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Morphine is commonly utilized to provide comfort, despite limited empiric evidence supporting safety and efficacy. Dexmedetomidine represents an interesting alternative, with preclinical data suggesting direct efficacy against shivering during induced hypothermia and neuroprotection in the setting of HIE. Pharmacokinetic properties must be considered when utilizing either agent, with safety dependent on conservative dosing and careful monitoring. HIE is the leading cause of neonatal seizures. Traditional therapies, including phenobarbital, fosphenytoin, and benzodiazepines, control seizures in the vast majority of neonates. Concerns about the acute and long-term effects of these agents have led to the exploration of alternative anticonvulsants, including levetiracetam. Unfortunately, levetiracetam is inferior to phenobarbital as first-line therapy for neonatal seizures. Considering both the benefits and risks of traditional anticonvulsant agents, treatment should be limited to the shortest duration indicated, with maintenance therapy reserved for neonates at high risk for recurrent seizures.<\/jats:p>","DOI":"10.1891\/0730-0832.39.4.227","type":"journal-article","created":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T18:45:17Z","timestamp":1594925117000},"page":"227-235","source":"Crossref","is-referenced-by-count":4,"title":["Provision of Sedation and Treatment of Seizures During Neonatal Therapeutic Hypothermia"],"prefix":"10.1891","volume":"39","author":[{"given":"Christopher","family":"McPherson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keliana","family":"O'Mara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"793","published-online":{"date-parts":[[2020,7,16]]},"reference":[{"key":"2020071611451276000_39.4.227.1","doi-asserted-by":"crossref","unstructured":"Jacobs SE , Berg M , Hunt R , Tarnow-Mordi WO , Inder TE , Davis PG . 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