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While most of the evidence is negative [24,25], a few studies report in vivo effects of phthalates on estrogen-dependent endpoints. Christiansen et al. found that BBP, but not DBP, induced vitellogenin in rainbow trout at concentrations of 500 and 1,000 mg\/kg administered via intraperitoneal injection [26]. Kim et al. found that DEHP elicited potentially antiestrogenic effects in female medaka, as evidenced by decreased vitellogenin levels, decreased gonadal-somatic indices, and immature oocytes in DEHP-treated females as compared to their control counter-parts [27].<\/jats:p>","DOI":"10.1897\/09-018.1","type":"journal-article","created":{"date-parts":[[2009,5,19]],"date-time":"2009-05-19T21:45:48Z","timestamp":1242769548000},"page":"2175-2181","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Comparison of chemical binding to recombinant fathead minnow and human estrogen receptors alpha in whole cell and cell-free binding assays"],"prefix":"10.1093","volume":"28","author":[{"given":"Cynthia V.","family":"Rider","sequence":"first","affiliation":[{"name":"Endocrinology Branch, Reproductive Toxicology Division, U.S. Environmental Protection Agency, MD-72, Research Triangle Park, North Carolina 27711"},{"name":"Department of Molecular Biomedical Sciences, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip C.","family":"Hartig","sequence":"additional","affiliation":[{"name":"Endocrinology Branch, Reproductive Toxicology Division, U.S. Environmental Protection Agency, MD-72, Research Triangle Park, North Carolina 27711"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary C.","family":"Cardon","sequence":"additional","affiliation":[{"name":"Endocrinology Branch, Reproductive Toxicology Division, U.S. Environmental Protection Agency, MD-72, Research Triangle Park, North Carolina 27711"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vickie S.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Endocrinology Branch, Reproductive Toxicology Division, U.S. Environmental Protection Agency, MD-72, Research Triangle Park, North Carolina 27711"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,10,1]]},"reference":[{"key":"2025010317062804500_bib1","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1021\/es9710870","article-title":"Widespread sexual disruption in wild fish","volume":"32","author":"Jobling","year":"1998","journal-title":"Environ Sci Technol"},{"key":"2025010317062804500_bib2","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1021\/es9707973","article-title":"Identification of estrogenic chemicals in STW effluent. 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