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Although numerous interventions have been extensively studied, a lack of consensus persists in clinical practice, and until recently no formal evidence-based guidelines were available. Developing a bundle of evidence-based interventions available at specific Level III NICUs may increase stabilization and decrease the need for transfer to a Level IV NICU in this high-risk population.<\/jats:p>","DOI":"10.1891\/nn-2025-0032","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T05:45:20Z","timestamp":1772084720000},"page":"9-17","source":"Crossref","is-referenced-by-count":0,"title":["Evidence-Based Management of Persistent Pulmonary Hypertension"],"prefix":"10.1891","volume":"45","author":[{"given":"Carol","family":"Trees","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"793","published-online":{"date-parts":[[2026,2,25]]},"reference":[{"key":"2026071706150908000_45.1.9.1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2013.11.004"},{"key":"2026071706150908000_45.1.9.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2015.03.001"},{"issue":"14","key":"2026071706150908000_45.1.9.3","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1055\/a-1711-0778","article-title":"Evidence-based guidelines for acute stabilisation and management of neonates with persistent pulmonary hypertension of the newborn","volume":"40","year":"2023","journal-title":"Am J Perinatol"},{"key":"2026071706150908000_45.1.9.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2019.06.022"},{"key":"2026071706150908000_45.1.9.5","doi-asserted-by":"crossref","unstructured":"Steurer, MA , Jelliffe-Pawlowski, LL , Baer, RJ , Partridge, JC , Rogers, EE , Keller, RL . 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