{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,4]],"date-time":"2025-01-04T05:34:30Z","timestamp":1735968870759,"version":"3.32.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2005,2,1]],"date-time":"2005-02-01T00:00:00Z","timestamp":1107216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2009,12,9]],"date-time":"2009-12-09T00:00:00Z","timestamp":1260316800000},"content-version":"vor","delay-in-days":1772,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["setac.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2005,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Tralkoxydim is the active ingredient in a postemergent herbicide used in cereal crops. During preregistration trials, tralkoxydim was observed to cause hepatic porphyria and cholestasis in laboratory mice. Porphyria was not seen in similarly exposed rats or hamsters, but data were not collected regarding the susceptibility of any wild small mammal species to the tralkoxydim-induced porphyria. To address this data gap, we exposed small mammals to tralkoxydim, to 3,5-diethoxycarbonyl-1,4-dihydrocol-lidine (DDC; a known porphyrinogenic chemical), or to sunflower oil alone. We studied small mammal species that might be exposed following agricultural applications of the herbicide, including the white-footed mouse (Peromyscus leucopus), the deer mouse (P. maniculatus), and the meadow vole (Microtus pennsylvanicus). Because of their known susceptibility to both tralkoxydim-and DDC-induced porphyria, commercially supplied Mus musculus (CD-1 Swiss mice) were exposed as positive-control animals. We also exposed offspring of wild-caught M. musculus to compare their responses to those of the commercially supplied animals. Potential hepatotoxicity was determined by assessing the accumulation of liver protoporphyrin. Of the species tested, only M. musculus was susceptible to the porphyrinogenic action of tralkoxydim, and no significant accumulation of protoporphyrin was observed in any of the other species exposed to the herbicide.<\/jats:p>","DOI":"10.1897\/03-536.1","type":"journal-article","created":{"date-parts":[[2005,1,20]],"date-time":"2005-01-20T22:24:00Z","timestamp":1106259840000},"page":"450-456","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hepatic porphyria induced by the herbicide tralkoxydim in small mammals is species-specific"],"prefix":"10.1093","volume":"24","author":[{"given":"Bruce D.","family":"Pauli","sequence":"first","affiliation":[{"name":"Canadian Wildlife Service, National Wildlife Research Centre, Carleton University, Raven Road, Ottawa, Ontario K1A 0H3, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean W.","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Canadian Wildlife Service, National Wildlife Research Centre, Carleton University, Raven Road, Ottawa, Ontario K1A 0H3, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2005,2,1]]},"reference":[{"key":"2025010318052077200_bib1","volume-title":"The Pesticide Manual","author":"Tomlin","year":"1997","edition":"11th ed."},{"first-page":"19","year":"1987","author":"Warner","key":"2025010318052077200_bib2"},{"key":"2025010318052077200_bib3","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1104\/pp.94.3.1180","article-title":"Cross-resistance to herbicides in annual ryegrass (Lolium rigidum). I. Properties of the herbicide target enzymes acetylcoenzyme A carboxylase and acetolactate synthase","volume":"94","author":"Matthews","year":"1990","journal-title":"Plant Physiol"},{"key":"2025010318052077200_bib4","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1104\/pp.86.1.10","article-title":"Inhibition of acetyl-CoA carboxylase activity by haloxyfop and tralkoxydim","volume":"86","author":"Secor","year":"1988","journal-title":"Plant Physiol"},{"key":"2025010318052077200_bib5","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0300-483X(93)90117-B","article-title":"Effects of 2-[1-(ethoxyimino)propyl]-3-hydroxy-5-(2,4,6-trimethylphenyl) cyclohex-2-enone on hepatic heme biosynthesis: Species differences in hepatic porphyria","volume":"84","author":"Brady","year":"1993","journal-title":"Toxicology"},{"key":"2025010318052077200_bib6","first-page":"395","article-title":"Ferrochelatase-inhib-itory and porphyrin-inducing properties of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine and its analogues in chick embryo liver cells","volume":"20","author":"Cole","year":"1981","journal-title":"Mol Pharmacol"},{"volume-title":"The Mammals of Canada","year":"1974","author":"Banfield","key":"2025010318052077200_bib7"},{"key":"2025010318052077200_bib8","doi-asserted-by":"crossref","first-page":"403","DOI":"10.5962\/p.357643","article-title":"The distribution of small mammals on cultivated fields and in rights-of-way","volume":"109","author":"Marinelli","year":"1995","journal-title":"Can Field-Nat"},{"key":"2025010318052077200_bib9","doi-asserted-by":"crossref","first-page":"273","DOI":"10.5962\/p.345404","article-title":"Movements and habitat use among interacting Peromyscus leucopus as revealed by radio telemetry","volume":"91","author":"Madison","year":"1977","journal-title":"Can Field-Nat"},{"key":"2025010318052077200_bib10","doi-asserted-by":"crossref","first-page":"171","DOI":"10.2307\/2424787","article-title":"Geographic variation in habitat use by the white-footed mouse, Peromyscus leucopus","volume":"100","author":"Lackey","year":"1978","journal-title":"Am Midl Nat"},{"key":"2025010318052077200_bib11","doi-asserted-by":"crossref","first-page":"322","DOI":"10.5962\/p.357460","article-title":"Microhabitats of two Peromyscus (deer and white-footed mice) species in old fields and prairies of Wisconsin","volume":"110","author":"Kantak","year":"1996","journal-title":"Can Field-Nat"},{"key":"2025010318052077200_bib12","doi-asserted-by":"crossref","first-page":"209","DOI":"10.2307\/2426575","article-title":"Agricultural influences on movement patterns of white-footed mice (Peromyscus leucopus)","volume":"132","author":"Cummings","year":"1994","journal-title":"Am Midl Nat"},{"key":"2025010318052077200_bib13","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0378-4347(93)80455-D","article-title":"Improved method to extract and concentrate porphyrins from liver tissue for analysis by high-performance liquid chromatography","volume":"619","author":"Kennedy","year":"1993","journal-title":"J Chromatogr Biomed Appl"},{"year":"1992","author":"Systat","key":"2025010318052077200_bib14"},{"key":"2025010318052077200_bib15","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1006\/taap.1996.0317","article-title":"Species difference in protoporphyrin IX accumulation produced by an N-phenylimide herbicide in embryos between rats and rabbits","volume":"141","author":"Kawamura","year":"1996","journal-title":"Toxicol Appl Pharmacol"},{"key":"2025010318052077200_bib16","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1139\/y97-149","article-title":"Herbicide-induced experimental variegate porphyria in mice: Tissue porphyrinogen accumulation and response to porphyrinogenic drugs","volume":"75","author":"Krijt","year":"1997","journal-title":"Can J Physiol Pharmacol"},{"key":"2025010318052077200_bib17","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1016\/0006-2952(74)90042-2","article-title":"Biochemical effects of 3,5-diethoxycarbonyl-1,4-dihydrocollidine in mouse liver","volume":"23","author":"Gayathri","year":"1974","journal-title":"Biochem Pharmacol"},{"key":"2025010318052077200_bib18","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/0020-711X(80)90200-1","article-title":"Studies on the mechanism of experimental porphyria and ferrochelatase inhibition produced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine","volume":"12","author":"Tephly","year":"1980","journal-title":"Int J Biochem"},{"key":"2025010318052077200_bib19","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1042\/bj1460285","article-title":"Stimulation of the pathway of porphyrin synthesis in the liver of rats and mice by griseofulvin, 3,5-diethoxycarbonyl-1,4-dihydrocollodine and related drugs: Evidence for two basically different mechanisms","volume":"146","author":"De Matteis","year":"1975","journal-title":"Biochem J"},{"key":"2025010318052077200_bib20","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1006\/taap.1997.8282","article-title":"Cytochrome P450 induction, uroporphyrinogen decarboxylase depression, porphyrin accumulation and excretion, and gender influence in a three-week rat model of porphyria cutanea tarda","volume":"147","author":"Franklin","year":"1997","journal-title":"Toxicol Appl Pharmacol"}],"container-title":["Environmental Toxicology and Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1897%2F03-536.1","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/etc\/article-pdf\/24\/2\/450\/59673817\/5620240226.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/etc\/article-pdf\/24\/2\/450\/59673817\/5620240226.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T18:14:54Z","timestamp":1735928094000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/etc\/article\/24\/2\/450\/7770397"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,2,1]]},"references-count":20,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2005,2,1]]},"published-print":{"date-parts":[[2005,2,1]]}},"URL":"https:\/\/doi.org\/10.1897\/03-536.1","relation":{},"ISSN":["0730-7268","1552-8618"],"issn-type":[{"type":"print","value":"0730-7268"},{"type":"electronic","value":"1552-8618"}],"subject":[],"published-other":{"date-parts":[[2005,2,1]]},"published":{"date-parts":[[2005,2,1]]},"assertion":[{"value":"2003-09-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2004-08-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-12-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}