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In conclusion, neonatal HSV infection represents a preventable cause of significant infant morbidity and mortality. Clinical awareness among health care providers is crucial for early recognition and prompt treatment. Prevention strategies include antiviral suppressive therapy for pregnant women with known HSV history and cesarean delivery when active lesions are present. The challenge remains in identifying asymptomatic maternal infections, as most neonatal cases occur in mothers without known HSV diagnosis.<\/jats:p>","DOI":"10.1891\/nn-2025-0046","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T05:45:20Z","timestamp":1772084720000},"page":"57-62","source":"Crossref","is-referenced-by-count":0,"title":["Basics of Neonatal Herpes Simplex Virus"],"prefix":"10.1891","volume":"45","author":[{"given":"Jocquelin V.","family":"Jones","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Falke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"793","published-online":{"date-parts":[[2026,2,25]]},"reference":[{"key":"2026071706150675000_45.1.57.1","doi-asserted-by":"publisher","DOI":"10.1542\/hpeds.2020-0033"},{"issue":"3","key":"2026071706150675000_45.1.57.2","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1093\/jpids\/piab105","article-title":"Neonatal herpes simplex virus infection: epidemiology and outcomes in the modern era","volume":"11","year":"2022","journal-title":"J Pediatric Infect Dis Soc"},{"issue":"5):","key":"2026071706150675000_45.1.57.3","article-title":"Increasing incidence of neonatal HSV in the United States: a public health challenge","volume":"155","year":"2025","journal-title":"Pediatrics"},{"issue":"2):","key":"2026071706150675000_45.1.57.4","article-title":"Neonatal HSV disease: balancing the low incidence with the need to treat promptly","volume":"141","year":"2018","journal-title":"Pediatrics"},{"key":"2026071706150675000_45.1.57.5","doi-asserted-by":"crossref","unstructured":"Thompson, C , Whitley, R . 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