{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T09:56:56Z","timestamp":1770976616662,"version":"3.50.1"},"reference-count":34,"publisher":"Raiya Academic International LLC","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Review of Diabetic Studies"],"published-print":{"date-parts":[[2022,3,9]]},"abstract":"<jats:p>\n                    <jats:bold>OBJECTIVE:<\/jats:bold>\n                    In this study, we aimed to evaluate the prevalence of high sensitivity C-reactive protein (hsCRP) as an inflammatory mediator and its association with renal function and other biochemical markers in patients with type 2 diabetes mellitus.\n                    <jats:bold>METHODS:<\/jats:bold>\n                    We carried\n out a cross-sectional study at private healthcare center. We included 453 patients (48.6% males and 51.4% females) with type 2 diabetes mellitus. We obtained socio- demographic, clinical, and laboratory data from patient medical records. We carried out statistical analysis to ascertain associations\n between parameters.\n                    <jats:bold>RESULTS:<\/jats:bold>\n                    The overall risk of cardiovascular disease (hsCRP &gt; 1 mg\/L) among the study participants was 27.2%. Age, gender, body mass index, fasting blood glucose and serum creatinine were significantly associated with risk of cardiovascular disease (hsCRP &gt;\n 1 mg\/L) whereas estimated glomerular filtration rate, vitamin B12, calcium, sodium and metformin users were negatively associated with the hsCRP.\n                    <jats:bold>CONCLUSIONS:<\/jats:bold>\n                    We found a significant positive association of elevated level of C-reactive protein with type 2 diabetes mellitus. Moreover,\n additional to increased cardiovascular disease risk, hsCRP also seems to be a major inflammatory risk marker indicating renal function loss.\n                  <\/jats:p>","DOI":"10.1900\/rds.2022.18.27","type":"journal-article","created":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T00:37:22Z","timestamp":1647563842000},"page":"27-33","source":"Crossref","is-referenced-by-count":6,"title":["Abnormal High-sensitivity C-reactive Protein is Associated with an Increased Risk of Cardiovascular Disease and Renal Dysfunction among Patients Diagnosed with Type 2 Diabetes Mellitus in Palestine"],"prefix":"10.70082","volume":"18","author":[{"given":"Mohammed Husham","family":"Khattab","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, College of Pharmacy and Health Sciences, Ajman University, Ajman, United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moyad 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