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The aim of this study was to (a) assess the usability and naturalness of videoconference exposure and (b) to compare it with face-to-face exposure at an inpatient clinic and exposure at home alone regarding therapeutic alliance, patients\u2019 expectancies, and credibility of the treatment and an overall rating of the exposure session. Mean differences and effect sizes suggested a slight general advantage of videoconference-based ERP and the interaction with the therapist felt natural to the participants. 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