{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T03:43:47Z","timestamp":1752551027908,"version":"3.37.3"},"reference-count":39,"publisher":"Springer Publishing Company","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatal Network"],"published-print":{"date-parts":[[2020,7,1]]},"abstract":"<jats:p>Neonatal encephalopathy (NE) is defined as a condition of impaired neurological function often caused by a peripartum event that impairs gas exchange resulting in hypoxia, hypercapnia, cerebral ischemia, and metabolic acidosis. NE is a significant cause of neonatal morbidity and mortality. Therapeutic hypothermia (TH) is the standard of care for the treatment of moderate and severe NE and has significantly improved long-term outcomes for affected infants. There are extensive systemic physiologic effects associated with TH that clinicians need to be aware of to optimize care for these infants. There is a paucity of literature that comprehensively identifies causal relationships between the physiologic and biochemical effects of TH. This can leave neonatal clinicians devoid of a comprehensive understanding of the medical management of NE. Therefore, this article seeks to help fill this gap, improve clinician knowledge base, and ultimately improve the care of infants undergoing TH.<\/jats:p>","DOI":"10.1891\/0730-0832.39.4.205","type":"journal-article","created":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T18:45:17Z","timestamp":1594925117000},"page":"205-214","source":"Crossref","is-referenced-by-count":2,"title":["System Specific Effects of Therapeutic Hypothermia with Neonatal Encephalopathy: Pearls for Clinicians"],"prefix":"10.1891","volume":"39","author":[{"given":"Megan L.","family":"Di Salvo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0326-3984","authenticated-orcid":false,"given":"Sarah L.","family":"Hargett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Jnah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Desi","family":"Newberry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"793","published-online":{"date-parts":[[2020,7,16]]},"reference":[{"issue":"9","key":"2020071611451284000_39.4.205.1","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.paed.2018.07.002","article-title":"Managing hypoxic ischaemic encephalopathy in term newborn infant","volume":"28","year":"2018","journal-title":"Paediatr Child Health"},{"key":"2020071611451284000_39.4.205.2","doi-asserted-by":"crossref","unstructured":"Inder TE , Volpe JJ . 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