{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T10:30:32Z","timestamp":1785148232126,"version":"3.55.0"},"reference-count":36,"publisher":"Springer Publishing Company","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatal Network"],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:p>A female infant born at 23 0\/7 weeks\u2019 gestation with a birth weight of 570 g was admitted to the NICU due to extreme prematurity, extremely low birth weight, and respiratory distress syndrome. At approximately 2 weeks of life, she underwent an evaluation for late-onset sepsis because of escalating respiratory support requirements. Empiric antibiotics were initiated while awaiting culture results. Sequential broadening of antibiotic coverage occurred in response to worsening clinical status. Despite maximal medical therapy, the infant continued to deteriorate and ultimately died following an acute bradycardic\/desaturation event requiring CPR. Blood culture results returned after her death revealed Gram-negative bacteremia. This case emphasizes the treatment challenges of late-onset sepsis in periviable infants, in whom rapid decompensation from infection can occur even with aggressive antimicrobial therapy.<\/jats:p>","DOI":"10.1891\/nn-2025-0049","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T13:20:22Z","timestamp":1783430422000},"page":"170-177","source":"Crossref","is-referenced-by-count":1,"title":["Late-Onset Sepsis in the Periviable Neonate"],"prefix":"10.1891","volume":"45","author":[{"given":"Denise","family":"Kirsten","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Sulo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"793","published-online":{"date-parts":[[2026,7,7]]},"reference":[{"key":"2026070804305603000_45.3.170.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31002-4"},{"key":"2026070804305603000_45.3.170.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2023.04.039"},{"issue":"2","key":"2026070804305603000_45.3.170.3","first-page":"142","article-title":"Neonatal sepsis","volume":"54","year":"2020","journal-title":"Sisli Etfal Hastan Tip Bul"},{"key":"2026070804305603000_45.3.170.4","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(24)00495-1"},{"issue":"2","key":"2026070804305603000_45.3.170.5","doi-asserted-by":"crossref","DOI":"10.3390\/antibiotics11020284","article-title":"Early- and late-onset neonatal sepsis: epidemiology and effectiveness of empirical antibacterial therapy in a level III neonatal intensive care unit","volume":"11","year":"2022","journal-title":"Antibiotics"},{"key":"2026070804305603000_45.3.170.6","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00031-13"},{"issue":"1","key":"2026070804305603000_45.3.170.7","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.clp.2024.10.003","article-title":"Late-onset sepsis: epidemiology, microbiology, and controversies in practice","volume":"52","year":"2025","journal-title":"Clin Perinatol"},{"key":"2026070804305603000_45.3.170.8","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003668"},{"key":"2026070804305603000_45.3.170.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2015.09.007"},{"issue":"9","key":"2026070804305603000_45.3.170.10","article-title":"Insight into neonatal sepsis: an overview","volume":"15","year":"2023","journal-title":"Cureus"},{"issue":"6","key":"2026070804305603000_45.3.170.11","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2022-058813","article-title":"Late-onset sepsis among very preterm infants","volume":"150","year":"2022","journal-title":"Pediatrics"},{"issue":"11","key":"2026070804305603000_45.3.170.12","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1542\/neo.23-10-e738","article-title":"Updates in late-onset sepsis: risk assessment, therapy, and outcomes","volume":"23","year":"2022","journal-title":"Neoreviews"},{"key":"2026070804305603000_45.3.170.13","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2023.1191254","article-title":"Clinical chorioamnionitis: where do we stand now?","volume":"10","year":"2023","journal-title":"Front Med"},{"issue":"1","key":"2026070804305603000_45.3.170.14","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1542\/pir.2020-001164","article-title":"Early-onset sepsis in newborns","volume":"44","year":"2023","journal-title":"Pediatr Rev"},{"key":"2026070804305603000_45.3.170.15","doi-asserted-by":"crossref","unstructured":"American Academy of Pediatrics. 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