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Magnesium has been extensively studied for its neuroprotective effects in the preterm population. Studies in neonates with HIE have produced mixed outcomes. Erythropoietin use in HIE with or without therapeutic hypothermia appears to be safe and may provide additional benefit. Dexmedetomidine, N-acetylcysteine, xenon, and topiramate all have promising animal data, but need additional human trials to elucidate what role they may play in HIE. Frequent review of existing literature is required to ensure provision of evidence-based pharmacologic agents for neuroprotection following HIE.<\/jats:p>","DOI":"10.1891\/11-t-755","type":"journal-article","created":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T15:50:15Z","timestamp":1638201015000},"page":"406-413","source":"Crossref","is-referenced-by-count":12,"title":["Neuroprotective Agents for Neonates with Hypoxic-Ischemic Encephalopathy"],"prefix":"10.1891","volume":"40","author":[{"given":"Keliana","family":"O'Mara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"McPherson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"793","published-online":{"date-parts":[[2021,11,29]]},"reference":[{"issue":"4","key":"2021112907501058000_40.6.406.1","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1001\/jamapediatrics.2014.3269","article-title":"Hypoxic-ischemic encephalopathy: A review for the clinician","volume":"169","year":"2015","journal-title":"JAMA Pediatr"},{"issue":"1","key":"2021112907501058000_40.6.406.2","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1186\/s12884-017-1610-3","article-title":"Intrapartum factors associated with neonatal hypoxic ischemic encephalopathy: A case-controlled study","volume":"17","year":"2017","journal-title":"BMC Pregnancy Childbirth"},{"key":"2021112907501058000_40.6.406.3","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.freeradbiomed.2019.04.028","article-title":"Novel interventions to reduce oxidative-stress related brain injury in neonatal asphyxia","volume":"142","year":"2019","journal-title":"Free Radic Biol Med"},{"issue":"6","key":"2021112907501058000_40.6.406.4","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.pedneo.2016.11.001","article-title":"Therapeutic hypothermia for neonates with hypoxic ischemic encephalopathy","volume":"58","year":"2017","journal-title":"Pediatr Neonatol"},{"key":"2021112907501058000_40.6.406.5","doi-asserted-by":"publisher","DOI":"10.1001\/archpediatrics.2011.1772"},{"issue":"1","key":"2021112907501058000_40.6.406.6","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1001\/jama.2017.7218","article-title":"Effect of depth and duration of cooling on death or disability at age 18 months among neonates with hypoxic-ischemic encephalopathy: A randomized clinical trial","volume":"318","year":"2017","journal-title":"JAMA"},{"key":"2021112907501058000_40.6.406.7","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.14972"},{"key":"2021112907501058000_40.6.406.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.09.018"},{"key":"2021112907501058000_40.6.406.9","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1350184"},{"key":"2021112907501058000_40.6.406.10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2006.00398.x"},{"key":"2021112907501058000_40.6.406.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2011.11.024"},{"key":"2021112907501058000_40.6.406.12","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2014.186"},{"issue":"8","key":"2021112907501058000_40.6.406.13","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/dmcn.12415","article-title":"Is melatonin ready to be used in preterm infants as a neuroprotectant?","volume":"56","year":"2014","journal-title":"Dev Med Child Neurol"},{"key":"2021112907501058000_40.6.406.14","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12092"},{"key":"2021112907501058000_40.6.406.15","doi-asserted-by":"crossref","unstructured":"Paprocka J , Kijonka M , Rzepka B , Sokol M . 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