{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:44:09Z","timestamp":1791337449349,"version":"4.3.1"},"reference-count":145,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2010,1,6]],"date-time":"2010-01-06T00:00:00Z","timestamp":1262736000000},"content-version":"vor","delay-in-days":158,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["setac.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2009,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The interaction between mercury (Hg) and selenium (Se) is one of the best known examples of biological antagonism, yet the underlying mechanism remains unclear. This review focuses on the possible pathways leading to the Hg-Se antagonism, with an emphasis on the potential Hg-Se compounds that are responsible for the antagonism at the molecular level (i.e., bis[methylmercuric]selenide, methylmercury selenocysteinate, selenoprotein P-bound HgSe clusters, and the biominerals HgSexS1\u2212x). The presence of these compounds in biological systems has been suggested by direct or indirect evidence, and their chemical properties support their potentially key roles in alleviating the toxicity of Hg and Se (at high Hg and Se exposures, respectively) and deficiency of Se (at low Se exposures). Direct analytical evidences are needed, however, to confirm their in vivo presence and metabolic pathways, as well as to identify the roles of other potential Hg-Se compounds. Further studies are also warranted for the determination of thermodynamic properties of these compounds under physiological conditions toward a better understanding of the Hg-Se antagonism in biota, particularly under real world exposure scenarios.<\/jats:p>","DOI":"10.1897\/08-375.1","type":"journal-article","created":{"date-parts":[[2009,7,15]],"date-time":"2009-07-15T12:31:20Z","timestamp":1247661080000},"page":"1567-1577","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":429,"title":["Mercury-selenium compounds and their toxicological significance: Toward a molecular understanding of the mercury-selenium antagonism"],"prefix":"10.1093","volume":"28","author":[{"given":"Mohammad A.K.","family":"Khan","sequence":"first","affiliation":[{"name":"Department of Chemistry, University of Manitoba, Winnipeg MB R3T 2N2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feiyue","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Environment and Geography, University of Manitoba, Winnipeg MB R3T 2N2, Canada"},{"name":"Department of Chemistry, University of Manitoba, Winnipeg MB R3T 2N2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,8,1]]},"reference":[{"key":"2025010317061177500_bib1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1579\/0044-7447(2007)36[3:MEAHEI]2.0.CO;2","article-title":"Methylmercury exposure and health effects in humans: A worldwide concern","volume":"36","author":"Mergler","year":"2007","journal-title":"Ambio"},{"key":"2025010317061177500_bib2","volume-title":"Methylmercury","author":"World Health Organization","year":"1990"},{"key":"2025010317061177500_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/10408449509089885","article-title":"Minamata disease: Methylmercury poisoning in Japan caused by environmental pollution","volume":"25","author":"Harada","year":"1995","journal-title":"Crit Rev Toxicol"},{"key":"2025010317061177500_bib4","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0140-6736(58)90348-9","article-title":"Minamata disease: An unusual neurological disorder caused by contaminated fish","volume":"2","author":"McAlpine","year":"1958","journal-title":"Lancet"},{"key":"2025010317061177500_bib5","doi-asserted-by":"crossref","first-page":"230241","DOI":"10.1126\/science.181.4096.230","article-title":"Methylmercury poisoning in Iraq","volume":"181","author":"Bakir","year":"1973","journal-title":"Science"},{"key":"2025010317061177500_bib6","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0300-483X(80)90006-2","article-title":"The role of biotransformation in organic mercury neurotoxicity","volume":"15","author":"Gallagher","year":"1980","journal-title":"Toxicology"},{"key":"2025010317061177500_bib7","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1080\/15287399309531777","article-title":"Intrarenal distribution of inorganic mercury and albumin after coadministration","volume":"40","author":"Zalups","year":"1993","journal-title":"J Toxicol Environ Health"},{"key":"2025010317061177500_bib8","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0300-483X(95)03297-S","article-title":"Nephrotoxicity of inorganic mercury co-administered with L-cysteine","volume":"109","author":"Zalups","year":"1996","journal-title":"Toxicology"},{"key":"2025010317061177500_bib9","first-page":"1225","article-title":"Renal tubular lesions caused by mercuric chloride. 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