{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T12:15:54Z","timestamp":1783512954431,"version":"3.55.0"},"reference-count":10,"publisher":"Springer Publishing Company","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatal Network"],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:p>\n                    Neonatal sepsis continues to be a leading cause of mortality, frequently presenting with vague clinical characteristics. Rarely, it might present with hyperleukocytosis, which closely resembles congenital leukemia and creates a diagnostic difficulty. A preterm male neonate born at 34 weeks\u2019 gestation with a birth weight of 1.8 kg was delivered to a 27-year-old G2, P1 woman in a nonconsanguineous marriage. The neonate developed respiratory distress shortly after birth. Laboratory evaluation revealed a total leukocyte count of 108 \u00d7 10\n                    <jats:sup>3<\/jats:sup>\n                    \/\u00b5L (108 \u00d7 10\n                    <jats:sup>9<\/jats:sup>\n                    \/L), raising concern for congenital leukemia. However, peripheral blood smear showed cytoplasmic vacuolation and toxic granules without any blast cells, and flow cytometry excluded malignancy and leukocyte adhesion deficiency. Blood culture grew\n                    <jats:italic>Acinetobacter baumannii<\/jats:italic>\n                    . A diagnosis of sepsis-induced hyperleukocytosis was made. The leukocyte count normalized with broad-spectrum antibiotics, and the neonate recovered fully. Hyperleukocytosis in neonates is not always indicative of congenital leukemia. Differentiating between malignant and reactive causes is crucial as management and prognosis differ widely.\n                  <\/jats:p>","DOI":"10.1891\/nn-2025-0059","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T13:20:22Z","timestamp":1783430422000},"page":"196-200","source":"Crossref","is-referenced-by-count":0,"title":["Sepsis Presenting as Hyperleukocytosis Mimicking Congenital Leukemia in a Preterm Neonate: A Case Report"],"prefix":"10.1891","volume":"45","author":[{"given":"Bablu Kumar","family":"Gaur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishita","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"793","published-online":{"date-parts":[[2026,7,7]]},"reference":[{"key":"2026070804305600000_45.3.196.1","unstructured":"Kliegman RM , St Geme JW , Blum NJ , Shah SS , Tasker RC , Wilson KM , eds. Nelson Textbook of Pediatrics . Vol 2. 21 st ed. Elsevier; 2019."},{"issue":"3","key":"2026070804305600000_45.3.196.2","doi-asserted-by":"crossref","first-page":"298","DOI":"10.3126\/jnps.v36i3.15611","article-title":"Neonatal leukemoid reaction: a diagnostic dilemma","volume":"36","year":"2017","journal-title":"J Nepal Paedtr Soc"},{"issue":"Suppl 1","key":"2026070804305600000_45.3.196.3","first-page":"131","article-title":"Hyperleukocytosis in newborn: a diagnosis of concern","volume":"30","year":"2014","journal-title":"Indian J Hematol Blood Transfus"},{"key":"2026070804305600000_45.3.196.4","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15246"},{"issue":"10","key":"2026070804305600000_45.3.196.5","article-title":"Congenital leukemia: presentation of three cases","volume":"17","year":"2025","journal-title":"Cureus"},{"issue":"24","key":"2026070804305600000_45.3.196.6","doi-asserted-by":"crossref","DOI":"10.1182\/blood-2012-07-440917","article-title":"Transient myeloproliferative disorder","volume":"120","year":"2012","journal-title":"Blood"},{"issue":"546","key":"2026070804305600000_45.3.196.7","first-page":"1","article-title":"Two cases of leukemoid reaction in premature infants caused by fetal inflammatory response syndrome","volume":"24","year":"2024","journal-title":"BMC Pediatr"},{"issue":"9","key":"2026070804305600000_45.3.196.8","article-title":"Sepsis-induced hyperleukocytosis in a preterm","volume":"11","year":"2019","journal-title":"Cureus"},{"issue":"10","key":"2026070804305600000_45.3.196.9","article-title":"An unusual presentation of neonatal sepsis as hyperleukocytosis with firm lymphadenopathy: a diagnostic challenge","volume":"14","year":"2022","journal-title":"Cureus"},{"issue":"4","key":"2026070804305600000_45.3.196.10","doi-asserted-by":"crossref","first-page":"215","DOI":"10.4103\/ipcares.ipcares_62_23","article-title":"Transient hyperleukocytosis in one of the extreme preterm twins: a case report with review of literature","volume":"3","year":"2023","journal-title":"Indian Pediatr Case Rep"}],"container-title":["Neonatal Network"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1891\/NN-2025-0059","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T11:31:06Z","timestamp":1783510266000},"score":1,"resource":{"primary":{"URL":"http:\/\/connect.springerpub.com\/lookup\/doi\/10.1891\/NN-2025-0059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,1]]},"references-count":10,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,7,7]]},"published-print":{"date-parts":[[2026,7,1]]}},"alternative-id":["10.1891\/NN-2025-0059"],"URL":"https:\/\/doi.org\/10.1891\/nn-2025-0059","relation":{},"ISSN":["0730-0832","1539-2880"],"issn-type":[{"value":"0730-0832","type":"print"},{"value":"1539-2880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,1]]}}}