{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:48:03Z","timestamp":1791215283489,"version":"4.1.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2005,2,1]],"date-time":"2005-02-01T00:00:00Z","timestamp":1107216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2009,12,9]],"date-time":"2009-12-09T00:00:00Z","timestamp":1260316800000},"content-version":"vor","delay-in-days":1772,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["setac.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2005,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The present study investigated the whole-carcass residue carried by resistant and susceptible laboratory rat strains following 5, 10, or 20 d of feeding on a diet of 25 mg difenacoum\/kg bait. The mean whole-carcass residue of difenacoum was determined by high-performance liquid chromatography to be between 0.52 and 0.74 mg\/kg body weight in all three rat strains tested. These values were considerably lower than some comparable data previously reported for other species and second-generation rodenticides as well as from mathematical models. The whole-carcass residue of extractable (i.e., nonrefractory) parent compound carried by highly resistant rats fed for 20 d (0.74 mg\/kg body wt) is unlikely to present a significantly increased risk to predators compared to the amount carried by susceptible rats after 5 d of feeding (0.52 mg\/kg body wt). However, resistant rats are more likely to be available for predation and to be carrying a whole-carcass residue of anticoagulant throughout the duration of a control program.<\/jats:p>","DOI":"10.1897\/04-022r.1","type":"journal-article","created":{"date-parts":[[2005,1,20]],"date-time":"2005-01-20T22:22:33Z","timestamp":1106259753000},"page":"318-323","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Whole-carcass residues of the rodenticide difenacoum in anticoagulant-resistant and -susceptible rat strains (<i>Rattus norvegicus<\/i>)"],"prefix":"10.1093","volume":"24","author":[{"given":"Helen","family":"Atterby","sequence":"first","affiliation":[{"name":"Central Science Laboratory, Sand Hutton, York, North Yorkshire YO18 8TA, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard M.","family":"Kerins","sequence":"additional","affiliation":[{"name":"Central Science Laboratory, Sand Hutton, York, North Yorkshire YO18 8TA, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan D.","family":"MacNicoll","sequence":"additional","affiliation":[{"name":"Central Science Laboratory, Sand Hutton, York, North Yorkshire YO18 8TA, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,2,1]]},"reference":[{"key":"2025010318040475900_bib1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1017\/S0022172400046957","article-title":"Laboratory evaluation of difenacoum as a rodenticide","volume":"74","author":"Hadler","year":"1975","journal-title":"J Hyg"},{"key":"2025010318040475900_bib2","author":"Garthwaite","year":"1999"},{"key":"2025010318040475900_bib3","author":"Dawson","year":"2003"},{"key":"2025010318040475900_bib4","first-page":"203","article-title":"The threats to birds of prey in the UK from second-generation rodenticides","volume":"67","author":"Burn","year":"2002","journal-title":"Aspects of Applied Biology"},{"key":"2025010318040475900_bib5","first-page":"149","author":"Kerins","year":"2001"},{"key":"2025010318040475900_bib6","first-page":"192","article-title":"Problems with rodenticides: The threat to red kites and other wildlife","volume":"11","author":"Carter","year":"2000","journal-title":"British Wildlife"},{"key":"2025010318040475900_bib7","author":"Shore","year":"2000"},{"key":"2025010318040475900_bib8","author":"Shore","year":"2001"},{"key":"2025010318040475900_bib9","first-page":"347","author":"Newton","year":"1999"},{"key":"2025010318040475900_bib10","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0269-7491(02)00297-X","article-title":"Spatial and temporal analysis of second-generation anticoagulant rodenticide residues in polecats (Mustela putorius) from throughout their range in Britain, 1992\u20131999","volume":"122","author":"Shore","year":"2003","journal-title":"Environ Pollut"},{"key":"2025010318040475900_bib11","first-page":"193","author":"Atterby","year":"2001"},{"key":"2025010318040475900_bib12","first-page":"389","volume-title":"Current Advances in Vitamin K Research","author":"Greaves","year":"1988"},{"key":"2025010318040475900_bib13","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/ps.2780450308","article-title":"Control of a population of Norway rats resistant to anticoagulant rodenticides","volume":"45","author":"Quy","year":"1995","journal-title":"Pestic Sci"},{"key":"2025010318040475900_bib14","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1365-2338.1975.tb02786.x","article-title":"Guidelines for the development and biological evaluation of rodenticides","volume":"5","author":"European and Mediterranean Plant Protection Organisation.","year":"1975","journal-title":"EPPO Bull"},{"key":"2025010318040475900_bib15","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/ps.2780320111","article-title":"A barn owl feeding study with [14C]flocoumafen-dosed mice: Validation of a non-invasive method of monitoring exposure of barn owls to anticoagulant rodenticides in their prey","volume":"32","author":"Eadsforth","year":"1991","journal-title":"Pestic Sci"},{"key":"2025010318040475900_bib16","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0021-9673(01)96372-1","article-title":"Determination of coumarin anticoagulant rodenticide residues in animal tissue by high-performance liquid chromatography. 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