanaroff and Martin's Neonatal-Perinatal Medecine: Diseases of the Fetus and Infant . 9th ed. St Louis, MO: Elsevier; 2011:1141\u20131170."},{"key":"2020060812492719000_38.6.357.22","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2011.06.011"},{"key":"2020060812492719000_38.6.357.23","doi-asserted-by":"publisher","DOI":"10.1097\/01.PCC.0000235256.00265.C8"},{"key":"2020060812492719000_38.6.357.24","doi-asserted-by":"crossref","unstructured":"Das A , Shah PS . Octreotide for the treatment of chylothorax in neonates. Cochrane Database Syst Rev . 2010 Sept 8 (9):CD006388.","DOI":"10.1002\/14651858.CD006388.pub2"},{"key":"2020060812492719000_38.6.357.25","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-2694"},{"key":"2020060812492719000_38.6.357.26","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3400\/avd.cr.15-00002","article-title":"Management of aortic replacement-induced chylothorax by lipiodol lymphangiography","volume":"8","year":"2015","journal-title":"Ann Vasc Dis"},{"key":"2020060812492719000_38.6.357.27","first-page":"1177","article-title":"Early experience in the management of postoperative lymphatic leakage using lipiodol lymphangiography and adjunctive glue embolization","volume":"22","year":"2016","journal-title":"J Vasc Interv Radiolo"},{"key":"2020060812492719000_38.6.357.28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2011.05.003"},{"key":"2020060812492719000_38.6.357.29","first-page":"891","article-title":"Chylothorax after esophagectomy cured by intranodal lymphangiography: A case report","volume":"35","year":"2015","journal-title":"Anticancer Res"},{"key":"2020060812492719000_38.6.357.30","unstructured":"Taha D . Case study: innovative treatment for neonatal chylothorax. In: Neonatology Updates . Philadelphia, PA: Childrens Hospital of Philadelphia; September 15, 2017."},{"key":"2020060812492719000_38.6.357.31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.epsc.2016.03.014","article-title":"Massive fetal chylothorax successfully treated with postnatal talc pleurodesis: A case report and review of the literature","volume":"9","year":"2016","journal-title":"J Pediatr Surg Case Rep"},{"issue":"10","key":"2020060812492719000_38.6.357.32","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1016\/j.jpedsurg.2015.03.069","article-title":"Pleurodesis with povidone-iodine for refractory chylothorax in newborns; personal experience and literature review","volume":"50","year":"2015","journal-title":"J Pediatr Surg"},{"key":"2020060812492719000_38.6.357.33","doi-asserted-by":"crossref","unstructured":"Nath DS , Savla J , Khumani RG , et al. Thoracic duct ligation for persistent chylothorax after pediatric cardiothoracic surgery. Ann Thoracic Surg 2009;88(1):246\u2013251.","DOI":"10.1016\/j.athoracsur.2009.03.083"},{"issue":"5","key":"2020060812492719000_38.6.357.34","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3345\/kjp.2012.55.5.177","article-title":"Successful pleurodesis with OK-432 in preterm infants with persistent pleural effusion","volume":"55","year":"2012","journal-title":"Korean J Pediatr"},{"key":"2020060812492719000_38.6.357.35","doi-asserted-by":"publisher","DOI":"10.1086\/676533"}],"container-title":["Neonatal Network"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1891\/0730-0832.38.6.357","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T19:50:06Z","timestamp":1591645806000},"score":1,"resource":{"primary":{"URL":"http:\/\/connect.springerpub.com\/lookup\/doi\/10.1891\/0730-0832.38.6.357"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,1]]},"references-count":35,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2019,11,11]]},"published-print":{"date-parts":[[2019,11,1]]}},"alternative-id":["10.1891\/0730-0832.38.6.357"],"URL":"https:\/\/doi.org\/10.1891\/0730-0832.38.6.357","relation":{},"ISSN":["0730-0832","1539-2880"],"issn-type":[{"value":"0730-0832","type":"print"},{"value":"1539-2880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,1]]}}}