{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:13:45Z","timestamp":1778804025254,"version":"3.51.4"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2009,12,9]],"date-time":"2009-12-09T00:00:00Z","timestamp":1260316800000},"content-version":"vor","delay-in-days":222,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["setac.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2009,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Embryonic survival, pipping and hatching success, and sublethal biochemical, endocrine, and histological endpoints were examined in hatchling chickens (Gallus gallus), mallards (Anas platyrhynchos), and American kestrels (Falco sparverius) following air cell administration of a pentabrominated diphenyl ether (penta-BDE; DE-71) mixture (0.01\u201320 \u03bcg\/g egg) or poly-chlorinated biphenyl (PCB) congener 126 (3,3\u2032,4,4\u2032,5-pentachlorobiphenyl; 0.002 \u03bcg\/g egg). The penta-BDE decreased pipping and hatching success at concentrations of 10 and 20 \u03bcg\/g egg in kestrels but had no effect on survival endpoints in chickens or mallards. Sublethal effects in hatchling chickens included ethoxyresorufin-O-dealkylase (EROD) induction and histological changes in the bursa, but these responses were not observed in other species. Polychlorinated biphenyl congener 126 (positive control) reduced survival endpoints in chicken and kestrel embryos and caused sublethal effects (EROD induction, reduced bursal mass and follicle size) in chickens. Mallards were clearly less sensitive than the other species to administered penta-BDE and PCB 126. In a second experiment, the absorption of penta-BDE (11.1 \u03bcg\/g egg, air cell administered during early development) into the contents of chicken and kestrel eggs was determined at various intervals (24 h postinjection, midincubation, and pipping). By pipping, 29% of the penta-BDE administered dose was present in the egg contents in chickens, and 18% of the administered dose was present in kestrel egg contents. Based on uptake in kestrels, the lowest-observed-effect level on pipping and hatching success may be as low as 1.8 \u03bcg total penta-BDE\/g egg, which approaches concentrations detected in eggs of free-ranging birds. Because some penta-BDE congeners are still increasing in the environment, the toxic effects observed in the present study are cause for concern in wildlife.<\/jats:p>","DOI":"10.1897\/08-318.1","type":"journal-article","created":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T21:52:20Z","timestamp":1228168340000},"page":"1007-1017","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":89,"title":["Toxicity of polybrominated diphenyl ethers (de-71) in chicken (<i>Gallus gallus<\/i>), mallard (<i>Anas platyrhynchos<\/i>), and American kestrel (<i>Falco sparverius<\/i>) embryos and hatchlings"],"prefix":"10.1093","volume":"28","author":[{"given":"Moira A.","family":"McKernan","sequence":"first","affiliation":[{"name":"U.S. Geological Survey, Patuxent Wildlife Research Center, BARC-East, Building 308, 10300 Baltimore Avenue, Beltsville, Maryland 20705"},{"name":"Marine, Estuarine, and Environmental Sciences and Department of Animal and Avian Sciences, University of Maryland, College Park, Maryland 20742, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barnett A.","family":"Rattner","sequence":"additional","affiliation":[{"name":"U.S. Geological Survey, Patuxent Wildlife Research Center, BARC-East, Building 308, 10300 Baltimore Avenue, Beltsville, Maryland 20705"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert C.","family":"Hale","sequence":"additional","affiliation":[{"name":"Department of Environmental and Aquatic Animal Health, Virginia Institute of Marine Science, College of William and Mary, Gloucester Point, Virginia 23062, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Ann","family":"Ottinger","sequence":"additional","affiliation":[{"name":"Marine, Estuarine, and Environmental Sciences and Department of Animal and Avian Sciences, University of Maryland, College Park, Maryland 20742, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2009,5,1]]},"reference":[{"key":"2025010317061054900_bib1","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0045-6535(01)00225-9","article-title":"An overview of brominated flame retardants in the environment","volume":"46","author":"de Wit","year":"2002","journal-title":"Chemosphere"},{"key":"2025010317061054900_bib2","doi-asserted-by":"crossref","first-page":"4783","DOI":"10.1021\/es025831e","article-title":"Geographical distribution (2000) and temporal trends (1981\u20132000) of brominated diphenyl ethers in Great Lakes herring gull eggs","volume":"36","author":"Norstrom","year":"2002","journal-title":"Environ Sci Technol"},{"key":"2025010317061054900_bib3","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1021\/es702382k","article-title":"Dramatic changes in the temporal trends of polybrominated diphenyl ethers (PBDEs) in herring gull eggs from the Laurentian Great Lakes: 1982\u20132006","volume":"42","author":"Gauthier","year":"2008","journal-title":"Environ Sci Technol"},{"key":"2025010317061054900_bib4","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s00244-003-3160-0","article-title":"Contaminant exposure and reproductive success of ospreys (Pandion haliaetus) nesting in Chesapeake Bay regions of concern","volume":"47","author":"Rattner","year":"2004","journal-title":"Arch Environ Contam Toxicol"},{"key":"2025010317061054900_bib5","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1897\/04-141R.1","article-title":"Environmental contaminant exposure and reproduction of ospreys nesting in the Delaware River and Bay","volume":"24","author":"Toschik","year":"2005","journal-title":"Environ Toxicol Chem"},{"key":"2025010317061054900_bib6","doi-asserted-by":"crossref","first-page":"7594","DOI":"10.1021\/es8010749","article-title":"Polybrominated diphenyl ethers in peregrine falcon (Falco peregrinus) eggs from the northeastern U.S","volume":"42","author":"Chen","year":"2008","journal-title":"Environ Sci Technol"},{"key":"2025010317061054900_bib7","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.envpol.2005.04.008","article-title":"Evidence of immunomodulation in nestling American kestrels (Falco sparverius) exposed to environmentally relevant PBDEs","volume":"138","author":"Fernie","year":"2005","journal-title":"Environ Pollut"},{"key":"2025010317061054900_bib8","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1093\/toxsci\/kfi295","article-title":"Exposure to polybrominated diphenyl ethers (PBDEs): Changes in thyroid, vitamin A, glutathione homeostasis, and oxidative stress in American kestrels (Falco sparverius)","volume":"88","author":"Fernie","year":"2005","journal-title":"Toxicol Sci"},{"key":"2025010317061054900_bib9","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1080\/15287390500468753","article-title":"Changes in the growth, but not the survival, of American kestrels (Falco sparverious) exposed to environmentally relevant polybrominated diphenyl ethers","volume":"69","author":"Fernie","year":"2006","journal-title":"J Toxicol Environ Health A"},{"key":"2025010317061054900_bib10","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1093\/toxsci\/kfm295","article-title":"Changes in reproductive courtship behaviors of adult American kestrels (Falco sparverius) exposed to environmentally relevant levels of the polybrominated diphenyl ether mixture, DE-71","volume":"102","author":"Fernie","year":"2008","journal-title":"Toxicol Sci"},{"key":"2025010317061054900_bib11","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0300-483X(90)90176-H","article-title":"Induction of rat liver microsomal cytochrome P450 by the pentabromo diphenyl ether Bromkal 70 and half-lives of its components in the adipose tissue","volume":"61","author":"von Meyerinck","year":"1990","journal-title":"Toxicology"},{"key":"2025010317061054900_bib12","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0300-483X(94)90052-3","article-title":"Immunologic and endocrine effects of the flame-retardant pen-tabromodiphenyl ether (DE-71) in C57BL\/6J mice","volume":"86","author":"Fowles","year":"1994","journal-title":"Toxicology"},{"key":"2025010317061054900_bib13","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1289\/ehp.01109903","article-title":"Brominated flame retardants: A novel class of developmental neurotoxicants in our environment?","volume":"109","author":"Eriksson","year":"2001","journal-title":"Environ Health Perspect"},{"key":"2025010317061054900_bib14","doi-asserted-by":"crossref","first-page":"3749","DOI":"10.1021\/es0107475","article-title":"Synthesis of polybrominated diphenyl ethers and their capacity to induce CYP1A by the Ah receptor-mediated pathway","volume":"35","author":"Chen","year":"2001","journal-title":"Environ Sci Technol"},{"key":"2025010317061054900_bib15","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1093\/toxsci\/61.1.76","article-title":"Effects of short-term in vivo exposure to polybrominated diphenyl ethers on thyroid hormones and hepatic enzyme activities in weanling rats","volume":"61","author":"Zhou","year":"2001","journal-title":"Toxicol Sci"},{"key":"2025010317061054900_bib16","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1007\/s00244-004-1006-2","article-title":"Environmental toxicity studies using chickens as surrogates for wildlife: Effects of vehicle volume","volume":"48","author":"de Witt","year":"2005","journal-title":"Arch Environ Contam Toxicol"},{"key":"2025010317061054900_bib17","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/s00244-005-1002-y","article-title":"Factors affecting the toxicity of methylmercury injected into eggs","volume":"50","author":"Heinz","year":"2006","journal-title":"Arch Environ Contam Toxicol"},{"key":"2025010317061054900_bib18","doi-asserted-by":"crossref","first-page":"2724","DOI":"10.1897\/07-291.1","article-title":"Egg orientation affects toxicity of air cell administered polychlorinated biphenyl 126 (3,3\u2032,4,4\u2032,5-pentachlorobiphenyl) in chicken (Callus gallus) embryos","volume":"26","author":"McKernan","year":"2007","journal-title":"Environ Toxicol Chem"},{"key":"2025010317061054900_bib19","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1002\/etc.5620170432","article-title":"Comparative and developmental toxicity of planar poly-chlorinated biphenyl congeners in chickens, American kestrels, and common terns","volume":"17","author":"Hoffman","year":"1998","journal-title":"Environ Toxicol Chem"},{"key":"2025010317061054900_bib20","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1080\/15287390600882226","article-title":"Effects of in ovo exposure to PCBs 126 and 77 on mortality, deformities and posthatch immune function in chickens","volume":"70","author":"Lavoie","year":"2007","journal-title":"J Toxicol Environ Health A"},{"key":"2025010317061054900_bib21","first-page":"194","volume-title":"Teratology: Principles and Techniques","author":"Karnofsky","year":"1965"},{"key":"2025010317061054900_bib22","first-page":"95","volume-title":"Environmental Toxicology and Risk Assessment: Biomarkers and Risk Assessment","author":"Melancon","year":"1996"},{"key":"2025010317061054900_bib23","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0016-6480(85)90340-5","article-title":"Thyroid development in altricial ring doves, Streptopelia risoria","volume":"58","author":"McNabb","year":"1985","journal-title":"Gen Comp Endocrinol"},{"key":"2025010317061054900_bib24","doi-asserted-by":"crossref","first-page":"4585","DOI":"10.1021\/es010845q","article-title":"Polybrominated diphenyl ether flame retardants in Virginia freshwater fishes (USA)","volume":"35","author":"Hale","year":"2001","journal-title":"Environ Sci Technol"},{"key":"2025010317061054900_bib25","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3382\/ps.0670052","article-title":"Sensitivity of embryos from duck, goose, herring gull, and various chicken breeds to 3,3\u2032,4,4\u2032-tetrachlo-robiphenyl","volume":"67","author":"Brunstr\u00f6m","year":"1988","journal-title":"Poult Sci"},{"key":"2025010317061054900_bib26","first-page":"213","article-title":"EROD induction by environmental contaminants in avian embryo livers","volume":"121","author":"Brunstr\u00f6m","year":"1998","journal-title":"Comp Biochem Physiol C Toxicol Pharmacol"},{"key":"2025010317061054900_bib27","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0143-1471(86)90043-7","article-title":"Differences in sensitivity of some avian species to the embryotoxicity of a PCB, 3,3\u2032,4,4\u2032-tetrachlorobiphenyl, injected into the eggs","volume":"42","author":"Brunstr\u00f6m","year":"1986","journal-title":"Environ Pollut Ser A"},{"key":"2025010317061054900_bib28","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1006\/taap.2001.9150","article-title":"Role of oxidative stress and antioxidant defense in 3,3\u2032,4,4\u2032,5-pentachlo-robiphenyl-induced toxicity and species-differential sensitivity in chicken and duck embryos","volume":"172","author":"Jin","year":"2001","journal-title":"Toxicol Appl Pharmacol"},{"key":"2025010317061054900_bib29","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1080\/009841099157313","article-title":"Effects of PCB 126 on primary immune organ development in chicken embryos","volume":"58","author":"Fox","year":"1999","journal-title":"J Toxicol Environ Health"},{"key":"2025010317061054900_bib30","first-page":"113","volume-title":"Progress in Drug Metabolism","author":"Walker","year":"1980"},{"key":"2025010317061054900_bib31","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1021\/es034614q","article-title":"Higher brominated diphenyl ethers and hexabromocyclododecane found in eggs of peregrine falcons (Falco peregrinus) breeding in Sweden","volume":"38","author":"Lindberg","year":"2004","journal-title":"Environ Sci Technol"},{"key":"2025010317061054900_bib32","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/BF00332485","article-title":"Toxicity of 7-ethoxyresorufin O-deethylase-inducing potency of coplanar polychlorinated biphenyls (PCBs) in chick embryos","volume":"62","author":"Brunstr\u00f6m","year":"1988","journal-title":"Arch Environ Contam Toxicol"},{"key":"2025010317061054900_bib33","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1007\/BF00212680","article-title":"Effects of 3,3\u2032,4,4\u2032,5-pentachlo-robiphenyl (PCB 126) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) injected into the yolks of chicken (Gallus domesticus) eggs prior to incubation","volume":"31","author":"Powell","year":"1996","journal-title":"Arch Environ Contam Toxicol"},{"key":"2025010317061054900_bib34","volume-title":"Brominated diphenyl ethers","author":"International Program on Chemical Safety","year":"1994"},{"key":"2025010317061054900_bib35","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1897\/06-246R.1","article-title":"Immunotoxicity of the commercial polybrominated diphenyl ether mixture DE-71 in ranch mink (Mustela vison)","volume":"26","author":"Martin","year":"2007","journal-title":"Environ Toxicol Chem"},{"key":"2025010317061054900_bib36","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/0045-6535(93)90322-V","article-title":"Occurrence and effects of PCBs, PCDDs, and PCDFs in hatchlings of the common tern (Sterna hirundo)","volume":"27","author":"Bosveld","year":"1993","journal-title":"Chemosphere"},{"key":"2025010317061054900_bib37","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1002\/etc.5620131112","article-title":"Relation among cytochrome P450, Ah-active PCB congeners and dioxin equivalents in pipping black-crowned night-heron embryos","volume":"13","author":"Rattner","year":"1994","journal-title":"Environ Toxicol Chem"},{"key":"2025010317061054900_bib38","doi-asserted-by":"crossref","first-page":"6252","DOI":"10.1073\/pnas.0509950103","article-title":"The molecular basis for differential dioxin sensitivity in birds: Role of aryl hydrocarbon receptor","volume":"103","author":"Karchner","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"2025010317061054900_bib39","doi-asserted-by":"crossref","first-page":"7535","DOI":"10.1021\/es801082a","article-title":"Key amino acids in the aryl hydrocarbon receptor predict dioxin sensitivity in avian species","volume":"42","author":"Head","year":"2008","journal-title":"Environ Sci Technol"},{"key":"2025010317061054900_bib40","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1093\/toxsci\/kfg236","article-title":"Polybrominated diphenyl ethers as Ah receptor agonists and antagonists","volume":"76","author":"Chen","year":"2003","journal-title":"Toxicol Sci"},{"key":"2025010317061054900_bib41","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1093\/toxsci\/kfh284","article-title":"Effects of polybrominated diphenyl ethers on basal and TCDD-induced ethoxyresorufin activity and cytochrome P450\u20131A1 expression in MCF-7, HepG2, and H411E cells","volume":"82","author":"Peters","year":"2004","journal-title":"Toxicol Sci"},{"key":"2025010317061054900_bib42","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1093\/toxsci\/kfj186","article-title":"Interactions of polybrominated diphenyl ethers with the aryl hydrocarbon receptor pathway","volume":"92","author":"Peters","year":"2006","journal-title":"Toxicol Sci"},{"key":"2025010317061054900_bib43","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0041-008X(84)90319-3","article-title":"Coordinate induction of cytochrome P-448 mediated mixed function oxidases and histopathologic changes produced acutely in chick embryo liver by polychlorinated biphenyl congeners","volume":"72","author":"Rifkind","year":"1984","journal-title":"Toxicol Appl Pharmacol"},{"key":"2025010317061054900_bib44","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1289\/ehp.98106775","article-title":"Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife","volume":"106","author":"Van den Berg","year":"1998","journal-title":"Environ Health Perspect"},{"key":"2025010317061054900_bib45","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1006\/faat.1996.0189","article-title":"Developmental toxicity of PCB 126 (3,3\u2032,4,4\u2032,5-pentachlorobiphenyl) in nestling American kestrels (Falco sparverius)","volume":"34","author":"Hoffman","year":"1996","journal-title":"Fund Appl Toxicol"},{"key":"2025010317061054900_bib46","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1080\/15287390701384536","article-title":"Health of herring gulls (Larus argentatus) in relation to breeding location in the early 1990s. II. Cellular and histopathological measures","volume":"70","author":"Fox","year":"2007","journal-title":"J Toxicol Environ Health A"},{"key":"2025010317061054900_bib47","doi-asserted-by":"crossref","first-page":"736","DOI":"10.2307\/4085270","article-title":"Thyroid development in precocial and altricial avian embryos","volume":"94","author":"McNabb","year":"1977","journal-title":"Auk"},{"key":"2025010317061054900_bib48","first-page":"393","volume-title":"The Endocrinology of Growth, Development and Metabolism in Vertebrates","author":"McNabb","year":"1992"},{"key":"2025010317061054900_bib49","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1046\/j.1525-142X.2003.03012.x","article-title":"Avian thyroid development in chemically contaminated environments: Is there evidence of alterations in thyroid function and development?","volume":"5","author":"McNabb","year":"2003","journal-title":"Evol Dev"},{"key":"2025010317061054900_bib50","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1093\/toxsci\/kfh247","article-title":"Does thyroid function in developing birds adapt to sustained ammonium perchlorate exposure?","volume":"82","author":"McNabb","year":"2004","journal-title":"Toxicol Sci"},{"key":"2025010317061054900_bib51","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1897\/03-362","article-title":"Ammonium perchlorate effects on thyroid function and growth in bobwhite quail chicks","volume":"23","author":"McNabb","year":"2004","journal-title":"Environ Toxicol Chem"},{"key":"2025010317061054900_bib52","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/s002040000208","article-title":"Effects of polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) on thyroid hormone and vitamin A levels in rats and mice","volume":"75","author":"Hallgren","year":"2001","journal-title":"Arch Toxicol"},{"key":"2025010317061054900_bib53","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0300-483X(02)00222-6","article-title":"Polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs) and chlorinated paraffins (CPs) in rats\u2014Testing interactions and mechanisms for thyroid hormone effects","volume":"177","author":"Hallgren","year":"2002","journal-title":"Toxicology"},{"key":"2025010317061054900_bib54","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.taap.2007.09.015","article-title":"Possible mechanisms of thyroid hormone disruption in mice by BDE-47, a major polybrominated diphenyl ether congener","volume":"226","author":"Richardson","year":"2008","journal-title":"Toxicol Appl Pharmacol"},{"key":"2025010317061054900_bib55","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1080\/15287390590903720","article-title":"Effects of PCB 126 on primary immune organs and thymocyte apoptosis in chicken embryos","volume":"68","author":"Goff","year":"2005","journal-title":"J Toxicol Environ Health A"},{"key":"2025010317061054900_bib56","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s00244-006-0150-z","article-title":"Effect of in ovo exposure to an organochlorine mixture extracted from double-crested cormorant eggs (Phalacrocorax auritus) and PCB 126 on immune function of juvenile chickens","volume":"53","author":"Lavoie","year":"2007","journal-title":"Arch Environ Contam Toxicol"},{"key":"2025010317061054900_bib57","first-page":"165","volume-title":"Environmental Contaminants in Wildlife: Interpreting Tissue Concentrations","author":"Hoffman","year":"1996"},{"key":"2025010317061054900_bib58","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s00244-008-9160-3","article-title":"Species differences in the sensitivity of avian embryos to methylmercury","volume":"56","author":"Heinz","year":"2009","journal-title":"Arch Environ Contam Toxicol"},{"key":"2025010317061054900_bib59","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0045-6535(02)00063-2","article-title":"Uptake of injected PCBs from the yolk by the developing embryo","volume":"48","author":"de Roode","year":"2002","journal-title":"Chemosphere"},{"key":"2025010317061054900_bib60","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1897\/04-266R.1","article-title":"Uptake and tissue-specific distribution of selected polychlorinated biphenyls in developing chicken embryos","volume":"24","author":"Maervoet","year":"2005","journal-title":"Environ Toxicol Chem"}],"container-title":["Environmental Toxicology and Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1897%2F08-318.1","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/etc\/article-pdf\/28\/5\/1007\/59854453\/5620280515.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/etc\/article-pdf\/28\/5\/1007\/59854453\/5620280515.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T01:53:11Z","timestamp":1738720391000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/etc\/article\/28\/5\/1007\/7763825"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5,1]]},"references-count":60,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2009,5,1]]},"published-print":{"date-parts":[[2009,5,1]]}},"URL":"https:\/\/doi.org\/10.1897\/08-318.1","relation":{},"ISSN":["0730-7268","1552-8618"],"issn-type":[{"value":"0730-7268","type":"print"},{"value":"1552-8618","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2009,5,1]]},"published":{"date-parts":[[2009,5,1]]},"assertion":[{"value":"2008-07-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-11-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-12-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}